TR202009555A2 - Robotic mechanism unit in vitro diagnostic tests and analysis - Google Patents
Robotic mechanism unit in vitro diagnostic tests and analysis Download PDFInfo
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- TR202009555A2 TR202009555A2 TR2020/09555A TR202009555A TR202009555A2 TR 202009555 A2 TR202009555 A2 TR 202009555A2 TR 2020/09555 A TR2020/09555 A TR 2020/09555A TR 202009555 A TR202009555 A TR 202009555A TR 202009555 A2 TR202009555 A2 TR 202009555A2
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- 238000002405 diagnostic procedure Methods 0.000 title claims abstract description 17
- 238000000338 in vitro Methods 0.000 title claims abstract description 13
- 238000004458 analytical method Methods 0.000 title abstract description 14
- 239000003814 drug Substances 0.000 claims abstract description 10
- 238000003745 diagnosis Methods 0.000 claims abstract description 7
- 238000012543 microbiological analysis Methods 0.000 claims abstract description 3
- 238000012360 testing method Methods 0.000 claims description 25
- 238000000034 method Methods 0.000 claims description 18
- 238000002360 preparation method Methods 0.000 claims description 10
- 230000001954 sterilising effect Effects 0.000 claims description 6
- 238000004659 sterilization and disinfection Methods 0.000 claims description 6
- 239000000463 material Substances 0.000 claims description 3
- 239000002906 medical waste Substances 0.000 claims description 3
- 238000012545 processing Methods 0.000 claims description 3
- 238000000605 extraction Methods 0.000 claims description 2
- 108020004707 nucleic acids Proteins 0.000 claims description 2
- 150000007523 nucleic acids Chemical class 0.000 claims description 2
- 102000039446 nucleic acids Human genes 0.000 claims description 2
- 241000282414 Homo sapiens Species 0.000 abstract description 14
- 229940079593 drug Drugs 0.000 abstract description 2
- 241000711573 Coronaviridae Species 0.000 description 4
- 230000008030 elimination Effects 0.000 description 4
- 238000003379 elimination reaction Methods 0.000 description 4
- 208000025721 COVID-19 Diseases 0.000 description 3
- 241000700605 Viruses Species 0.000 description 3
- 238000006243 chemical reaction Methods 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
- 208000015181 infectious disease Diseases 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 230000035945 sensitivity Effects 0.000 description 2
- 238000009589 serological test Methods 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 238000009534 blood test Methods 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 230000002068 genetic effect Effects 0.000 description 1
- 210000000987 immune system Anatomy 0.000 description 1
- 206010022000 influenza Diseases 0.000 description 1
- 230000003834 intracellular effect Effects 0.000 description 1
- 238000009533 lab test Methods 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 238000005192 partition Methods 0.000 description 1
- 230000003252 repetitive effect Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 210000002345 respiratory system Anatomy 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 210000003296 saliva Anatomy 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 230000002459 sustained effect Effects 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 231100000167 toxic agent Toxicity 0.000 description 1
- 239000003440 toxic substance Substances 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/0099—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor comprising robots or similar manipulators
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N2035/00178—Special arrangements of analysers
- G01N2035/00306—Housings, cabinets, control panels (details)
Abstract
Buluş mikrobiyolojik analizler, moleküler tanı, adli tıp, gıda, ilaç analizleri gibi her türlü in vitro tanı testleri ve analizlerinde kullanımı amaçlanan robotik mekanizmaya ilişkindir. Robotik mekanizmanın kullanımı sayesinde in vitro insan faktörü minimuma indirilmekte ve yüksek doğrulukta, hızlı ve verimli analizler yapılması sağlanmaktadır.The invention relates to a robotic mechanism intended for use in all kinds of in vitro diagnostic tests and analyzes such as microbiological analysis, molecular diagnosis, forensic medicine, food, drug analysis. Thanks to the use of robotic mechanism, in vitro human factor is minimized and high accuracy, fast and efficient analyzes are provided.
Description
TARIFNAME IN VITRO TANI TESTLERI VE ANALIZLERIINDE KULLANIM AMAÇLANÂN ROBOTIK MEKANIZMA ÜNITESI Teknik Alan BUIUS mikrobiyolojik analizler, noleküler tani, adli tip, gida, ilaç gibi her türlü in vitro tani testleri ve analizlerinde kullanimi anaçlanan robotik nekaniznaya iliskindir. Robotik mekanizmanin kullanini sayesinde in vitro insan faktörü devreden çikartilnakta ve yüksek d0grulukta, hizli ve verimli analizler yapilma& saglanmaktadir Teknigin Bilinen Durunu Fransizca tenelli bir sözcük olan laboratuvar, sözlük anlamiyla “türlü arastirnn, incelene ve deneylerin yapildigi ve bunlar için gereken araç, nadde ve aygitlarin bulundugu yer” olarak taninianabilir. DESCRIPTION INTENDED FOR USE IN IN VITRO DIAGNOSTIC TESTS AND ANALYSIS ROBOTIC MECHANISM UNIT Technical Area BUIUS microbiological analysis, nolecular diagnosis, forensic medicine, all kinds of in vitro diagnostic tests such as food, medicine, and robotic nekaniznaya, the use of which is intended for analysis is related. Thanks to the use of the robotic mechanism In vitro human factor is deactivated and high Accurate, fast and efficient analysis & is provided State of the Art laboratory, a French-sounding word, dictionary literally "all kinds of research, study and experimentation made and the tools, materials and devices required for these known as “the place where it is located”.
Laboratuvar ortaminda tip, ilaç, gida, tarint hayvancilik sektörlerindeki klinik laboratuvar testleri, bakteriler, HIV, influenza, h1n1, toksik nadde tespiti, tür tayinlen solununi yolu virüsleri vb. anaçli çok farkli analizler yapilabilnektedin Laboratuvar ortaninda gerçeklestirilen bu analizler, örneklerin ve reaktiflerin eklennesi, çikartilnasi, karistirilnasi ve dagitilnasi gibi zorlu, tekrarli ve hassas farkli operasyonlarin isletilnesi ile gerçeklestirilnektedin Günümüzde ortaya çikan CDVID 19 salgini ile birlikte bu tip laboratuvar analizlerinin önemi de giderek artnaktadir. Medicine, medicine, food, tarint animal husbandry in laboratory environment clinical laboratory tests, bacteria, HIV, influenza, h1n1, toxic substance detection, species determination respiratory tract viruses etc. many different analyzes with rootstock you can do These analyzes carried out in the middle of the laboratory, addition, subtraction of samples and reagents, difficult, repetitive and with the precise operation of different operations you have been performing With the current CDVID 19 epidemic, this type of The importance of laboratory analyzes is also increasing.
Enfekte OIWUS kisilerin ortaya çikartilnasi salginin önüne geçilnesi ya da yavaslatilnasi için önemli bir avantaj saglayacaktin Yeni tip koronavirüsün (SARS-CoV-Z) yol açtigi Covid-19'u test edebilnek için baslica iki yönteninevcuttur. Bunlardan biri nevcut enfeksiyonu tespit etnek için yapilan npleküler tani testi, digeriyse yakin zananli enfeksiyonu ortaya çikaran serolojik test, yani kan testidir. Revealing infected OIWUS people ahead of the epidemic an important advantage for overtaking or slowing down you would provide Covid-19 caused by the new type of coronavirus (SARS-CoV-Z) There are basically two ways to test it. Of these nplecular examination to detect an existing infection diagnostic test, the other revealing imminent infection It is a serological test, that is, a blood test.
Kisinin CDVId-lg hastasi olup olnadigini anlananin ilk yolu olan nnleküler tani testi için alinan örneklerde, yeni tip koronavirüse özgü genetik diziler arannaktadir. Bunun için burundan ya da genizden sürüntü çubuklariyla alinan örnekler veya tükürük örnekleri kullanilnaktadir. The first way to know if a person has CDVId-lg In the samples taken for the molecular diagnostic test, the new type coronavirus-specific genetic sequences are sought. For this nasal or nasal swab samples or saliva samples are used.
Alinan örnekler laboratuvara ulastiginda genonun parçalari, gen analizini mümkün kilmak amaciyla polineraz zincir reaksiyonuyla (PCR) ç0galtilnaktadir. Sürecin sonunda eger yeni tip koronavirüse özgü 2 gen bulunursa, bu kisinin enfekte oldugu anlamina gelnekte ve sonuç pozitif olarak bildirilnektedir. û ger test yöntemindeyse kisinin yakin zamanda enfekte olup olmadiginin tespit edilnesi üzerinden isletilnektedir. When the samples reach the laboratory, the parts of the geno polynerase chain to enable gene analysis reaction (PCR). At the end of the process if If 2 genes specific to the new type of coronavirus are found, that person's means infected and the result is positive. is reported. û in the case of the test method, whether the person has been recently infected It is operated through the detection of non-existence.
Serolojik test adi verilen bu yöntende, kanda virüse karsi bagisiklik sisteni tarafindan üretilen antikorlara bakilnaktadir. In this method, called serological test, against virus in blood. antibodies produced by the immune system is in stock.
COVID 19 salgini sürecinde npleküler tani testleH d0grulugu yüksek, hizli ve veriMi olnasi nedeni ile ön plana çiknaktadir. Nuclecular diagnostic testing during the COVID 19 epidemic Due to its high accuracy, fast and efficient is on the plan.
Ancak noleküler tani testlerinin teneli olan polineraz zincir reaksiyonu (PCR) islemlerinin alaninda uznan tecrübeli personeller tarafindan hassas ortam k0sullari altinda gerçeklestirilnesi gereknektedir. Sürdürülen prosesin islem adimlari yüksek dikkat ve operasyon hassasiyeti gerektirnektedir. Bu sebeple d0grulanmis bir PCR i sleninin basarisi, isleni gerçeklestiren personelin hassasiyeti ve tekrarlanabilirligine baglidir. However, polynerase, which is the basis of nolecular diagnostic tests, specializing in chain reaction (PCR) processes sensitive environmental conditions by experienced personnel should be performed below. sustained high attention and operation steps of the process requires precision. For this reason, a d0grouped The success of the PCR operator is dependent on the personnel performing the process. its sensitivity and reproducibility.
Bu tip islenlerin sadece ve ancak yetkin personeller tarafindan gerçeklestirilebilnesi bir taraftan islem naliyetini arttirirken diger bir taraftan islem sayisinin yetkin personel sayisi ile kisitlannasina sebep olnaktadir. This type of work can only be carried out by competent personnel. On the one hand, the process can be carried out by while increasing the cost, on the other hand, the number of transactions This causes the number of competent personnel to be limited.
Ozellikle günümüzde OIUsan pandeni döneminde nnleküler tan islemlerinin maliyeti ve islemlerin uygulanabilne kapasitesi daha da önemli hale gelnektedir. Particularly today, in the OIUsan pandemic period, molecular diagnosis cost of transactions and the feasibility of transactions capacity becomes even more important.
Nbvcut teknik dahilinde npleküler tani testlerinin insan narifeti ile gerçeklestirilnesi, testlerin standardizasyonu açisindan da önemli bir handikap olusturnaktadir. Çok tecrübeli operatörün islem hassasiyeti daha yukarida olabilnekteyken, az tecrübeli operatörün islem hassasiyeti daha asagida olabilnektedir. Yine ayni operatör yapnis oldugu tünitestleri ayni hassasiyetle gerçeklestireneyecegi için, ayni operatörün kendi yaptigi testler arasinda bile standartlasna saglanmasi mümkün olnayabilir. Human plecular diagnostic tests within the current technique with the skill, standardization of tests It also constitutes an important handicap in terms of A lot the operation precision of the experienced operator is higher operation sensitivity of the less experienced operator may be further down. Same operator again. that it will not be able to perform the tunitests with the same precision. even between tests performed by the same operator himself. standardization may not be possible.
Yeni tip koronavirüs (SARS-CoV-Z) gibi tehlike arz eden testlerin gerçeklestirilnesi durumunda testi yapan operatör için ciddi riskler 0IUsabilnektedir. Islemi uygulayan operatörün virüsler tarafindan enfekte edilebilmesi mümkün olabilecegi gibi kullanici üzerinde bulunan farki mikroorganiznalar test ortamini enfekte edebilnekte ve test sonuçlarini etkileyebilnektedir. dangers such as the new type of coronavirus (SARS-CoV-Z) operator performing the test in case the tests are performed Serious risks are possible for 0IUs. implementing the action it is possible for the operator to be infected by viruses as possible, the difference on the user microorganisms can infect the test medium and may affect the results.
Bu tip testlerin insan narifetiyle gerçeklestirilnesi sonucunda ortaya çikan bir diger teknik engel ise uygulananin insan tarafindan yapilnasi sebebiyle ortaya çikan hata yapna olasiliklaridir. û ger taraftan uygulanan testlerin insan tarafindan yapilmasi toplam islem süresini ciddi sekilde arttirnakta ve testin tekrarlanabilirligini azaltnakta ve kalitesini düsnektedir. Performing this type of tests with human ingenuity Another technical obstacle that arises as a result of occur due to the fact that what is applied is done by human beings. are the possibilities of making mistakes. û tests performed on the back This significantly increases the total processing time. and reduces the reproducibility of the test and its quality. is correct.
Insan narifetiyle uzmanlik ve tecrübe setlerinin kazanilmasi ve/veya aktarilnasi aylar alnaktadir. Ozellikle günümüzde yasanan COVID 19 pandenisi süreci gibi anlik ortaya çikan riskler ile nücadele edilebilnesi için daha fazla uznan operatöre ihtiyaç duyuldugunda. uznan operatörlerin yetistirilnesi uzun süreler alacagindan pandemiye müdahale etnek oldukça zorlasacaktir. Bu sebepten, yetismis personelin naksinum sayida testi yüksek d0gruluk oraninda yapmasi oldukça önenlidir. Expertise and experience sets with human ingenuity It takes months to acquire and/or transfer it. Especially instantaneous, such as the COVID 19 pandemic process experienced today. in order to cope with the emerging risks, when more specialized operators are needed. your expert Since it will take a long time to train operators Responding to the pandemic will be very difficult. Because of that, high number of tests of qualified personnel It is very important to do so.
Yine yOgun insan faktörü kullanimi sebebiyle ortaya çikan hatalarin sonuçlari çok ciddi olabilir. Bunlarin arasinda asagidakiler sayilabilin o Chreksiz tedavi, - `Tedavi komplikasyonlari, o Uygun tedavinin saglannanasi, o Dogru tanida gecikne, 0 Ek ve gereksiz tani anaçli testler. Again, due to the intense use of human factor, The consequences of mistakes can be very serious. Among them the following can be counted o Chrekless treatment, - `Treatment complications, o Providing appropriate treatment, o Delay in the correct diagnosis, 0 Additional and unnecessary diagnostic rooted tests.
Bu sonuçlar zanan kaybi ve personel çabasi nedeniyle naliyetin artnasina ve ç0gu zanan hasta çiktilarinin Laboratuvar analizleri sirasinda insan faktörü sebebiyle ortaya çikan bu problemlerin ortadan kaldirilabilnesi anaciyla, analizler sirasinda uygulanan islem adimlarindan en az bir bölümünün nakineler yardimiyla yapilnasina imkan veren uygulanalar ortaya çiknaya baslanistin Ancak bahsi geçen uygulanalar tüm islemlerin izole edilnis bir ortanda, tananiyla robotik nekaniznalar tarafindan otonatik olarak yapilmasina uygun yapida degildir. Islem adiniarinda sadece bir tanesinin bile insan marifetiyle izole edilnenis k0sullarda yapilnasi operatörün enfekte olma riski, toplam test süresinin naliyeti/süresinin artmasi, tecrübeli operatör kullanilmasi gibi teknik problenlerin tekrar ortaya çikmasina sebep olacagindan tamamiyla insan narifetiyle isletilen test süreçleri gim olunsuzluklar ortaya çikartnayi sürdürecektir. These results are due to loss of knowledge and staff effort. increase in cost and patient outcomes, which most of them believe Due to human factor during laboratory analysis Elimination of these emerging problems with the rootstock, from the processing steps applied during the analyzes It is possible to make at least a part of it with the help of machines. you are starting to come up with applications that give However, the aforementioned applications are isolated from all processes. in the middle of nowhere, recognized by robotic nekaniznas It is not in a structure suitable to be done automatically. Process by the human ingenuity of even just one of them It should be done in isolated conditions so that the operator is infected. the risk of occurrence is the cost/time of the total test technical increase, such as the use of experienced operators as it will cause the problems to re-emerge. fully human-operated testing processes Inconsistencies will continue to emerge.
BuIUSun Çözümünü Amaçladigi Problemler Bulus, dis ortandan tamamiyla izole edilmis bir analiz haznesi içinde otononi isletilebilen, en az bir robotik nekanizma narifetiyle, her türlü in vitro tani testlerinin ve analizlerinin uygulannasina inkan veren robotik nekaniznayi olusturnayi anaçlanaktadir. Problems This IUS Aims To Solve The invention is an analysis completely isolated from the external environment. at least one robotic device that can be operated autonomously in its chamber by the mechanism of all kinds of in vitro diagnostic tests and robotics that allow analysis to be applied nekaniznayi is intended to form.
BUIUS konusu robotik nekanizma kendisine taninianan ver setleri ile otomatik olarak isletilebilecektir. Bu sayede in vitro tani testlerinin ve analizlerinin uygulannosi için gerekli olan insan ihtiyaci tamamiyla ortadan kaldirilabilnektedir. BUIUS subject robotic necanism can be operated automatically with sets. In this way For the application of in vitro diagnostic tests and analyzes the human need that is necessary is completely eliminated. can be removed.
Bu sayede tani süreçlerinde çalisan uznan personelin sayisinda artisa ihtiyaç duyulnadan personel is yükünü hafifleterek, daha hassas, daha d0gru. daha fazla sayida test yapilabilecektir. In this way, specialist personnel working in diagnostic processes without the need for an increase in the number of personnel workload lighter, more precise, more accurate. more numbers testing can be done.
Test ve analiz süreçlerinin insan narifeti olnaksizin isletilnesi yüksek hassasiyette islemler yapilabilnesine (yaklasik 10 kat) ve islemin çok daha hizli yapilabilnesine (5-10 kat) imkan verirken diger taraftan islem tekrarlanabilirliginin tartismasiz çok yüksek düzeyde (%99,99) tutulabilnesine inkan vernektedir. Without human ingenuity of testing and analysis processes It is possible to carry out high-precision operations. (approximately 10 times) and the fact that the process can be done much faster (5-10 times) while allowing operation on the other hand unquestionably very high level of repeatability (99.99%) deny that it can be retained.
Bu duruni özellikle CDVIE) 19 salgini gibi hizli yayilan hastaliklara anlik ve hizli nüdahale edilnesi için büyük avantaj saglanaktadir. This is especially true of the fast-spreading epidemic like the CDVIE) 19 epidemic. great for instant and rapid intervention to diseases advantage is provided.
Tamamiyla otonasyon ile isletilen robotik nekaniznanin kullanilnasi ile insan faktöründen kaynaklanan beklene süreleri ortadan kalknakta, ara operasyon hazirliklari için kaybedilen zanani sifira indirilnekte ve innün plazma tedavisi için gereken testlerin hizlica yapilmas saglanmaktadin Robotik mekaniznanin hiç duraksatilnaksizin 7/24 isletilebilnesi de bir diger önenli avantaji OIUsturmaktadir. Robotic nekaniznanin operated with full automation expected from human factor time is eliminated, for intermediate operation preparations The lost zanani is reduced to zero and the innumerable plasma the tests required for the treatment of you are being provided 24/7 without any pause of the robotic mechanism Another important advantage is that it can be operated It is working.
Robotik nekanizmanin kullanilmasi ve insan faktörünün neredeyse ortadan kaldirilmasi, uzman personelin naruz kaldigi tüm riskler dahil olnak üzere, özellikle iki yönlü kontaminasyon faktörlerinin %907a yakin oranda ortadan kaldirnasina imkan vermektedir. û ger taraftan insan faktörüne bagli hata yapna olasiligini %90 oraninda ortadan kaldirilnasi anaçlanmaktadir. sekillerin Açiklannasi sekil 1. fhr türlü in vitro tani testleri ve analizlerinde kullanini amaçlanan robotik nekaniznan ünitesinin önden perspektif görünümü, sekil 2. fhr türlü in vitro tani testleri ve analizlerinde kullanimi anaçlanan robotik nekanizna ünitesinin önden ayrintili perspektif görünümü, sekil 3. Fbr türlü in vitro tani testleri ve analizlerinde kullanimi amaçlanan robotik nekanizma ünitesinin üstten görünümü, Sekillerdeki Referanslarin Açiklanasi L Numune giris birimi Tüp üniteü Solüsyon Giris ve Saklana Ünitesi Numune Hazirlana Ünitesi Pipetör Ünitesi Tüp Kapak Açna Ünitesi Nbdikal Atik Kutusu Numune Beklene Ünitesi F) 9› F1 ou F` P* 9) F” Barkod Okuyucu Birim . Vortex Cihazi lL Santrifüj Cihaz 12. PCR Cihazi 13. Robotik elenan 14. Ekran . Tutucu elenan 16. Kanera birini 17. Sterilizasyon birim 18. Filtreli hücre BUIUSUH Açiklanmasi Ü S ortandan izole edilmis bir filtreli hücre (18) içerisinde; numune giris birini (1), tüp ünitesi (2), solüsyon giris ve saklann ünitesi (3), nunune hazirlana ünitesi (4), pipetör ünitesi (5), tüp kapak açma ünitem (6), nedikal atik kutusu (7), numune bekleme ünitesi (8), okuyucu birini (9), vortex cihazi (10), santrifüj cihazi (11), PCR Cihazi (12), robotik elenan (13) ve sterilizasyon Izole edilnis hazne sekil 1'de gösterildigi üzere kutu fornunda filtreli bir hücre (18) olarak OIUsturuImustur. The use of robotic mechanism and the human factor almost elimination, exposure of expert personnel especially two-way, including all risks Elimination of nearly 907% of contamination factors allows it to be removed. û on the other hand, do not make mistakes due to the human factor 90% elimination of the possibility is rooted. Description of figures Figure 1. fhr types of in vitro diagnostic tests and robotic nekaniznan, which is intended to be used in analysis front perspective view of the unit, Figure 2. fhr types of in vitro diagnostic tests and robotic nekanizna, which is used in analysis front detailed perspective view of the unit, Figure 3. All kinds of in vitro diagnostic tests and robotic necanism intended for use in analysis top view of the unit Explanation of References in Figures L Sample input unit tube unit Solution Entry and Storage Unit Sample Preparation Unit Pipettor Unit Tube Capping Unit Nbdikal Waste Box Sample Waiting Unit F) 9› F1 ou F` P* 9) F” Barcode Scanner Unit . Vortex Device l Centrifuge Device 12. PCR Device 13. Robotic elenan 14. Display . holder element 16. Kanera someone 17. Sterilization unit 18. Filtered cell BUIUSUH Explanation A filtered cell (18) isolated from the U S medium in; sample inlet (1), tube unit (2), solution inlet and storage unit (3) unit (4), pipettor unit (5), tube uncapping unit (6), medical waste box (7), sample waiting unit (8), reader (9), vortex device (10), centrifuge device (11), PCR Device (12), robotic element (13) and sterilization Insulated chamber box as shown in figure 1 It is formed as a filtered cell (18) in the form.
BUIUSUH tercih edilen uygulannsina göre filtreli hücre (18), hücre içerisindeki havanin disaridaki havadan ayristirilnasi anaciyla hepa filtre bulundurnaktadir. Filtered cell (18) according to the preferred application of BUIUSUH, air inside the cell than outside air It has a hepa filter with its separating rootstock.
Numune giris birimi (1), alinan numunelerin robotik nekaniznnya yerlestirilnesi için kullanilnnktadir. sekil 1'de gösterilen uygulanaya göre robotik nekanizna ünitesi 2 numune giris birimi (1) ile donatilmistir. Sample entry unit (1), robotic It is used for the placement of nekaniznya. shape robotic nekanizna unit 2 according to the application shown in 1 Equipped with sample input unit (1).
Standart tüp, plate, solüsyon gibi sarf nalzeneler filtrel hücre (18) yan duvarlarindan biri üzerinde oluSturulnuS materyal giris zarfi üzerinden sistene yüklenebilnektedir. Consumables such as standard tube, plate, solution are filtered. cell (18) is formed on one of its side walls material can be loaded into the system via the input envelope.
Tüp ünitesi (2), test hazirlik sürecinde ihtiyaç duyulan tüpler bulundurnaktadir. The tubing unit (2) is the required test preparation process. contains tubes.
Solüsyon giris ve saklana ünitesi (3) ise test için kullanilacak solüsyonlari bulundurnaktadir. BuluSun tercih edilen uygulamasina göre solüsyon giris ve saklama ünitesinde (3) solüsyonlar -20°C,da saklannaktadir. The solution inlet and storage unit (3) is used for testing. It has solutions to be used. BuluSun prefer Solution introduction and storage according to the intended application The solutions are stored in the unit (3) at -20°C.
Numune hazirlana ünitesi (4), robotik elenanin (13) numune hazirlama islemini gerçeklestirdigi bölündür. Sample preparation unit (4), robotic elenanin (13) sample preparation unit It is the partition where the preparation process is carried out.
Pipetör ünitesi (5), numunelerin alinnasi ve solüsyonun hazirlannasi islenlerinde kullanilan birini tanimlanaktadir. The pipettor unit (5) is used to collect samples and It describes the one used in the preparation operations.
Tüp kapak açna ünitesi (6), tüplerin kapaklarinin açilmas ve kapatilnasini saglayan birindir. Tube capping unit (6), capping of tubes and he is the one who ensures that it is closed.
Pipetör uçlari, kapak vb. kullanildiktan sonra atildigi bölümü medikal atik kutusu (7) olarak tanimlamaktadir. Pipettor tips, cap etc. discarded after use defines the section as the medical waste box (7).
Numune beklene ünitesi (8) ise test hazirlik sürecinde beklenesi gereken nununeler tutuldugu alandir. The sample waiting unit (8) is in the test preparation process. It is the area where the samples that should be expected are kept.
Okuyucu birim (9), tüpler ve solüsyonlar üzerindeh etiketleri okuyan birini taninlanaktadir. Bulusun tercih edilen uygulanasi dahilinde okuyucu birim (9) barkod okuyucu fornundadir. The reader (9) is on tubes and solutions. Recognizing someone who reads tags. Find your choice barcode reader unit (9) within its application reader form.
Robotik elenan (13), izole edilnis hazne içerisinde islem yapan birimi tanimlamaktadin BuluSun tercih edilen uygulanasi dahilinde robotik elenan (13) en az 2 kol bulundurur. sekil llde tarif edilen uygulana dahilinde robotik elenan (13) 2 koldan OIUSnaktadir. Robotic element (13), process in an insulated chamber you were describing the unit that made Robotic element within the preferred application of BuluSun (13) has at least 2 arms. described in fig. robotic element (13) from 2 arms OIUS is in cash.
Yine sekil 1'de tarif edilen uygulanaya göre robotik elenan (13), 13 eksenli olarak tasarlanmistir. Robotic element according to the application described in Fig. 1 (13) is designed with 13 axis.
BuluSun sekil 1'de gösterilen uygulamasina. göre 2 koldan OlUSan robotik elenan (13), en az bir kolu üzerinde tutucu birimi (15) ve/veya kanera birinini (16) bulundurur. To the application of BuluSun shown in figure 1. by 2 arms Formed robotic element (13), gripper on at least one arm unit (15) and/or one (16).
BquSun tercih edilen uygulanasi dahilinde tutucu birim (15) kiskaç formundadir. Holder unit (15) within the preferred application of BquSun in clamp form.
Sterilizasyon birini (17), filtreli hücre (18) içinin sterilize edilnesi anaciyla kullanilnaktadir. Bulusun tercih edilen uygulanasina göre sterilizasyon birimi (17) UV-C kaynagi formundadir ve filtreli hücre (18) duvarlari üzerine konumludur. Sterilize one (17) inside the filter cell (18). It is used with its rootstock to be sterilized. find it sterilization unit (17) according to preferred application It is in the form of a UV-C source and has filtered cell (18) walls. is located on.
Uygulanacak test ya da analiz tamamlandiktan sonra filtrel hücre (18) içi sterilizasyon birimi (17) olarak görev yapan UV-C kaynagi ile sterilize edilnektedir. After the test or analysis to be applied is completed, the filter is filtered. acting as an intracellular sterilization unit (17) (18) It is sterilized by UV-C source.
BUIUS konusu robotik mekanizna ünitesi dahilinde konuniu olan robotik elenanlar (13) birbirleri ile is birligi içerisinde ve/veya birbirlerinden baginsiz olarak çalisabilecek sekilde OIUSturulnUStur. The subject of BUIUS is covered within the robotic mechanism unit. robotic workers (13) who are within and/or independently of each other It is OIUSturulnUS so that it can work.
BuluSun tercih edilen uygulanasina göre robotik elenana (13) ait olan her bir kol üzerinde ayni zamanda tutucu birim (15) ve kanera birinini (16) bulundurabilnektedir. Bu sayede tüni süreç gerçek zananli takip edilebilnekte ve süreçlerin kontrolü gerçeklestirilnektedir. According to the preferred application of BuluSun, robotic elenana (13) holding unit at the same time on each arm belonging to (15) and a caner (16). This In this way, the whole process can be followed up with real suspect and processes are controlled.
Bulusun tercih edilen uygulamasi dahilinde filtreli hücre (18) en az bir ekran (14) ile iliskilendirilmistir. Numune hazirlik süreci ve test sonuçlari es zamanli olarak ekran (14) üzerinde görüntülenebilnektedir. The filter cell in the preferred embodiment of the invention (18) is associated with at least one screen (14). Sample The preparation process and test results are displayed simultaneously. (14) can be viewed on it.
BUIUS konusu birden fazla robotik mekanizma ünitesi tek bir yazilina bagli olarak isletilebilir. Ortak yazilim üstünden tek bir admin bütün ünitelere iliskin verileri izleyip yönlendirebilnektedir. BUIUS subject is more than one robotic mechanism unit. can be operated depending on the software. Via common software a single admin can monitor the data of all units and can be directed.
Yine okuyucu birininin (9) takibi ile tüm süreçlerde izlenebilirlik saglannistin Takip ara yüzüne önceden yüklennis farkli operasyon reçeteleri ile farkli programlarda isletilebilnektedir. Again, with the follow-up of a reader (9), in all processes you have provided traceability Different operation preloaded in the tracking interface It can be operated in different programs with prescriptions.
Yine tüni operasyonlara iliskin isleni adinlari, veriler, hatalar, gerçek zananli kayit altina alinabilmektedir. Again, the operand names, data, errors can be recorded with the real suspect.
Yine kullanilan ortak yazilim vasitasiyla hasta ve nunune bazli tüm kayitlar güvenli olarak veri tabaninda saklanabilir ve hastane yönetim sistemi ile entegre çalisabilin Bulus konusu robotik nekanizma ünitesinin nbleküler tan için kullanilan uygulanasi asagidaki sekilde isletilnektedir. o Numune giris birini (1) üzerinden numunenin sistene girilnesi, - Numunelerin teste hazir hale getirilnesi, Nükleik asit ekstraksiyonu, PCR cihazina numunenin verilnßsi, PCR cihazinin çalistirilnasi ve test sonucunun olusturulnasi isleniadiniarindan olusnaktadir. Again, through the common software used, the patient and the sample All records based on data are stored securely in the database. can be stored and integrated with the hospital management system you can work In the blecular diagnosis of the robotic necanism unit, which is the subject of the invention, The application used for is being operated. o Input the sample into the system via one (1) of the sample inlets. to be entered, - Preparing the samples for testing, nucleic acid extraction, Giving the sample to the PCR device, Operation of the PCR device and test result Its creation consists of operandnames.
Claims (1)
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| TR2020/09555A TR202009555A2 (en) | 2020-06-19 | 2020-06-19 | Robotic mechanism unit in vitro diagnostic tests and analysis |
| PCT/TR2021/050631 WO2021257041A1 (en) | 2020-06-19 | 2021-06-19 | Robotic mechanism unit intended to be used in in-vitro diagnostic tests and analysis |
| DE212021000370.2U DE212021000370U1 (en) | 2020-06-19 | 2021-06-19 | Robot mechanism assembly for use in in vitro diagnostic testing and analysis |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| TR2020/09555A TR202009555A2 (en) | 2020-06-19 | 2020-06-19 | Robotic mechanism unit in vitro diagnostic tests and analysis |
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| Publication Number | Publication Date |
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| TR202009555A2 true TR202009555A2 (en) | 2020-07-21 |
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| Application Number | Title | Priority Date | Filing Date |
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| TR2020/09555A TR202009555A2 (en) | 2020-06-19 | 2020-06-19 | Robotic mechanism unit in vitro diagnostic tests and analysis |
Country Status (3)
| Country | Link |
|---|---|
| DE (1) | DE212021000370U1 (en) |
| TR (1) | TR202009555A2 (en) |
| WO (1) | WO2021257041A1 (en) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| EP3731959A4 (en) | 2017-12-29 | 2021-10-13 | Clear Labs Inc. | Automated priming and library loading device |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5656493A (en) * | 1985-03-28 | 1997-08-12 | The Perkin-Elmer Corporation | System for automated performance of the polymerase chain reaction |
| DE10017802A1 (en) * | 2000-04-10 | 2001-10-11 | Bilatec Ges Zur Entwicklung Bi | Laboratory robot, useful for automated isolation of nucleic acid, includes orientation device to ensure proper alignment between robotic arm and unit being transported |
| WO2005009202A2 (en) * | 2003-05-12 | 2005-02-03 | Isis Pharmaceuticals, Inc. | Automatic identification of bioagents |
| US9114399B2 (en) * | 2010-08-31 | 2015-08-25 | Canon U.S. Life Sciences, Inc. | System and method for serial processing of multiple nucleic acid assays |
| AU2015261711B2 (en) * | 2010-10-29 | 2017-11-09 | Thermo Fisher Scientific Oy | Automated system for sample preparation and analysis |
| JP6165755B2 (en) * | 2011-11-07 | 2017-07-19 | ベックマン コールター， インコーポレイテッド | Robot arm |
-
2020
- 2020-06-19 TR TR2020/09555A patent/TR202009555A2/en unknown
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2021
- 2021-06-19 DE DE212021000370.2U patent/DE212021000370U1/en active Active
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| WO2021257041A1 (en) | 2021-12-23 |
| DE212021000370U1 (en) | 2023-01-12 |
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