TR201907379T4 - New anti-human PAI-1 antibody. - Google Patents
New anti-human PAI-1 antibody. Download PDFInfo
- Publication number
- TR201907379T4 TR201907379T4 TR2019/07379T TR201907379T TR201907379T4 TR 201907379 T4 TR201907379 T4 TR 201907379T4 TR 2019/07379 T TR2019/07379 T TR 2019/07379T TR 201907379 T TR201907379 T TR 201907379T TR 201907379 T4 TR201907379 T4 TR 201907379T4
- Authority
- TR
- Turkey
- Prior art keywords
- human pai
- antibody
- pai
- seq
- new anti
- Prior art date
Links
- 102000012335 Plasminogen Activator Inhibitor 1 Human genes 0.000 title abstract 3
- 108010022233 Plasminogen Activator Inhibitor 1 Proteins 0.000 title abstract 3
- 101000609255 Homo sapiens Plasminogen activator inhibitor 1 Proteins 0.000 abstract 2
- 150000001413 amino acids Chemical group 0.000 abstract 2
- 102000043283 human SERPINE1 Human genes 0.000 abstract 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 abstract 1
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 208000005069 pulmonary fibrosis Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/38—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against protease inhibitors of peptide structure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- A61K2039/507—Comprising a combination of two or more separate antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
- C12N2510/02—Cells for production
Abstract
Aktif insan PAI-1'e bağlanmak ve aktif insan PAI-1'in aracılık ettiği etkileri inhibe etmek suretiyle pulmoner fibrozu önlemek veya tedavi etmek için bir anti-insan PAI-1 antikoru sağlamak. [Çözüm için Araçlar] Mevcut buluşun sahipleri anti-PAI-1 antikorlarını incelemiş ve sonuç olarak SEQ ID NO:2'deki 1 ila 118 numaralı amino asitlerden oluşan amino asit dizisinden meydana gelen bir ağır zincir değişken bölgesini ve SEQ ID NO:4'teki 1 ila 108 numaralı amino asitlerden oluşan amino asit dizisinden meydana gelen bir hafif zincir değişken bölgesini içeren bir anti-insan PAI-1 antikoru sağlamıştır.Providing an anti-human PAI-1 antibody to prevent or treat pulmonary fibrosis by binding to active human PAI-1 and inhibiting effects mediated by active human PAI-1. [Tools for Solution] The present inventors examined anti-PAI-1 antibodies and as a result, a heavy chain variable region consisting of amino acids sequence 1 to 118 in SEQ ID NO: 2 and in SEQ ID NO: It provided an anti-human PAI-1 antibody containing a light chain variable region consisting of amino acid sequence of amino acids 1 to 108.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2014031319 | 2014-02-21 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TR201907379T4 true TR201907379T4 (en) | 2019-06-21 |
Family
ID=53878402
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TR2019/07379T TR201907379T4 (en) | 2014-02-21 | 2015-02-20 | New anti-human PAI-1 antibody. |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US9803024B2 (en) |
| EP (1) | EP3109320B1 (en) |
| JP (1) | JP6512213B2 (en) |
| KR (1) | KR20160124840A (en) |
| CN (1) | CN106029884B (en) |
| BR (1) | BR112016019332A2 (en) |
| CA (1) | CA2939897A1 (en) |
| ES (1) | ES2726915T3 (en) |
| MX (1) | MX2016010852A (en) |
| PL (1) | PL3109320T3 (en) |
| PT (1) | PT3109320T (en) |
| RU (1) | RU2016137486A (en) |
| TR (1) | TR201907379T4 (en) |
| WO (1) | WO2015125904A1 (en) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW202123962A (en) * | 2016-12-15 | 2021-07-01 | 大陸商深圳瑞健生命科學研究院有限公司 | Method for preventing and treating kidney fibrosis |
| TWI657823B (en) * | 2016-12-15 | 2019-05-01 | 大陸商深圳瑞健生命科學研究院有限公司 | Method for preventing and treating systemic sclerosis |
| CA3067890A1 (en) | 2017-06-19 | 2018-12-27 | Talengen International Limited | Method for regulating and controling glp-1/glp-1r and drug |
| EP4039276A4 (en) | 2019-09-30 | 2023-11-15 | Renascience Inc. | Inhibitor against expression of immune checkpoint molecule |
| CN111072780B (en) * | 2020-03-24 | 2020-06-23 | 深圳汉盛汇融再生医学科技有限公司 | Leukemia stem cell inhibitor and application thereof in treating chronic granulocytic leukemia |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3742997A1 (en) * | 1987-12-18 | 1989-06-29 | Behringwerke Ag | PEPTIDES, METHOD FOR THE PRODUCTION THEREOF, THEIR USE FOR THE OBTAINING OF ANTIBODIES, AND THEIR USE FOR BLOCKING THE PAI-1 ACTIVITY OF HUMAN BLOOD |
| AU2002216847A1 (en) * | 2000-10-26 | 2002-05-06 | K.U. Leuven Research And Development | Epitopes of pai-1 |
| AU2003301809A1 (en) * | 2002-05-13 | 2004-06-07 | Children's Hospital Los Angeles | Treatment and prevention of abnormal scar formation in keloids and other cutaneous or internal wounds or lesions |
| US7771720B2 (en) * | 2007-09-07 | 2010-08-10 | Cisthera, Inc. | Humanized PAI-1 antibodies |
| CN101654405A (en) * | 2008-08-19 | 2010-02-24 | 信谊药厂 | Anticoagulant compound, composition and application thereof |
| US20100254979A1 (en) | 2009-03-06 | 2010-10-07 | Cisthera, Incorporated | Humanized PAI-1 Antibodies and Uses Thereof |
| EP2566514A4 (en) * | 2010-05-03 | 2013-11-27 | Abbvie Inc | Methods of inhibiting fibrosis using anti-pai-1 antibodies |
-
2015
- 2015-02-20 CA CA2939897A patent/CA2939897A1/en not_active Abandoned
- 2015-02-20 PL PL15751458T patent/PL3109320T3/en unknown
- 2015-02-20 ES ES15751458T patent/ES2726915T3/en active Active
- 2015-02-20 CN CN201580009780.9A patent/CN106029884B/en active Active
- 2015-02-20 MX MX2016010852A patent/MX2016010852A/en unknown
- 2015-02-20 KR KR1020167025778A patent/KR20160124840A/en unknown
- 2015-02-20 WO PCT/JP2015/054704 patent/WO2015125904A1/en active Application Filing
- 2015-02-20 RU RU2016137486A patent/RU2016137486A/en not_active Application Discontinuation
- 2015-02-20 BR BR112016019332A patent/BR112016019332A2/en not_active IP Right Cessation
- 2015-02-20 US US15/120,257 patent/US9803024B2/en active Active
- 2015-02-20 TR TR2019/07379T patent/TR201907379T4/en unknown
- 2015-02-20 PT PT15751458T patent/PT3109320T/en unknown
- 2015-02-20 JP JP2016504181A patent/JP6512213B2/en active Active
- 2015-02-20 EP EP15751458.9A patent/EP3109320B1/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| RU2016137486A (en) | 2018-03-22 |
| CN106029884A (en) | 2016-10-12 |
| BR112016019332A2 (en) | 2017-10-10 |
| PT3109320T (en) | 2019-06-06 |
| US9803024B2 (en) | 2017-10-31 |
| US20160369008A1 (en) | 2016-12-22 |
| MX2016010852A (en) | 2016-10-26 |
| WO2015125904A1 (en) | 2015-08-27 |
| PL3109320T3 (en) | 2019-08-30 |
| EP3109320A4 (en) | 2017-09-20 |
| EP3109320A1 (en) | 2016-12-28 |
| CA2939897A1 (en) | 2015-08-27 |
| KR20160124840A (en) | 2016-10-28 |
| EP3109320B1 (en) | 2019-03-27 |
| RU2016137486A3 (en) | 2018-07-27 |
| JPWO2015125904A1 (en) | 2017-03-30 |
| ES2726915T3 (en) | 2019-10-10 |
| JP6512213B2 (en) | 2019-05-15 |
| CN106029884B (en) | 2019-06-25 |
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