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Publication of TR201906892T4publicationCriticalpatent/TR201906892T4/en
Pharmaceuticals Containing Other Organic And Inorganic Compounds
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Abstract
Pd katalizi altında ve Bileşik I'in verilmesi için fosfin ligandlarının varlığında formül (II, III, IV)'e ait bileşiklerin tepkime girmesini kapsayan, 1-[2-(2,4-dimetil-fenilsülfanil)-fenil]-piperazin ve bunun farmasötik olarak kabul edilebilir tuzlarının üretimine yönelik bir proses açıklanmaktadır.1- [2- (2,4-dimethyl-phenylsulfanyl) -phenyl] -piperazine, which involves the reaction of compounds of formula (II, III, IV) under Pd catalysis and in the presence of phosphine ligands to give Compound I A process for the production of pharmaceutically acceptable salts is disclosed.
TR2019/06892T2012-01-032012-12-20
Process for the production of 1- [2- (2,4-dimethyl-phenylsulfanyl) -phenyl] -piperazine.
TR201906892T4
(en)
Novel method for SYNTHESISING (2E)-3-(3,4-DIMETHOXYPHENYL)PROP-2-ENENITRILE, AND USE FOR SYNTHESISING IVABRADINE AND THE ADDED SALTS THEREOF WITH A PHARMACEUTICALLY ACCEPTABLE ACID
Process for the synthesis of 3-(2-bromo-4,5-dimethoxyphenyl)propanenitrile, and application in the synthesis of ivabradine and addition salts threof with a pharmaceutically acceptable acid