TR201904095A2 - THE METHOD OF OBTAINING A BIO-DEGRADABLE GEL - Google Patents
THE METHOD OF OBTAINING A BIO-DEGRADABLE GEL Download PDFInfo
- Publication number
- TR201904095A2 TR201904095A2 TR2019/04095A TR201904095A TR201904095A2 TR 201904095 A2 TR201904095 A2 TR 201904095A2 TR 2019/04095 A TR2019/04095 A TR 2019/04095A TR 201904095 A TR201904095 A TR 201904095A TR 201904095 A2 TR201904095 A2 TR 201904095A2
- Authority
- TR
- Turkey
- Prior art keywords
- obtaining
- biodegradable gel
- gel
- biodegradable
- linking
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims abstract description 36
- 230000004044 response Effects 0.000 claims abstract description 8
- 229920001971 elastomer Polymers 0.000 claims abstract description 5
- 239000000806 elastomer Substances 0.000 claims abstract description 5
- 238000006243 chemical reaction Methods 0.000 claims description 17
- 239000000463 material Substances 0.000 claims description 16
- 238000004132 cross linking Methods 0.000 claims description 14
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 8
- CXMXRPHRNRROMY-UHFFFAOYSA-N sebacic acid Chemical compound OC(=O)CCCCCCCCC(O)=O CXMXRPHRNRROMY-UHFFFAOYSA-N 0.000 claims description 8
- 230000017423 tissue regeneration Effects 0.000 claims description 7
- 239000002202 Polyethylene glycol Substances 0.000 claims description 6
- 229920001223 polyethylene glycol Polymers 0.000 claims description 6
- 238000011069 regeneration method Methods 0.000 claims description 6
- 230000001588 bifunctional effect Effects 0.000 claims description 5
- RYYVLZVUVIJVGH-UHFFFAOYSA-N caffeine Chemical compound CN1C(=O)N(C)C(=O)C2=C1N=CN2C RYYVLZVUVIJVGH-UHFFFAOYSA-N 0.000 claims description 4
- 239000003054 catalyst Substances 0.000 claims description 4
- 238000009833 condensation Methods 0.000 claims description 4
- 230000005494 condensation Effects 0.000 claims description 4
- 230000007423 decrease Effects 0.000 claims description 3
- 230000008439 repair process Effects 0.000 claims description 3
- LPHGQDQBBGAPDZ-UHFFFAOYSA-N Isocaffeine Natural products CN1C(=O)N(C)C(=O)C2=C1N(C)C=N2 LPHGQDQBBGAPDZ-UHFFFAOYSA-N 0.000 claims description 2
- 229960001948 caffeine Drugs 0.000 claims description 2
- VJEONQKOZGKCAK-UHFFFAOYSA-N caffeine Natural products CN1C(=O)N(C)C(=O)C2=C1C=CN2C VJEONQKOZGKCAK-UHFFFAOYSA-N 0.000 claims description 2
- 238000012377 drug delivery Methods 0.000 claims description 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 2
- 239000012528 membrane Substances 0.000 claims description 2
- 230000000399 orthopedic effect Effects 0.000 claims description 2
- 239000002245 particle Substances 0.000 claims description 2
- 239000004753 textile Substances 0.000 claims description 2
- 239000002407 tissue scaffold Substances 0.000 claims description 2
- -1 polyethylene Polymers 0.000 claims 2
- 239000004698 Polyethylene Substances 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 229920000573 polyethylene Polymers 0.000 claims 1
- 239000000499 gel Substances 0.000 description 27
- 239000000017 hydrogel Substances 0.000 description 8
- 210000001519 tissue Anatomy 0.000 description 7
- 210000003205 muscle Anatomy 0.000 description 4
- 230000008929 regeneration Effects 0.000 description 4
- 238000002360 preparation method Methods 0.000 description 3
- 210000002435 tendon Anatomy 0.000 description 3
- 229920001661 Chitosan Polymers 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 230000007613 environmental effect Effects 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 231100000252 nontoxic Toxicity 0.000 description 2
- 230000003000 nontoxic effect Effects 0.000 description 2
- 239000004033 plastic Substances 0.000 description 2
- 229920003023 plastic Polymers 0.000 description 2
- 210000004872 soft tissue Anatomy 0.000 description 2
- 238000001356 surgical procedure Methods 0.000 description 2
- 238000003786 synthesis reaction Methods 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 230000004872 arterial blood pressure Effects 0.000 description 1
- 239000003124 biologic agent Substances 0.000 description 1
- 239000012620 biological material Substances 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 239000002649 leather substitute Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000005499 meniscus Effects 0.000 description 1
- 210000004165 myocardium Anatomy 0.000 description 1
- 239000003345 natural gas Substances 0.000 description 1
- 229920005615 natural polymer Polymers 0.000 description 1
- 239000008239 natural water Substances 0.000 description 1
- 230000005693 optoelectronics Effects 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical class [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
- C08G63/02—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds
- C08G63/12—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds derived from polycarboxylic acids and polyhydroxy compounds
- C08G63/40—Polyesters derived from ester-forming derivatives of polycarboxylic acids or of polyhydroxy compounds, other than from esters thereof
- C08G63/42—Cyclic ethers; Cyclic carbonates; Cyclic sulfites; Cyclic orthoesters
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
- C08G63/66—Polyesters containing oxygen in the form of ether groups
- C08G63/668—Polyesters containing oxygen in the form of ether groups derived from polycarboxylic acids and polyhydroxy compounds
- C08G63/672—Dicarboxylic acids and dihydroxy compounds
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
- C08G63/78—Preparation processes
- C08G63/82—Preparation processes characterised by the catalyst used
- C08G63/87—Non-metals or inter-compounds thereof
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Biological Depolymerization Polymers (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Materials For Medical Uses (AREA)
- Processes Of Treating Macromolecular Substances (AREA)
Abstract
Buluş, oda sıcaklığında herhangi bir dış etkiye gerek duyulmadan kendi kendini (otonom olarak) iyileştirebilen, yüksek mukavemet ve esneme özelliklerine aynı anda sahip olan ve küçük gerinim değerlerinde lineer kapasitans cevabını nanomikro Farad seviyelerinde sunabilen transparan biyobozunur bir jel (elastomer) elde etme yöntemi (100) ile ilgilidir.The invention is a method of obtaining a transparent biodegradable gel (elastomer) that can heal itself (autonomously) at room temperature without the need for any external influence, has high strength and elastic properties at the same time, and can offer a linear capacitance response at small strain values at nanomicro Farad levels (100 ) is about.
Description
TARIFNAME BIYOBOZUNUR BIR JE L ELDE ETME YÖNTEMI Teknik Alan Bulus, oda sicakliginda herhangi bir dis etkiye gerek duyulmadan kendi kendini (otonom olarak) iyilestirebilen, yüksek mukavemet ve esneme özelliklerine ayni anda sahip olan ve küçük geriniin degerlerinde lineer kapasitans cevabini nano- mikro Farad seviyelerinde sunabilen transparan biyobozunur bir jel (elastomer) elde etme yöntemi ile ilgilidir. Önceki Teknik Biyobozunur malzemeler, biyolojik ajanlarin etkinliginde bozunarak dogadaki döngüye katilabilen malzemelerdir. Bu parçalanmanin sonunda ortaya COz, N2 gibi bazi dogal gazlar, su ve inorganik tuzlar çikmaktadir. Biyobozunur malzemeler günümüzde plastiklerin çevreye verdigi zarardan dolayi tercih konusu olmus ve gelistirilmeleri amaciyla birçok çalisma yapilmis, yapilmaya da devam edilmektedir. Bu teknoloji ile üretilmis olan ürünler çevre dostudur. Biyobozunur malzemeler, plastik sektörünün yani sira saglik sektöründe de kullanim alanina sahiptir. Bu malzemeler hammadde kaynagina göre nisasta bazli, selüloz bazli, kimyasal sentez yoluyla elde edilenler ve bakteri tarafindan üretilenler olarak gruplandirilmaktadir. Biyobozunur malzemelerin bir türü olan biyobozunur jeller elastomer yapisinda üretilebilinektedir. Sentez sirasinda olusturulan çapraz baglarin miktari arttikça malzemenin nihai dayanimi artmakta ancak esneme özellikleri düsmektedir. B u sebeple giyilebilir elektronik cihaz uygulamalari, biyomaizeme ve doku mühendisligi alanlarinda kullanilmak üzere, esneme özellikleri ve mukavemetleri es zamanli olarak yüksek olan ayni zamanda zamanla bozunabilen, zarar görme durumunda ise herhangi bir dis uyarana ihtiyaç duymadan kendini iyilestiren biyobozunur bir jele ihtiyaç duyulmaktadir. DESCRIPTION METHOD OF OBTAINING A BIODEGRADABLE GEL Technical Area The invention is self-sufficient at room temperature without any external influence. same high strength and resilience properties, able to (autonomously) recover The linear capacitance response at the values of small strain and obtain a transparent biodegradable gel (elastomer) that can deliver at micro Farad levels. relates to the method. Prior Art Biodegradable materials are degraded in the activity of biological agents and materials that can be included in the cycle. At the end of this disintegration, such as CO2, N2 some natural gases, water and inorganic salts are released. Biodegradable materials Nowadays, plastics have become the subject of preference because of the damage they cause to the environment and Many studies have been done and continue to be done in order to develop is being done. The products produced with this technology are environmentally friendly. Biodegradable materials are used in the health sector as well as the plastics industry. has. These materials are starch-based, cellulose-based, as those obtained by chemical synthesis and those produced by bacteria are grouped. Biodegradable gels, a type of biodegradable materials It can be produced in elastomer structure. Crosslinks formed during synthesis As the amount increases, the ultimate strength of the material increases, but its flexural properties increase. is falling. For this reason, wearable electronic device applications, biomaize and for use in tissue engineering, its flexural properties and whose strengths are simultaneously high and which can degrade over time, in case of damage, it can self-stimulate without the need for any external stimulus. There is a need for a biodegradable gel that improves
Teknigin bilinen durumunda yer alan CN106750416 sayili Çin patent dokümaninda kendi kendini iyilestirme ve pH yanit özelliklerine sahip enjekte edilebilir bir hidrojelden bahsedilmektedir. Hidrojel elde etme islemi sirasinda kimyasal reaktiflerin eklenmesi gerekmez ve sonradan saflastirmaya ihtiyaç duyulmaz. Elde edilen hidrojel toksik degildir ve kullanima hazirdir. Hidrojel; N-karboksietil kitosan çözeltisi ve PEGDA polimer çözeltisinin birbirine karistirilmasi ve çapraz baglanmasi ile elde edilinektedir. Bu çözeltiler ile elde edilen hidrojel, kendi kendini iyilestirme özelligine sahip olur ve bu özellik için çevresel uyarima ihtiyaç duymaz. Elde edilen hidrojel, biyolojik olarak parçalanabilen biyomedikal malzemelerin yapiminda kullanilmaktadir. Hidrojel disaridan uygulanan gerinim degisikliklerinden sonra kendi kendini iyilestirme performansi sergiler. In the Chinese patent document numbered CN106750416, which is in the state of the art an injectable with self-healing and pH-response properties. hydrogel is mentioned. During the hydrogel making process, chemical reagents do not need to be added and no post-purification is required. in hand The hydrogel produced is non-toxic and ready to use. hydrogel; N-carboxyethyl mixing chitosan solution and PEGDA polymer solution and cross obtained by binding. The hydrogel obtained with these solutions It has the ability to heal itself and requires environmental stimulation for this feature. does not hear. The resulting hydrogel is a biodegradable biomedical used in the manufacture of materials. Hydrogel externally applied strain exhibits self-healing performance after changes.
Teknigin bilinen durumunda yer alan CN106009003 sayili Çin patent dokümaninda enjekte edilebilir kendi kendini tamir eden bir hidrojel, hazirlama yöntemi ve biyolojik doku mühendisliginde uygulanmasindan bahsedilmektedir. Jel suda çözünürlügü artirilan dogal polimer kitosan ve sodyum hiyalüronat türevi çözeltisinin karistirilmasi ile elde edilir. Elde edilen jel, yüksek mukavemete, iyi biyouyumluluga ve bozunurluga sahiptir ve ticari biyomedikal ürünlerde kullanilmaktadir. Kullanilacak yara alanina göre istenildigi gibi sekillendirilebilir. In the Chinese patent document numbered CN106009003, which is in the state of the art an injectable self-healing hydrogel, its preparation method and Its application in biological tissue engineering is mentioned. in gel water Natural polymer chitosan and sodium hyaluronate derivative with increased solubility obtained by mixing the solution. The resulting gel has high strength, good It is biocompatible and degradable and is used in commercial biomedical products. is used. It can be shaped as desired according to the wound area to be used.
Jel, ortasindan mekanik hasar gördügünde, ara bosluk zamanla kademeli olarak küçülür ve sonunda tamamen kaybolur. When the gel is mechanically damaged in the middle, the intermediate space will gradually decrease over time. shrinks and eventually disappears completely.
Yukarida yer alan patent dokümanlarindan da görülecegi üzere Önceki teknikte kendi kendini iyilestiren jellerin olmasina ragmen bunlarin hiçbiri sicaklik, UV ve diger etmenler olinaksizin kendi kendini tedavi etme özelligine sahip degildir. As can be seen from the above patent documents, in the previous art Although there are self-healing gels, none of them are heat, UV and It does not have the ability to self-medicate, regardless of other factors.
Bulusun Kisa Açiklamasi Bu bulusun amaci, esneme özelligi ve mukavemeti es zamanli olarak yüksek olan ve yapay deri, kas: tendon vb. esneyebilir yumusak doku rejenerasyonuna yardimci olacak doku iskelelerinin hazirlanmasinda kullanilan biyobozunur bir jel elde etme yöntemi gerçeklestirmektir. Brief Description of the Invention The aim of this invention is to provide high flexibility and strength simultaneously. and artificial leather, muscle: tendon etc. Aids in stretchable soft tissue regeneration Obtaining a biodegradable gel used in the preparation of scaffolds to be to implement the method.
Bu bulusun bir baska amaci, Vücut içine yerlestirildikten sonra zamanla bozunup, yerini yeni olusan dokuya birakarak ikinci bir cerrahi islein ihtiyacini ortadan kaldiran biyobozunur bir jel elde etme yöntemi gerçeklestirmektir. Another purpose of this invention is to decompose over time after being placed in the Body, It is replaced by newly formed tissue, eliminating the need for a second surgical procedure. is to perform a method of obtaining a biodegradable gel that removes
Bu bulusun bir baska amaci, kopan parçalarinin birbirine temas ettirilmesi ile otonom sekilde kendini iyilestiren ve tamamen ilk halindeki özelliklere sahip olan biyobozunur bir jel elde etme yöntemi gerçeklestirmektir. Another object of this invention is to bring the broken parts into contact with each other. autonomously self-healing and fully primitive is to realize a method of obtaining a biodegradable gel.
Bu bulusun baska bir amaci, çok küçük gerinim degerlerinde nano-mikro Farad seviyelerinde kapasitif cevap verine özelligi sunan biyobozunur bir jel elde etme yöntemi gerçeklestinnektir. Another object of this invention is nano-micro Farad at very small strain values. Obtaining a biodegradable gel capable of capacitive response at levels method is to be implemented.
Bulusun Ayrintili Açiklamasi Bu bulusun amacina ulasmak için gerçeklestirilen “Biyobozunur Bir Jel E ide Etme Yöntemi” ekli sekilde gösterilmis olup, söz konusu sekil; Sekil 1. Bulus konusu biyobozunur jel elde etme yönteminin akis diyagraminm görünüsüdür. Detailed Description of the Invention To achieve the aim of this invention, “Ideation of a Biodegradable Gel” Method” is shown in the attached figure, the figure in question; Figure 1. The flow diagram of the method of obtaining the biodegradable gel of the invention. is the view.
Sekilde yer alan parçalar tek tek numaralandirilmis olup bu numaralarin karsiliklari asagida verilmistir: 100. Yöntem Bulus konusu oda sicakliginda herhangi bir dis etkiye gerek duyulmadan kendi kendini (Otonom olarak) iyilestirebilen, yüksek mukavemet ve gerinim özelliklerine ayni anda sahip ve küçük gerinim degerlerinde lineer kapasitans cevabini nano- mikro Farad seviyelerinde sunabilen biyobozunurjel elde etme yöntemi (100), -Iki fonksiyonlu bir polietilenglikol molekülünün bir diaSit ile katalizör varliginda bir reaktörde prepolimer reaksiyonunun gerçeklestirilmesi (101) ve -prepolimer reaksiyonunda elde edilen prepolimerin çapraz baglanmasi ile -OH kondenzasyonu gerçeklestirilmesi (102] adimlarini içermektedir. The parts in the figure are numbered one by one and the corresponding numbers are given below: 100. Method The subject of the invention is at room temperature without the need for any external effect. Self-healing, high strength and strain properties at the same time and at small strain values, the linear capacitance response is nano- method of obtaining a biodegradable gel that can deliver at micro Farad levels (100), -In the presence of a bifunctional polyethyleneglycol molecule with a diaSite as a catalyst performing the prepolymer reaction in a reactor (101) and -OH by cross-linking the prepolymer obtained in the -prepolymer reaction performing the condensation (102] steps.
Bulus konusu yöntemde (100) prepolimer reaksiyonu gerçeklestirilmesi (101] adiminda iki fonksiyonlu polietilenglikol molekülü bir polIetilenglikoldiglisidil eterdir. Kullanilan diasit bir sebasik asittir (C10H1804). Polietilenglikoldiglisidil eter ve sebasik asit arasindaki reaksiyonun gerçeklestirilebilmesi için katalizör olarak kafein kullanilmaktadir. Söz konusu prepolimer reaksiyonu tercihen bir mikrodalga reaktörde gerçeklestirilmektedir. Gerçeklestirilen prepolimer reaksiyonu 3-10 dakika arasinda bir sürede tamamlanmaktadir. Performing the prepolymer reaction in the method (100) of the invention (101] In step one, the bifunctional polyethyleneglycol molecule is a polyethyleneglycoldiglycidyl is ether. The diacid used is a sebacic acid (C10H1804). Polyethyleneglycoldiglycidyl ether as a catalyst for the reaction between sebacic acid and caffeine is used. Said prepolymer reaction is preferably a microwave carried out in the reactor. Performed prepolymer reaction 3-10 It is completed in minutes.
Bulus konusu yöntemde (100) gerçeklestirilen prepolimer reaksiyonu (101 l; seklindedir. Reaksiyonun sonunda polietilenglikolsebakat prepolimeri elde edilmektedir. The prepolymer reaction (101 l; is in the form. At the end of the reaction, polyethyleneglycolsebacate prepolymer is obtained. is being done.
Bulus konusu yöntemde (100) çapraz baglanma ile -OH kondenzasyonu gerçeklestirilmesi (102) adiminda, prepolimer reaksiyonu gerçeklestirilme (101) adiminda elde edilen prepolimerde ortaya çikan -OH (hidroksil) gruplari 110- 160°C sicaklik araliginda çapraz baglanmaktadir. Tercih edilen bir uygulamada optimum sicaklik olarak 120°C seçilmektedir. Çapraz baglanma 100 mBar`dan düsük vakum degerlerinde gerçeklestirilmektedir. Çapraz baglanma için gereken süre 24-48 saat arasindadir. Tercih edilen bir uygulamada istenilen özelliklere 24 saatte gerçeklestirilen çapraz baglanma ile ulasilmaktadir. 32-48 saat dilimi arasinda ise uygun malzeme elde edilmekte ancak süre uzadikça elde edile esneklik özelliginde düsüs meydana gelmektedir. Çapraz baglanma sonucunda -OH gruplari tüketilmekte ve polietilenglikolsebakat yani biyobozunur jel (elastomer) elde edilmektedir. In the method of the invention (100), -OH condensation with cross-linking In step (102), performing the prepolymer reaction (101) -OH (hydroxyl) groups formed in the prepolymer obtained in step 110- It is cross-linked in the temperature range of 160°C. In a preferred embodiment 120°C is selected as the optimum temperature. Cross-linking from 100 mBar performed at low vacuum values. Required for cross-linking time is between 24-48 hours. 24 to the desired properties in a preferred application. It can be reached by cross-linking carried out per hour. 32-48 time zones In between, suitable material is obtained, but the flexibility obtained as the time increases decrease occurs in the feature. -OH groups as a result of cross-linking are consumed and polyethyleneglycolsebacate, that is, biodegradable gel (elastomer), is obtained. is being done.
Bulus konusu yöntem (100) ile elde edilen biyobozunur jel fiber halinde ameliyat iplikleri veya örgülü-örgüsüz medikal tekstil ürünleri, yara yanik örtü malzemeleri, membranlar, tibbi yamalar, yumusak ve sert doku onarim/rejenerasyonu için doku iskelesi, yönlendirilmis doku onarim malzemesi, ortopedik uygulamalar için çivi, plaka ve vidalar, partikül formlari da dahil olmak üzere ilaç salim sistemi platformu, kas-tendon onarim malzemesi olarak kullanim alanina sahiptir. Bu alanlarin yaninda biyobozunur olma, esneme ve kapasitif özellikleri bakimindan giyilebilir sensör platformlarinin gelistirilmesinde, biyomedikal alanda farkli yumusak robot (soft robotics) uygulamalarinda algilayici birimlerde, gida, çevre ve diger medikal disi konularda da kullanim potansiyeline sahiptir. Biodegradable gel fiber obtained by the method (100) of the invention yarns or knitted-non-woven medical textile products, wound and burn dressing materials, membranes, medical patches, tissue for soft and hard tissue repair/regeneration scaffolding, guided tissue repair material, nails for orthopedic applications, plate and screws, drug delivery system platform, including particle forms, It is used as a muscle-tendon repair material. of these areas besides, it is wearable in terms of biodegradability, stretching and capacitive properties. In the development of sensor platforms, different soft robots in the biomedical field (soft robotics) applications in sensor units, food, environmental and other medical It has the potential to be used in other matters as well.
Bulus konusu yöntem (100) ile elde edilen biyobozunur jelin sahip oldugu çapraz baglar ile mukavemeti artarken esneme özelligi de kullanilan hammaddeler ve elde etme kosullari sebebiyle es zamanli olarak artmaktadir. Bununla beraber esnetildiginde yüksek transparan özellik göstermektedir. Yüksek mukavemet ve yüksek esneme özelligine ayni anda sahip olabilen söz konusujel; yapay deri, kas, tendon gibi pek çok esneyebilir yumusak dokunun rejenerasyonuna yardimci olabilecek doku iskelelerinin hazirlanmasinda kullanilmaktadir. Bu sekilde kullanilan rejenerasyon malzemeleri ikinci bir cerrahi islem ihtiyacini ortadan kaldirmakta, zamanla bozunarak yerini yeni olusan dokuya birakmaktadir. Jelin kendisi gibi bozunma sonucu olusan ürünlerde toksik olmayan ürünlerdir. The cross of the biodegradable gel obtained by the method (100) of the invention While its strength increases with bonds, its stretching feature also increases with the raw materials used and the hand. increases simultaneously due to the conditions of delivery. With this It shows high transparency when stretched. High strength and the aforementioned gel, which can have high stretching properties at the same time; artificial skin, muscle, Helps regeneration of many flexible soft tissues such as tendons It is used in the preparation of possible tissue scaffolds. In this way The regeneration materials used eliminate the need for a second surgical procedure. removes it, decomposes over time and leaves its place to the newly formed tissue. your gel products formed as a result of decomposition, such as itself, are non-toxic products.
Bulus konusu yöntem (100) ile elde edilen biyobozunur jel, kendi kendini sicaklik, UV ve diger etmenler olmaksizin otonom bir sekilde tedavi etme özelligine sahiptir. The biodegradable gel obtained by the method (100) of the invention, self-temperature, It has the feature of treating autonomously without UV and other factors.
Biyobozunur jel, kopan iki parçanin birbirine temas ettirilmesi ile kendi kendini kisa bir süre içerisinde iyilestirmekte ve tamamen ilk halindeki mukavemet ve eSneme özelligini yeniden kazanmaktadir. Bu özelligi sebebiyle menisküs onarim malzemesi olarak endüstride uygulama bulabilir ve yükler altinda parçalanmasinin ardindan yine temas sonrasinda birleserek eski haline gelebilir. Kas, tendon ve benzeri diger uygulamalarda bu özelligi ile rejenerasyon süresinde gereken dayanimi ilgili dokuya aktararak var olan bir problemi çözebilir. The biodegradable gel becomes self-sufficient by contacting the two broken pieces. heals in a short time and is completely in its original strength and It regains its stretching feature. Due to this feature, meniscus repair It can find application in industry as a material and it can be disintegrated under loads. then it can reunite after contact again and become old. Muscle, tendon and In other similar applications, with this feature, it is necessary for the regeneration period. can solve an existing problem by transferring strength to the relevant tissue.
Bulus konusu yöntem (100) ile elde edilen biyobozunur jel, çok küçük gerinim degerlerinde nano-mikro Farad seviyelerinde kapasitif cevap verme özelligine sahiptir. Bu özellikteki jel esnek ve giyilebilir optoelektronik uygulamalarda platformlarin hazirlanabilmesine yönelik halihazirda var olan ihtiyaci giderme potansiyeli sunar. Söz konusu jel ile hazirlanan kapasitif sensör doku rejenerasyonunun (örnegin kalp kasi) veya fizyolojik bir verinin (arteryel basinç) in VIVO olarak biyobozunur bir sensör ile izlenebilmesine yardimci olur. Benzer sekilde giyilebilir esnek ve biyobozunur pek çok elektronik veya biyomedikal uyg ula mada jel in bu özelliginden dolayi farkli platformlarda yararlanilabilmektedir. Bir sensör olarak yapilandirilmasi durumunda, sensör üzerine düsecek çok küçük gerinime (örnegin bir kas hareketi) veya baskiya duyarli olarak sensör eleinanindan dogrusal bir tepki alinir. The biodegradable gel obtained by the method (100) of the invention is very small strain. It has a capacitive response feature at nano-micro Farad levels. has. The gel with this feature is used in flexible and wearable optoelectronic applications. Addressing the existing need for platforms to be prepared offers potential. Capacitive sensor tissue prepared with the gel in question regeneration (for example, heart muscle) or a physiological data (arterial pressure) It helps to be monitored with a biodegradable sensor as VIVO. Similar wearable, flexible and biodegradable in many electronic or biomedical Due to this feature of the gel in application, it can be used on different platforms. can be used. If configured as a sensor, the sensor sensitive to very small strain (for example, a muscle movement) or pressure to fall on As a result, a linear response is received from the sensor element.
Bu temel kavramlar etrafinda, bulus konusu biyobOZunur jel elde etme yönteini (100) için çok çesitli uygulamalarin gelistirilmesi mümkün olup, bulus burada açiklanan örneklerle sinirlandirilamaz, esas olarak istemlerde belirtildigi gibidir.Around these basic concepts, the method of obtaining a biodegradable gel is the subject of the invention. It is possible to develop a wide variety of applications for (100), and the invention is presented here. not limited to the examples described, essentially as claimed in the claims.
Claims (1)
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| TR2019/04095A TR201904095A2 (en) | 2019-03-19 | 2019-03-19 | THE METHOD OF OBTAINING A BIO-DEGRADABLE GEL |
| PCT/TR2020/050212 WO2020190240A2 (en) | 2019-03-19 | 2020-03-17 | A method for obtaining a biodegradable gel |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| TR2019/04095A TR201904095A2 (en) | 2019-03-19 | 2019-03-19 | THE METHOD OF OBTAINING A BIO-DEGRADABLE GEL |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TR201904095A2 true TR201904095A2 (en) | 2020-10-21 |
Family
ID=72520454
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TR2019/04095A TR201904095A2 (en) | 2019-03-19 | 2019-03-19 | THE METHOD OF OBTAINING A BIO-DEGRADABLE GEL |
Country Status (2)
| Country | Link |
|---|---|
| TR (1) | TR201904095A2 (en) |
| WO (1) | WO2020190240A2 (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114853952B (en) * | 2022-06-10 | 2024-03-08 | 闽江学院 | Super-stretching self-repairing nanocellulose gel and preparation method thereof |
| CN115490841B (en) * | 2022-11-22 | 2023-03-21 | 颢箔医疗科技(上海)有限公司 | Polyether diol polyazelaic acid fatty triol ester and preparation method and application thereof |
-
2019
- 2019-03-19 TR TR2019/04095A patent/TR201904095A2/en unknown
-
2020
- 2020-03-17 WO PCT/TR2020/050212 patent/WO2020190240A2/en active Application Filing
Also Published As
| Publication number | Publication date |
|---|---|
| WO2020190240A3 (en) | 2020-10-22 |
| WO2020190240A2 (en) | 2020-09-24 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Liu et al. | Hydrogen bonds autonomously powered gelatin methacrylate hydrogels with super-elasticity, self-heal and underwater self-adhesion for sutureless skin and stomach surgery and E-skin | |
| Zhang et al. | Zn2+-loaded TOBC nanofiber-reinforced biomimetic calcium alginate hydrogel for antibacterial wound dressing | |
| Liu et al. | A highly-stretchable and adhesive hydrogel for noninvasive joint wound closure driven by hydrogen bonds | |
| Yu et al. | Ultrathin κ-carrageenan/chitosan hydrogel films with high toughness and antiadhesion property | |
| Gharibi et al. | Stimulation of wound healing by electroactive, antibacterial, and antioxidant polyurethane/siloxane dressing membranes: in vitro and in vivo evaluations | |
| Lu et al. | Insoluble and flexible silk films containing glycerol | |
| Lin et al. | Bacterial cellulose and bacterial cellulose–chitosan membranes for wound dressing applications | |
| Yang et al. | H-bonding supramolecular hydrogels with promising mechanical strength and shape memory properties for postoperative antiadhesion application | |
| Liu et al. | Biomimetic strain-stiffening in chitosan self-healing hydrogels | |
| Xiao et al. | Adhesion mechanism and application progress of hydrogels | |
| Li et al. | Hydrogel/nanofibrous membrane composites with enhanced water retention, stretchability and self-healing capability for wound healing | |
| FR2616318A1 (en) | ARTIFICIAL SKIN AND PROCESS FOR PREPARING THE SAME | |
| Hodge et al. | Evaluating polymeric biomaterials to improve next generation wound dressing design | |
| CN102921050A (en) | Preparation method of anti-adhesion fibrous membrane with hemostatic function | |
| Laidmäe et al. | Salmon fibrinogen and chitosan scaffold for tissue engineering: in vitro and in vivo evaluation | |
| Mostafavi et al. | Highly tough and ultrafast self-healable dual physically crosslinked sulfated alginate-based polyurethane elastomers for vascular tissue engineering | |
| EP3021881B1 (en) | Cross-linked hyaluronic acid, process for the preparation thereof and use thereof in the aesthetic field | |
| Kumar et al. | Polysaccharides, proteins, and synthetic polymers based multimodal hydrogels for various biomedical applications: A review | |
| TR201904095A2 (en) | THE METHOD OF OBTAINING A BIO-DEGRADABLE GEL | |
| Correia et al. | Adhesive and biodegradable membranes made of sustainable catechol-functionalized marine collagen and chitosan | |
| Tang et al. | Multifunctional hydrogels for wound dressings using xanthan gum and polyacrylamide | |
| CN111481735A (en) | Medical antibacterial wound-protecting hydrogel dressing and preparation method thereof | |
| Mao et al. | The relationship between crosslinking structure and silk fibroin scaffold performance for soft tissue engineering | |
| Lu et al. | Silk fibroin-based tough hydrogels with strong underwater adhesion for fast hemostasis and wound sealing | |
| Luo et al. | Fabrication and characterization of Chinese giant salamander skin composite collagen sponge as a high-strength rapid hemostatic material |