TR201903197A2 - ISOTONIC WET WIPES - Google Patents
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- TR201903197A2 TR201903197A2 TR2019/03197A TR201903197A TR201903197A2 TR 201903197 A2 TR201903197 A2 TR 201903197A2 TR 2019/03197 A TR2019/03197 A TR 2019/03197A TR 201903197 A TR201903197 A TR 201903197A TR 201903197 A2 TR201903197 A2 TR 201903197A2
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- 238000004140 cleaning Methods 0.000 claims abstract description 29
- 239000000463 material Substances 0.000 claims abstract description 19
- 239000007788 liquid Substances 0.000 claims description 43
- 239000000203 mixture Substances 0.000 claims description 40
- 239000000835 fiber Substances 0.000 claims description 24
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 23
- 239000000126 substance Substances 0.000 claims description 22
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 20
- 150000003839 salts Chemical class 0.000 claims description 14
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 12
- 239000011780 sodium chloride Substances 0.000 claims description 10
- -1 polypropylene Polymers 0.000 claims description 9
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 8
- 239000003974 emollient agent Substances 0.000 claims description 7
- 239000004166 Lanolin Substances 0.000 claims description 6
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 claims description 6
- 239000003795 chemical substances by application Substances 0.000 claims description 6
- 229940039717 lanolin Drugs 0.000 claims description 6
- 235000019388 lanolin Nutrition 0.000 claims description 6
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- 239000004599 antimicrobial Substances 0.000 claims description 5
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- 235000015334 Phyllostachys viridis Nutrition 0.000 claims description 4
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- 229940061632 dehydroacetic acid Drugs 0.000 claims description 4
- PGRHXDWITVMQBC-UHFFFAOYSA-N dehydroacetic acid Natural products CC(=O)C1C(=O)OC(C)=CC1=O PGRHXDWITVMQBC-UHFFFAOYSA-N 0.000 claims description 4
- 235000011187 glycerol Nutrition 0.000 claims description 4
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- CHHHXKFHOYLYRE-UHFFFAOYSA-M 2,4-Hexadienoic acid, potassium salt (1:1), (2E,4E)- Chemical compound [K+].CC=CC=CC([O-])=O CHHHXKFHOYLYRE-UHFFFAOYSA-M 0.000 claims description 2
- QCDWFXQBSFUVSP-UHFFFAOYSA-N 2-phenoxyethanol Chemical compound OCCOC1=CC=CC=C1 QCDWFXQBSFUVSP-UHFFFAOYSA-N 0.000 claims description 2
- ANZUDYZHSVGBRF-UHFFFAOYSA-N 3-ethylnonane-1,2,3-triol Chemical compound CCCCCCC(O)(CC)C(O)CO ANZUDYZHSVGBRF-UHFFFAOYSA-N 0.000 claims description 2
- 239000005711 Benzoic acid Substances 0.000 claims description 2
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- 235000012209 glucono delta-lactone Nutrition 0.000 claims description 2
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- 229940040102 levulinic acid Drugs 0.000 claims description 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 2
- GOQYKNQRPGWPLP-UHFFFAOYSA-N n-heptadecyl alcohol Natural products CCCCCCCCCCCCCCCCCO GOQYKNQRPGWPLP-UHFFFAOYSA-N 0.000 claims description 2
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- 230000001105 regulatory effect Effects 0.000 claims description 2
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 claims description 2
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- 239000005020 polyethylene terephthalate Substances 0.000 claims 1
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- 229920000915 polyvinyl chloride Polymers 0.000 claims 1
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- 230000002335 preservative effect Effects 0.000 claims 1
- 239000000644 isotonic solution Substances 0.000 abstract description 2
- 238000004806 packaging method and process Methods 0.000 abstract description 2
- 210000001124 body fluid Anatomy 0.000 abstract 1
- 239000010839 body fluid Substances 0.000 abstract 1
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- 230000003204 osmotic effect Effects 0.000 description 9
- 230000008014 freezing Effects 0.000 description 8
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- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 6
- 238000005259 measurement Methods 0.000 description 6
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- SNPLKNRPJHDVJA-ZETCQYMHSA-N D-panthenol Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCCO SNPLKNRPJHDVJA-ZETCQYMHSA-N 0.000 description 2
- 210000000170 cell membrane Anatomy 0.000 description 2
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- XEFAJZOBODPHBG-UHFFFAOYSA-N 1-phenoxyethanol Chemical compound CC(O)OC1=CC=CC=C1 XEFAJZOBODPHBG-UHFFFAOYSA-N 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 1
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- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
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- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 description 1
- 238000004364 calculation method Methods 0.000 description 1
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Abstract
Buluş, bebek, çocuk ve yetişkinlerin ciltlerini temizlemek amacıyla evde, tuvalette ya da günlük kullanıma uygun, vücut sıvısına eş izotonik değerde solüsyon emdirilmiş dokunmamış materyalden yapılmış bir ıslak mendil ile ilgilidir. Bu buluş cilt ile uyumlu, kullanımı kolay, ikinci bir temizlemeye gerek bırakmayan, ambalajı içinde bir ıslak mendil ürününü kullanıma sunmaktadırThe invention relates to a wet wipe made of nonwoven material impregnated with an isotonic solution equivalent to body fluid, suitable for home, toilet or daily use for cleansing the skin of babies, children and adults. The present invention provides a skin-compatible, easy-to-use wet wipe product in its packaging that does not require a second cleaning.
Description
TARIFNAME IZOTONIK ISLAK MENDIL TEKNIK ALAN Bulus, sivi emdirilmis dokunmamis bir materyalden yapilmis bir islak mendille ilgilidir. Söz konusu islak mendile emdirilmis sivi insan cildine izotonik olup cilde yöneliktir. DESCRIPTION ISOTONIC WET WIPES TECHNICAL FIELD The invention relates to a wet wipe made of a liquid-impregnated non-woven material. is relevant. The liquid impregnated with the said wet wipe is isotonic to human skin. intended for the skin.
TEKNIGIN BILINEN DURUMU Teknolojinin gelismesi ile birlikte gündelik hayat hiz kazanmis ve kullanilan her tüketim ürünü buna ayak uydurmaya baslamistir. Çesitli avantajlar sunan ürünler arasinda kullanilip atilan temizleme ürünleri, bilhassa islak mendiller önemli bir yere sahiptir. tekli ya da çoklu paketlerde muhafaza edilen temizlik ürünleridir. Söz konusu islak mendiller muhafaza edildigi paketten tek tek çikarilarak kullanilan ve kullanildiktan sonra atilan tek kullanimlik temizlik ürünleridir. ve bulunun, emici bez kullananlarin temizligi, makyaj temizligi gibi birçok alanda kullanimi bulunmaktadir. etmektedir. Bu sivi, nemlendirici ajan, emoliyan, yüzey aktif madde, antimikrobiyal ajanlar, inorganik tuzlar içerebilmektedir. Örnegin, burun temizliginde kullanilan islak mendiller, burun akintilarinda sik mendil kullaniminin yol açtigi derin tahrislerin önlenmesine ve giderilmesine yönelik olarak emoliyanlar, yaglar içeren farkli bir içerige sahip oldugundan, bu mendillerin vücudun diger bölümlerinin temizliginde kullanimlari tercih edilmemektedir. KNOWN STATE OF THE TECHNIQUE With the development of technology, daily life has accelerated and every consumer product has started to keep up with this. Products that offer various benefits Disposable cleaning products, especially wet wipes, are an important has place. These are cleaning products stored in single or multiple packages. Aforementioned Wet wipes are used by removing one by one from the package in which they are kept. They are disposable cleaning products that are thrown away after use. and be found in many areas such as cleaning of those who use absorbent cloths, cleaning of make-up. has usage. is doing. This liquid is a moisturizing agent, emollient, surfactant, antimicrobial agents may contain inorganic salts. For example, the nose wet wipes used in cleaning, frequent wipes for nasal discharge for the prevention and elimination of deep irritations caused by the use of Since emollients have a different content that includes oils, this The use of wipes for cleaning other parts of the body is preferred. is not done.
Vücudumuzun büyük bir kismi sudan olusmaktadir. Insan vücudu ve onu olusturan hücreler su, hücre bölümleri, bunlari olusturan kimyasal maddelerden olusmakta ve hücre içi ile çevresi ozmotik bir denge içerisinde bulunmaktadir. Bu ozmotik denge vücudumuzu saran deri ile dis çevresi arasinda da bulunmaktadir. A large part of our body consists of water. The human body and it The cells that form them are made up of water, cell parts, chemical substances that make them up. and the cell and its surroundings are in an osmotic balance. This The osmotic balance is also between the skin surrounding our body and the outer environment.
Hücre içinde veya disindaki sivi ortamda bulunan bilesikler iyonik kuvvetlerine, konsantrasyonlarina göre bir ozmotik basinç olusturmaktadir. Compounds in the liquid environment inside or outside the cell have ionic strengths, creates an osmotic pressure according to their concentration.
Ozmotik basinç çözücünün içindeki bilesiklerin konsantrasyonuna göre ifade edilen ozmolaliteye neden olmaktadir. Ozmolalite çözünen maddelerin, çözeltinin ozmotik basincina katkisini gösteren bir ölçümdür, 1 kg suda çözünmüs total bilesik konsantrasyonunu ifade eder, birimi osmol/kg7dir, genellikle milliosmol; mosmol/kg birimi kullanilir (European pharmacopeia 6.0 2.2.35 Osmolality). Osmotic pressure is expressed by the concentration of the compounds in the solvent. causes osmolality. Osmolality of solutes, solution It is a measurement that shows its contribution to osmotic pressure, 1 kg of water dissolved in total expresses the compound concentration, its unit is osmol/kg7, usually milliosmol; mosmol/kg unit is used (European pharmacopeia 6.0 2.2.35 Osmolality).
Söz konusu bilesikler; moleküller, iyonlar, iyon kompleksleri gibi çözücüde çözünmüs maddelerdir. Ozmolalite, böylelikle çözeltinin olusturdugu ozmotik basinci karakterize etmektedir. % 0.9 sulu Sodyum Klorür (NaCl) çözeltisine esit ozmolalite gösteren solüsyonlar izotonik olarak adlandirilmaktadir. Bu, vücut ve deri hücrelerinin ozmotik basincina da esdeger kabul edilmektedir. % 0.9 sulu NaCl çözeltisinin ölçülmüs ozmolalite degeri 286 mosmol/kg dir. Vücut ve deri hücrelerinin ozmotik basincina izotonik solüsyonlarin teorik olarak hesaplanmis ozmolalite degeri 239-376 mosmol/L araligindadir (Russian General Pharmacopoeia GPM 1.2.1. 0003.15). Bu ozmolalite araligindaki çözeltiler vücut ve cilt hücreleri ile izotonik bir davranis sergilemektedirler. Bu degerlerin üzerindekiler hiperozmolalite, altindakiler hipoozmolalite özellikleri göstermektedirler. Said compounds; in solvent such as molecules, ions, ion complexes are dissolved substances. Osmolality, thus the osmotic generated by the solution characterizes the pressure. Equivalent to 0.9% aqueous Sodium Chloride (NaCl) solution Solutions showing osmolality are called isotonic. It is the body and It is also accepted as equivalent to the osmotic pressure of skin cells. 0.9% aqueous The measured osmolality value of the NaCl solution is 286 mosmol/kg. body and skin theoretical calculation of isotonic solutions to the osmotic pressure of the cells osmolality value is between 239-376 mosmol/L (Russian General Pharmacopoeia GPM 1.2.1. 0003.15). Solutions in this range of osmolality and exhibit an isotonic behavior with skin cells. These values Above is hyperosmolality, below is hypoosmolality. they show.
Ozmolalite inefektif ve efektif kisimlardan olusmakta; efektif kisim tonisite olarak adlandirilmakta olup hücre içi ile disi arasindaki ozmotik basinç farkini ifade eder. Osmolality consists of ineffective and effective parts; as effective part tonicity It is called the osmotic pressure difference between the inside and outside of the cell.
Bebek, çocuk ve yetiskinlerin ciltleri temas halinde bulundugu sivinin, cilt ile izotonik olup olmamasina göre reaksiyon verir. Düsük tonisiteye sahip sivilarda cildin nem alip sismesi, kabarmasi, yumusamasi ve tahrise yatkin olmasi; yüksek tonisiteye sahip sivilarda ise, ciltten su çekilmelerinde cildin sivi kaybina neden olmaktadir. The liquid in contact with the skin of infants, children and adults, It reacts according to whether it is isotonic or not. In liquids with low tonicity the skin becomes hydrated, swollen, swollen, soft and prone to irritation; high On the other hand, in liquids with tonicity, water withdrawal from the skin causes fluid loss of the skin. is happening.
WO99024551 numarali patent dokümaninda, ciltte fazla tahrise yol açmadan cilt temizligi saglamak amaciyla mono alkil fosfat ve yüzey aktif maddeler içeren bir bilesime sahip islak mendil ürünleri tarif edilmektedir. Söz konusu ürünlerin bebek cildi temizligi, yüz ve makyaj temizliginde kullanilabilecegi belirtilmistir. In the patent document numbered WO99024551, it can be used without causing excessive irritation to the skin. A product containing mono alkyl phosphate and surfactants to ensure cleanliness. Wet wipe products with composition are described. The products in question It has been stated that it can be used for baby skin cleaning, face and make-up cleaning.
Ancak, patentte bahsedilen islak mendillerle uygulama sonrasinda cilt silinmeyeceginden ciltte yüzey aktif madde kalintilari kalacaktir. Bu durum, seyrek kullanimda normal ciltlerde az tahrise yol açsa da, bilhassa bebek ve çocuk ciltlerine, cildin hassas bölgelerine uygulamalarda ve sik kullanimlarda cilt üzerinde kalan yüzey aktif madde kalintilari kuruluga neden olmasindan dolayi tahrislerin artmasina sebep olur. Bilhassa çocuk bezi kullaniminda, kirli ve nemli ortamda çocuk ve bebeklerin cildi tahrislere daha meyillidir. Bu durum, söz konusu islak mendillerle cilt temizligi yapilmasindan sonra cildin tekrar sulu islak bir mendille silinmesini gerektinnektedir. Bu da, akarsuyun bulunmadigi ortamlarda saf sulu mendil bulundurma zorunlulugu dogurmakta ve kullanim açisindan bir dezavantaj olusturmaktadir. However, after application with wet wipes mentioned in the patent, the skin will not be erased, surfactant residues will remain on the skin. This situation, Although it causes little irritation to normal skin in infrequent use, it is especially suitable for infants and children. skin, sensitive areas of the skin in applications and frequent use. residues of surfactant on it cause dryness. causes increased damage. Especially when using diapers, dirty and damp In the environment, the skin of children and babies is more prone to irritations. In this situation, the word After cleaning the skin with wet wipes, the skin is wet again. It needs to be wiped with a tissue. This means that there is no stream. It is obligatory to have pure water wipes in the environment and usage constitutes a disadvantage.
Yukarida tarif edilen durum, TRZOl l 1 1365 numarali patent dokümaninda dikkate alinarak, sabunlu ve saf sulu ikili islak mendil kiti tarif edilmistir. El, yüz temizleme ve çocuk bakimi için kullanilan islak mendiller alkol ve temizleme sivilari içermekte, bu maddelerin cilt yüzeyinde biraktigi kalintilar da bebeklerin hassas tenlerinde tahrise neden olmaktadir. Söz konusu patentte, bu probleme çözüm getirmek için islak mendilin yaninda bir adet saf su içeren mendil sunulmakta ve saf su içeren bu mendil ile islak mendil kalintilari silinebilmektedir. Sabunlu mendil ile cilt temizligi yapildiktan sonra cildin silinmeden birakilmasi durumunda ciltte rahatsizlik hissi ve tahrisler olacagindan, yaninda verilen saf sulu mendille cildin silinmesi ve kalan sabun artiklarinin uzaklastirilmasi gerekmektedir. Ancak, patentte tarif edilen iki adet farkli mendilin ayni ambalajda bir arada bulunmasi gerekliligi üretim açisindan güçlüklere yol açmakta ve daha pahaliya mal olmaktadir. Ayrica, günlük kullanimda ardi ardina iki farkli mendilin kullanimi pratik olmamaktadir. The situation described above is taken into account in the patent document TRZOL l 1 1365. Soapy and pure water double wet wipes kit is described. hand, face wet wipes used for cleaning and child care alcohol and cleaning contains liquids, the residues left by these substances on the skin surface are also It causes irritation to sensitive skin. The patent in question addresses this problem. To bring a solution, a handkerchief containing pure water next to the wet wipe and wet wipe residues with this wipe containing pure water. can be deleted. After cleaning the skin with a soapy tissue, the skin If it is left without wiping, there will be a feeling of discomfort and irritation on the skin, wiping the skin with the supplied pure water wipe and removing the remaining soap residues. must be removed. However, there are two different The necessity of the handkerchief to be together in the same package is important in terms of production. causes difficulties and costs more. Also, daily In use, it is not practical to use two different wipes one after the other.
Günümüzde, çocuk bezi kullanan çocuklarin cilt temizliginde kullanilan islak mendillerin sivi bilesim formülasyonlari izotonikligi saglamaya yönelik degildir. Today, wet wipes used for skin cleaning of children using diapers Liquid composition formulations of wipes are not intended to provide isotonicity.
Insan cildi ile izotonik olan, temizleme, silme amaçli kullanima uygun ve yukarida belirtilen dezavantajlari bertaraf edebilecek bir islak mendile ihtiyaç duyulmaktadir. It is isotonic with human skin, suitable for cleaning, wiping and There is a need for a wet wipe that can eliminate the above mentioned disadvantages. is heard.
SEKILLERIN AÇIKLAMASI Sekil 1: Z katlanmis bulus konusu islak mendilin (l) görünümü Sekil 2: Bulus konusu islak mendili (l) içeren, dagitma açikligi (4) olan bir kapama sistemine (3) sahip olan ambalajin (2) üstten görünüsü Sekillerdeki parçalar numaralandirilmis olup karsiliklari asagida verilmistir: 1. Islak mendil 2. Ambalaj 3. Kapama sistemi 4. Dagitma açikligi BULUSUN TANIMI Bulus yukarda belirtilen eksiklikleri karsilayip dezavantajlari gideren bir islak mendil ile ilgilidir. EXPLANATION OF FIGURES Figure 1: The view of the Z-folded wet wipe (l) which is the subject of the invention Figure 2: A wet wipe (l) which is the subject of the invention, with a dispensing opening (4). Top view of the package (2) with the closure system (3) The parts in the figures are numbered and their equivalents are given below: 1. Wet wipes 2. Packing 3. Closing system 4. Distribution clearance DESCRIPTION OF THE INVENTION The invention is a wet material that meets the above-mentioned deficiencies and eliminates the disadvantages. It's about the handkerchief.
Isbu bulus, bebek, çocuk ve yetiskinlerin ciltlerini temizlemek için sivi bir bilesim emdirilmis dokunmamis bir materyalden yapilmis bir islak mendil olup söz konusu sivi bilesimin özelligi izotonik olmasidir. This invention is a liquid composition for cleansing the skin of infants, children and adults. is a wet wipe made of an impregnated non-woven material. The property of the liquid composition in question is that it is isotonic.
Isbu bulusta söz konusu izotonik sivi bilesim 239-376 mosmol/kg araliginda bir ozmolalite degerine sahiptir. In the present invention, the said isotonic liquid composition is in the range of 239-376 mosmol/kg. It has an osmolality value.
Bulus konusu islak mendil uygulandiginda, solüsyon kaynakli cilt iritasyonunu azaltmaktadir. When wet wipes, which are the subject of the invention are applied, solution-induced skin irritation can be prevented. decreases.
Bulus konusu islak mendilin özelligi, islak mendilin sivi bilesiminin cilt ile izotonik olmasi ve belirli bir ozmolalite araligina sahip olmasi ve bunun cilde Cilt ile kullanilan islak mendilin izotonik olmasi, cilt hücrelerine disaridan madde geçisinin dengeli olmasini saglayarak cilt dengesini bozmamakta ve dolayisiyla ciltte stres olusturmamaktadir. The property of the wet wipe, which is the subject of the invention, is that the liquid composition of the wet wipe is in contact with the skin. being isotonic and having a certain range of osmolality and this The fact that the wet wipes used with the skin are isotonic means that the skin cells are exposed to external substances. It does not disturb the balance of the skin by ensuring that the transition is balanced and therefore It does not cause stress on the skin.
BULUSUN AÇIKLAMASI Bulus, bebek, çocuk ve yetiskinlerin ciltlerini temizlemek için bir islak mendil ile ilgilidir. Söz konusu islak mendil sivi bir bilesim emdirilmis dokunmamis bir materyalderi olusmaktadir. DESCRIPTION OF THE INVENTION Bulus with a wet wipe to clean the skin of babies, children and adults. is relevant. Said wet wipe is a non-woven fabric impregnated with a liquid composition. material is formed.
Söz konusu islak mendilin özelligi sivi bilesiminin molalitesinin cilt ile benzer degerler göstermesi, bir diger deyisle izotonik olmasidir. The characteristic of the said wet wipe is that the molality of the liquid composition is similar to that of the skin. values, in other words, it is isotonic.
Söz konusu izotoniklik 239-376 mosmol/kg arasi ozmolalite degerlerinde saglanmaktadir. The said isotonicity is at osmolality values between 239-376 mosmol/kg. is provided.
Hücrelerin hücre içi sivisinda barindirdigi çesitli protein, organik moleküller, inorganik tuzlar, iyonlar ve diger bilesiklerle belirli bir ozmolalite düzeyi olusturmakta ve dis ortamdan hücre zari ile ayrismaktadir. Hücre zari dis ortama tamamen kapali degildir ve dis ortamdan maddeler alinip salinabilmektedir. Bu olgu bilhassa dis ortam ile hücre içi arasinda söz konusu maddelerin konsantrasyon farkliliklari olustugunda daha çok devreye girmektedir. Various proteins, organic molecules contained in the intracellular fluid of the cells, a certain level of osmolality with inorganic salts, ions and other compounds and is separated from the external environment by the cell membrane. Cell membrane external media it is not completely closed and substances can be taken and released from the external environment. This phenomenon, especially between the external environment and the intracellular It comes into play more when concentration differences occur.
Hücre içi ozmolalitenin dis ortamdan fazla oldugu durumda, ki bu dis ortam açisindan hipotonik dis ortam olarak tarif edilmektedir; her iki ortam ozmolalitesi dis ortamdan hücre içine su geçisi saglanarak dengelenmektedir. Bu durumda hücreler siser cilt hassaslasir ve sürtünmelerde tahris olmaya daha meyilli olurlar. In the case where the intracellular osmolality is higher than the external environment, which is the external environment It is described as a hypotonic external environment in terms of; both media osmolality It is balanced by providing the passage of water from the external environment into the cell. In this case the cells swell, the skin becomes sensitive and they are more prone to be irritated by friction.
Ayrica deplazmoliz olarak adlandirilan hücrenin asiri sividan kaynakli patlamasi meydana gelebilir. Söz konusu durum sivi bilesenin ozmolalitesinin 239 mosmol/kgidan az oldugu durumlarda olmaktadir. Explosion of the cell due to excess fluid, also called deplasmolysis may occur. The situation in question is due to the osmolality of the liquid component. It happens in cases where it is less than mosmol/kg.
Hücre içi ozmolalitenin dis ortamdan az oldugu durumda ise hücre içinden hücre disina dogru su çikisi olur. Hücre içi suyunun azalmasindan kaynaklanan basinç azalmasi nedeniyle hücre büzülür. Su kaybeden hücre nemini kaybeder ve olusan kuru cilt rahatsizlik veren bir kuruluk hissi olusturur, cildin canliligi ve elastikiyeti azalir, cilt hassaslasir ve tahris olmaya daha meyilli olur. In the case where the intracellular osmolality is less than the external environment, the cell inside the cell there is a water outlet towards the outside. Pressure caused by a decrease in intracellular water cell shrinks due to decrease. The cell that loses water loses its moisture and dry skin creates an uncomfortable feeling of dryness, vitality and elasticity of the skin decreases, the skin becomes sensitive and more prone to irritation.
Bilhassa çok hassas olan bebek, yeni dogmus bebek ve çocuklarin ciltlerini, özellikle emici bez kullananlarda kirlenen ilgili bölgelerin oldukça hassas cilde sahip olmasindan dolayi bulus konusu izotonik sivi içeren islak mendil ile temizlemek isbu bulusun avantajlarindandir. Ayrica, söz konusu izotonik sivi bilesim, cilt ile izotonik bir denge olusturdugundan cilt temizlendikten sonra kurudugunda herhangi bir tahrise yol açmaz ve ikinci bir saf su içeren islak mendil kullanilarak cildin durulanmasina gerek duyulmadan temizlik saglayarak teknikte karsilasilan sorunlara çözüm getirir. Especially the very sensitive skin of babies, newborn babies and children, Especially in those who use absorbent cloth, it is necessary to apply to the very sensitive skin of the contaminated areas. The subject of the invention can be used with wet wipes containing isotonic liquid due to its cleaning is one of the advantages of this invention. In addition, the isotonic liquid in question After cleaning the skin, the composition creates an isotonic balance with the skin. When dry, it does not cause any irritation and is wet with a second distilled water. by providing cleaning without the need for rinsing the skin by using wipes. It provides solutions to the problems encountered in the technique.
Düsük ozmolalite su miktarinin fazla, ozmolaliteyi olusturan maddelerin az olmasindan dolayi olusmaktadir. Özellikle tuz, inorganik tuzlar ve iyonik karakterdeki bilesikler, dipol momenti yüksek bilesikler ve bunlarin yüksek konsantrasyonlari ozmolaliteyi yükseltmektedir. The amount of low osmolality water is high, the substances that make up the osmolality are less. occurs because of it. Especially salt, inorganic salts and ionic character compounds, compounds with high dipole moment and their high concentrations increase osmolality.
Bulus konusu islak mendilde ozmolaliteye özellikle etki eden maddeler iyon kuvveti yüksek tuzlar, dipol momenti yüksek bilesiklerdir. lyon kuvveti yüksek tuzlar kuvvetli elektropozitif katyon ve kuvvetli elektronegatif anyonlarin kombinasyonundan olusan tuzlardir. Bu tuzlar organik veya inorganik iyonlar içerebilir. Bulus konusu islak mendil sivi bilesiminde iyonik kuvveti yüksek olan ve cilde uyumlu tuzlar kullanilabilir. Bu tuzlar, vücuda uyumlu metal katyonlari bilhassa sodyum, potasyum gibi katyonlari ve yine vücuda uyumlu anyonlari, klorür, sitrat gibi anyonlari içerebilir. Substances that particularly affect osmolality in the wet wipes, which are the subject of the invention, Salts with high strength are compounds with high dipole moment. high strength salts are composed of strongly electropositive cations and strongly electronegative anions. salts formed from the combination. These salts are organic or inorganic ions. may contain. The subject of the invention is the wet wipes with high ionic strength in the liquid composition. and skin compatible salts can be used. These salts are metal cations compatible with the body. especially cations such as sodium, potassium and anions compatible with the body, may contain anions such as chloride, citrate.
Bilhassa inorganik tuzlar, özellikle NaCl, KCl, deniz suyu hem ozmolaliteyi önemli oranda etkilemesi, hem de insan fizyolojisinde bulunmasi, güvenilirliginin kanitlanmis olmasi ve bol bulunmalari, ucuz olmalari nedeniyle bilhassa NaCl bulus konusu islak mendilde tercih edilmektedir. NaCl ozmolaliteye büyük oranda etkisiyle diger tuzlara oranla daha düsük miktarlarda kullanilmasina ragmen tonisiteyi ayarlamada etkinliginden dolayi tercih edilmektedir. Especially inorganic salts, especially NaCl, KCl, sea water and osmolality significant impact, as well as being in human physiology, its reliability NaCl in particular, as it has been proven and is abundant and inexpensive. The subject of the invention is preferred in wet wipes. NaCl has a large effect on osmolality. Although it is used in lower amounts compared to other salts, It is preferred because of its effectiveness in adjusting tonicity.
Isbu bulusta dokunmamis islak mendil materyali sentetik veya dogal kaynakli elyaf veya filamentlerden hazirlanabilir. Söz konusu sentetik elyaf poliolefin, polipropilen, polietileneteraftalat, poliamid, poliester, viskon, poliakrilik, PVC, selüloz asetat, polietilen gibi sentetik kaynakli elyaf veya filamentlerden olusabilir. Söz konusu dogal elyaf pamuk, bambu, keten, kenevir, jüt, sisal, hindistan cevizi lifi olabilir. In the present invention, the non-woven wet wipe material is synthetic or of natural origin. It can be prepared from fibers or filaments. The synthetic fiber in question is polyolefin, polypropylene, polyethyleneetherephthalate, polyamide, polyester, viscose, polyacrylic, PVC, of synthetic origin fibers or filaments such as cellulose acetate, polyethylene may occur. The natural fibers in question are cotton, bamboo, linen, hemp, jute, sisal, Could be coconut fiber.
Isbu bulusta kullanilan dogal ya da sentetik elyaf kesikli ya da devamli elyaf olabilir. Sentetik devamli elyaf spunbond, spunbond meltblown karisimi ve diger uygun devamli sentetik elyaf olabilir. Sentetik kesikli elyaf spunlace ve diger kesikli sentetik elyaf olabilir. Dogal devamli elyaf keten, bambu, jüt, kenevir, sisal ve benzeri selülozik lifler ve kesikli dogal elyaf pamuk, bambu ve benzeri kesikli selülozik liflerden olusabilir. Devamli ya da kesikli elyaf ayri ayri ya da Isbu bulusun bir uygulamasinda, islak mendiller (l) Z-katlamali konfigürasyondadir ve en az bir bitisik mendil ile birlestirilmistir. Mevcut bulusun baska bir uygulamasinda, dokunmamis islak mendiller (1) Z katlanmis halde 50 cm2 ila 1000 cm2 arasinda bir alana sahip olabilir. Bu bulusun bir örneginde, 304 cm2`lik alana sahip bir islak mendil (l) elde edilir. The natural or synthetic fiber used in the present invention is staple or continuous fiber. it could be. Synthetic continuous fiber spunbond, spunbond meltblown mixture and other suitable continuous synthetic fiber. Synthetic staple fiber spunlace and other It can be staple synthetic fiber. Natural continuous fiber flax, bamboo, jute, hemp, sisal and similar cellulosic fibers and staple natural fibers cotton, bamboo and similar may consist of staple cellulosic fibers. Continuous or staple fiber separately or In one embodiment of the present invention, wet wipes (1) are Z-folded configuration and combined with at least one adjacent wipe. present invention In another embodiment, the non-woven wet wipes (1) are 50 in Z-folded form. It can have an area between cm2 and 1000 cm2. In one example of this invention, 304 A wet wipe (l) having an area of cm2 is obtained.
Ticari olarak temin edilebilir islak mendiller (l) çogunlukla, bitisik mendiller arasindaki yüzey-yüzeye yapismayi arttirdigina inanilan elyaf liflerinden olusan spunlace kesikli elyaf kullanilarak hazirlanmaktadir. Isbu bulusta kullanima uygun olan ticari olarak temin edilebilir islak mendillerin (l) dokunmamis materyallerinin baz agirliklari, 30 gsm ila 90 gsm arasinda degisebilir, tercihen 35 gsm ila 50 gsm araligindadir. Commercially available wet wipes (l) are mostly adjacent wipes composed of fiber fibers believed to increase surface-to-surface adhesion between It is prepared using spunlace staple fiber. use in this invention nonwovens of suitable commercially available wet wipes (l) The base weights of the materials may vary from 30 gsm to 90 gsm, preferably 35 It ranges from gsm to 50 gsm.
Isbu bulusta islak mendili olusturan sivi bilesim koruyucu ajan veya ajanlar içermektedir. Söz konusu koruyucu ajan veya ajanlar; fenoksietanol, dehidroasetik asit, etilheksil gliserin, glukonolakton, benzil alkol, organik asitler ve benzeri bilesikler ya da bunlarin tuzlari olabilir, örnegin benzoik asit, sodyum benzoat, sorbik asit, potasyum sorbat, levulinik asit, anisik asit ve dehidroasetik asit veya bunlarin kombinasyonlarini içerebilir. The liquid composition preserving agent or agents constituting the wet wipes in the present invention contains. Said protective agent or agents; phenoxyethanol, dehydroacetic acid, ethylhexyl glycerine, gluconolactone, benzyl alcohol, organic acids and similar compounds or salts thereof, for example benzoic acid, sodium benzoate, sorbic acid, potassium sorbate, levulinic acid, anisic acid and dehydroacetic acid or combinations thereof.
Bulusa göre sivi bilesim emoliyan madde veya maddeler içermektedir. Söz konusu emoliyan madde veya maddeler; monopropilen glikol, gliserin, lanolin, PEG 75 lanolin, metil gluset 20 benzoat, Ciz-Cis alkil benzoat, etoksillenmis setil stearil alkol veya bunlarin kombinasyonlari olabilir. According to the invention, the liquid composition contains emollient substance or substances. Promise the subject emollient substance or substances; monopropylene glycol, glycerin, lanolin, PEG 75 lanolin, methyl glucet 20 benzoate, C 8 -C 18 alkyl benzoate, ethoxylated cetyl may be stearyl alcohol or combinations thereof.
Bulusa göre sivi bilesim, büyük oranda su içermektedir. Sivi bilesimin su içerigi en az %50, tercihen en az %70, daha da tercihen en az %80 oranindadir. According to the invention, the liquid composition contains a large proportion of water. Water content of the liquid composition at least 50%, preferably at least 70%, more preferably at least 80%.
Söz konusu sivi bilesim istege bagli olarak; asit düzenleyici ajan veya ajanlar, metal tutucu ajan veya ajanlar, yüzey aktif maddeler, antimikrobiyal ajan veya ajanlar, parfüm°den bir veya birkaçini içerebilir. Örnegin PEG 40 hidrojene hint yagi, trietanolamin, EDTA, NaCl, Sitrik asit, pantenol, propilen glikol, gliserin, lanolin ve benzerlerini içerebilir. Said liquid composition optionally; acid regulating agent or agents, metal sequestering agent or agents, surfactants, antimicrobial agent or agents may include one or more of the perfume. For example, PEG 40 hydrogenated castor oil, triethanolamine, EDTA, NaCl, Citric acid, panthenol, propylene glycol, glycerin, may contain lanolin and the like.
Bulusa konu olan izotonik islak mendilin özelligi, söz konusu islak mendilin bebek bezi, çocuk bezi, külot tipi çocuk bezi, yetiskin bezi, kadin pedi, emici bez kullanan kisilerde vücudun temizlenmesinde kullanilmasidir. The feature of the isotonic wet wipe that is the subject of the invention is that the wet wipes in question diaper, diaper, panty-type diaper, adult diaper, napkin, absorbent diaper It is used for cleaning the body in people who use it.
Söz konusu islak mendil, el, yüz temizligi, makyaj temizligi, genital bölge temizligi, vücut temizligi ve hasta bakiminda kullanilabilir. The wet wipes in question are hand, face cleaning, make-up removal, genital area. It can be used for cleaning, body cleaning and patient care.
Söz konusu islak mendil cilde hassas, izotonik olmasi sebebiyle ciltle uyumlu temizlik saglamaktadir. The wet wipes in question are sensitive to the skin and compatible with the skin as they are isotonic. provides cleaning.
Söz konusu izotonik islak mendil kapali bir ambalaj içerisindedir ve söz konusu ambalaj bir veya daha fazla islak mendil içerebilmektedir. Said isotonic wet wipe is in a closed package and the package may contain one or more wet wipes.
Asagidaki örnekler, mevcut bulusun uygulamasini açiklamak amaci ile verilmis olup, bulus bu örneklerle sinirli degildir. ÖRNEKLER karisimi spunlace dokunmamis materyale asagidaki örneklerde verilmis sivilar emprenye edilmistir: ÖRNEK 1: Izotonik Yenidogan Losyonu ÖRNEK 3: Hipotonik Bebe Losyonu Örnek 2'deki maddeler suda çözülmüs, sodyum klorür kullanilmamistir. ÖRNEK 4: Izotonik Pisik Losyonu ÖRNEK 5: Hipertonik Pisik Losyonu Örnek 4Steki maddeler suda çözünmüs, % 0.9 oraninda sodyum klorür kullanilmistir. The following examples are given to illustrate the application of the present invention. and the invention is not limited to these examples. EXAMPLES Liquids given in the following examples to the mixed spunlace nonwoven material impregnated with: EXAMPLE 1: Isotonic Newborn Lotion EXAMPLE 3: Hypotonic Baby Lotion The substances in Example 2 were dissolved in water, sodium chloride was not used. EXAMPLE 4: Isotonic Pimp Lotion EXAMPLE 5: Hypertonic Pimp Lotion The substances in Example 4 are dissolved in water, 0.9% sodium chloride used.
Tablo 1: Örnek 1-5 için Sivi Bir Bilesim Emdirilmis Dokunmamis Bir Materyalden Yapilmis Islak Mendil Içerigi Bilesen Miktar (% agirlik) Asit, Dehidroasetik Asit 1 karisimi Monopropilen Glikol - 1 1 - - Fenoksietanol, 0.8 0.8 - - Etilheksilgliserin - karisimi Parfüm - 0.5 0.5 0.5 0.5 PEG-4O Hidrojene Hint 0.5 0.5 0.8 0.8 Gliserin - - - 1 1 Pantenol, Propilen Glikol - - 0.1 0.1 karisimi _ Lanolin - - - 0.01 0.01 Sitrik Asit - 0.03 0.03 - - Trietanolamin 0.3 - - 0.03 0.03 Elde edilen islak mendilde, 1 gr spunlace dokunmamis materyal Örnek 1 için 3.5 gr, Örnek 2 için 2.9 gr sivi bilesim içermektedir. Table 1: Nonwoven Impregnated with a Liquid Composition for Examples 1-5 Wet Wipes Made of Material Component Amount (% by weight) Acid, Dehydroacetic Acid 1 mix Monopropylene Glycol - 1 1 - - Phenoxyethanol, 0.8 0.8 - - Ethylhexylglycerine - mix Perfume - 0.5 0.5 0.5 0.5 PEG-4O Hydrogenated Indian 0.5 0.5 0.8 0.8 Glycerin - - - 1 1 Panthenol, Propylene Glycol - - 0.1 0.1 mix _ Lanolin - - - 0.01 0.01 Citric Acid - 0.03 0.03 - - Triethanolamine 0.3 - - 0.03 0.03 In the resulting wet wipe, 1 g of spunlace nonwoven material is 3.5 for Example 1. g contains 2.9 g of liquid composition for Example 2.
Söz konusu sivi emprenye edilmis dokunmamis materyaller sivi geçirmez kapali ambalajlara tek tek veya birkaç tanesi bir arada konulabilir. Dokunmamis materyaller katlanir veya tek tek ardisik çikarmayi saglayacak sekilde iç içe geçmis halde olabilir. Ambalajin kapanabilir kapagi olabilir. The liquid impregnated non-woven materials in question are liquid-tight sealed. can be put into packages individually or several of them together. untouched materials are folded or nested together to allow sequential removal one by one. may be in the past. The packaging may have a closable lid.
OZMOLALITE ÖLÇÜMLERI: Ölçümlerde Metod Pharmacopoeia GPM 1.2.1. 0003.15). OZMOLITY MEASUREMENTS: Method in Measurements Pharmacopoeia GPM 1.2.1. 0003.15).
Kriyoskopik kullanilmaktadir (Russian General Bu metotta çözeltinin donma noktasinin düsmesi baz alinir. Örnek çözeltinin donma derecesinin saf çözücünün donma derecesinden farki baz alinarak elde edilen degerdir. Ozmolalite birimi osmol/kg dir ve 1 kg suyun donma noktasini 1.86OC derece düsürmek için gereklidir. mosmol/kg birimi miliosmol dür. Cryoscopic is used (Russian General This method is based on the lowering of the freezing point of the solution. sample solution obtained based on the difference of the freezing point from the freezing point of the pure solvent. is the given value. The unit of osmolality is osmole/kg and it is the freezing point of 1 kg of water. Required to lower 1.86C degrees. The unit of mosmol/kg is milliosmol.
Formül 1: Cosm : [(T2-T1) / K ]x1000 (mosmol/kg) Cosm: Çözeltinin ozmolalitesi T2: saf çözücünün donma derecesi Tl: Test edilen solüsyonun donma derecesi K: çözücünün kriyoskopik sabiti; su için 1.86 Ölçüm için belirlenen miktar örnek solüsyon otomatik kriyoskopi ölçüm cihazinin ölçüm hücresine konur, donma noktasi ölçülür. Ayni sekilde saf çözücünün; suyun donma noktasi ölçülür. Bulunan degerler Forinül 1, de yerine konarak örnek solüsyonun ozmolalitesi hesap edilir. ÖLÇÜM SONUÇLARI: Tablo 2: Örnek 1- 5 için Ozmolalite Ölçüm Sonuçlari Ozmolalite (mosmOI/kg) Bulus konusu ürünler olan Örnek 1, 2 ve 4`teki ozmolalite sonuçlari izotoniktir. Formula 1: Cosm : [(T2-T1) / K ]x1000 (mosmol/kg) Cosm: Osmolality of solution T2: freezing point of pure solvent Tl: degree of freezing of the tested solution K: cryoscopic constant of the solvent; 1.86 for water The amount of sample solution determined for measurement is transferred to the automatic cryoscopy measuring device. is placed in the measuring cell, the freezing point is measured. Likewise, the pure solvent; The freezing point of water is measured. Substituting the found values in Formula 1, Calculate the osmolality of the sample solution. RESULTS OF THE MEASUREMENT: Table 2: Osmolality Measurement Results for Example 1-5 Osmolality (mosmOI/kg) The osmolality results in the products of the invention, Examples 1, 2 and 4, are isotonic.
Bu ürünler cilde uygulandiginda ciltte kizariklik, kabarma, iritasyon, kuruluk Vb rahatsizliklar olusturmaz. Örnek 3°teki ürün hipotonik olup uzun süre cilt ile temas etmesi sonunda ciltte kabarikliklar ve sürtünmelerde tahris olusturabilir. Örnek 5”teki ürün hipertoniktir, ciltten sivi emerek tonisiteyi dengeleyeceginden ciltte kuruluga ve buna bagli rahatsizliklara neden olabilir, bilhassa yenidogan, bebek, yasli ve hassas Ciltlilerde bu rahatsizliklar kendini daha hizli gösterecektir. When these products are applied to the skin, skin redness, blistering, irritation, dryness, etc. does not cause inconvenience. The product in Example 3 is hypotonic and can be applied to the skin for a long time. contact, it may cause irritation in skin blisters and friction. The product in Example 5 is hypertonic, since it will balance the tonicity by absorbing the liquid from the skin. may cause skin dryness and related discomfort, especially newborn, These discomforts will manifest themselves more quickly in babies, old and sensitive skin.
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