TR201720155A2 - Koji̇k asi̇t türevi̇ bi̇leşi̇kleri̇n anti̇kanser ve anti̇ti̇rozi̇naz akti̇vi̇teleri̇ - Google Patents
Koji̇k asi̇t türevi̇ bi̇leşi̇kleri̇n anti̇kanser ve anti̇ti̇rozi̇naz akti̇vi̇teleri̇ Download PDFInfo
- Publication number
- TR201720155A2 TR201720155A2 TR2017/20155A TR201720155A TR201720155A2 TR 201720155 A2 TR201720155 A2 TR 201720155A2 TR 2017/20155 A TR2017/20155 A TR 2017/20155A TR 201720155 A TR201720155 A TR 201720155A TR 201720155 A2 TR201720155 A2 TR 201720155A2
- Authority
- TR
- Turkey
- Prior art keywords
- acid derivative
- anticcenser
- antityrosinase
- activities
- derivative compounds
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 230000000694 effects Effects 0.000 title abstract 2
- 239000002253 acid Substances 0.000 title 1
- 210000004027 cell Anatomy 0.000 abstract 2
- 102000003425 Tyrosinase Human genes 0.000 abstract 1
- 108060008724 Tyrosinase Proteins 0.000 abstract 1
- 230000001472 cytotoxic effect Effects 0.000 abstract 1
- 210000002950 fibroblast Anatomy 0.000 abstract 1
- 230000002538 fungal effect Effects 0.000 abstract 1
- 150000004677 hydrates Chemical class 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- BEJNERDRQOWKJM-UHFFFAOYSA-N kojic acid Chemical class OCC1=CC(=O)C(O)=CO1 BEJNERDRQOWKJM-UHFFFAOYSA-N 0.000 abstract 1
- 230000003211 malignant effect Effects 0.000 abstract 1
- 230000003061 melanogenesis Effects 0.000 abstract 1
- 201000001441 melanoma Diseases 0.000 abstract 1
- 231100000065 noncytotoxic Toxicity 0.000 abstract 1
- 230000002020 noncytotoxic effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/34—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D309/36—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
- C07D309/40—Oxygen atoms attached in positions 3 and 4, e.g. maltol
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cosmetics (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Buluş, mantar tirozinazına (T3824) karşı yüksek inhibisyon gösteren, A375 (ATCC CRL-1619) insan malign hücre hattına karşı sitotoksik özellik gösterirken HGF-1 ve MRC-5 insan fibroblast hücre hatlarına karşı sitotoksik olmayan, bunun yanısıra A375 hücrelerinde melanogenezisi baskılayan ve görülen tüm bu etkilerinden dolayı melanom tedavisinde kullanılması amaçlanan kojik asit türevi mannich bazı yapısındaki bileşikler, bunların hidratları, solvatları, farmakolojik olarak kabul edilebilir tuzları veya geometrik izomerleri ile ilgilidir.
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
TR2017/20155A TR201720155A2 (tr) | 2017-12-12 | 2017-12-12 | Koji̇k asi̇t türevi̇ bi̇leşi̇kleri̇n anti̇kanser ve anti̇ti̇rozi̇naz akti̇vi̇teleri̇ |
PCT/TR2018/050724 WO2019194769A2 (en) | 2017-12-12 | 2018-11-26 | Anti cancer and anti tyrosinase activities of kojic acid derived compounds |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
TR2017/20155A TR201720155A2 (tr) | 2017-12-12 | 2017-12-12 | Koji̇k asi̇t türevi̇ bi̇leşi̇kleri̇n anti̇kanser ve anti̇ti̇rozi̇naz akti̇vi̇teleri̇ |
Publications (1)
Publication Number | Publication Date |
---|---|
TR201720155A2 true TR201720155A2 (tr) | 2019-06-21 |
Family
ID=67952530
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TR2017/20155A TR201720155A2 (tr) | 2017-12-12 | 2017-12-12 | Koji̇k asi̇t türevi̇ bi̇leşi̇kleri̇n anti̇kanser ve anti̇ti̇rozi̇naz akti̇vi̇teleri̇ |
Country Status (2)
Country | Link |
---|---|
TR (1) | TR201720155A2 (tr) |
WO (1) | WO2019194769A2 (tr) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2024509365A (ja) | 2021-02-12 | 2024-03-01 | シムライズ アーゲー | 色素沈着の予防及び治療のための医薬品 |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9975884B2 (en) * | 2015-06-22 | 2018-05-22 | Mutlu Aytemir | Kojic acid-derived mannich bases with biological effect |
-
2017
- 2017-12-12 TR TR2017/20155A patent/TR201720155A2/tr unknown
-
2018
- 2018-11-26 WO PCT/TR2018/050724 patent/WO2019194769A2/en active Application Filing
Also Published As
Publication number | Publication date |
---|---|
WO2019194769A2 (en) | 2019-10-10 |
WO2019194769A3 (en) | 2020-01-09 |
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