TR201106573A2 - İnsulin parçalayan enzimin (IDE) aktivitesini düzenleyen bir molekül. - Google Patents

İnsulin parçalayan enzimin (IDE) aktivitesini düzenleyen bir molekül.

Info

Publication number
TR201106573A2
TR201106573A2 TR2011/06573A TR201106573A TR201106573A2 TR 201106573 A2 TR201106573 A2 TR 201106573A2 TR 2011/06573 A TR2011/06573 A TR 2011/06573A TR 201106573 A TR201106573 A TR 201106573A TR 201106573 A2 TR201106573 A2 TR 201106573A2
Authority
TR
Turkey
Prior art keywords
degrading enzyme
molecule
ide
activity
insulin
Prior art date
Application number
TR2011/06573A
Other languages
English (en)
Inventor
Türkay Meti̇n
Kizilel Seda
Hali̇l Kavakli İbrahi̇m
Dağliyan Onur
Çakir Bi̇lal
Original Assignee
Koç Üni̇versi̇tesi̇
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Koç Üni̇versi̇tesi̇ filed Critical Koç Üni̇versi̇tesi̇
Priority to TR2011/06573A priority Critical patent/TR201106573A2/tr
Priority to PCT/EP2012/062404 priority patent/WO2013004556A1/en
Publication of TR201106573A2 publication Critical patent/TR201106573A2/tr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Obesity (AREA)
  • Hospice & Palliative Care (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Psychiatry (AREA)
  • Emergency Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Mevcut buluş, insülin parçalayan enzim (IDE)'in aktivitesini değiştiren küçük bir molekül ile Alzheimer ve tip II diyabet (şeker) hastalıklarının tedavisi ile ilgilidir. İnsülin parçalayıcı enzimin dış bölgesine bağlanan bu molekül, amiloid betanın kesimini hızlandırmaktadır.
TR2011/06573A 2011-07-01 2011-07-01 İnsulin parçalayan enzimin (IDE) aktivitesini düzenleyen bir molekül. TR201106573A2 (tr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
TR2011/06573A TR201106573A2 (tr) 2011-07-01 2011-07-01 İnsulin parçalayan enzimin (IDE) aktivitesini düzenleyen bir molekül.
PCT/EP2012/062404 WO2013004556A1 (en) 2011-07-01 2012-06-27 A molecule regulating activity of insulin degrading enzyme (ide)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
TR2011/06573A TR201106573A2 (tr) 2011-07-01 2011-07-01 İnsulin parçalayan enzimin (IDE) aktivitesini düzenleyen bir molekül.

Publications (1)

Publication Number Publication Date
TR201106573A2 true TR201106573A2 (tr) 2013-01-21

Family

ID=46516692

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2011/06573A TR201106573A2 (tr) 2011-07-01 2011-07-01 İnsulin parçalayan enzimin (IDE) aktivitesini düzenleyen bir molekül.

Country Status (2)

Country Link
TR (1) TR201106573A2 (tr)
WO (1) WO2013004556A1 (tr)

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002069965A1 (en) * 2001-03-05 2002-09-12 Transtech Pharma, Inc. Benzimidazole derivatives as therapeutic agents

Also Published As

Publication number Publication date
WO2013004556A1 (en) 2013-01-10

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