TR200402443T4 - Process for the preparation of 1- (4-hydroxyphenyl) -2- (4-hydroxy-4-phenylpiperidin-1-yl) -1-propanol and useful intermediates mesylate salt trihydrates. - Google Patents

Process for the preparation of 1- (4-hydroxyphenyl) -2- (4-hydroxy-4-phenylpiperidin-1-yl) -1-propanol and useful intermediates mesylate salt trihydrates.

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Publication number
TR200402443T4
TR200402443T4 TR2004/02443T TR200402443T TR200402443T4 TR 200402443 T4 TR200402443 T4 TR 200402443T4 TR 2004/02443 T TR2004/02443 T TR 2004/02443T TR 200402443 T TR200402443 T TR 200402443T TR 200402443 T4 TR200402443 T4 TR 200402443T4
Authority
TR
Turkey
Prior art keywords
preparation
phenylpiperidin
hydroxyphenyl
propanol
hydroxy
Prior art date
Application number
TR2004/02443T
Other languages
Turkish (tr)
Inventor
Philip Rainville Joseph
Terry Gene Sinay Jr.
Walter Walinsky Stanley
Original Assignee
Pfizer Products Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Products Inc. filed Critical Pfizer Products Inc.
Publication of TR200402443T4 publication Critical patent/TR200402443T4/en

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Abstract

Mevcut bulus, formül (I)'deki (1S,2S)-1-(4-hidroksifenil)-2- (4-hidroksi-4-fenilpiperidin-1-il)-1-propanol bilesiminin mesilat trihidratinin hazirlanmasina yarayan bir prosese iliskin: Buna yani sira mevcut bulus, formül (II)'deki (2S)-(+)- bilesimin hazirlanmasina yarayan bir prosese iliskin: olup özelligi, R1'in, benzil, (C1-C6)alkilbenzil, (c1-C6alkoksilbenzil, tri(C1-C6)alkilsilil, asil (örnegin asetil) ve aroil (örnegin benzoat)'tan olusan gruptan seçilmis, koruyucu bir grup olmasidir. Buna ek olarak, mevcut bulus bu proseslerde yararli olan araci ürünlere iliskindir.The present invention relates to a process for the preparation of mesylate trihydrate of the compound (1S, 2S) -1- (4-hydroxyphenyl) -2- (4-hydroxy-4-phenylpiperidin-1-yl) -1-propanol of formula (I). The present invention also relates to a process for the preparation of the (2S) - (+) - compound of formula (II): wherein R1 is benzyl, (C1-C6) alkylbenzyl, (C1-C6alkoxylbenzyl, tri). It is a protecting group selected from the group consisting of (C1-C6) alkylsilyl, acyl (for example acetyl) and aroyl (for example benzoate), and the present invention relates to intermediates useful in these processes.

TR2004/02443T 2000-04-02 2001-04-24 Process for the preparation of 1- (4-hydroxyphenyl) -2- (4-hydroxy-4-phenylpiperidin-1-yl) -1-propanol and useful intermediates mesylate salt trihydrates. TR200402443T4 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US20041700A 2000-04-02 2000-04-02

Publications (1)

Publication Number Publication Date
TR200402443T4 true TR200402443T4 (en) 2004-12-21

Family

ID=33489061

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2004/02443T TR200402443T4 (en) 2000-04-02 2001-04-24 Process for the preparation of 1- (4-hydroxyphenyl) -2- (4-hydroxy-4-phenylpiperidin-1-yl) -1-propanol and useful intermediates mesylate salt trihydrates.

Country Status (1)

Country Link
TR (1) TR200402443T4 (en)

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