TR200402443T4 - Process for the preparation of 1- (4-hydroxyphenyl) -2- (4-hydroxy-4-phenylpiperidin-1-yl) -1-propanol and useful intermediates mesylate salt trihydrates. - Google Patents
Process for the preparation of 1- (4-hydroxyphenyl) -2- (4-hydroxy-4-phenylpiperidin-1-yl) -1-propanol and useful intermediates mesylate salt trihydrates.Info
- Publication number
- TR200402443T4 TR200402443T4 TR2004/02443T TR200402443T TR200402443T4 TR 200402443 T4 TR200402443 T4 TR 200402443T4 TR 2004/02443 T TR2004/02443 T TR 2004/02443T TR 200402443 T TR200402443 T TR 200402443T TR 200402443 T4 TR200402443 T4 TR 200402443T4
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- TR
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- preparation
- phenylpiperidin
- hydroxyphenyl
- propanol
- hydroxy
- Prior art date
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Abstract
Mevcut bulus, formül (I)'deki (1S,2S)-1-(4-hidroksifenil)-2- (4-hidroksi-4-fenilpiperidin-1-il)-1-propanol bilesiminin mesilat trihidratinin hazirlanmasina yarayan bir prosese iliskin: Buna yani sira mevcut bulus, formül (II)'deki (2S)-(+)- bilesimin hazirlanmasina yarayan bir prosese iliskin: olup özelligi, R1'in, benzil, (C1-C6)alkilbenzil, (c1-C6alkoksilbenzil, tri(C1-C6)alkilsilil, asil (örnegin asetil) ve aroil (örnegin benzoat)'tan olusan gruptan seçilmis, koruyucu bir grup olmasidir. Buna ek olarak, mevcut bulus bu proseslerde yararli olan araci ürünlere iliskindir.The present invention relates to a process for the preparation of mesylate trihydrate of the compound (1S, 2S) -1- (4-hydroxyphenyl) -2- (4-hydroxy-4-phenylpiperidin-1-yl) -1-propanol of formula (I). The present invention also relates to a process for the preparation of the (2S) - (+) - compound of formula (II): wherein R1 is benzyl, (C1-C6) alkylbenzyl, (C1-C6alkoxylbenzyl, tri). It is a protecting group selected from the group consisting of (C1-C6) alkylsilyl, acyl (for example acetyl) and aroyl (for example benzoate), and the present invention relates to intermediates useful in these processes.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US20041700A | 2000-04-02 | 2000-04-02 |
Publications (1)
Publication Number | Publication Date |
---|---|
TR200402443T4 true TR200402443T4 (en) | 2004-12-21 |
Family
ID=33489061
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TR2004/02443T TR200402443T4 (en) | 2000-04-02 | 2001-04-24 | Process for the preparation of 1- (4-hydroxyphenyl) -2- (4-hydroxy-4-phenylpiperidin-1-yl) -1-propanol and useful intermediates mesylate salt trihydrates. |
Country Status (1)
Country | Link |
---|---|
TR (1) | TR200402443T4 (en) |
-
2001
- 2001-04-24 TR TR2004/02443T patent/TR200402443T4/en unknown
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