TR200301723T4 - 1,3 Dihydro-2H-indol-2 one derivatives and their use as binding agents for V1B or V1B receptors of arginine-vasopressin - Google Patents

1,3 Dihydro-2H-indol-2 one derivatives and their use as binding agents for V1B or V1B receptors of arginine-vasopressin

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Publication number
TR200301723T4
TR200301723T4 TR2003/01723T TR200301723T TR200301723T4 TR 200301723 T4 TR200301723 T4 TR 200301723T4 TR 2003/01723 T TR2003/01723 T TR 2003/01723T TR 200301723 T TR200301723 T TR 200301723T TR 200301723 T4 TR200301723 T4 TR 200301723T4
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TR
Turkey
Prior art keywords
receptors
vasopressin
arginine
indol
dihydro
Prior art date
Application number
TR2003/01723T
Other languages
Turkish (tr)
Inventor
Schoent Jes Bruno
Serradeil-Le Gal Claudine
Wagnon Jean
Original Assignee
Sanofi-Synthelabo
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Publication date
Application filed by Sanofi-Synthelabo filed Critical Sanofi-Synthelabo
Publication of TR200301723T4 publication Critical patent/TR200301723T4/en

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
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  • Health & Medical Sciences (AREA)
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  • Heart & Thoracic Surgery (AREA)
  • Immunology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Obesity (AREA)
  • Pain & Pain Management (AREA)
  • Pulmonology (AREA)
  • Hematology (AREA)
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  • Hospice & Palliative Care (AREA)
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  • Urology & Nephrology (AREA)
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Abstract

Bulus, arginin-vasopressin V1b reseptörleri veya hem V1b hem V1a resptörlerine yakinlik gösteren formül bilesimleri ve bunlarin çözeltileri ve/veya hidratlariyla ilgilidir. Bulus ayrica bunlarin hazirlik islemi, hazirlanmalari için kullanilan ara formül (II) bilesimleri, bunlari içeren farmasötik bilesimler ve bunlarin ilçalrain hazirlanmasi için kullanimiyla ilgilidir.The invention relates to compounds of formula and solutions and / or hydrates thereof that are close to arginine-vasopressin V1b receptors or both V1b and V1a receptors. The invention also relates to the preparation process, the compounds of the intermediate formula (II) used for their preparation, the pharmaceutical compositions containing them and their use for the preparation of the medicament.

TR2003/01723T 2000-01-25 2001-01-24 1,3 Dihydro-2H-indol-2 one derivatives and their use as binding agents for V1B or V1B receptors of arginine-vasopressin TR200301723T4 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0000958A FR2804115B1 (en) 2000-01-25 2000-01-25 NOVEL 1,3-DIHYDRO-2H-INDOL-2-ONE DERIVATIVES, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

Publications (1)

Publication Number Publication Date
TR200301723T4 true TR200301723T4 (en) 2004-02-23

Family

ID=8846308

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2003/01723T TR200301723T4 (en) 2000-01-25 2001-01-24 1,3 Dihydro-2H-indol-2 one derivatives and their use as binding agents for V1B or V1B receptors of arginine-vasopressin

Country Status (13)

Country Link
US (1) US6624164B2 (en)
EP (1) EP1254134B1 (en)
JP (1) JP4861591B2 (en)
AT (1) ATE245644T1 (en)
AU (1) AU2001235596A1 (en)
DE (1) DE60100506T2 (en)
DK (1) DK1254134T3 (en)
ES (1) ES2203596T3 (en)
FR (1) FR2804115B1 (en)
HU (1) HU225157B1 (en)
PT (1) PT1254134E (en)
TR (1) TR200301723T4 (en)
WO (1) WO2001055134A2 (en)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2805536B1 (en) * 2000-02-25 2002-08-23 Sanofi Synthelabo NOVEL 1,3-DIHYDRO-2H-INDOL-2-ONE DERIVATIVES, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
EP1659121A4 (en) * 2003-08-28 2008-11-26 Taisho Pharmaceutical Co Ltd 1,3-dihydro-2h-indol-2-one derivative
US20050070718A1 (en) * 2003-09-30 2005-03-31 Abbott Gmbh & Co. Kg Heteroaryl-substituted 1,3-dihydroindol-2-one derivatives and medicaments containing them
US8580842B2 (en) 2003-09-30 2013-11-12 Abbott Gmbh & Co. Kg Heteroaryl-substituted 1,3-dihydroindol-2-one derivatives and medicaments containing them
US7414052B2 (en) 2004-03-30 2008-08-19 Wyeth Phenylaminopropanol derivatives and methods of their use
US7517899B2 (en) 2004-03-30 2009-04-14 Wyeth Phenylaminopropanol derivatives and methods of their use
EP1842555A4 (en) * 2004-12-27 2009-08-19 Univ Kyoto Tolerance development inhibitor for narcotic analgesic agent
JP5125501B2 (en) * 2005-01-28 2013-01-23 大正製薬株式会社 1,3-dihydro-2H-indol-2-one compound and pyrrolidin-2-one compound condensed with aromatic heterocycle
DE102005014904A1 (en) * 2005-03-26 2007-02-01 Abbott Gmbh & Co. Kg New substituted oxindole derivatives are vasopressin receptor binders useful to treat e.g. diabetes insipidus, enuresis nocturna, incontinence, hypertonia, heart failure, myocardial infarction, coronary spasm and renal disorders
MX2007011693A (en) * 2005-03-24 2008-03-11 Abbott Gmbh & Co Kg Substituted oxindol derivatives, drugs containing said derivatives and the use thereof.
DE102005014936A1 (en) 2005-03-24 2006-12-14 Abbott Gmbh & Co. Kg New substituted oxindole derivatives are vasopressin receptor binders useful to treat e.g. diabetes insipidus, enuresis nocturna, incontinence, hypertonia, heart failure, myocardial infarction, coronary spasm and renal disorders
US8044079B2 (en) 2005-12-02 2011-10-25 Abbott Gmbh & Co. Kg Substituted oxindole derivatives, medicaments containing said derivatives and use thereof
DE102006040915A1 (en) * 2006-08-26 2008-03-20 Abbott Gmbh & Co. Kg New oxindole derivatives useful for treating vasopressin- or oxytocin-dependent diseases
MX2009002125A (en) * 2006-08-26 2009-03-09 Abbott Gmbh & Co Kg Substituted benzimidazolone derivatives, medicaments comprising them and their use.
US8486979B2 (en) 2006-12-12 2013-07-16 Abbvie Inc. 1,2,4 oxadiazole compounds and methods of use thereof
US20080167286A1 (en) 2006-12-12 2008-07-10 Abbott Laboratories Pharmaceutical compositions and their methods of use
UY30846A1 (en) 2006-12-30 2008-07-31 Abbott Gmbh & Amp OXINDOL DERIVATIVES REPLACED, MEDICINES THAT UNDERSTAND AND USE THEMSELVES
JP5645217B2 (en) 2007-12-07 2014-12-24 アッヴィ・ドイチュラント・ゲー・エム・ベー・ハー・ウント・コー・カー・ゲー 5,6-disubstituted oxindole derivatives and their use to treat vasopressin-dependent diseases
US8703775B2 (en) 2007-12-07 2014-04-22 AbbVie Deutschland GmbH & Co. KG Amidomethyl-substituted oxindole derivatives and the use thereof for the treatment of vasopressin-dependent illnesses
WO2010009775A1 (en) 2007-12-07 2010-01-28 Abbott Gmbh & Co. Kg Carbamate-substituted oxindole derivatives and use thereof for the treatment of vasopressin-dependent diseases
RU2484090C2 (en) 2007-12-07 2013-06-10 Эбботт Гмбх Унд Ко.Кг 5-halogen-substituted oxindole derivatives and use thereof in treating vasopressin-dependent diseases
MX2010007151A (en) 2007-12-27 2010-12-06 Abbott Gmbh & Co Kg Substituted oxindole-derivatives and the use thereof for the treatment of vasopressin-dependent illnesses.
FR2927625B1 (en) * 2008-02-19 2010-03-12 Sanofi Aventis NOVEL 3-AMINOALKYL-1,3-DIHYDRO-2H-INDOL-2-ONE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC USE
FR2930249B1 (en) 2008-04-21 2010-05-14 Sanofi Aventis NOVEL 3-AMINOALKYL-1,3-DIHYDRO-2H-INDOL-2-ONE DERIVATIVES, THEIR PREPARATION AND THERAPEUTIC USE THEREOF
WO2010138600A2 (en) 2009-05-29 2010-12-02 Abbott Laboratories Pharmaceutical compositions for the treatment of pain

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5940149B2 (en) * 1977-11-09 1984-09-28 大塚製薬株式会社 Oxindole derivative
JPS55129284A (en) * 1979-03-27 1980-10-06 Shionogi & Co Ltd 3-(1-imipazolyl)indolin-2-one
US4760083A (en) * 1986-04-10 1988-07-26 E. I. Dupont De Nemours & Company 3,3-disubstituted indolines
US5338755A (en) * 1990-07-31 1994-08-16 Elf Sanofi N-sulfonylindoline derivatives, their preparation and the pharmaceutical compositions in which they are present
FR2714378B1 (en) 1993-12-24 1996-03-15 Sanofi Sa Indol-2-one derivatives substituted in 3 with a nitrogen group, their preparation, pharmaceutical compositions containing them.
FR2757157B1 (en) 1996-12-13 1999-12-31 Sanofi Sa INDOLIN-2-ONE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

Also Published As

Publication number Publication date
US20030139413A1 (en) 2003-07-24
JP4861591B2 (en) 2012-01-25
JP2003523354A (en) 2003-08-05
HUP0204157A3 (en) 2005-04-28
US6624164B2 (en) 2003-09-23
EP1254134A2 (en) 2002-11-06
HU225157B1 (en) 2006-07-28
ES2203596T3 (en) 2004-04-16
AU2001235596A1 (en) 2001-08-07
WO2001055134A2 (en) 2001-08-02
WO2001055134A3 (en) 2002-03-14
HUP0204157A2 (en) 2003-04-28
ATE245644T1 (en) 2003-08-15
FR2804115A1 (en) 2001-07-27
DE60100506T2 (en) 2004-05-13
EP1254134B1 (en) 2003-07-23
DK1254134T3 (en) 2003-11-03
DE60100506D1 (en) 2003-08-28
PT1254134E (en) 2003-11-28
FR2804115B1 (en) 2002-03-08

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