TR200201204T2 - Prevention of plaque rupture with ACAT inhibitors. - Google Patents
Prevention of plaque rupture with ACAT inhibitors.Info
- Publication number
- TR200201204T2 TR200201204T2 TR2002/01204T TR200201204T TR200201204T2 TR 200201204 T2 TR200201204 T2 TR 200201204T2 TR 2002/01204 T TR2002/01204 T TR 2002/01204T TR 200201204 T TR200201204 T TR 200201204T TR 200201204 T2 TR200201204 T2 TR 200201204T2
- Authority
- TR
- Turkey
- Prior art keywords
- prevention
- plaque rupture
- acat inhibitors
- relates
- rupture
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/18—Sulfonamides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/255—Esters, e.g. nitroglycerine, selenocyanates of sulfoxy acids or sulfur analogues thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/27—Esters, e.g. nitroglycerine, selenocyanates of carbamic or thiocarbamic acids, meprobamate, carbachol, neostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Abstract
Bu bulus, ateroskleroz lezyonlarinda monosit-makrofaz birikmesini ve MMP ifadesini önlemek için bir ACAT inhibitörü verilmesiyle ilgilidir. Dahasi bu bulus, aterosklerotik plaklarin destabilizasyonu ve/veya da kopmasini inhibe etme ve stabil olmayan anjin tedavisi yöntemleri ile de ilgilidir.This invention relates to the administration of an ACAT inhibitor to prevent monocyte-macrophase accumulation and MMP expression in atherosclerosis lesions. Moreover, this invention relates to methods of inhibiting destabilization and / or rupture of atherosclerotic plaques and treatment of unstable angina.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US16381499P | 1999-11-05 | 1999-11-05 |
Publications (1)
Publication Number | Publication Date |
---|---|
TR200201204T2 true TR200201204T2 (en) | 2002-08-21 |
Family
ID=22591694
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TR2002/01204T TR200201204T2 (en) | 1999-11-05 | 2000-10-17 | Prevention of plaque rupture with ACAT inhibitors. |
Country Status (19)
Country | Link |
---|---|
EP (1) | EP1229907A1 (en) |
JP (1) | JP2003513909A (en) |
KR (1) | KR20020050257A (en) |
CN (1) | CN1414848A (en) |
AR (1) | AR026354A1 (en) |
AU (1) | AU1210401A (en) |
CA (1) | CA2382676A1 (en) |
CO (1) | CO5270017A1 (en) |
GT (1) | GT200000193A (en) |
HU (1) | HUP0203160A3 (en) |
IL (1) | IL149145A0 (en) |
PA (1) | PA8506101A1 (en) |
PE (1) | PE20011027A1 (en) |
PL (1) | PL355148A1 (en) |
SV (1) | SV2001000207A (en) |
TR (1) | TR200201204T2 (en) |
UY (1) | UY26427A1 (en) |
WO (1) | WO2001034127A1 (en) |
ZA (1) | ZA200201755B (en) |
Families Citing this family (43)
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KR20060111898A (en) | 2003-08-29 | 2006-10-30 | 교와 가부시키가이샤 | Method of stabilizing lipid-rich plaque and method of preventing rupture thereof |
US20080044404A1 (en) * | 2004-04-15 | 2008-02-21 | Anna Cederholm | Annexin V for Preventing Atherothrombosis and Plaque Rupture |
ES2775125T3 (en) | 2010-11-03 | 2020-07-23 | Dow Agrosciences Llc | Pesticide compositions and related procedures |
US8937083B2 (en) | 2011-10-26 | 2015-01-20 | DowAgroSciences, LLC | Pesticidal compositions and processes related thereto |
US9282739B2 (en) | 2012-04-27 | 2016-03-15 | Dow Agrosciences Llc | Pesticidal compositions and processes related thereto |
JP6189937B2 (en) | 2012-04-27 | 2017-08-30 | ダウ アグロサイエンシィズ エルエルシー | Agrochemical compositions and methods relating thereto |
US9708288B2 (en) | 2012-04-27 | 2017-07-18 | Dow Agrosciences Llc | Pesticidal compositions and processes related thereto |
JP2016536296A (en) | 2013-10-17 | 2016-11-24 | ダウ アグロサイエンシィズ エルエルシー | Method for producing pest control compound |
JP2016536295A (en) | 2013-10-17 | 2016-11-24 | ダウ アグロサイエンシィズ エルエルシー | Method for producing pest control compound |
CN105636446B (en) | 2013-10-17 | 2018-07-13 | 美国陶氏益农公司 | The method for preparing Pesticidal compound |
KR20160072155A (en) | 2013-10-17 | 2016-06-22 | 다우 아그로사이언시즈 엘엘씨 | Processes for the preparation of pesticidal compounds |
JP2016535010A (en) | 2013-10-17 | 2016-11-10 | ダウ アグロサイエンシィズ エルエルシー | Method for producing pest control compound |
US9102655B2 (en) | 2013-10-17 | 2015-08-11 | Dow Agrosciences Llc | Processes for the preparation of pesticidal compounds |
KR20160072154A (en) | 2013-10-17 | 2016-06-22 | 다우 아그로사이언시즈 엘엘씨 | Processes for the preparation of pesticidal compounds |
EP3060052A4 (en) | 2013-10-22 | 2017-04-05 | Dow AgroSciences LLC | Synergistic pesticidal compositions and related methods |
AR098098A1 (en) | 2013-10-22 | 2016-05-04 | Dow Agrosciences Llc | SYNERGIC PESTICIATED COMPOSITIONS AND RELATED METHODS |
CN105828610B (en) | 2013-10-22 | 2019-07-19 | 美国陶氏益农公司 | Pesticidal combination and relative method |
JP2016534086A (en) | 2013-10-22 | 2016-11-04 | ダウ アグロサイエンシィズ エルエルシー | Synergistic pest control compositions and related methods |
MX2016005316A (en) | 2013-10-22 | 2017-03-01 | Dow Agrosciences Llc | Synergistic pesticidal compositions and related methods. |
CA2926438A1 (en) | 2013-10-22 | 2015-04-30 | Dow Agrosciences Llc | Pesticidal compositions and related methods |
MX2016005323A (en) | 2013-10-22 | 2016-08-12 | Dow Agrosciences Llc | Pesticidal compositions and related methods. |
JP2016535025A (en) | 2013-10-22 | 2016-11-10 | ダウ アグロサイエンシィズ エルエルシー | Synergistic pest control compositions and related methods |
WO2015061155A1 (en) | 2013-10-22 | 2015-04-30 | Dow Agrosciences Llc | Pesticidal compositions and related methods |
KR20160074621A (en) | 2013-10-22 | 2016-06-28 | 다우 아그로사이언시즈 엘엘씨 | Synergistic pesticidal compositions and related methods |
CN105848480A (en) | 2013-10-22 | 2016-08-10 | 美国陶氏益农公司 | Synergistic pesticidal compositions and related methods |
TW201519780A (en) | 2013-10-22 | 2015-06-01 | Dow Agrosciences Llc | Pesticidal compositions and related methods |
MX2016005325A (en) | 2013-10-22 | 2016-08-08 | Dow Agrosciences Llc | Synergistic pesticidal compositions and related methods. |
EP3060055A4 (en) | 2013-10-22 | 2017-03-29 | Dow AgroSciences LLC | Synergistic pesticidal compositions and related methods |
US9808008B2 (en) | 2013-10-22 | 2017-11-07 | Dow Agrosciences Llc | Synergistic pesticidal compositions and related methods |
CA2927202A1 (en) | 2013-10-22 | 2015-04-30 | Dow Agrosciences Llc | Synergistic pesticidal compositions and related methods |
AU2014340430B2 (en) | 2013-10-22 | 2017-05-25 | Dow Agrosciences Llc | Pesticidal compositions and related methods |
CN106470976A (en) | 2014-07-31 | 2017-03-01 | 美国陶氏益农公司 | The method of preparation 3 (3 chlorine 1H pyrazoles 1 base) pyridine |
EP3186229A4 (en) | 2014-07-31 | 2018-01-10 | Dow AgroSciences LLC | Process for the preparation of 3-(3-chloro-1h-pyrazol-1-yl)pyridine |
EP3174856A4 (en) | 2014-07-31 | 2018-01-10 | Dow AgroSciences LLC | Process for the preparation of 3-(3-chloro-1h-pyrazol-1-yl)pyridine |
US9024031B1 (en) | 2014-08-19 | 2015-05-05 | Dow Agrosciences Llc | Process for the preparation of 3-(3-chloro-1H-pyrazol-1-yl)pyridine |
BR112017004613A2 (en) | 2014-09-12 | 2017-12-05 | Dow Agrosciences Llc | Process for the preparation of 3- (3-chloro-1h-pyrazol-1-yl) pyridine |
CA2961166C (en) * | 2014-10-21 | 2021-04-13 | Council Of Scientific And Industrial Research | Alkylidene phosphonate esters as p-glycoprotein inducers |
US20190275012A9 (en) * | 2016-07-29 | 2019-09-12 | Lupin Limited | Substituted thiazolo-pyridine compounds as malt1 inhibitors |
WO2018093966A1 (en) * | 2016-11-16 | 2018-05-24 | Purdue Research Foundation | Compositions and methods for regulating body weight and metabolic syndromes |
WO2018125817A1 (en) | 2016-12-29 | 2018-07-05 | Dow Agrosciences Llc | Processes for the preparation of pesticidal compounds |
EP3562807B1 (en) | 2016-12-29 | 2022-08-03 | Corteva Agriscience LLC | Processes for the preparation of pesticidal compounds |
CU20200038A7 (en) | 2017-10-27 | 2021-03-11 | Bayer Ag | COMPOUNDS DERIVED FROM PYRAZOLO-PIRROLO-PYRIMIDINE-DIONA AS INHIBITORS OF P2X3 |
US11034669B2 (en) | 2018-11-30 | 2021-06-15 | Nuvation Bio Inc. | Pyrrole and pyrazole compounds and methods of use thereof |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2067254T3 (en) * | 1990-10-30 | 1995-03-16 | Warner Lambert Co | OXISULFONILCARBAMATOS. |
IL109431A (en) * | 1993-05-14 | 2001-01-11 | Warner Lambert Co | Pharmaceutical compositions containing n-acyl sulfamic acid esters (or thioesters), n-acyl sulfonamides, and n-sulfonyl carbamic acid esters (or thioesters), for regulating plasma cholesterol concentration, and certain such novel compounds |
IT1270976B (en) * | 1993-08-06 | 1997-05-26 | Pierrel Spa | INHIBITIVE COMPOUNDS OF ACYL ENZYME-A-CHOLESTEROL-O-ACYL TRANSFERASE TO THERAPEUTIC ACTIVITIES, THEIR USE AND PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM |
EE9800037A (en) * | 1995-08-04 | 1998-08-17 | Warner-Lambert Company | Use of sulphamic acid derivatives, acylsulphonamides or sulphonylcarbamates in the manufacture of a medicament for reducing lipoprotein levels |
WO1997016184A1 (en) * | 1995-11-02 | 1997-05-09 | Warner-Lambert Company | Method and pharmaceutical composition for regulating lipid concentration |
OA11584A (en) * | 1998-07-21 | 2004-07-20 | Warner Lambert Co | Coadministration of ACAT and MMP inhibitors for the treatment of atherosclerotic lesions. |
-
2000
- 2000-10-17 CA CA002382676A patent/CA2382676A1/en not_active Abandoned
- 2000-10-17 TR TR2002/01204T patent/TR200201204T2/en unknown
- 2000-10-17 CN CN00812939A patent/CN1414848A/en active Pending
- 2000-10-17 JP JP2001536127A patent/JP2003513909A/en active Pending
- 2000-10-17 WO PCT/US2000/028705 patent/WO2001034127A1/en not_active Application Discontinuation
- 2000-10-17 HU HU0203160A patent/HUP0203160A3/en unknown
- 2000-10-17 EP EP00973608A patent/EP1229907A1/en not_active Withdrawn
- 2000-10-17 KR KR1020027005801A patent/KR20020050257A/en not_active Application Discontinuation
- 2000-10-17 PL PL00355148A patent/PL355148A1/en not_active Application Discontinuation
- 2000-10-17 AU AU12104/01A patent/AU1210401A/en not_active Abandoned
- 2000-10-17 IL IL14914500A patent/IL149145A0/en unknown
- 2000-10-25 SV SV2000000207A patent/SV2001000207A/en unknown
- 2000-11-01 PA PA20008506101A patent/PA8506101A1/en unknown
- 2000-11-03 PE PE2000001173A patent/PE20011027A1/en not_active Application Discontinuation
- 2000-11-03 GT GT200000193A patent/GT200000193A/en unknown
- 2000-11-03 UY UY26427A patent/UY26427A1/en not_active Application Discontinuation
- 2000-11-03 AR ARP000105803A patent/AR026354A1/en unknown
- 2000-11-03 CO CO00083934A patent/CO5270017A1/en not_active Application Discontinuation
-
2002
- 2002-03-01 ZA ZA200201755A patent/ZA200201755B/en unknown
Also Published As
Publication number | Publication date |
---|---|
WO2001034127A1 (en) | 2001-05-17 |
CN1414848A (en) | 2003-04-30 |
PE20011027A1 (en) | 2001-10-16 |
CO5270017A1 (en) | 2003-04-30 |
PL355148A1 (en) | 2004-04-05 |
GT200000193A (en) | 2002-04-27 |
AU1210401A (en) | 2001-06-06 |
CA2382676A1 (en) | 2001-05-17 |
PA8506101A1 (en) | 2002-10-28 |
JP2003513909A (en) | 2003-04-15 |
UY26427A1 (en) | 2000-12-29 |
ZA200201755B (en) | 2003-08-27 |
SV2001000207A (en) | 2001-10-16 |
HUP0203160A3 (en) | 2006-02-28 |
AR026354A1 (en) | 2003-02-05 |
IL149145A0 (en) | 2002-11-10 |
EP1229907A1 (en) | 2002-08-14 |
KR20020050257A (en) | 2002-06-26 |
HUP0203160A2 (en) | 2003-01-28 |
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