TR200101255T2 - Method for rapid screening of analytes - Google Patents

Method for rapid screening of analytes

Info

Publication number
TR200101255T2
TR200101255T2 TR2001/01255T TR200101255T TR200101255T2 TR 200101255 T2 TR200101255 T2 TR 200101255T2 TR 2001/01255 T TR2001/01255 T TR 2001/01255T TR 200101255 T TR200101255 T TR 200101255T TR 200101255 T2 TR200101255 T2 TR 200101255T2
Authority
TR
Turkey
Prior art keywords
analytes
analyte
solid support
solid
supports
Prior art date
Application number
TR2001/01255T
Other languages
Turkish (tr)
Inventor
Wilfried Jan Pauwels Rudi
Hubert Simon Roelant Christiaan
Lodewijk August Van Acker Koenraad
Original Assignee
Tibotec N.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tibotec N.V. filed Critical Tibotec N.V.
Publication of TR200101255T2 publication Critical patent/TR200101255T2/en

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5085—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00497—Features relating to the solid phase supports
    • B01J2219/00511—Walls of reactor vessels
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00497—Features relating to the solid phase supports
    • B01J2219/00513—Essentially linear supports
    • B01J2219/00518—Essentially linear supports in the shape of tapes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00497—Features relating to the solid phase supports
    • B01J2219/00513—Essentially linear supports
    • B01J2219/0052—Essentially linear supports in the shape of elongated tubes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00497—Features relating to the solid phase supports
    • B01J2219/00527—Sheets
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00497—Features relating to the solid phase supports
    • B01J2219/00527—Sheets
    • B01J2219/00531—Sheets essentially square
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00497—Features relating to the solid phase supports
    • B01J2219/00527—Sheets
    • B01J2219/00533—Sheets essentially rectangular
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00497—Features relating to the solid phase supports
    • B01J2219/00527—Sheets
    • B01J2219/00536—Sheets in the shape of disks
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00585—Parallel processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00596—Solid-phase processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/0061—The surface being organic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00614—Delimitation of the attachment areas
    • B01J2219/00621—Delimitation of the attachment areas by physical means, e.g. trenches, raised areas
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00659—Two-dimensional arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068—Means for controlling the apparatus of the process
    • B01J2219/00702—Processes involving means for analysing and characterising the products
    • B01J2219/00707—Processes involving means for analysing and characterising the products separated from the reactor apparatus

Abstract

Potansiyel ilaç adaylari gibi analitlerin süratle taranmasi için bir yöntem; yöntem taranacak çok sayida analiti, birbirlerinden ayri kalacak sekilde bir veya birden fazla kati destek üzerinde uygulamak; sözü geçen analit-tasiyan kati destegi (destekleri) yari-kati veya sivi bir ortama içinde temin edilen hedeflele temas ettirmek; sözü geçen analitler kati destekten (desteklerden) hedeflere birakilir; ve analit-hedef etkilesimlerini ölçmek. Bu yöntem binlerce farkli analitin eszamanli olarak islenmesini saglar. Bir aday ilaç için doz tepki egirisi gerektigi taktirde analit kati destege uygulandiginda bir konsantrasyon gradyenti ve seri analit seyreltmesi üretecek sekilde üzerinde dagilir. Tarif edilen yöntem otomatiklestirilebilir.A method for quickly scanning analytes, such as potential drug candidates; the method is to apply a plurality of analytes to be scanned, one or more solid supports, separately; contacting said analyte-carrying solid support (s) with targets provided in a semi-solid or liquid medium; said analytes are dropped from solid support (supports) to targets; and measuring analyte-target interactions. This method allows thousands of different analytes to be processed simultaneously. If a candidate dose response response is required for the drug, the analyte will be dispersed over the solid support to produce a concentration gradient and serial analyte dilution. The described method can be automated.

TR2001/01255T 1998-09-08 1998-09-08 Method for rapid screening of analytes TR200101255T2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/IB1998/001399 WO2000014540A1 (en) 1998-09-08 1998-09-08 Method for the rapid screening of analytes

Publications (1)

Publication Number Publication Date
TR200101255T2 true TR200101255T2 (en) 2001-10-22

Family

ID=11004751

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2001/01255T TR200101255T2 (en) 1998-09-08 1998-09-08 Method for rapid screening of analytes

Country Status (15)

Country Link
EP (1) EP1112494A1 (en)
JP (1) JP2003517575A (en)
KR (1) KR100562872B1 (en)
CN (1) CN1315001A (en)
AU (1) AU771520B2 (en)
BR (1) BR9816009A (en)
CA (1) CA2342627A1 (en)
IL (1) IL141810A (en)
MX (1) MXPA01002431A (en)
NZ (1) NZ510765A (en)
PL (1) PL346565A1 (en)
RU (1) RU2225985C2 (en)
TR (1) TR200101255T2 (en)
TW (1) TW429312B (en)
WO (1) WO2000014540A1 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6800437B1 (en) 1999-08-06 2004-10-05 Tibotec Bvba Method of monitoring a biological system by labeling with an apo metal binding protein
DE10034570A1 (en) * 2000-07-14 2002-01-31 Max Delbrueck Centrum Process for the production of microarray chips with nucleic acids, proteins or other test substances
US7235215B2 (en) 2000-09-07 2007-06-26 Tibotec Bvba Capillary filler
US7524455B2 (en) * 2003-11-24 2009-04-28 General Electric Company Methods for deposition of sensor regions onto optical storage media substrates and resulting devices
JP2005172475A (en) * 2003-12-08 2005-06-30 Mitsubishi Rayon Co Ltd Bioassay plate and bioassay method using the same
DE102007056398A1 (en) * 2007-11-23 2009-05-28 Febit Holding Gmbh Flexible extraction method for the preparation of sequence-specific molecule libraries
CN101339167B (en) * 2008-08-27 2011-12-14 中国药科大学 Active ingredient high throughput screen method based on target protein and selection
RU2558229C2 (en) * 2013-04-19 2015-07-27 Общество с ограниченной ответственностью "Ген Эксперт" Set and method for preparing multi-layered agarose blocks on surface of micro-slides for microscoly
WO2018175500A1 (en) * 2017-03-21 2018-09-27 Hexanomics, Inc. Sealed microwell assay

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE431257B (en) * 1977-11-03 1984-01-23 Du Pont SET AND DEVICE FOR IMMUNAL ANALYSIS WITH MAGNETIC METAL OR METAL OXIDE AS A BRAND
US4276048A (en) * 1979-06-14 1981-06-30 Dynatech Ag Miniature reaction container and a method and apparatus for introducing micro volumes of liquid to such a container
US5011779A (en) * 1988-01-21 1991-04-30 Long Island Jewish Medical Center Apparatus for rapid deposition of test samples on an absorbent support
GB9321650D0 (en) * 1993-10-20 1993-12-08 Genome Research Limited Improvements in or relating to electrophoresis
US5856083A (en) * 1994-05-06 1999-01-05 Pharmacopeia, Inc. Lawn assay for compounds that affect enzyme activity or bind to target molecules
CN1230216A (en) * 1996-07-08 1999-09-29 伯斯坦恩实验室股份有限公司 Cleavable signal element device and method
CA2270665A1 (en) * 1996-11-11 1998-05-22 Novartis Ag Use of biosensors to diagnose plant diseases

Also Published As

Publication number Publication date
TW429312B (en) 2001-04-11
KR100562872B1 (en) 2006-03-23
NZ510765A (en) 2003-09-26
IL141810A0 (en) 2002-03-10
PL346565A1 (en) 2002-02-11
EP1112494A1 (en) 2001-07-04
RU2225985C2 (en) 2004-03-20
AU2251200A (en) 2000-03-27
BR9816009A (en) 2001-06-05
WO2000014540A1 (en) 2000-03-16
KR20010106467A (en) 2001-11-29
AU771520B2 (en) 2004-03-25
JP2003517575A (en) 2003-05-27
MXPA01002431A (en) 2002-05-08
CN1315001A (en) 2001-09-26
CA2342627A1 (en) 2000-03-16
IL141810A (en) 2005-08-31

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