TR200003333T2 - Benzothiophins useful in the treatment of insulin resistance and hyperglycemia - Google Patents
Benzothiophins useful in the treatment of insulin resistance and hyperglycemiaInfo
- Publication number
- TR200003333T2 TR200003333T2 TR2000/03333T TR200003333T TR200003333T2 TR 200003333 T2 TR200003333 T2 TR 200003333T2 TR 2000/03333 T TR2000/03333 T TR 2000/03333T TR 200003333 T TR200003333 T TR 200003333T TR 200003333 T2 TR200003333 T2 TR 200003333T2
- Authority
- TR
- Turkey
- Prior art keywords
- hyperglycemia
- useful
- treatment
- insulin resistance
- benzothiophins
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/92—Naphthofurans; Hydrogenated naphthofurans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/58—[b]- or [c]-condensed
- C07D209/60—Naphtho [b] pyrroles; Hydrogenated naphtho [b] pyrroles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/74—Naphthothiophenes
Abstract
Bu bulus,ensülin direngenligine veya hiperglisemiye bagli metabolik bozukluklarin tedavisinde yararli olan formül (I)'e iliskin bilesikleri saglamakta olup Ar burada (a), (b) veya (c)'dir. A,B,C,D,E,X,Y,Z1 ve Z2 burada tanim bölümünde tarif edildigi gibidir veya bunlarin farmakolojik olarak kabul edilebilir tuzlaridir.This invention provides compounds of formula (I) useful for the treatment of metabolic disorders due to insulin resistance or hyperglycemia, where Ar is (a), (b) or (c). A, B, C, D, E, X, Y, Z1 and Z2 are as described herein or their pharmacologically acceptable salts.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US7671298A | 1998-05-12 | 1998-05-12 |
Publications (1)
Publication Number | Publication Date |
---|---|
TR200003333T2 true TR200003333T2 (en) | 2001-02-21 |
Family
ID=22133746
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TR2000/03333T TR200003333T2 (en) | 1998-05-12 | 1999-05-10 | Benzothiophins useful in the treatment of insulin resistance and hyperglycemia |
Country Status (22)
Country | Link |
---|---|
EP (1) | EP1077969A1 (en) |
JP (1) | JP2002516321A (en) |
KR (1) | KR20010043539A (en) |
CN (1) | CN1308626A (en) |
AR (1) | AR015294A1 (en) |
AU (1) | AU756337B2 (en) |
BG (1) | BG104918A (en) |
BR (1) | BR9911779A (en) |
CA (1) | CA2330620A1 (en) |
EA (1) | EA200001175A1 (en) |
EE (1) | EE200000653A (en) |
HR (1) | HRP20000767A2 (en) |
HU (1) | HUP0101792A3 (en) |
ID (1) | ID26244A (en) |
IL (1) | IL139132A0 (en) |
NO (1) | NO20005677L (en) |
PL (1) | PL344081A1 (en) |
SK (1) | SK16992000A3 (en) |
TR (1) | TR200003333T2 (en) |
TW (1) | TW510900B (en) |
WO (1) | WO1999061435A1 (en) |
ZA (1) | ZA200005961B (en) |
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---|---|---|---|---|
US6472545B2 (en) | 2000-08-29 | 2002-10-29 | Abbott Laboratories | Protein tyrosine phosphatase inhibitors |
WO2002018363A2 (en) * | 2000-08-29 | 2002-03-07 | Abbott Laboratories | 3-phenyl-propanoic acid derivatives as protein tyrosine phosphatase inhibitors |
US6498182B2 (en) | 2000-09-26 | 2002-12-24 | Biovitrum Ab | Compounds |
WO2002026707A1 (en) * | 2000-09-26 | 2002-04-04 | Biovitrum Ab | Novel compounds |
US6969730B2 (en) | 2001-03-16 | 2005-11-29 | Abbott Laboratories | Amines as histamine-3 receptor ligands and their therapeutic applications |
US20020198201A1 (en) * | 2001-06-07 | 2002-12-26 | Wyeth | Combination of a PTPase inhibitor and an aldose reductase inhibitor |
US20030013709A1 (en) * | 2001-06-07 | 2003-01-16 | Wyeth | Combination of a PTPase inhibitor and an alpha-glucosidase inhibitor |
WO2002098409A1 (en) * | 2001-06-07 | 2002-12-12 | Wyeth | Combination therapy for type ii diabetes or syndrome x |
WO2002100398A1 (en) * | 2001-06-07 | 2002-12-19 | Wyeth | Combination of a ptpase inhibitor and an ace inhibitor |
WO2002098408A1 (en) * | 2001-06-07 | 2002-12-12 | Wyeth | Ptpase inhibitors for improving cardiovascular risk profile |
WO2002100396A1 (en) * | 2001-06-07 | 2002-12-19 | Wyeth | COMBINATION OF A PTPase INHIBITOR AND A THIAZOLIDINEDIONE AGENT |
WO2002098414A1 (en) * | 2001-06-07 | 2002-12-12 | Wyeth | Methods using ptpase inhibitors and insulin |
WO2002098410A1 (en) * | 2001-06-07 | 2002-12-12 | Wyeth | Combination of a ptpase inhibitor and a sulfonylurea agent |
WO2002100397A1 (en) * | 2001-06-07 | 2002-12-19 | Wyeth | COMBINATION OF A PTPase INHIBITOR AND AN ANTILIPEMIC AGENT |
TWI224101B (en) | 2001-06-20 | 2004-11-21 | Wyeth Corp | Substituted naphthyl indole derivatives as inhibitors of plasminogen activator inhibitor type-1 (PAI-1) |
ATE367812T1 (en) | 2001-06-20 | 2007-08-15 | Wyeth Corp | SUBSTITUTED INDOLIC ACID DERIVATIVES AS INHIBITORS OF PLASMINOGEN ACTIVATOR INHIBITOR-1 (PAI-1) |
JP2005508355A (en) | 2001-10-19 | 2005-03-31 | トランス テック ファーマ,インコーポレイテッド | Bis-heteroarylalkanes as therapeutic agents |
US7163952B2 (en) | 2001-12-03 | 2007-01-16 | Japan Tobacco Inc. | Azole compound and medicinal use thereof |
ITMI20022172A1 (en) * | 2002-10-14 | 2004-04-15 | Clariant Lsm Italia Spa | PROCESS FOR THE PREPARATION OF 3-ALCHYL-THIOPHENI-2, 5-REPLACED. |
DE60324183D1 (en) | 2002-12-10 | 2008-11-27 | Wyeth Corp | Aryl-, aryloxy- und alkyloxysubstituierte 1h-indol-3-yl-glyoxylsäurederivateals inhibitoren des plasminogenaktivatorinhibitors-1 (pai-1) |
US7056943B2 (en) | 2002-12-10 | 2006-06-06 | Wyeth | Substituted indole oxo-acetyl amino acetic acid derivatives as inhibitors of plasminogen activator inhibitor-1 (PAI-1) |
BR0316574A (en) | 2002-12-10 | 2005-10-04 | Wyeth Corp | Substituted 3-carbonyl-1h-indol-1-yl acetic acid derivatives as plasminogen activator inhibitor-1 inhibitors (parent-1) |
EP1569899B1 (en) | 2002-12-10 | 2006-06-28 | Wyeth | Substituted 3-alkyl- and 3-arylalkyl-1h-indol-1-yl-acetic acid derivatives as inhibitors of plasminogen activator inhibitor-1 (pai-1) |
UA80453C2 (en) | 2002-12-10 | 2007-09-25 | Derivatives of substituted dyhydropyranoindol-3,4-dion as inhibitors of plasminogen activator inhibitor-1 (pai-1) | |
US7718377B2 (en) | 2003-05-29 | 2010-05-18 | Kyoto Pharmaceutical Industries, Ltd. | Insulin resistance curative and method of screening the same |
US7504401B2 (en) | 2003-08-29 | 2009-03-17 | Locus Pharmaceuticals, Inc. | Anti-cancer agents and uses thereof |
US7265148B2 (en) | 2003-09-25 | 2007-09-04 | Wyeth | Substituted pyrrole-indoles |
US7411083B2 (en) | 2003-09-25 | 2008-08-12 | Wyeth | Substituted acetic acid derivatives |
US7332521B2 (en) | 2003-09-25 | 2008-02-19 | Wyeth | Substituted indoles |
US7446201B2 (en) | 2003-09-25 | 2008-11-04 | Wyeth | Substituted heteroaryl benzofuran acids |
US7442805B2 (en) | 2003-09-25 | 2008-10-28 | Wyeth | Substituted sulfonamide-indoles |
US7351726B2 (en) | 2003-09-25 | 2008-04-01 | Wyeth | Substituted oxadiazolidinediones |
US7163954B2 (en) | 2003-09-25 | 2007-01-16 | Wyeth | Substituted naphthyl benzothiophene acids |
US7268159B2 (en) | 2003-09-25 | 2007-09-11 | Wyeth | Substituted indoles |
US7141592B2 (en) | 2003-09-25 | 2006-11-28 | Wyeth | Substituted oxadiazolidinediones |
US7342039B2 (en) | 2003-09-25 | 2008-03-11 | Wyeth | Substituted indole oximes |
US7582773B2 (en) | 2003-09-25 | 2009-09-01 | Wyeth | Substituted phenyl indoles |
US7420059B2 (en) | 2003-11-20 | 2008-09-02 | Bristol-Myers Squibb Company | HMG-CoA reductase inhibitors and method |
FR2862645B1 (en) * | 2003-11-20 | 2007-06-22 | Merck Sante Sas | ANTIDIABETIC COMPOUNDS CONTAINING BENZOFURAN, BENZOTHIOPHENIC DERIVATIVES |
CN101039936A (en) | 2004-08-23 | 2007-09-19 | 惠氏公司 | Oxazolo-naphthyl acids as plasminogen activator inhibitor type-1(pai-1) modulators useful in the treatment of thrombosis and cardiovascular diseases |
EP1919866A2 (en) | 2005-08-17 | 2008-05-14 | Wyeth a Corporation of the State of Delaware | Substituted indoles and use thereof |
US8969514B2 (en) | 2007-06-04 | 2015-03-03 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases |
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JP2011522828A (en) | 2008-06-04 | 2011-08-04 | シナジー ファーマシューティカルズ インコーポレイテッド | Guanylate cyclase agonists useful for the treatment of gastrointestinal disorders, inflammation, cancer, and other disorders |
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GB0822486D0 (en) | 2008-12-10 | 2009-01-14 | Univ Liverpool | Compounds for use in the treatment of pain |
US9616097B2 (en) | 2010-09-15 | 2017-04-11 | Synergy Pharmaceuticals, Inc. | Formulations of guanylate cyclase C agonists and methods of use |
WO2014057522A1 (en) | 2012-10-12 | 2014-04-17 | Mochida Pharmaceutical Co., Ltd. | Compositions and methods for treating non-alcoholic steatohepatitis |
US10441560B2 (en) | 2013-03-15 | 2019-10-15 | Mochida Pharmaceutical Co., Ltd. | Compositions and methods for treating non-alcoholic steatohepatitis |
CN105592846A (en) | 2013-03-15 | 2016-05-18 | 持田制药株式会社 | Compositions and methods for treating non-alcoholic steatohepatitis |
US9486494B2 (en) | 2013-03-15 | 2016-11-08 | Synergy Pharmaceuticals, Inc. | Compositions useful for the treatment of gastrointestinal disorders |
EP2970384A1 (en) | 2013-03-15 | 2016-01-20 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase and their uses |
JP6606491B2 (en) | 2013-06-05 | 2019-11-13 | シナジー ファーマシューティカルズ インコーポレイテッド | Ultra high purity agonist of guanylate cyclase C, method for producing and using the same |
CN106749169B (en) * | 2016-11-07 | 2020-04-21 | 浙江工业大学 | Chiral preparation method of Ertiprotafib |
CN107033122B (en) * | 2017-05-19 | 2019-06-14 | 南方医科大学 | A kind of N- aryl -2- thiophene-carboxamides analog derivative and its preparation method and application |
WO2019208713A1 (en) | 2018-04-26 | 2019-10-31 | 国立大学法人東京工業大学 | Method for promoting differentiation of pluripotent stem cells |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CH505846A (en) * | 1968-08-15 | 1971-04-15 | Parke Davis & Co | Process for the preparation of new heterocyclic compounds |
US3639422A (en) * | 1969-07-28 | 1972-02-01 | Parke Davis & Co | 4-phenylindole-1 (and 7)-acetic acids |
US3682976A (en) * | 1970-02-16 | 1972-08-08 | Parke Davis & Co | Phenyl benzofuran acetic acid compounds |
GB8417559D0 (en) * | 1984-07-10 | 1984-08-15 | Pfizer Ltd | Anti-diarrhoeal agents |
FR2599740B1 (en) * | 1986-06-05 | 1988-08-12 | Rhone Poulenc Sante | BENZO (B) THIOPHENE DERIVATIVES OF BENZO (B) FURANNECARBOXAMIDES, PROCESSES FOR THEIR PREPARATION AND MEDICINES CONTAINING THEM |
JPH01135766A (en) * | 1987-11-20 | 1989-05-29 | Tanabe Seiyaku Co Ltd | Biphenyl derivative |
US5110825A (en) * | 1989-12-28 | 1992-05-05 | Shionogi & Co., Ltd. | Benzofuran derivative |
US5340833A (en) * | 1992-05-01 | 1994-08-23 | Eisai Co., Ltd. | Urokinase inhibitors |
DE4425613A1 (en) * | 1994-07-20 | 1996-01-25 | Bayer Ag | 5-membered heteroaryl oxazolidinones |
-
1999
- 1999-05-10 PL PL99344081A patent/PL344081A1/en not_active Application Discontinuation
- 1999-05-10 BR BR9911779-7A patent/BR9911779A/en not_active IP Right Cessation
- 1999-05-10 TW TW088107532A patent/TW510900B/en active
- 1999-05-10 AU AU38939/99A patent/AU756337B2/en not_active Ceased
- 1999-05-10 EE EEP200000653A patent/EE200000653A/en unknown
- 1999-05-10 ID IDW20002311A patent/ID26244A/en unknown
- 1999-05-10 JP JP2000550841A patent/JP2002516321A/en active Pending
- 1999-05-10 CA CA002330620A patent/CA2330620A1/en not_active Abandoned
- 1999-05-10 CN CN99808367A patent/CN1308626A/en active Pending
- 1999-05-10 TR TR2000/03333T patent/TR200003333T2/en unknown
- 1999-05-10 EP EP99921829A patent/EP1077969A1/en not_active Withdrawn
- 1999-05-10 SK SK1699-2000A patent/SK16992000A3/en unknown
- 1999-05-10 EA EA200001175A patent/EA200001175A1/en unknown
- 1999-05-10 HU HU0101792A patent/HUP0101792A3/en unknown
- 1999-05-10 WO PCT/US1999/010209 patent/WO1999061435A1/en not_active Application Discontinuation
- 1999-05-10 KR KR1020007012649A patent/KR20010043539A/en not_active Application Discontinuation
- 1999-05-10 IL IL13913299A patent/IL139132A0/en unknown
- 1999-05-12 AR ARP990102229A patent/AR015294A1/en unknown
-
2000
- 2000-10-24 ZA ZA200005961A patent/ZA200005961B/en unknown
- 2000-11-07 BG BG104918A patent/BG104918A/en unknown
- 2000-11-10 HR HR20000767A patent/HRP20000767A2/en not_active Application Discontinuation
- 2000-11-10 NO NO20005677A patent/NO20005677L/en not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
AR015294A1 (en) | 2001-04-18 |
WO1999061435A1 (en) | 1999-12-02 |
JP2002516321A (en) | 2002-06-04 |
TW510900B (en) | 2002-11-21 |
EE200000653A (en) | 2002-04-15 |
AU3893999A (en) | 1999-12-13 |
KR20010043539A (en) | 2001-05-25 |
EP1077969A1 (en) | 2001-02-28 |
CN1308626A (en) | 2001-08-15 |
SK16992000A3 (en) | 2001-04-09 |
ZA200005961B (en) | 2001-10-24 |
HRP20000767A2 (en) | 2001-10-31 |
PL344081A1 (en) | 2001-09-24 |
NO20005677D0 (en) | 2000-11-10 |
ID26244A (en) | 2000-12-07 |
HUP0101792A2 (en) | 2002-01-28 |
BR9911779A (en) | 2001-02-06 |
NO20005677L (en) | 2000-12-05 |
CA2330620A1 (en) | 1999-12-02 |
BG104918A (en) | 2001-08-31 |
EA200001175A1 (en) | 2001-06-25 |
HUP0101792A3 (en) | 2003-01-28 |
IL139132A0 (en) | 2001-11-25 |
AU756337B2 (en) | 2003-01-09 |
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