TR199900193T2 - Plasminogen activator that can be activated with thrombin. - Google Patents

Plasminogen activator that can be activated with thrombin.

Info

Publication number
TR199900193T2
TR199900193T2 TR1999/00193T TR9900193T TR199900193T2 TR 199900193 T2 TR199900193 T2 TR 199900193T2 TR 1999/00193 T TR1999/00193 T TR 1999/00193T TR 9900193 T TR9900193 T TR 9900193T TR 199900193 T2 TR199900193 T2 TR 199900193T2
Authority
TR
Turkey
Prior art keywords
plasminogen activator
thrombin
activated
fibrin
simogenicity
Prior art date
Application number
TR1999/00193T
Other languages
Turkish (tr)
Inventor
Kohnert Ulrich
Fischer Stephan
Original Assignee
Boehringer Mannheim Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Mannheim Gmbh filed Critical Boehringer Mannheim Gmbh
Publication of TR199900193T2 publication Critical patent/TR199900193T2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21069—Protein C activated (3.4.21.69)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

a) Plazminojen aktiflestiricisi trombin tarafindan ayristirilabilecek ve böyle bir ayristirma ile iki halkali formuna geçirilebilecek sekilde degistirilmis olan, b) simojenitesi t-PA'a karsilik en az faktör 1.2'den büyük olacak sekilde degistirilmis olan ve c) fibrin bagi plazminojen aktiflestiricisi bir kan pihtisina % 50'den daha fazla nüfuz edecek kadar indirgenmis olan bir plazminojen aktiflestiricisi (t-PA), gelistirilmis bir fibrin spesivitesi ve daha cüzi yan etkiler göstermektedir.a) The plasminogen activator has been modified to be separated by thrombin and can be transformed into a two-ring form with such a separation, b) has been changed to be at least a factor greater than 1.2 for the simogenicity t-PA, and c) a fibrin-binding plasminogen activator. A plasminogen activator (t-PA), reduced to penetrate more than 50%, shows improved fibrin specificity and milder side effects.

TR1999/00193T 1996-08-02 1997-07-21 Plasminogen activator that can be activated with thrombin. TR199900193T2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP96112487 1996-08-02

Publications (1)

Publication Number Publication Date
TR199900193T2 true TR199900193T2 (en) 1999-03-22

Family

ID=8223069

Family Applications (1)

Application Number Title Priority Date Filing Date
TR1999/00193T TR199900193T2 (en) 1996-08-02 1997-07-21 Plasminogen activator that can be activated with thrombin.

Country Status (11)

Country Link
EP (1) EP0917567A1 (en)
JP (1) JP2000504941A (en)
KR (1) KR20000029755A (en)
CN (1) CN1226926A (en)
AU (1) AU3769797A (en)
BR (1) BR9711015A (en)
CA (1) CA2262751A1 (en)
TR (1) TR199900193T2 (en)
TW (1) TW450996B (en)
WO (1) WO1998005762A1 (en)
ZA (1) ZA976876B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR19990081421A (en) * 1998-04-29 1999-11-15 성재갑 Method for producing human platelet promoter (TPO) using animal cells
CN101886066A (en) * 2009-05-13 2010-11-17 南京大学 Treatment effect of tissue plasminogen activator kringle-2 on stroke and preparation method for tissue plasminogen activator kringle-2
AU2018271424A1 (en) 2017-12-13 2019-06-27 Playable Pty Ltd System and Method for Algorithmic Editing of Video Content

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5200340A (en) * 1987-05-22 1993-04-06 Zymogenetics, Inc. Thrombin-activated tissue plasminogen activators
JPH02438A (en) * 1987-10-09 1990-01-05 Collaborative Res Inc Modified low molecular weight plasminogen activated factor and production thereof
US5504001A (en) * 1987-11-25 1996-04-02 Zymogenetics, Inc. Hybrid plasminogen activator
US4999194A (en) * 1988-01-14 1991-03-12 Collaborative Research, Inc. Two-chain urokinase plasminogen activators for treatment of thrombotic disease
GB8927722D0 (en) * 1989-12-07 1990-02-07 British Bio Technology Proteins and nucleic acids
GB9222758D0 (en) * 1992-10-29 1992-12-09 British Bio Technology Proteins and nucleic acids

Also Published As

Publication number Publication date
EP0917567A1 (en) 1999-05-26
TW450996B (en) 2001-08-21
WO1998005762A1 (en) 1998-02-12
JP2000504941A (en) 2000-04-25
AU3769797A (en) 1998-02-25
CA2262751A1 (en) 1998-02-12
CN1226926A (en) 1999-08-25
BR9711015A (en) 1999-08-17
ZA976876B (en) 1999-02-01
KR20000029755A (en) 2000-05-25

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