TNSN95062A1 - NEW DIALKOXY-PYRIDINYLE-BENZIMIDAZOLE DERIVATIVES - Google Patents

NEW DIALKOXY-PYRIDINYLE-BENZIMIDAZOLE DERIVATIVES

Info

Publication number
TNSN95062A1
TNSN95062A1 TNTNSN95062A TNSN95062A TNSN95062A1 TN SN95062 A1 TNSN95062 A1 TN SN95062A1 TN TNSN95062 A TNTNSN95062 A TN TNSN95062A TN SN95062 A TNSN95062 A TN SN95062A TN SN95062 A1 TNSN95062 A1 TN SN95062A1
Authority
TN
Tunisia
Prior art keywords
compounds
methyl
pyridinyle
dialkoxy
new
Prior art date
Application number
TNTNSN95062A
Other languages
French (fr)
Inventor
Per Lennart Lindberg
Gunnel Elisabeth Sunden
Unge Per Oskar Sverker Von
Original Assignee
Astra Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astra Ab filed Critical Astra Ab
Publication of TNSN95062A1 publication Critical patent/TNSN95062A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

LES COMPOSES NOUVEAUX OPTIQUEMENT PURS, SOIT, LES COMPOSES ENANTIOMERES SIMPLES (+)-5-CARBOMETHOXY-6-METHYL-2-[[(3,4-DIMETHOXY-2- PYRIDINYL) METHYL] SULFINYL] -1-H- BENZIMIDAZOLE ET (-) -5- CARBOMETHOXY-6-METHYL-2- [[(3,4-DIMETHOXY-2- PYRIDINYL) METHYL] SULFINYL] -1H-BENZIMIDAZOLE, OU DES SELS THERAPEUTIQUEMENT ACCEPTABLES DE CEUX-CI TELS QUE SELS NA+, Mg2+, Li+, K+, Ca2+ ET N+(R4), OU R EST UN GROUPE ALKYLE AVEC 1 A 4 ATOMES DE CARBONE, DES PROCEDES POUR LEUR PREPARATION ET DES PREPARATIONS PHARMACEUTIQUES CONTENANT LES COMPOSES COMME INGREDIENTS ACTIFS, AINSI QUE L'EMPLOI DES COMPOSES DANS DES PREPARATIONS PHARMACEUTIQUES, ET LES INTERMEDIAIRES OBTENUS EN PREPARANT LES COMPOSESTHE OPTICALLY PURE NEW COMPOUNDS, EITHER, THE SIMPLE ENANTIOMERIC COMPOUNDS (+) - 5-CARBOMETHOXY-6-METHYL-2 - [[(3,4-DIMETHOXY-2- PYRIDINYL) METHYL] SULFINYL] -1-H- BENZIMIDAZOLE AND (-) -5- CARBOMETHOXY-6-METHYL-2- [[(3,4-DIMETHOXY-2- PYRIDINYL) METHYL] SULFINYL] -1H-BENZIMIDAZOLE, OR THERAPEUTICALLY ACCEPTABLE SALTS SUCH AS NA + SALTS, Mg2 +, Li +, K +, Ca2 + AND N + (R4), OR R IS AN ALKYL GROUP WITH 1 TO 4 CARBON ATOMS, METHODS FOR THEIR PREPARATION AND PHARMACEUTICAL PREPARATIONS CONTAINING THE COMPOUNDS AS ACTIVE INGREDIENTS, AS WELL AS THE USE OF THE COMPOUNDS IN PHARMACEUTICAL PREPARATIONS, AND THE INTERMEDIATES OBTAINED BY PREPARING THE COMPOUNDS

TNTNSN95062A 1994-05-27 1994-05-29 NEW DIALKOXY-PYRIDINYLE-BENZIMIDAZOLE DERIVATIVES TNSN95062A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE9400511 1994-05-27

Publications (1)

Publication Number Publication Date
TNSN95062A1 true TNSN95062A1 (en) 1996-02-06

Family

ID=20392945

Family Applications (1)

Application Number Title Priority Date Filing Date
TNTNSN95062A TNSN95062A1 (en) 1994-05-27 1994-05-29 NEW DIALKOXY-PYRIDINYLE-BENZIMIDAZOLE DERIVATIVES

Country Status (18)

Country Link
EP (1) EP0712401A1 (en)
JP (1) JPH09504557A (en)
CN (1) CN1128997A (en)
AU (1) AU2633095A (en)
BR (1) BR9506235A (en)
CA (1) CA2166988A1 (en)
CZ (1) CZ24396A3 (en)
EE (1) EE9600011A (en)
FI (1) FI960367A (en)
HU (1) HU9600005D0 (en)
IL (1) IL113604A0 (en)
IS (1) IS4321A (en)
MA (1) MA23563A1 (en)
NO (1) NO960268L (en)
PL (1) PL312692A1 (en)
TN (1) TNSN95062A1 (en)
WO (1) WO1995032959A1 (en)
ZA (1) ZA954125B (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9423970D0 (en) * 1994-11-28 1995-01-11 Astra Ab Oxidation
GB9423968D0 (en) * 1994-11-28 1995-01-11 Astra Ab Resolution
US5840737A (en) 1996-01-04 1998-11-24 The Curators Of The University Of Missouri Omeprazole solution and method for using same
US6489346B1 (en) 1996-01-04 2002-12-03 The Curators Of The University Of Missouri Substituted benzimidazole dosage forms and method of using same
KR100619200B1 (en) 1998-11-18 2006-09-05 아스트라제네카 아베 Improved Chemical Process and Pharmaceutical Formulation
US8206741B2 (en) 2001-06-01 2012-06-26 Pozen Inc. Pharmaceutical compositions for the coordinated delivery of NSAIDs
US8993599B2 (en) 2003-07-18 2015-03-31 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
US8906940B2 (en) 2004-05-25 2014-12-09 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
EP2086543A2 (en) 2006-10-27 2009-08-12 The Curators of the University of Missouri Compositions comprising at least one acid labile proton pump inhibiting agents, optionally other pharmaceutically active agents and methods of using same
WO2009105568A1 (en) 2008-02-20 2009-08-27 The Curators Of The University Of Missouri Composition comprising a combination of omeprazole and lansoprazole, and a buffering agent, and methods of using same
EA201100313A1 (en) 2008-09-09 2011-10-31 Астразенека Аб METHOD OF DELIVERY OF THE PHARMACEUTICAL COMPOSITION TO THE PATIENT NEEDING THIS
CA2764963C (en) 2009-06-25 2016-11-01 Astrazeneca Ab Method for treating a patient at risk for developing an nsaid-associated ulcer
WO2013101897A2 (en) 2011-12-28 2013-07-04 Pozen Inc. Improved compositions and methods for delivery of omeprazole plus acetylsalicylic acid

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE184602T1 (en) * 1990-06-20 1999-10-15 Astra Ab DIALKOXYPYRIDINYLBENZIMIDAZOLE DERIVATIVES, PROCESS FOR PRODUCTION AND PHARMACEUTICAL USE THEREOF
DE4035455A1 (en) * 1990-11-08 1992-05-14 Byk Gulden Lomberg Chem Fab ENANTIOMER SEPARATION

Also Published As

Publication number Publication date
HU9600005D0 (en) 1996-03-28
EP0712401A1 (en) 1996-05-22
IL113604A0 (en) 1995-08-31
NO960268D0 (en) 1996-01-23
CN1128997A (en) 1996-08-14
AU2633095A (en) 1995-12-21
EE9600011A (en) 1996-04-15
JPH09504557A (en) 1997-05-06
WO1995032959A1 (en) 1995-12-07
FI960367A0 (en) 1996-01-26
CA2166988A1 (en) 1995-12-07
BR9506235A (en) 1997-08-12
NO960268L (en) 1996-01-23
MA23563A1 (en) 1995-12-31
ZA954125B (en) 1995-11-27
IS4321A (en) 1996-01-17
FI960367A (en) 1996-01-26
PL312692A1 (en) 1996-05-13
CZ24396A3 (en) 1996-06-12

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