TNSN95062A1 - NEW DIALKOXY-PYRIDINYLE-BENZIMIDAZOLE DERIVATIVES - Google Patents

NEW DIALKOXY-PYRIDINYLE-BENZIMIDAZOLE DERIVATIVES

Info

Publication number
TNSN95062A1
TNSN95062A1 TNTNSN95062A TNSN95062A TNSN95062A1 TN SN95062 A1 TNSN95062 A1 TN SN95062A1 TN TNSN95062 A TNTNSN95062 A TN TNSN95062A TN SN95062 A TNSN95062 A TN SN95062A TN SN95062 A1 TNSN95062 A1 TN SN95062A1
Authority
TN
Tunisia
Prior art keywords
compounds
methyl
pyridinyle
dialkoxy
new
Prior art date
Application number
TNTNSN95062A
Other languages
French (fr)
Inventor
Per Lennart Lindberg
Gunnel Elisabeth Sunden
Unge Per Oskar Sverker Von
Original Assignee
Astra Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astra Ab filed Critical Astra Ab
Publication of TNSN95062A1 publication Critical patent/TNSN95062A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

LES COMPOSES NOUVEAUX OPTIQUEMENT PURS, SOIT, LES COMPOSES ENANTIOMERES SIMPLES (+)-5-CARBOMETHOXY-6-METHYL-2-[[(3,4-DIMETHOXY-2- PYRIDINYL) METHYL] SULFINYL] -1-H- BENZIMIDAZOLE ET (-) -5- CARBOMETHOXY-6-METHYL-2- [[(3,4-DIMETHOXY-2- PYRIDINYL) METHYL] SULFINYL] -1H-BENZIMIDAZOLE, OU DES SELS THERAPEUTIQUEMENT ACCEPTABLES DE CEUX-CI TELS QUE SELS NA+, Mg2+, Li+, K+, Ca2+ ET N+(R4), OU R EST UN GROUPE ALKYLE AVEC 1 A 4 ATOMES DE CARBONE, DES PROCEDES POUR LEUR PREPARATION ET DES PREPARATIONS PHARMACEUTIQUES CONTENANT LES COMPOSES COMME INGREDIENTS ACTIFS, AINSI QUE L'EMPLOI DES COMPOSES DANS DES PREPARATIONS PHARMACEUTIQUES, ET LES INTERMEDIAIRES OBTENUS EN PREPARANT LES COMPOSESTHE OPTICALLY PURE NEW COMPOUNDS, EITHER, THE SIMPLE ENANTIOMERIC COMPOUNDS (+) - 5-CARBOMETHOXY-6-METHYL-2 - [[(3,4-DIMETHOXY-2- PYRIDINYL) METHYL] SULFINYL] -1-H- BENZIMIDAZOLE AND (-) -5- CARBOMETHOXY-6-METHYL-2- [[(3,4-DIMETHOXY-2- PYRIDINYL) METHYL] SULFINYL] -1H-BENZIMIDAZOLE, OR THERAPEUTICALLY ACCEPTABLE SALTS SUCH AS NA + SALTS, Mg2 +, Li +, K +, Ca2 + AND N + (R4), OR R IS AN ALKYL GROUP WITH 1 TO 4 CARBON ATOMS, METHODS FOR THEIR PREPARATION AND PHARMACEUTICAL PREPARATIONS CONTAINING THE COMPOUNDS AS ACTIVE INGREDIENTS, AS WELL AS THE USE OF THE COMPOUNDS IN PHARMACEUTICAL PREPARATIONS, AND THE INTERMEDIATES OBTAINED BY PREPARING THE COMPOUNDS

TNTNSN95062A 1994-05-27 1994-05-29 NEW DIALKOXY-PYRIDINYLE-BENZIMIDAZOLE DERIVATIVES TNSN95062A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE9400511 1994-05-27

Publications (1)

Publication Number Publication Date
TNSN95062A1 true TNSN95062A1 (en) 1996-02-06

Family

ID=20392945

Family Applications (1)

Application Number Title Priority Date Filing Date
TNTNSN95062A TNSN95062A1 (en) 1994-05-27 1994-05-29 NEW DIALKOXY-PYRIDINYLE-BENZIMIDAZOLE DERIVATIVES

Country Status (18)

Country Link
EP (1) EP0712401A1 (en)
JP (1) JPH09504557A (en)
CN (1) CN1128997A (en)
AU (1) AU2633095A (en)
BR (1) BR9506235A (en)
CA (1) CA2166988A1 (en)
CZ (1) CZ24396A3 (en)
EE (1) EE9600011A (en)
FI (1) FI960367A (en)
HU (1) HU9600005D0 (en)
IL (1) IL113604A0 (en)
IS (1) IS4321A (en)
MA (1) MA23563A1 (en)
NO (1) NO960268D0 (en)
PL (1) PL312692A1 (en)
TN (1) TNSN95062A1 (en)
WO (1) WO1995032959A1 (en)
ZA (1) ZA954125B (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9423968D0 (en) * 1994-11-28 1995-01-11 Astra Ab Resolution
GB9423970D0 (en) * 1994-11-28 1995-01-11 Astra Ab Oxidation
US6489346B1 (en) 1996-01-04 2002-12-03 The Curators Of The University Of Missouri Substituted benzimidazole dosage forms and method of using same
US5840737A (en) 1996-01-04 1998-11-24 The Curators Of The University Of Missouri Omeprazole solution and method for using same
IL142629A0 (en) * 1998-11-18 2002-03-10 Astra Ab Improved chemical process and pharmaceutical formulation
US8206741B2 (en) 2001-06-01 2012-06-26 Pozen Inc. Pharmaceutical compositions for the coordinated delivery of NSAIDs
US8993599B2 (en) 2003-07-18 2015-03-31 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
US8906940B2 (en) 2004-05-25 2014-12-09 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
EP2086543A2 (en) 2006-10-27 2009-08-12 The Curators of the University of Missouri Compositions comprising at least one acid labile proton pump inhibiting agents, optionally other pharmaceutically active agents and methods of using same
JP2011512416A (en) 2008-02-20 2011-04-21 ザ・キュレイターズ・オブ・ザ・ユニバーシティー・オブ・ミズーリ Composition comprising a combination of omeprazole and lansoprazole and a buffer and method of using the same
KR20110079641A (en) 2008-09-09 2011-07-07 아스트라제네카 아베 Method for delivering a pharmaceutical composition to patient in need thereof
AU2010263304A1 (en) 2009-06-25 2012-02-02 Astrazeneca Ab Method for treating a patient at risk for developing an NSAID-associated ulcer
EP2797600A4 (en) 2011-12-28 2015-09-16 Pozen Inc Improved compositions and methods for delivery of omeprazole plus acetylsalicylic acid

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2083606C (en) * 1990-06-20 2001-08-21 Arne Elof Brandstrom Dialkoxy-pyridinyl-benzimidazole derivatives, process for their preparation and their pharmaceutical use
DE4035455A1 (en) * 1990-11-08 1992-05-14 Byk Gulden Lomberg Chem Fab ENANTIOMER SEPARATION

Also Published As

Publication number Publication date
FI960367A0 (en) 1996-01-26
IS4321A (en) 1996-01-17
JPH09504557A (en) 1997-05-06
NO960268L (en) 1996-01-23
HU9600005D0 (en) 1996-03-28
NO960268D0 (en) 1996-01-23
IL113604A0 (en) 1995-08-31
CA2166988A1 (en) 1995-12-07
PL312692A1 (en) 1996-05-13
AU2633095A (en) 1995-12-21
MA23563A1 (en) 1995-12-31
BR9506235A (en) 1997-08-12
FI960367A (en) 1996-01-26
EP0712401A1 (en) 1996-05-22
CN1128997A (en) 1996-08-14
WO1995032959A1 (en) 1995-12-07
ZA954125B (en) 1995-11-27
EE9600011A (en) 1996-04-15
CZ24396A3 (en) 1996-06-12

Similar Documents

Publication Publication Date Title
TNSN95062A1 (en) NEW DIALKOXY-PYRIDINYLE-BENZIMIDAZOLE DERIVATIVES
FR2421889A1 (en) NEW DERIVATIVES OF THIAZOLIDINECARBOXYLIC-4 ACID USEFUL AS ANTIHYPERTENSIVE MEDICINAL PRODUCTS AND METHODS FOR THEIR PREPARATION
MY121192A (en) New compounds.
EG17795A (en) Process for preparing of 3-substituted 2-oxindole-1-carboxaimes as analgese and anti-inflammatory agents
KR930700482A (en) Neuroprotective Andolone and Related Derivatives
HUP9802937A2 (en) Benzo[g]quuinoline derivatives, pharmaceutical compositions containing them and their use
TNSN91049A1 (en) SUBSTITUTED BENZIMIDAZOLES, PROCESSES FOR THEIR PREPARATION, AND THEIR PHARMACEUTICAL USE
IL85988A (en) 1-phenyl-3-naphthalenyloxy-propanamines,process for their preparation and pharmaceutical compositions containing them
BE888052A (en) NOVEL MORPHOLINO COMPOUNDS, PROCESS FOR THEIR PREPARATION AND MEDICAMENTS CONTAINING THEM
FR2438654A1 (en) 2-METHYL-DIHYDROPYRIDINE COMPOUND, METHODS FOR OBTAINING SAME, AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME
FR2397403A1 (en) NEW DERIVATIVES OF 1-ACYL 2-CYANO-AZIRIDINE, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS
KR950005823A (en) 5-Amino-8-methyl-7-pyrrolidinylquinoline-3-carboxylic acid derivative
YU47338B (en) NEW COMPOUND 4-FLUORO-2 - // (4-METHOXY-2-PYRIDINYL) METHYL / SULPHINYL - 1H-BENZIMIDAZOL AND PROCEDURE FOR ITS PREPARATION
IT1196041B (en) (8S) -8-FLUOROERITROMICINE, THE PROCEDURE FOR THEIR PREPARATION AND FORMULATIONS SUITABLE FOR THE ORAL ADMINISTRATION CONTAINING THE PRODUCTS
TNSN95063A1 (en) NEW SUBSTITUTED BENZIMIDAZOLES
FR2440353A1 (en) NOVEL ARYLETHANOLS, PROCESSES FOR OBTAINING THEM AND THEIR USE AS A MEDICINAL PRODUCT
HUP0004058A2 (en) Compositions and methods for reversibly increasing permeability of biomembranes
KR890009912A (en) Quinoline derivatives and their preparation
FR2603587A1 (en) 2,3,4,5,6,7-HEXAHYDRO-2,7-METHANO-1,5-BENZOXAZONINE (OR -1,4-BENZOXAZONINE) DERIVATIVES, PROCESS FOR THEIR PREPARATION, MEDICAMENTS CONTAINING THEM AND INTERMEDIATE COMPOUNDS
AU687023B2 (en) Use of idazoxan and derivatives thereof in preparing a drug for treating parkinson's disease and its development
FR2355839A1 (en) OPTICALLY ACTIVE DERIVATIVES OF BENZOXAZOLYL-PROPIONIC ACID, PROCESS FOR THEIR PREPARATION AND THERAPEUTIC COMPOSITIONS CONTAINING THEM
ES487631A1 (en) Hexahydro-1,4-oxazepines, process for their preparation and pharmaceutical compositions containing them.
FR2506767A1 (en) HETEROCYCLIC DERIVATIVES OF AMIDOXIMES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION
TNSN92073A1 (en) QUATERNARY AMMONIUM DERIVATIVES OF (+) AND (-) 10- (1-AZABICYCLO [2,2,2] OCT-3-YL-METHYL) -10-H-PHENOTHIAZINE, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND PROCESS FOR THEIR PREPARATION
ES8703441A1 (en) 6-Oxomorpholine derivatives, process for their preparation, intermediates, and pharmaceutical compositions containing these derivatives.