TNSN08237A1 - SPIROCYCLIC DERIVATIVES - Google Patents

SPIROCYCLIC DERIVATIVES

Info

Publication number
TNSN08237A1
TNSN08237A1 TNP2008000237A TNSN08237A TNSN08237A1 TN SN08237 A1 TNSN08237 A1 TN SN08237A1 TN P2008000237 A TNP2008000237 A TN P2008000237A TN SN08237 A TNSN08237 A TN SN08237A TN SN08237 A1 TNSN08237 A1 TN SN08237A1
Authority
TN
Tunisia
Prior art keywords
pain
compounds
spirocyclic derivatives
solvates
alkyl
Prior art date
Application number
TNP2008000237A
Other languages
French (fr)
Inventor
David James Rawson
Nigel Alan Swain
Original Assignee
Pfizer Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/IB2006/003388 external-priority patent/WO2007063391A2/en
Application filed by Pfizer Ltd filed Critical Pfizer Ltd
Publication of TNSN08237A1 publication Critical patent/TNSN08237A1/en

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Landscapes

  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

la presente invention propose des composés de formule (I) dans laquelle: m est egal à 0, 1 ou 2; X représente O, S ou un groupe N-CN; R représente un groupe F, Cl ou CN; A représente un groupe cycloalkylène en C3 à C6 facultativement substitué avec un groupe alkyle en C1 à C4 , et B représente une liaison simple ou un groupe alkylène en C1 OU C2; ou un de leurs sels, produits de solvatation , produit polymorphe ou precurseurs medicamenteux pharmaceutiquement acceptables . Les composés sont des inhibiteurs de PDE7 et ont un certain nombre d'applications thérapeutiques, en particulier dans le traitement de la douleur, notamment la douleur neuropathique.the present invention provides compounds of formula (I) wherein: m is 0, 1 or 2; X is O, S or N-CN; R is F, Cl or CN; A represents a C3-C6 cycloalkylene group optionally substituted with C1-C4 alkyl, and B represents a single bond or C1-C2 alkylene group; or a salt thereof, solvates, polymorphic product or pharmaceutically acceptable drug precursors. The compounds are PDE7 inhibitors and have a number of therapeutic applications, particularly in the treatment of pain, including neuropathic pain.

TNP2008000237A 2005-12-02 2008-05-30 SPIROCYCLIC DERIVATIVES TNSN08237A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US74185405P 2005-12-02 2005-12-02
PCT/IB2006/003388 WO2007063391A2 (en) 2005-12-02 2006-11-23 Spirocyclic quinazoline derivatives as pde7 inhibitors

Publications (1)

Publication Number Publication Date
TNSN08237A1 true TNSN08237A1 (en) 2009-10-30

Family

ID=40181219

Family Applications (1)

Application Number Title Priority Date Filing Date
TNP2008000237A TNSN08237A1 (en) 2005-12-02 2008-05-30 SPIROCYCLIC DERIVATIVES

Country Status (3)

Country Link
CN (1) CN101321738A (en)
TN (1) TNSN08237A1 (en)
ZA (1) ZA200803878B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103068394A (en) * 2010-04-15 2013-04-24 皇家学习促进学会/麦吉尔大学 Topical treatments for pain
CN107903161A (en) * 2017-11-23 2018-04-13 上海毕路得医药科技有限公司 A kind of synthetic method of cis 3 hydroxycyclobutyl formic acid
CN108129288B (en) * 2017-12-27 2021-01-22 上海毕得医药科技股份有限公司 Synthesis method of trans-3-hydroxycyclobutylformic acid

Also Published As

Publication number Publication date
ZA200803878B (en) 2009-10-28
CN101321738A (en) 2008-12-10

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