TNSN08237A1 - SPIROCYCLIC DERIVATIVES - Google Patents
SPIROCYCLIC DERIVATIVESInfo
- Publication number
- TNSN08237A1 TNSN08237A1 TNP2008000237A TNSN08237A TNSN08237A1 TN SN08237 A1 TNSN08237 A1 TN SN08237A1 TN P2008000237 A TNP2008000237 A TN P2008000237A TN SN08237 A TNSN08237 A TN SN08237A TN SN08237 A1 TNSN08237 A1 TN SN08237A1
- Authority
- TN
- Tunisia
- Prior art keywords
- pain
- compounds
- spirocyclic derivatives
- solvates
- alkyl
- Prior art date
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
la presente invention propose des composés de formule (I) dans laquelle: m est egal à 0, 1 ou 2; X représente O, S ou un groupe N-CN; R représente un groupe F, Cl ou CN; A représente un groupe cycloalkylène en C3 à C6 facultativement substitué avec un groupe alkyle en C1 à C4 , et B représente une liaison simple ou un groupe alkylène en C1 OU C2; ou un de leurs sels, produits de solvatation , produit polymorphe ou precurseurs medicamenteux pharmaceutiquement acceptables . Les composés sont des inhibiteurs de PDE7 et ont un certain nombre d'applications thérapeutiques, en particulier dans le traitement de la douleur, notamment la douleur neuropathique.the present invention provides compounds of formula (I) wherein: m is 0, 1 or 2; X is O, S or N-CN; R is F, Cl or CN; A represents a C3-C6 cycloalkylene group optionally substituted with C1-C4 alkyl, and B represents a single bond or C1-C2 alkylene group; or a salt thereof, solvates, polymorphic product or pharmaceutically acceptable drug precursors. The compounds are PDE7 inhibitors and have a number of therapeutic applications, particularly in the treatment of pain, including neuropathic pain.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US74185405P | 2005-12-02 | 2005-12-02 | |
PCT/IB2006/003388 WO2007063391A2 (en) | 2005-12-02 | 2006-11-23 | Spirocyclic quinazoline derivatives as pde7 inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
TNSN08237A1 true TNSN08237A1 (en) | 2009-10-30 |
Family
ID=40181219
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TNP2008000237A TNSN08237A1 (en) | 2005-12-02 | 2008-05-30 | SPIROCYCLIC DERIVATIVES |
Country Status (3)
Country | Link |
---|---|
CN (1) | CN101321738A (en) |
TN (1) | TNSN08237A1 (en) |
ZA (1) | ZA200803878B (en) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103068394A (en) * | 2010-04-15 | 2013-04-24 | 皇家学习促进学会/麦吉尔大学 | Topical treatments for pain |
CN107903161A (en) * | 2017-11-23 | 2018-04-13 | 上海毕路得医药科技有限公司 | A kind of synthetic method of cis 3 hydroxycyclobutyl formic acid |
CN108129288B (en) * | 2017-12-27 | 2021-01-22 | 上海毕得医药科技股份有限公司 | Synthesis method of trans-3-hydroxycyclobutylformic acid |
-
2006
- 2006-11-23 CN CNA200680045333XA patent/CN101321738A/en active Pending
-
2008
- 2008-05-07 ZA ZA200803878A patent/ZA200803878B/en unknown
- 2008-05-30 TN TNP2008000237A patent/TNSN08237A1/en unknown
Also Published As
Publication number | Publication date |
---|---|
ZA200803878B (en) | 2009-10-28 |
CN101321738A (en) | 2008-12-10 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
MA30014B1 (en) | SPIROCYCLIC DERIVATIVES | |
MA28270A1 (en) | Pyrido [2,3-D] pyrimidine-2,4-diamines as PDE 2 inhibitors | |
RU2207341C2 (en) | Novel diamine cyclic compounds medicinal agents comprising thereof and methods of treatment | |
TNSN02021A1 (en) | NOVEL BENZIMIDAZOLE DERIVATIVES AND COMPOSITIONS CONTAINING THEM | |
MA28747B1 (en) | Pyridine Derivatives | |
TNSN01077A1 (en) | NEW TROPANE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND COMPOSITIONS CONTAINING THEM | |
RU2342367C2 (en) | Non-nucleozide inhibitors i of reverse transcriptase, intended for treatment of hiv-mediated diseases | |
MA31894B1 (en) | Organic compositions | |
GEP20053619B (en) | Pyrazole Derivatives for Treating HIV | |
TNSN04156A1 (en) | SUBSTITUTED PYRIDINONES AS MODULATORS OF MAP-KINASE P38 | |
MA31754B1 (en) | CIS-IMIDAZOLINES CHIRALES | |
HUP0204083A2 (en) | 2-amino-nicotinamide derivatives and their use as vegf-receptor tyrosine kinase inhibitors, process for their preparation and pharmaceutical compositions containing them | |
NO20071719L (en) | Pyridyl inhibitors for "hedgehog" signaling | |
DK1678166T3 (en) | protein kinase inhibitors | |
MA29926B1 (en) | PYRAZINE DERIVATIVES | |
MA29791B1 (en) | THERAPEUTIC COMPOUNDS. | |
HRP20090159T1 (en) | Use of glucosidase inhibitors for therapy of mucovisidosis | |
MA28742B1 (en) | PYRIDO-PYRIMIDINE DERIVATIVES, THEIR PREPARATION, THEIR THERAPEUTIC APPLICATION | |
MA31873B1 (en) | Peptide inhibitors dformylase | |
MX2023014630A (en) | Dimethoxyphenylalkylamine activators of serotonin receptors. | |
IS2387B (en) | Anti-tumor agents | |
TNSN08237A1 (en) | SPIROCYCLIC DERIVATIVES | |
MA27795A1 (en) | CYCLIC AMINE DERIVATIVES, PROCESSES FOR PREPARING THE SAME, AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | |
GB0223232D0 (en) | Chemical compounds | |
HUP0301594A2 (en) | Pharmaceutical compositions containing e-meta-nicotine diacyl tartaric acid salt and their use for treating of cns-disorders |