TNSN07386A1 - Treatment of severe community-acquired pneumonia by administration of tissue factor pathway inhibitor (tfpi) - Google Patents

Treatment of severe community-acquired pneumonia by administration of tissue factor pathway inhibitor (tfpi)

Info

Publication number
TNSN07386A1
TNSN07386A1 TNP2007000386A TNSN07386A TNSN07386A1 TN SN07386 A1 TNSN07386 A1 TN SN07386A1 TN P2007000386 A TNP2007000386 A TN P2007000386A TN SN07386 A TNSN07386 A TN SN07386A TN SN07386 A1 TNSN07386 A1 TN SN07386A1
Authority
TN
Tunisia
Prior art keywords
tfpi
administration
tissue factor
pathway inhibitor
factor pathway
Prior art date
Application number
TNP2007000386A
Inventor
Abla Creasey
Original Assignee
Novartis Vaccines & Diagnostics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Vaccines & Diagnostics Inc filed Critical Novartis Vaccines & Diagnostics Inc
Publication of TNSN07386A1 publication Critical patent/TNSN07386A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/727—Heparin; Heparan
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A61K38/57—Protease inhibitors from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

Methods for prophylactically or therapeutically treating severe pneumonia involve administration of tissue factor pathway inhibitor (TFPI) or a TFPI analog to patients suffering from or at risk of developing this condition. The methods involve the use of continuous intravenous infusion of TFPI or a TFPI analog, preferably at low doses to avoid adverse side effects.
TNP2007000386A 2005-04-15 2007-10-11 Treatment of severe community-acquired pneumonia by administration of tissue factor pathway inhibitor (tfpi) TNSN07386A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US67146605P 2005-04-15 2005-04-15
PCT/US2006/013890 WO2006113360A2 (en) 2005-04-15 2006-04-14 Treatment of severe community-acquired pneumonia by administration of tissue factor pathway inhibitor(tfpi)

Publications (1)

Publication Number Publication Date
TNSN07386A1 true TNSN07386A1 (en) 2009-03-17

Family

ID=36951247

Family Applications (1)

Application Number Title Priority Date Filing Date
TNP2007000386A TNSN07386A1 (en) 2005-04-15 2007-10-11 Treatment of severe community-acquired pneumonia by administration of tissue factor pathway inhibitor (tfpi)

Country Status (13)

Country Link
EP (1) EP1871408A2 (en)
JP (1) JP2008536859A (en)
KR (1) KR20080033151A (en)
CN (1) CN101180074A (en)
AU (1) AU2006236698A1 (en)
BR (1) BRPI0610549A2 (en)
CA (1) CA2605057A1 (en)
IL (1) IL186548A0 (en)
MX (1) MX2007012619A (en)
RU (1) RU2007142192A (en)
TN (1) TNSN07386A1 (en)
WO (1) WO2006113360A2 (en)
ZA (1) ZA200708700B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009129164A1 (en) * 2008-04-15 2009-10-22 Novartis Ag Pharmaceutical combinations of tfpi-fragments and an antibiotic

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL372138A1 (en) * 2001-10-15 2005-07-11 Chiron Corporation Treatment of sepsis by low dose administration of tissue factor pathway inhibitor (tfpi)

Also Published As

Publication number Publication date
RU2007142192A (en) 2009-05-20
CN101180074A (en) 2008-05-14
WO2006113360A2 (en) 2006-10-26
CA2605057A1 (en) 2006-10-26
KR20080033151A (en) 2008-04-16
ZA200708700B (en) 2008-12-31
AU2006236698A1 (en) 2006-10-26
WO2006113360A3 (en) 2007-04-12
BRPI0610549A2 (en) 2010-07-06
IL186548A0 (en) 2008-01-20
MX2007012619A (en) 2008-01-11
JP2008536859A (en) 2008-09-11
EP1871408A2 (en) 2008-01-02

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