[0331] LA PRESENTE INVENTION CONCERNE LES ANTICORPS ET LES PARTIES ANTIGENE-LIANTES DE TEL ANTICORPS QUI LIENT SPECIFIQUEMENT A CD40, CD40 DE PREFERENCE HUMAIN, ET QUI FONCTIONNENT COMME DES AGONISTES DE CD40. L'INVENTION SE RELIE EGALEMENT AUX ANTICORPS ANTI-CD40 HUMAINS ET AUX PARTIES ANTIGENE-LIANTES DE CELA. L'INVENTION SE RELIE EGALEMENT AUX ANTICORPS QUI SONT LES ANTICORPS OU LES PARTIES DE PROTEINES DE FUSION CHIMERIQUES, BISPECIFIQUES, DERIVATISES, A CHAINE SEULE. L'INVENTION SE RELIE EGALEMENT AUX IMMUNOGLOBULINES A CHAINE LOURDE ET LEGERE ISOLEE DERIVEE DES ANTICORPS ANTI-CD40 HUMAINS ET DES MOLECULES D'ACIDE NUCLEIQUE CODANT DE TELLES IMMUNOGLOBULINES. LA PRESENTE INVENTION SE RELIE EGALEMENT AUX METHODES DE LA FABRICATION DES ANTICOPRS ANTI-CD40 HUMAINS, COMPOSITIONS COMPORTANT CES ANTICORPS ET METHODES D'EMPLOYER LES ANTICORPS ET LES COMPOSITIONS POUR LE DIAGNOSTIC ET LE TRAITEMENT. L'INVENTION FOURNIT EGALEMENT DES METHODES DE THERAPIE DE GENE EN UTILISANT DES MOLECULES D'ACIDE NUCLEIQUE CODANT LES MOLECULES LOURDES ET/OU LEGERES D'IMMUNOGLOBULINE QUI COMPORTENT LES ANTICORPS ANTI-CD40 HUMAINS. L'IINVENTION SE RELIE EGALEMENT AUX ANIMAUX DE TRANFEREMENT GENIQUE (TRANSGENIQUES) COMPORTANT DES MOLECULES D'ACIDE NUCLEIQUE DE LA PRESENTE INVENTION.THE PRESENT INVENTION CONCERNS ANTIBODIES AND ANTIGEN-BINDING PARTS OF SUCH ANTIBODIES WHICH SPECIFICALLY BIND TO CD40, CD40 PREFERABLY HUMAN, AND WHICH FUNCTION AS AGONISTS OF CD40. THE INVENTION ALSO RELATES TO HUMAN ANTI-CD40 ANTIBODIES AND TO THE ANTIGEN-BINDING PARTS THEREOF. THE INVENTION ALSO RELATES TO ANTIBODIES WHICH ARE THE ANTIBODIES OR PARTS OF CHEMICAL, BISPECIFIC, DERIVATIVE, CHAIN-ONLY FUSION PROTEINS. THE INVENTION ALSO RELATES TO ISOLATED LIGHT HEAVY CHAIN IMMUNOGLOBULINS DERIVED FROM HUMAN ANTI-CD40 ANTIBODIES AND NUCLEIC ACID MOLECULES ENCODING SUCH IMMUNOGLOBULINS. THIS INVENTION ALSO RELATES TO METHODS OF MANUFACTURING HUMAN ANTI-CD40 ANTIBODIES, COMPOSITIONS COMPRISING SUCH ANTIBODIES, AND METHODS OF USING THE ANTIBODIES AND COMPOSITIONS FOR DIAGNOSIS AND TREATMENT. THE INVENTION ALSO PROVIDES GENE THERAPY METHODS USING NUCLEIC ACID MOLECULES ENCODING HEAVY AND / OR LIGHT IMMUNOGLOBULIN MOLECULES THAT COMPRISE HUMAN ANTI-CD40 ANTIBODIES. THE INVENTION ALSO RELATES TO GENE TRANSFER ANIMALS (TRANSGENIC) COMPRISING NUCLEIC ACID MOLECULES OF THE PRESENT INVENTION.