TN2014000149A1 - Antibody polypeptides that antagonize cd40l - Google Patents

Antibody polypeptides that antagonize cd40l

Info

Publication number
TN2014000149A1
TN2014000149A1 TNP2014000149A TN2014000149A TN2014000149A1 TN 2014000149 A1 TN2014000149 A1 TN 2014000149A1 TN P2014000149 A TNP2014000149 A TN P2014000149A TN 2014000149 A TN2014000149 A TN 2014000149A TN 2014000149 A1 TN2014000149 A1 TN 2014000149A1
Authority
TN
Tunisia
Prior art keywords
antibody polypeptides
cd40l
bind human
diseases
polypeptides
Prior art date
Application number
TNP2014000149A
Inventor
Steven G Nadler
James K Tamura
Laura Price
Robert P Rehfuss
Suzanne J Suchard
Anish Suri
James William Bryson
Aaron Yamniuk
Steven Grant
Olga Ignatovich
Philip Drew
Original Assignee
Bristol Myers Squibb Co
Domantis Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US2012/059977 external-priority patent/WO2013056068A1/en
Application filed by Bristol Myers Squibb Co, Domantis Ltd filed Critical Bristol Myers Squibb Co
Publication of TN2014000149A1 publication Critical patent/TN2014000149A1/en

Links

Landscapes

  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Antibody polypeptides that specifically bind human CD40L are provided. The antibody polypeptides do not activate platelets. The antibody polypeptides are useful in the treatment of diseases involving CD40L activation, such as graft-related diseases and autoimmune diseases. The antibody polypeptides may be domain antibodies (dAbs) comprising a single VH or VK domain. The half-life of the antibody polypeptides may be increased by modifying the antibody polypeptides to be dual specific reagents that can also bind human serum albumin (HSA) or another antigen.
TNP2014000149A 2012-06-04 2014-04-10 Antibody polypeptides that antagonize cd40l TN2014000149A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261655110P 2012-06-04 2012-06-04
PCT/US2012/059977 WO2013056068A1 (en) 2011-10-13 2012-10-12 Antibody polypeptides that antagonize cd40l

Publications (1)

Publication Number Publication Date
TN2014000149A1 true TN2014000149A1 (en) 2015-09-30

Family

ID=59799097

Family Applications (1)

Application Number Title Priority Date Filing Date
TNP2014000149A TN2014000149A1 (en) 2012-06-04 2014-04-10 Antibody polypeptides that antagonize cd40l

Country Status (1)

Country Link
TN (1) TN2014000149A1 (en)

Similar Documents

Publication Publication Date Title
MX357231B (en) Antibody polypeptides that antagonize cd40l.
TN2013000417A1 (en) Antibody polypeptides that antagonize cd40
TN2014000120A1 (en) Cd27l antigen binding proteins
CA2886433C (en) Human monoclonal anti-pd-l1 antibodies and methods of use
WO2013051878A3 (en) Antibody specifically binding to epitope in sema domain of c-met
NZ717673A (en) Anti-alpha-synuclein antibodies and methods of use
PH12014502527B1 (en) St2 antigen binding proteins
EP4219552A3 (en) Il-11r binding proteins and uses thereof
MX2013013832A (en) Fc RECEPTOR BINDING PROTEINS.
WO2012064792A3 (en) Protein complexes for antigen binding and methods of use
MX351502B (en) Albumin binding antibodies and binding fragments thereof.
CA2872308A1 (en) Novel ha binding agents
WO2012064836A9 (en) Methods and compositions for neural disease immunotherapy
NZ629553A (en) Anti-big-endothelin-1 (big-et-1) antibodies and uses thereof
MX2015003150A (en) Human islet amyloid polypeptide (hiapp) specific antibodies and uses thereof.
WO2012054929A3 (en) Use of human serum albumin to decrease antigenicity of therapeutic proteins
PH12015500752A1 (en) Her3 antigen binding proteins binding to the beta-hairpin of her3
PH12015500751A1 (en) Anti-her3/her4 antigen binding proteins binding to the beta-hairpin of her3 and beta-hairpin of her4
MX343580B (en) Antibodies against g-csfr and uses thereof.
WO2014165524A3 (en) Methods and compositions for treating and preventing disease associated with avb8 integrin
WO2015006337A3 (en) Compositions and methods for increasing protein half-life in a serum
WO2013122544A3 (en) IL-1β NEUTRALIZING HUMAN MONOCLONAL ANTIBODIES
UA109148C2 (en) Compositions based on anti-vegfr-3 antibody
TN2014000149A1 (en) Antibody polypeptides that antagonize cd40l
MX2016014726A (en) Her1 antigen binding proteins binding to the beta-hairpin of her1.