TN2010000610A1 - Calcium ion channel modulators & uses thereof - Google Patents
Calcium ion channel modulators & uses thereofInfo
- Publication number
- TN2010000610A1 TN2010000610A1 TNP2010000610A TN2010000610A TN2010000610A1 TN 2010000610 A1 TN2010000610 A1 TN 2010000610A1 TN P2010000610 A TNP2010000610 A TN P2010000610A TN 2010000610 A TN2010000610 A TN 2010000610A TN 2010000610 A1 TN2010000610 A1 TN 2010000610A1
- Authority
- TN
- Tunisia
- Prior art keywords
- hydrogen
- alkyl
- halogen
- dialkylamino
- nitro
- Prior art date
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Compounds of formula (1), salts and pro-drugs wherein : R1,R2 ,R3 and R4 are hydrogen, alkyl, hydroxyalkyl, halogen, haloalkyl, alkoxy, haloalkoxy, alkoxycarbonyl, carboxyl, hydroxyl, nitro, amino, monalkylamino,dialkylamino, acylamino, amkoxycarbonylamino, alkylsulphonyl, arylsulphonyl, alkylsulphonylamino, arylsulphonylamino, aminosulphonyl or cyano, or any two of R1 to R4 that are adjacent on the ring may together represent the moiety -O-(CH2)n -O- wherein n is 1 to 3 ; R5 is hydrogen or alkyl; R6 is hydrogen or alkyl ; and X is selected from the group consisting of : (a) groups of formula OR7 wherein R7 is hydrogen or alkyl which is optionally substituted with a substituent selected from alkylsulphonylalkyl, saturated or partially unsaturated heterocyclic, alkoxy, carboxyl, nitro, amino, monalkylamino, dialkylamino, halogen, and alkoxycarbonyl, provided that when R7 is hydrogen or ethyl, then R1, R2, R3 and R4 cannot be selected from hydrogen, halogen and alkyl; and (b) groups of formula NR8R9 wherein R8 and R9 together with the nitrogen atom to which they are attached form a saturated or partially unsaturated heterocyclic group which optionally contains at least one more heteroatom selected from nitrogen, oxygen and sulphur atoms, said saturated or partially unsaturated heterocyclic group optionally further being substituted by one or more substituents selected from alkyl, halogen, haloalkyl, alkoxy, alkoxycarbonyl, carboxyl, nitro, amino, monalkylamino, dialkylamino and hydroxyl, privided that: (i) when R8+R9+N = piperazine , and >= 1 of R1 to R4 are hydrogen, hydroxyl, nitro, amino, alkyllamino, dialkylamino, alkoxycarbonylamino, halogen, alkoxy or alkyl, the nitrogen atom at the 4-position of the piperazine is not alkyl substituted, (ii) when each of R1, R2, R3,R4 ,R5 and R6 is hydrogen, X is not unsubstituted piperazinyl or unsubstituted morpholino, (iii) when each of R1, R2 ,R4 ,R5 and R6 is hydrogen and R3 hydrogen, bromine or hydroxyl, X is not methoxy, (iv) when each of R2 and R3 is methoxy or they together represent -0-CH2-O- and each of R1, R4, R5 and R6 is hydrogen, X is not unsubstituted piperidine, are Cavx channel blockers and are of use in the treatment of various conditions including pain.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/GB2009/050787 WO2010001179A2 (en) | 2008-07-03 | 2009-07-03 | Calcium ion channel modulators & uses thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
TN2010000610A1 true TN2010000610A1 (en) | 2012-05-24 |
Family
ID=55024682
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TNP2010000610A TN2010000610A1 (en) | 2009-07-03 | 2010-12-27 | Calcium ion channel modulators & uses thereof |
Country Status (1)
Country | Link |
---|---|
TN (1) | TN2010000610A1 (en) |
-
2010
- 2010-12-27 TN TNP2010000610A patent/TN2010000610A1/en unknown
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