TN2010000470A1 - Phenyl substituted 2- imino 3 methyl pyrrolo pyrimidinone compounds as bace 1 inhibitors compositions and their use - Google Patents

Phenyl substituted 2- imino 3 methyl pyrrolo pyrimidinone compounds as bace 1 inhibitors compositions and their use

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Publication number
TN2010000470A1
TN2010000470A1 TNP2010000470A TN2010000470A TN2010000470A1 TN 2010000470 A1 TN2010000470 A1 TN 2010000470A1 TN P2010000470 A TNP2010000470 A TN P2010000470A TN 2010000470 A TN2010000470 A TN 2010000470A TN 2010000470 A1 TN2010000470 A1 TN 2010000470A1
Authority
TN
Tunisia
Prior art keywords
compounds
imino
bace
phenyl substituted
methyl pyrrolo
Prior art date
Application number
TNP2010000470A
Other languages
French (fr)
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US2009/041202 external-priority patent/WO2009131975A1/en
Application filed by Schering Corp filed Critical Schering Corp
Publication of TN2010000470A1 publication Critical patent/TN2010000470A1/en

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Abstract

In its many embodiments, the present invention provides provides certain 2-imino-3-methyl pyrrolo pyrimidone compounds, including compounds Formula (II): and include tautomers, steroisomers, or pharmaceutically acceptable salts or solvates of said compounds, stereoisomers, or said tautomers, wherein R2, R3, R4, R5, R6, R7, R8, and R9 are each selected independently and as defined herein. Pharmaceutical compositions comprising one or more such compounds, and methods for their preparation and use in treating pathologies associated with amyloid beta (Aβ) protein, including Alzheimer's Disease, are also disclosed.
TNP2010000470A 2009-04-21 2010-10-14 Phenyl substituted 2- imino 3 methyl pyrrolo pyrimidinone compounds as bace 1 inhibitors compositions and their use TN2010000470A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2009/041202 WO2009131975A1 (en) 2008-04-22 2009-04-21 Phenyl-substituted 2-imino-3-methyl pyrrolo pyrimidinone compounds as bace-1 inhibitors, compositions, and their use

Publications (1)

Publication Number Publication Date
TN2010000470A1 true TN2010000470A1 (en) 2012-05-24

Family

ID=55024581

Family Applications (1)

Application Number Title Priority Date Filing Date
TNP2010000470A TN2010000470A1 (en) 2009-04-21 2010-10-14 Phenyl substituted 2- imino 3 methyl pyrrolo pyrimidinone compounds as bace 1 inhibitors compositions and their use

Country Status (1)

Country Link
TN (1) TN2010000470A1 (en)

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