TN2010000346A1 - TRICYCLIC COMPOUNDS AS SYNTHESIS MODULATORS OF TNF-β LPHA AND PDE4 INHIBITORS - Google Patents

TRICYCLIC COMPOUNDS AS SYNTHESIS MODULATORS OF TNF-β LPHA AND PDE4 INHIBITORS

Info

Publication number
TN2010000346A1
TN2010000346A1 TNP2010000346A TN2010000346A TN2010000346A1 TN 2010000346 A1 TN2010000346 A1 TN 2010000346A1 TN P2010000346 A TNP2010000346 A TN P2010000346A TN 2010000346 A TN2010000346 A TN 2010000346A TN 2010000346 A1 TN2010000346 A1 TN 2010000346A1
Authority
TN
Tunisia
Prior art keywords
tnf
lpha
pde4 inhibitors
tricyclic compounds
synthesis modulators
Prior art date
Application number
TNP2010000346A
Other languages
French (fr)
Inventor
Adnan Mm Mjalli
Bapu Gaddam
Dharma Rao Polisetti
Matthew Kostura
Mustafa Guzel
Original Assignee
High Point Pharmaceuticals Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US2009/031819 external-priority patent/WO2009094528A1/en
Application filed by High Point Pharmaceuticals Llc filed Critical High Point Pharmaceuticals Llc
Publication of TN2010000346A1 publication Critical patent/TN2010000346A1/en

Links

Abstract

La présente invention concerne des composés chimiques de formule (I) répondant à la definition figurant dans le present mémoire, , des compositions pharmaceutiques et des procédés d'utilisation dans le traitement d'affections ou de troubles à mediation par le TNF-α ou par la PDE4, comprenant mais à titre non limitatif, la polyarthrite rhumatoïde.The present invention relates to chemical compounds of formula (I) as defined herein, pharmaceutical compositions and methods of use in the treatment of mediated affections or disorders by TNF-α or by PDE4, including but not limited to rheumatoid arthritis.

TNP2010000346A 2009-01-23 2010-07-23 TRICYCLIC COMPOUNDS AS SYNTHESIS MODULATORS OF TNF-β LPHA AND PDE4 INHIBITORS TN2010000346A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2009/031819 WO2009094528A1 (en) 2008-01-25 2009-01-23 TRICYCLIC COMPOUNDS AS MODULATORS OF TNF-α SYNTHESIS AND AS PDE4 INHIBITORS

Publications (1)

Publication Number Publication Date
TN2010000346A1 true TN2010000346A1 (en) 2011-12-29

Family

ID=55024478

Family Applications (1)

Application Number Title Priority Date Filing Date
TNP2010000346A TN2010000346A1 (en) 2009-01-23 2010-07-23 TRICYCLIC COMPOUNDS AS SYNTHESIS MODULATORS OF TNF-β LPHA AND PDE4 INHIBITORS

Country Status (1)

Country Link
TN (1) TN2010000346A1 (en)

Similar Documents

Publication Publication Date Title
MA33053B1 (en) INHIBITORS OF POLY (ADP-RIBOSE) POLYMERASE (PARP)
MA34474B1 (en) AGONISTS OF GPR40
MA35246B1 (en) 1,3-oxazines as inhibitors of bace1 and / or bace2
MA33920B1 (en) POSITIVE ALLOSTERIC MODULATORS OF M1 RECEPTOR BASED ON QUINOLINAMIDE
MA35191B1 (en) Spiro- [1,3] -oxazines and spiro- [1,4] -oxazepines as inhibitors of baec1 and / or bace2
MA47447B1 (en) 2-heteroaryl-3-oxo-2,3-dihydropyridazine-4-carboxamides for the treatment of cancer
MA35193B1 (en) Halogeno-1,3-alkyl oxazines as inhibitors of bace1 and / or bace2
MA30232B1 (en) HYDANTOIN BASED KINASE INHIBITORS
MA34819B1 (en) BICYCLO [3.2.1] OCTYLAMIDE DERIVATIVES AND USES THEREOF
EA201170705A1 (en) Arylmethylbenzoquinazolinones as POSITIVE Allosteric Modulators of M1 Receptor
MA34147B1 (en) SILYL FUSIONED TRICYCLIC COMPOUNDS AND METHODS OF USE IN THE TREATMENT OF VIRAL DISEASES
MA31117B1 (en) Tricyclic compounds and their use as receptor modulators of corticosteroids.
MA38260A1 (en) Novel cyclohexyl and quinuclidinyl carbamate derivatives having beta2 adrenergic agonist activity and muscarinic m3 antagonist activity
MA34331B1 (en) PYRAZOLE COMPOUNDS AS INHIBITORS OF THE SIGMA RECEPTOR
MA30207B1 (en) MODULATORS OF PROGESTERONE RECEPTORS BASED ON SULFONAMIDE INDOLE
MA37763A1 (en) Difluoro-hexahydro-cyclopentaoxazinyl and difluoro-hexahydro-benzooxazinyls as bace1 inhibitors
MA35444B1 (en) Ep1 receptor ligands
FR2981934B1 (en) NOVEL DI-SUBSTITUTED DIAMINO-3,4-CYCLOBUTENE-3-DIONE-1,2 COMPOUNDS USEFUL IN THE TREATMENT OF CHEMOKINE MEDIATED PATHOLOGIES.
MA35271B1 (en) Antagonists of trpm8 and their use in treatments
MA33302B1 (en) 2,4-DIAMINOPYRIMIDINES FOR THE TREATMENT OF DISEASES CHARACTERIZED BY AN EXCESSIVE OR ABNORMAL CELL PROLIFERATION
MA37742B1 (en) Derivatives of 3-substituted oestra-1,3,5 (10), 16-tetraene, processes for their preparation, pharmaceutical preparations containing them, and their use in the manufacture of medicaments
MA37691A1 (en) 5-amino [1,4] thiazines as bace1 inhibitors
MA35104B1 (en) Inhibitor of the hepatitis c virus
MA29723B1 (en) COMPOUNDS
MA33533B1 (en) Pharmaceutical formulations for the treatment of cancer and other diseases or disorders