TH98083B - A 2-piridone derivative that is an inhibitor of human neutrophil elastase. - Google Patents
A 2-piridone derivative that is an inhibitor of human neutrophil elastase.Info
- Publication number
- TH98083B TH98083B TH701002226A TH0701002226A TH98083B TH 98083 B TH98083 B TH 98083B TH 701002226 A TH701002226 A TH 701002226A TH 0701002226 A TH0701002226 A TH 0701002226A TH 98083 B TH98083 B TH 98083B
- Authority
- TH
- Thailand
- Prior art keywords
- piridone
- inhibitor
- derivative
- neutrophil elastase
- human neutrophil
- Prior art date
Links
- 101000851058 Homo sapiens Neutrophil elastase Proteins 0.000 title 1
- 102000052502 human ELANE Human genes 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims abstract 3
- 239000000126 substance Substances 0.000 claims abstract 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 1
- 125000004432 carbon atom Chemical group C* 0.000 claims 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 1
- 229910052736 halogen Inorganic materials 0.000 claims 1
- 150000002367 halogens Chemical class 0.000 claims 1
- 125000005842 heteroatom Chemical group 0.000 claims 1
- 125000000623 heterocyclic group Chemical group 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 239000001301 oxygen Substances 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
- 239000011593 sulfur Substances 0.000 claims 1
- SQUHHTBVTRBESD-UHFFFAOYSA-N Hexa-Ac-myo-Inositol Natural products CC(=O)OC1C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C1OC(C)=O SQUHHTBVTRBESD-UHFFFAOYSA-N 0.000 abstract 1
- 102000016387 Pancreatic elastase Human genes 0.000 abstract 1
- 108010067372 Pancreatic elastase Proteins 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- CDAISMWEOUEBRE-GPIVLXJGSA-N inositol Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](O)[C@@H]1O CDAISMWEOUEBRE-GPIVLXJGSA-N 0.000 abstract 1
- 229960000367 inositol Drugs 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 210000000440 neutrophil Anatomy 0.000 abstract 1
- 230000003287 optical effect Effects 0.000 abstract 1
- 230000000144 pharmacologic effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- CDAISMWEOUEBRE-UHFFFAOYSA-N scyllo-inosotol Natural products OC1C(O)C(O)C(O)C(O)C1O CDAISMWEOUEBRE-UHFFFAOYSA-N 0.000 abstract 1
Abstract
การประดิษฐ์นี้ให้สารประกอบของสูตร (สูตรเคมี) (I) ซึ่ง R1,R3,R4,R5,R6,R14, X และ W เป็นตามที่นิยามในรายละเอียด และออฟติคัลไอโซเมอร์, ราซิเมท และทอโทเมอร์ของมัน, และเกลือของมันที่เป็นที่ยอมรับเชิงเภสัชวิทยา; ร่วมกันกับกรรมวิธี สำหรับการเตรียมมัน, สารผสมเชิงเภสัชวิทยาที่มีมัน และการใช้มันในการรักษา สารประกอบเป็นตัว ยับยั้งของนิวโทรฟิล, อีลาสเทสของมนุษย์ This invention gives a compound of formula (chemical formula) (I), where R1, R3, R4, R5, R6, R14, X and W are defined in detail. And optical isomers, rasimates and their inositol, and their pharmacologically acceptable salts; Together with the process For the preparation of oily, pharmacological mixtures containing it And using it to treat Compound body Inhibition of neutrophils, human elastase
Claims (1)
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TH98083B true TH98083B (en) | 2009-09-03 |
| TH98083A TH98083A (en) | 2009-09-03 |
Family
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