TH97671B - Amino piperidine derivatives as a CETP inhibitor - Google Patents
Amino piperidine derivatives as a CETP inhibitorInfo
- Publication number
- TH97671B TH97671B TH701003563A TH0701003563A TH97671B TH 97671 B TH97671 B TH 97671B TH 701003563 A TH701003563 A TH 701003563A TH 0701003563 A TH0701003563 A TH 0701003563A TH 97671 B TH97671 B TH 97671B
- Authority
- TH
- Thailand
- Prior art keywords
- alkyl
- cetp inhibitor
- piperidine derivatives
- amino piperidine
- cetp
- Prior art date
Links
- 239000003354 cholesterol ester transfer protein inhibitor Substances 0.000 title abstract 2
- 229940125881 cholesteryl ester transfer protein inhibitor Drugs 0.000 title 1
- LWMPFIOTEAXAGV-UHFFFAOYSA-N piperidin-1-amine Chemical class NN1CCCCC1 LWMPFIOTEAXAGV-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims abstract 3
- 239000000126 substance Substances 0.000 claims abstract 2
- 125000000217 alkyl group Chemical group 0.000 claims 3
- 125000003118 aryl group Chemical group 0.000 claims 3
- 125000000753 cycloalkyl group Chemical group 0.000 claims 3
- 125000000623 heterocyclic group Chemical group 0.000 claims 2
- -1 nitro, carboxy, thio Chemical group 0.000 claims 2
- 125000003342 alkenyl group Chemical group 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 125000001589 carboacyl group Chemical group 0.000 claims 1
- 125000000000 cycloalkoxy group Chemical group 0.000 claims 1
- 125000001188 haloalkyl group Chemical group 0.000 claims 1
- 229910052736 halogen Inorganic materials 0.000 claims 1
- 150000002367 halogens Chemical class 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- KEWSCDNULKOKTG-UHFFFAOYSA-N 4-cyano-4-ethylsulfanylcarbothioylsulfanylpentanoic acid Chemical compound CCSC(=S)SC(C)(C#N)CCC(O)=O KEWSCDNULKOKTG-UHFFFAOYSA-N 0.000 abstract 2
- 102100037637 Cholesteryl ester transfer protein Human genes 0.000 abstract 2
- 101000880514 Homo sapiens Cholesteryl ester transfer protein Proteins 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 201000010099 disease Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
Abstract
การประดิษฐ์นี้ได้จัดเตรียมให้มีสารประกอบของสูตรที่ (I) (สูตรเคมี) (I) ในที่ซึ่ง ตัวแปร R1, R2, R3, R5, R6, R7 ถูกบ่งชี้เอาไว้ในที่นี้ และในที่ซึ่งสารประกอบดังกล่าวเป็น สารยับยั้งของ CETP และดังนั้นสามารถใช้ไปสำหรับการบำบัดรักษาของความผิดปกติ หรือ โรคที่เป็น สื่อกลางโดย CETP หรือ ตอบสนองกับการยับยั้งของ CETP This invention provides a compound of formula (I) (chemical formula) (I) where variables R1, R2, R3, R5, R6, R7 are identified here. And where the compound is CETP inhibitors and therefore can be used for the treatment of CETP-mediated disorders or diseases, or in response to CETP inhibition.
Claims (1)
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TH97671A TH97671A (en) | 2009-08-13 |
| TH97671B true TH97671B (en) | 2009-08-13 |
Family
ID=
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