TH96575B - HIV protease inhibitors type 2- (substitutated-amino) -benzothiazole sulfonamides - Google Patents
HIV protease inhibitors type 2- (substitutated-amino) -benzothiazole sulfonamidesInfo
- Publication number
- TH96575B TH96575B TH701003071A TH0701003071A TH96575B TH 96575 B TH96575 B TH 96575B TH 701003071 A TH701003071 A TH 701003071A TH 0701003071 A TH0701003071 A TH 0701003071A TH 96575 B TH96575 B TH 96575B
- Authority
- TH
- Thailand
- Prior art keywords
- amino
- substitutated
- protease inhibitors
- hiv protease
- sulfonamides
- Prior art date
Links
- 229940093912 Gynecological Sulfonamides Drugs 0.000 title abstract 3
- 229940079867 intestinal antiinfectives Sulfonamides Drugs 0.000 title abstract 3
- 229940005938 ophthalmologic antiinfectives Sulfonamides Drugs 0.000 title abstract 3
- 229940026752 topical Sulfonamides Drugs 0.000 title abstract 3
- 239000004030 hiv protease inhibitor Substances 0.000 title abstract 2
- 239000000126 substance Substances 0.000 claims abstract 5
- 150000001875 compounds Chemical class 0.000 claims abstract 4
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 5
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 claims 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 1
- 125000003884 phenylalkyl group Chemical group 0.000 claims 1
- 125000003386 piperidinyl group Chemical group 0.000 claims 1
- RWRDLPDLKQPQOW-UHFFFAOYSA-N pyrrolidine Chemical group C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000011780 sodium chloride Substances 0.000 claims 1
- 238000009007 Diagnostic Kit Methods 0.000 abstract 1
- 238000004458 analytical method Methods 0.000 abstract 1
- 230000002155 anti-virotic Effects 0.000 abstract 1
- 239000003153 chemical reaction reagent Substances 0.000 abstract 1
- 229940042399 direct acting antivirals Protease inhibitors Drugs 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000000137 peptide hydrolase inhibitor Substances 0.000 abstract 1
- 239000005426 pharmaceutical component Substances 0.000 abstract 1
Abstract
การประดิษฐ์นี้เกี่ยวข้องกับสารประกอบ และอนุพันธ์ 2-(ซับสติติวเตด-อะมิโน)- เบนโซไธอะโซลซัลโฟนาไมด์,การใช้ของสารเหล่านี้เป็นสารยับยั้งโปรทีเอส,โดยเฉพาะอย่างยิ่งเป็น สารยับยั้ง HIV โปรทีเอสของ บรอด-สเปกตรัม, กรรมวิธีสำหรับการเตรียมสารเหล่านี้ เช่นเดียวกับ องค์ประกอบทางเภสัชกรรม และชุดตรวจวินิจฉัยซึ่งประกอบรวมด้วยสารเหล่านี้ การประดิษฐ์นี้ยัง เกี่ยวข้องด้วยเช่นกันกับของผสมของสารประกอบ และอนุพันธ์ 2-(ซับสติติวเตด-อะมิโน)- เบนโซไธอะโซลซัลโฟนาไมด์ นี้ร่วมกับสารต้านเรโทรไวรัสอีกชนิดหนึ่ง การประดิษฐ์นี้ยังเกี่ยวข้อง เพิ่มเติมกับการใช้สารเหล่านี้เป้นสารประกอบอ้างอิง หรือเป็นรีเอเจนต์ในการวิเคราะห์ The invention involves compounds and derivatives 2- (substitutated-amino) -benzothiazole sulfonamides, the use of them as protease inhibitors, in particular. In particular, it is a broad-spectrum HIV protease inhibitor, a process for the preparation of these substances, as well as a pharmaceutical component. And a diagnostic kit consisting of these substances This invention also It is also related to a mixture of compounds and derivatives 2- (substitutated-amino) -benzothiazol sulfonamides. This is combined with another anti-virus. This invention is also relevant. In addition to the use of these substances as reference compounds. Or as an analysis reagent
Claims (1)
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TH96575B true TH96575B (en) | 2009-07-09 |
| TH96575A TH96575A (en) | 2009-07-09 |
Family
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