TH96043B - Pyrimidone compounds - Google Patents
Pyrimidone compoundsInfo
- Publication number
- TH96043B TH96043B TH1501000419A TH1501000419A TH96043B TH 96043 B TH96043 B TH 96043B TH 1501000419 A TH1501000419 A TH 1501000419A TH 1501000419 A TH1501000419 A TH 1501000419A TH 96043 B TH96043 B TH 96043B
- Authority
- TH
- Thailand
- Prior art keywords
- similar
- alkyl
- halogen
- integer
- formula
- Prior art date
Links
- 150000008318 pyrimidones Chemical class 0.000 title 1
- 229910052736 halogen Inorganic materials 0.000 claims abstract 4
- 125000004400 (C1-C12) alkyl group Chemical group 0.000 claims abstract 2
- 150000001875 compounds Chemical class 0.000 claims abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims abstract 2
- 150000003839 salts Chemical class 0.000 claims abstract 2
- 239000000126 substance Substances 0.000 claims abstract 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 1
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims 1
- 150000002367 halogens Chemical class 0.000 claims 1
- -1 hydroxyl halogen Chemical class 0.000 claims 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 1
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
- 206010012289 Dementia Diseases 0.000 abstract 1
- 206010037211 Psychomotor hyperactivity Diseases 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 108010061506 tau-protein kinase Proteins 0.000 abstract 1
Abstract
สารประกอบที่แสดงโดยสูตร (I) ไอโซเมอร์ที่มีฤทธิ์ทางทัศนศาสตร์ของมันหรือเกลือ ที่ยอมรับได้ทางเภสัชกรรมของมัน (สูตรเคมี) (I) โดยที่ R1 แทน C1-C12อัลคิล R2 แทนไฮโดรเจนอะตอมหรือที่คล้ายกัน R3 แทนฮาโลเจนหรือที่คล้าย กัน q แทนจำนวนเต็มจาก 1 ถึง 7 R4 แทนฮาโลเจนหรือที่คล้ายกัน p แทน 0 หรือจำนวนเต็มของ 1 ถึง 5 R5 แทน C6-C10เอริล เฮเทอโรไซเคิลหรือที่คล้ายกัน และ X แทนออกซิเจน NH หรือที่คล้ายกัน ซึ่งใช้เพื่อการป้องกัน และ/หรือรักษาเพื่อบำบัดโรคที่มีสาเหตุจากภาวะทำงานมากเกินของเทาโปรตีน ไคเนส 1 ดังเช่น โรคสมองเสื่อม (เช่นโรคอัลซ์ไฮเมอร์) The compound shown by formula (I) is its optically active isomer or salt. its pharmaceutically acceptable (chemical formula) (I) where R1 represents C1-C12 alkyl R2 represents hydrogen atom or similar R3 represents halogen or similar q represents an integer from 1 to 7 R4 represents halogen or similar, p for 0 or an integer of 1 to 5, R5 for C6-C10aryl heterocycle or similar, and X for oxygen, NH or similar. which is used for protection and/or treat diseases that are caused by an overactivity of tau protein kinase 1, such as dementia. (such as Alzheimer's disease)
Claims (1)
Publications (3)
| Publication Number | Publication Date |
|---|---|
| TH96043B true TH96043B (en) | 2009-06-18 |
| TH147979A TH147979A (en) | 2016-03-21 |
| TH1501000419A TH1501000419A (en) | 2016-03-21 |
Family
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