TH95060B - Indole-3-il-carbonyl-spiro-piperidine derivatives. - Google Patents
Indole-3-il-carbonyl-spiro-piperidine derivatives.Info
- Publication number
- TH95060B TH95060B TH1501007888A TH1501007888A TH95060B TH 95060 B TH95060 B TH 95060B TH 1501007888 A TH1501007888 A TH 1501007888A TH 1501007888 A TH1501007888 A TH 1501007888A TH 95060 B TH95060 B TH 95060B
- Authority
- TH
- Thailand
- Prior art keywords
- spiro
- indole
- carbonyl
- chemical formula
- piperidine derivatives
- Prior art date
Links
- 239000000126 substance Substances 0.000 claims abstract 7
- 150000001875 compounds Chemical class 0.000 claims abstract 2
- JUXAVSAMVBLDKO-UHFFFAOYSA-N 1-(1-azabicyclo[2.2.2]octan-3-yl)-3-[3-(1h-indol-3-yl)-1-oxo-1-spiro[1,2-dihydroindene-3,4'-piperidine]-1'-ylpropan-2-yl]urea Chemical group C1N(CC2)CCC2C1NC(=O)NC(C(=O)N1CCC2(C3=CC=CC=C3CC2)CC1)CC1=CNC2=CC=CC=C12 JUXAVSAMVBLDKO-UHFFFAOYSA-N 0.000 abstract 1
- 208000019901 Anxiety disease Diseases 0.000 abstract 1
- 206010007558 Cardiac failure chronic Diseases 0.000 abstract 1
- 208000020401 Depressive disease Diseases 0.000 abstract 1
- 208000005171 Dysmenorrhea Diseases 0.000 abstract 1
- 206010016654 Fibrosis Diseases 0.000 abstract 1
- 206010020772 Hypertension Diseases 0.000 abstract 1
- 206010029164 Nephrotic syndrome Diseases 0.000 abstract 1
- 208000021384 Obsessive-Compulsive disease Diseases 0.000 abstract 1
- GXBMIBRIOWHPDT-UHFFFAOYSA-N Vasopressin Natural products N1C(=O)C(CC=2C=C(O)C=CC=2)NC(=O)C(N)CSSCC(C(=O)N2C(CCC2)C(=O)NC(CCCN=C(N)N)C(=O)NCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(CCC(N)=O)NC(=O)C1CC1=CC=CC=C1 GXBMIBRIOWHPDT-UHFFFAOYSA-N 0.000 abstract 1
- 102000002852 Vasopressins Human genes 0.000 abstract 1
- 108010004977 Vasopressins Proteins 0.000 abstract 1
- 230000036506 anxiety Effects 0.000 abstract 1
- KBZOIRJILGZLEJ-LGYYRGKSSA-N argipressin Chemical compound C([C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CSSC[C@@H](C(N[C@@H](CC=2C=CC(O)=CC=2)C(=O)N1)=O)N)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)C1=CC=CC=C1 KBZOIRJILGZLEJ-LGYYRGKSSA-N 0.000 abstract 1
- 230000007882 cirrhosis Effects 0.000 abstract 1
- 208000019425 cirrhosis of liver Diseases 0.000 abstract 1
- -1 indole -3-yl Chemical group 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000002464 receptor antagonist Substances 0.000 abstract 1
- 229940044551 receptor antagonist Drugs 0.000 abstract 1
- 229960003726 vasopressin Drugs 0.000 abstract 1
Abstract
การประดิษฐ์นี้เกี่ยวข้องกับอนุพันธ์ อินดอล -3-อิล คาร์บอกนิล-สไปโร-พิเพอริดิน ซึ่งทำหน้าที่เป็น V1a รีเซฟเตอร์ แอนทาโกนิสต์ และซึ่งจะถูกแสดงแทนโดยสูตร I (สูตรเคมี) (I) โดยที่หมู่หัวสไปโรพิเพอริดีน A และเรสซิดิว R1, R2 และ R3 คือดังที่นิยามไว้ในที่นี้ การประดิษฐ์ จะเกี่ยวข้องต่อไปกับสารผสมเชิงเภสัชกรรมที่มีสารประกอบดังกล่าว, การใช้งานของพวกมันใน เวชภัณฑ์ต่อต้านอาการปวดระดู ความดันโลหิตสูง, หัวใจล้มเหลวเรื้อรัง, การหลั่งที่ไม่เหมาะสม ของวาโซเพรสซิน, โรคตับแข็ง, กลุ่มอาการโรคเกี่ยวกับไต, ความผิดปกติเกี่ยวกับการย้ำคิดย้ำทำ, ความวิตกกังวล และความผิดปกติเกี่ยวกับภาวะซึมเศร้า, และวิธีการสำหรับการจัดเตรียมพวกมัน: The present invention relates to the derivative indole -3-yl carboxyl-spiro-piperidin. It acts as a V1a receptor antagonist and is represented by the formula I (chemical formula) (I), where spiropiperidine head group A and residue R1. , R2 and R3 are as defined herein. The invention further relates to pharmaceutical mixtures containing such compounds, their use in Medical supplies against menstrual pain High blood pressure, chronic heart failure, improper ejaculation. of vasopressin, cirrhosis, nephrotic syndrome, obsessive-compulsive disorder, anxiety and depressive disorders, and methods for their preparation:
Claims (1)
Publications (3)
| Publication Number | Publication Date |
|---|---|
| TH95060B true TH95060B (en) | 2009-04-09 |
| TH1501007888B TH1501007888B (en) | 2017-04-20 |
| TH162050A TH162050A (en) | 2017-04-20 |
Family
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