TH89147A - A bone substitute made from a mixture of carboxymethylcellulose and bovine bone powder. - Google Patents

Abstract

DC60, a bone substitute material made from a composite of carboxymethyl cellulose and bovine bone powder, as described in this invention, is a biomaterial composed of 50% by weight of carboxymethyl cellulose, 23.33% by weight of bovine bone powder, and 10% by weight of gelatin, 8.33% by weight of granulated sugar, and 8.33% by weight of polymethyl alcohol as a crosslinking filler. Glycerol is used as a softening agent to allow for bending and folding. The components are processed into a colloidal form, then frozen into ice blocks and dried using a lyophilizer to form a porous, interconnected sheet. It can be used in the treatment of bone damage by being implanted to replace damaged bone. It consists of 50% by weight of carboxymethyl cellulose, 23.33% by weight of bovine bone powder, 10% by weight of gelatin powder, 8.33% by weight of granulated sugar, and 8.33% by weight of polymethyl alcohol as a filler for crosslinking. Glycerol is used as a softening agent, allowing it to be folded and bent. The components are processed into a colloidal form, then frozen into ice blocks and dried using a lyophilizer to create a porous, interconnected sheet. This material can be used in the treatment of bone damage by being implanted to replace bone at the affected site.

Claims (3)

------09/03/2023------(OCR) 1. Bone substitute material made from a mixture of carboxymethyl sulfurose and bovine bone powder, consisting of 0% carboxymethyl sulfurose by weight, 23.33% bovine bone powder by weight, and using 10% geladin by weight, 8.33% granulated sugar by weight, and 8.33% polyvinyl alcohol by weight as fillers for crosslinking, and glycerol as a softening agent for flexibility. 2. Method for making bone substitute material from the mixture of carboxymethyl sulfurose and bovine bone powder from patent!, which has the following steps: a. Weigh 3 grams of carboxymethyl sulfurose powder on a balance scale. Pour into a clean, sterilized beaker that has been heat-sterilized in an oven. Add 123 cubic centimeters of water. a. Heat and stir the solution on a hotplate and stirrer at 80°C until it becomes a clear solution. b. Weigh 0.6 grams of gelatin and pour it into a beaker containing 5 cubic centimeters of water. Heat and stir the solution on a hotplate and stirrer at 100°C. Add 2 cubic centimeters of 100% concentrated lactic acid and stir until it becomes a clear solution. c. Combine the solutions from steps a and b. Heat and stir the solution on a hotplate and stirrer at 100°C. After 10 minutes, add 5 cubic centimeters of a water-soluble polyvinyl alcohol (PVA) solution with a concentration of 10w9. Add 0.5 grams of granulated sugar and 1 cubic centimeter of glycerol. Stir until it becomes a clear solution. Then add 1.4 grams of cow bone powder and stir until the cow bone powder is evenly distributed in the solution. Remove from the hotplate & stirrer and stir with a glass rod until the solution cools in the air. Refrigerate the resulting solution at -20°C for 12 hours to solidify. Then place the solidified solution in a lyophilizer to remove water, leaving only the porous, sponge-like composite structure with interconnected pores. Bake the resulting sponge at 60°C for 4 hours. 3. The process for manufacturing bone substitute material from a composite of carboxymethyl cellulose and cow bone powder based on two patents: a. using cow bone powder with particle sizes ranging from 1 micrometer to 100 nanometers. 1. Bone substitute material made from a composite of carboxymethyl cellulose and bovine bone powder, consisting of 50% by weight of carboxymethyl cellulose, 23.33% by weight of bovine bone powder, 10% by weight of gelatin powder, 8.33% by weight of granulated sugar, and 8.33% by weight of polymethyl alcohol as a filler for crosslinking. Glycerol is used as a softening agent to allow for flexibility and bending. 2. The process of manufacturing bone substitute materials made from a composite material of carboxymethyl cellulose and... The bovine bone powder from Patent 1 is prepared using the following steps: A. Weigh 3 grams of pharmaceutical-grade carboxymethyl cellulose powder onto a scale. Pour into a clean, sterilized beaker (sterilized by heat in an oven). Add 125 cubic centimeters of water. Heat and stir the solution on a hotplate and stirrer at 80°C until a clear solution is formed. B. Weigh 0.6 grams of pharmaceutical-grade gelatin. Pour into a beaker containing 5 cubic centimeters of water. Heat and stir the solution on a hotplate and stirrer at 100°C. Add 2 cubic centimeters of 100% concentrated lactic acid and stir until a clear solution is formed. C. Combine the solutions from steps A and B. Heat and stir the solution on a hotplate and stirrer at 100°C. After 10 minutes, add a polymethyl alcohol (PVA) solution. Aqueous solution containing water as a solvent and 10wt% polymethyl alcohol (5 cubic centimeters) is prepared by adding 0.5 grams of granulated sugar and 1 cubic centimeter of glycerol. Stir until a clear solution is formed. Then, add 1.4 grams of cow bone powder and stir until the bone powder is evenly distributed in the solution. Remove from the hotplate and stir with a glass rod until the solution cools in the air. Refrigerate the resulting solution at -20°C for 12 hours to solidify. Place the solidified solution in a lyophilizer to remove water, leaving only the porous, sponge-like structure with interconnected pores. Bake the resulting sponge at 60°C for 4 hours. 3. A process for manufacturing bone substitute materials made from a composite of carboxymethyl cellulose and bovine bone powder based on two patents, using bovine bone powder with particle sizes ranging from 1 micrometer to 100 nanometers.