TH88744B - Bicyclic aryl-sulfonic acid [1,3,4] -thyadiazole-2-il-acid, a process for their preparation and their use. They are pharmaceutical substances. - Google Patents
Bicyclic aryl-sulfonic acid [1,3,4] -thyadiazole-2-il-acid, a process for their preparation and their use. They are pharmaceutical substances.Info
- Publication number
- TH88744B TH88744B TH601004764A TH0601004764A TH88744B TH 88744 B TH88744 B TH 88744B TH 601004764 A TH601004764 A TH 601004764A TH 0601004764 A TH0601004764 A TH 0601004764A TH 88744 B TH88744 B TH 88744B
- Authority
- TH
- Thailand
- Prior art keywords
- preparation
- acid
- bicyclic aryl
- sulfonic acid
- thyadiazole
- Prior art date
Links
- 239000000126 substance Substances 0.000 title claims abstract 4
- 125000002619 bicyclic group Chemical group 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 239000002253 acid Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims abstract 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 2
- 125000002947 alkylene group Chemical group 0.000 claims 2
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 125000000753 cycloalkyl group Chemical group 0.000 claims 1
- 150000003839 salts Chemical class 0.000 abstract 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 abstract 1
- 206010022489 Insulin Resistance Diseases 0.000 abstract 1
- 208000017170 Lipid metabolism disease Diseases 0.000 abstract 1
- 108010015181 PPAR delta Proteins 0.000 abstract 1
- 230000005856 abnormality Effects 0.000 abstract 1
- 239000000556 agonist Substances 0.000 abstract 1
- 210000003169 central nervous system Anatomy 0.000 abstract 1
- 230000007850 degeneration Effects 0.000 abstract 1
- 230000003210 demyelinating effect Effects 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 239000008103 glucose Substances 0.000 abstract 1
- 230000007257 malfunction Effects 0.000 abstract 1
- 210000001428 peripheral nervous system Anatomy 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 208000001072 type 2 diabetes mellitus Diseases 0.000 abstract 1
Abstract
การประดิษฐ์นี้เกี่ยวกับไบไซคลิคแอริล-ซัลโฟนิคแอซิด[1,3,4] ไธอะไดแอโซล-2-อิล-แอมีด ของสูตร 1 และเกลือของสารนั้นซึ่งเป็นที่ยอมรับทางเภสัชกรรม และอนุพันธ์ฟังก์ชันนัลทางสรีร วิทยาที่แสดง PPAR เดลตา, -แอลฟา และ แกมมาแอกโกนิสท์แอคทิวิที, (สูตรเคมี) 1 ซึ่งอนุมูลต่างๆ มีความหมายเหมือนที่ได้นิยามไว้ และเกลือซึ่งเป็นที่ยอมรับทางสรีรวิทยาของสาร เหล่านั้น และกรรมวิธีสำหรับการเตรียมสารเหล่านั้น สารประกอบเหล่านี้เหมาะสมสำหรับการรักษา และ/หรือการป้องกันความผิดปกติของการเมทาโบลิซึมของกรดไขมัน และความผิดปกติของการใช้ กลูโคสและรวมถึงความผิดปกติในซึ่งการต้านทานอินซูลินมีส่วนเกี่ยวข้อง และการขจัดดีไมอิลิเนทิง ออกจาเนื้อเยื่อประสาทและความผิดปกติอื่นๆ ที่เกี่ยวกับการเสื่อมของประสาทของส่วนกลางและ ระบบประสาทรอบนอก. The invention is concerned with bicyclic aryl-sulfonic acid [1,3,4], thiazole-2-il-amide of Formula 1 and its salts. That is accepted by pharmaceuticals And physiological functional derivatives showing PPAR delta, -alfa and gamma agonist activity, (chemical formula) 1, in which radicals Has the same meaning that has been defined And salts which are physiologically acceptable for those substances and the processes for their preparation. These compounds are suitable for treatment. And / or the prevention of fatty acid metabolism disorders. And malfunctions of use Glucose and this includes disorders in which insulin resistance is involved. And eliminating demyelinating Out of nervous tissue and other abnormalities Related to the degeneration of the central nervous system and Peripheral nervous system.
Claims (1)
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TH88744A TH88744A (en) | 2008-02-29 |
| TH88744B true TH88744B (en) | 2008-02-29 |
Family
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