TH8838B - Process for the preparation of perrolyidine carboxylic acid derivatives. - Google Patents
Process for the preparation of perrolyidine carboxylic acid derivatives.Info
- Publication number
- TH8838B TH8838B TH9201000295A TH9201000295A TH8838B TH 8838 B TH8838 B TH 8838B TH 9201000295 A TH9201000295 A TH 9201000295A TH 9201000295 A TH9201000295 A TH 9201000295A TH 8838 B TH8838 B TH 8838B
- Authority
- TH
- Thailand
- Prior art keywords
- carboxylic acid
- formula
- preparation
- chemical formula
- acid derivatives
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims abstract 6
- 150000001732 carboxylic acid derivatives Chemical class 0.000 title claims 2
- 239000000126 substance Substances 0.000 claims abstract 7
- 150000008044 alkali metal hydroxides Chemical class 0.000 claims abstract 4
- 150000003573 thiols Chemical class 0.000 claims abstract 3
- 239000002253 acid Substances 0.000 claims abstract 2
- 239000007864 aqueous solution Substances 0.000 claims abstract 2
- 150000001875 compounds Chemical class 0.000 claims abstract 2
- QGJOPFRUJISHPQ-UHFFFAOYSA-N Carbon disulfide Chemical compound S=C=S QGJOPFRUJISHPQ-UHFFFAOYSA-N 0.000 claims 3
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 claims 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims 3
- 229910001854 alkali hydroxide Inorganic materials 0.000 claims 3
- 229910052751 metal Inorganic materials 0.000 claims 3
- 239000002184 metal Substances 0.000 claims 3
- 239000002585 base Substances 0.000 claims 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- BWGNESOTFCXPMA-UHFFFAOYSA-N Dihydrogen disulfide Chemical compound SS BWGNESOTFCXPMA-UHFFFAOYSA-N 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- NYCVCXMSZNOGDH-UHFFFAOYSA-N pyrrolidine-1-carboxylic acid Chemical class OC(=O)N1CCCC1 NYCVCXMSZNOGDH-UHFFFAOYSA-N 0.000 abstract 1
Abstract
การประดิษฐ์นี้เกี่ยวข้อกับกรรมวิธีชนิดใหม่สำหรับการเตรียมอนุพันธ์พิร์โรลิดีน คาร์บอกซิลิค แอซิค ของสูตร (สูตรเคมี) (I) ซึ่งแสดงลักษณะเฉพาะโดยการนำสารที่นำหมู่ไธออลเข้าที่ได้จากปฎิกิริยาของคาร์บอน ไดซัลไฟด์ และโลหะแอลคาไล ไฮดรอกไซด์ ในสารละลายของน้ำ มาทำปฎิกิริยากับ 1-[3-โบรโม-(2S)-เมธิล โพรพิโอนิล]-พิร์โรลิดีน-(2S)-คาร์บอกซิลิค แอซิด ของสูตร (สูตรเคมี) (II) และแล้วนำสารประกอบมัธยันตร์ที่ได้นำมากระทำด้วยกรด และกระทำการรีดิวซ์เพื่อให้ได้ 1-[3-เมอร์แคปโท-(2S)-เมธิล โพรพิโอนิล]-พิร์โรลิดีน-(2S)-คาร์บอกซิลิค แอซิด (- +) สิทธิบัตรยา This invention relates to a new method for the preparation of pyrrolidine carboxylic acid derivatives of formula (chemical formula) (I), characterized by the introduction of thiol-containing substances. obtained from the reaction of carbon, disulfide and alkali metal hydroxide in aqueous solution. to react with 1-[3-bromo-(2S)-methyl Propionyl]-pyrrolidine-(2S)-carboxylic acid of the formula (chemical formula) (II), and then the median compound was treated with acid. and perform a reduction in order to obtain 1-[3-mercapto-(2S)-methyl Propionyl]-pyrrolidine-(2S)-carboxylic acid (- +) drug patent
Claims (4)
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TH12785A TH12785A (en) | 1993-06-05 |
| TH8838B true TH8838B (en) | 1999-02-12 |
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