TH87430B - Biological indications for pre-selection of patients for anti-IGFR therapy. - Google Patents
Biological indications for pre-selection of patients for anti-IGFR therapy.Info
- Publication number
- TH87430B TH87430B TH501005647A TH0501005647A TH87430B TH 87430 B TH87430 B TH 87430B TH 501005647 A TH501005647 A TH 501005647A TH 0501005647 A TH0501005647 A TH 0501005647A TH 87430 B TH87430 B TH 87430B
- Authority
- TH
- Thailand
- Prior art keywords
- patients
- therapy
- igfr
- selection
- igf1r
- Prior art date
Links
- 238000002560 therapeutic procedure Methods 0.000 title abstract 2
- 102100014263 IGF1R Human genes 0.000 claims abstract 5
- 101700025802 IGF1R Proteins 0.000 claims abstract 5
- 230000002401 inhibitory effect Effects 0.000 claims abstract 4
- 239000003112 inhibitor Substances 0.000 claims abstract 3
- 201000011510 cancer Diseases 0.000 claims abstract 2
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 claims 4
- 238000006366 phosphorylation reaction Methods 0.000 claims 4
- 230000000865 phosphorylative Effects 0.000 claims 4
- 102100002729 IRS1 Human genes 0.000 claims 3
- 101700048020 IRS1 Proteins 0.000 claims 3
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 102400000022 Insulin-Like Growth Factor II Human genes 0.000 claims 1
- 108090001117 Insulin-Like Growth Factor II Proteins 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 229940079593 drugs Drugs 0.000 claims 1
- 230000001093 anti-cancer Effects 0.000 abstract 1
- 102000004965 antibodies Human genes 0.000 abstract 1
- 108090001123 antibodies Proteins 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 150000003384 small molecules Chemical class 0.000 abstract 1
Abstract
การประดิษฐ์ครั้งนี้จะจัดหาวิธีการสำหรับการจำแนกผู้ป่วยที่ซึ่งมะเร็งของพวกเขา มีแนวโน้มที่จะตอบสนองต่อการบำบัดรักษาต่อต้านมะเร็ง โดยการยับยั้ง IGF1R ร่วมกับวิธีการ สำหรับการทรีตผู้ป่วยดังกล่าว ผู้ป่วยที่ถูกจำแนกโดยวิธีการตามการประดิษฐ์ครั้งนี้สามารถ ถูกทรีตด้วยชนิดใดๆ ของสารซึ่งให้การยับยั้ง IGF1R หลายอย่าง ซึ่งรวมถึงแอนติบอดี้, สารยับยั้ง โมเลกุลเล็ก และกรดนิวคลิอิกแอนตี้-เซนส์ This invention provides a method for identifying patients with whom their cancer Likely to respond to anti-cancer therapy By inhibiting IGF1R in conjunction with For the treatment of such patients Patients classified by this invention can Treated with any kind Of many IGF1R inhibitors including antibodies, small molecule inhibitors and anti-sensory nucleic acids.
Claims (2)
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TH87430B true TH87430B (en) | 2007-11-09 |
| TH87430A TH87430A (en) | 2007-11-09 |
Family
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