TH86773B - HCV NS3 protease inhibitor - Google Patents
HCV NS3 protease inhibitorInfo
- Publication number
- TH86773B TH86773B TH601003300A TH0601003300A TH86773B TH 86773 B TH86773 B TH 86773B TH 601003300 A TH601003300 A TH 601003300A TH 0601003300 A TH0601003300 A TH 0601003300A TH 86773 B TH86773 B TH 86773B
- Authority
- TH
- Thailand
- Prior art keywords
- hcv
- protease inhibitor
- alkyl
- formula
- protease
- Prior art date
Links
- 239000000137 peptide hydrolase inhibitor Substances 0.000 title 1
- 239000000126 substance Substances 0.000 claims abstract 2
- 125000000217 alkyl group Chemical group 0.000 claims 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 1
- 125000004209 (C1-C8) alkyl group Chemical group 0.000 claims 1
- 125000006528 (C2-C6) alkyl group Chemical group 0.000 claims 1
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 125000001475 halogen functional group Chemical group 0.000 claims 1
- 241000711549 Hepacivirus C Species 0.000 abstract 3
- 102000033147 ERVK-25 Human genes 0.000 abstract 1
- 108091005771 Peptidases Proteins 0.000 abstract 1
- 239000004365 Protease Substances 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 201000009910 diseases by infectious agent Diseases 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 150000002678 macrocyclic compounds Chemical class 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
- 230000002194 synthesizing Effects 0.000 abstract 1
Abstract
การประดิษฐ์นี้เกี่ยวข้องกับสารประกอบมาโครไซคลิคของสูตร (I) ซึ่งใช้ประโยชน์เป็น ตัวยับยั้งของ NS3 โปรตีเอสของไวรัสตับอักเสบซี (HCV), การสังเคราะห์ของสิ่งเหล่านี้, การใช้ของสิ่งเหล่านี้สำหรับการรักษาหรือการป้องกันการติดเชื้อ HCV (สูตรเคมี) I The invention relates to the macro-cyclic compound of formula (I), which is used as NS3 inhibitors of hepatitis C virus (HCV) protease, synthesis of them, use of them for the treatment or prevention of HCV infection (chemical formula) I.
Claims (1)
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TH86773B true TH86773B (en) | 2007-10-01 |
| TH86773A TH86773A (en) | 2007-10-01 |
Family
ID=
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