TH84747B - The N-amide derivative of 8-azebicclo [3.2.1] OCT-3-il is the antagonist CCR1. - Google Patents
The N-amide derivative of 8-azebicclo [3.2.1] OCT-3-il is the antagonist CCR1.Info
- Publication number
- TH84747B TH84747B TH601002697A TH0601002697A TH84747B TH 84747 B TH84747 B TH 84747B TH 601002697 A TH601002697 A TH 601002697A TH 0601002697 A TH0601002697 A TH 0601002697A TH 84747 B TH84747 B TH 84747B
- Authority
- TH
- Thailand
- Prior art keywords
- ccr1
- azebicclo
- antagonist
- amide derivative
- oct
- Prior art date
Links
- 239000005557 antagonist Substances 0.000 title abstract 2
- 102100031172 C-C chemokine receptor type 1 Human genes 0.000 title 1
- 101710149814 C-C chemokine receptor type 1 Proteins 0.000 title 1
- 239000012458 free base Substances 0.000 claims abstract 2
- 150000003839 salts Chemical class 0.000 claims abstract 2
- 239000000126 substance Substances 0.000 claims abstract 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 1
- 102000004500 CCR1 Receptors Human genes 0.000 abstract 2
- 108010017319 CCR1 Receptors Proteins 0.000 abstract 2
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
- 206010003210 Arteriosclerosis Diseases 0.000 abstract 1
- 206010018364 Glomerulonephritis Diseases 0.000 abstract 1
- 206010018852 Haematoma Diseases 0.000 abstract 1
- 101710151805 Mitochondrial intermediate peptidase 1 Proteins 0.000 abstract 1
- 206010040047 Sepsis Diseases 0.000 abstract 1
- 206010052779 Transplant rejections Diseases 0.000 abstract 1
- 230000008485 antagonism Effects 0.000 abstract 1
- 208000011775 arteriosclerosis disease Diseases 0.000 abstract 1
- 208000006673 asthma Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000024711 extrinsic asthma Diseases 0.000 abstract 1
- 230000003993 interaction Effects 0.000 abstract 1
- 239000003446 ligand Substances 0.000 abstract 1
- 206010025135 lupus erythematosus Diseases 0.000 abstract 1
- 230000004770 neurodegeneration Effects 0.000 abstract 1
- 208000015122 neurodegenerative disease Diseases 0.000 abstract 1
- 230000001575 pathological effect Effects 0.000 abstract 1
- 208000005069 pulmonary fibrosis Diseases 0.000 abstract 1
- 206010039073 rheumatoid arthritis Diseases 0.000 abstract 1
- 208000013223 septicemia Diseases 0.000 abstract 1
Abstract
อนุพันธ์ N- เอไมด์ของ 8- เอซาไบไซโคล [3.2.1] ออคแทน-3- อิล-ของสูตร (I) (สูตรเคมี) (I) ในรูปแบบเบสอิสระ, เกลือที่ยอมรับทางเภสัชกรรม หรือรูปสวิทเทอร์ไอออนิก, ซึ่งคือแอน ตาโกนิสต์ของปฏิกิริยาระหว่างกันระหว่างตัวรับคีโมคีน CCR1 และลิแกนด์ของมัน, ที่รวมถึง MIP- 1 อัลฟา (CCL3), และสามารถถูกใช้ในการรักษาของสภาวะทางพยาธิวิทยาหรือโรคที่สามารถแก้ไขไห้ดี ขึ้นได้โดยแอนตาโกนิสซึมของตัวรับ CCR1, ที่รวมถึง, เช่น, ข้ออักเสบรูมาตอยด์, โรคหืดภูมิแพ้, ภาวะเกิดพังพืดในปอด, กลูเมอรู โลเนฟริตัส, ปฏิกิริยาปฏิเสธสิ่งปลูกถ่ายไต, ภาวะพิษเหตุติดเชื้อ, โรค ท่อเลือดและหลอดเลือดแดงแข็ง, ซิสเทมิกลูปัสอีริทีมาโตซัส, โรคปลอดประสาทเสื่อมแข้ง และโรค แอลไซเมอร์: An N-amide derivative of 8-azebicclo [3.2.1] octan-3-il-of formula (I) (chemical formula) (I) in free base form, a chemically acceptable salt. Or the ionic switch, which is the antagonist of the interaction between the chemoakine CCR1 receptor and its ligand, including MIP-1 alpha. (CCL3), and can be used in the treatment of pathological conditions or diseases that can be corrected. This is caused by the antagonism of CCR1 receptors, including, e.g., rheumatoid arthritis, atopic asthma, pulmonary fibrosis, glomerulonephritis. S, renal transplant rejection, septicemia, hematoma and arteriosclerosis, cystamic lupus erythematosus, neurodegenerative disease and Alzheimer's disease. Jor:
Claims (1)
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TH84747B true TH84747B (en) | 2007-05-30 |
| TH84747A TH84747A (en) | 2007-05-30 |
Family
ID=
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE602006013493D1 (en) | OXADIAZOLYLPYRAZOLOPYRIMIDINES AS MGLUR2 ANTAGONISTS | |
| WO2008115098A3 (en) | Substituted 2,3,4,5-tetrahydro-1h-pyrido[4,3-b]indoles, methods for the production and the use thereof | |
| CY1113029T1 (en) | Azadicyclo derivatives [3.1.0] EXCELLENT USEFUL AS D3 DOPAMIN RECEPTOR REGULATORS | |
| DK2091948T3 (en) | Novel inhibitors of glutaminyl cyclase | |
| EA200900606A1 (en) | NEW SULPHONYLAMID DERIVATIVES AS ANTAGONISTS OF BRADIKININ RECEPTORS | |
| WO2008117269A3 (en) | Heterotri cyciii c compounds as serotonergic and/or dopaminergic agents and uses thereof | |
| WO2009010660A3 (en) | Substituted indazoles, the preparation thereof, and use of same in therapeutics | |
| EA200701745A1 (en) | CYCLOPROPANKARCARBOXAMID DERIVATIVES | |
| NZ561747A (en) | (Pyrrol-2-ylmethyl)-indol-1-yl-acetic acid derivatives with PGD2 antagonist activity | |
| EP2397476A3 (en) | Indole derivative having PGD2 receptor antagonist activity | |
| ATE340795T1 (en) | BENZESULFONIC ACID ESTER INDOL-5-YL AS A 5-HT6 RECEPTOR ANTAGONIST | |
| ATE486058T1 (en) | PROLINAMIDE DERIVATIVES AS NK3 ANTAGONISTS | |
| MA33675B1 (en) | Indazole and pyrazolobidine compound as ccr1 receptor antagonists | |
| EA201171167A1 (en) | CARBINOL COMPOUND CONTAINING A HETEROCYCLIC LINKER | |
| ATE495167T1 (en) | PIPERIDINE-4-YL-PYRIDAZINE-3-YL AMINE DERIVATIVES AS RAPID DISSOCIATION ANTAGONISTS OF THE DOPAMINE 2 RECEPTOR | |
| MX2012008147A (en) | Pyrrazolopyridine derivatives. | |
| WO2008133344A3 (en) | Piperidine derivative and use thereof | |
| RU2005131502A (en) | CATEPSYN S INHIBITORS | |
| MX2009010727A (en) | Heterocycles as orexin antagonists. | |
| NO20080165L (en) | Alpha (aryl-OR heteroaryl-methyl) -beta piperidinopropanamide compounds as ORL1 receptor antagonists | |
| MX2023007429A (en) | Use as selective agonist of malanocortin-4 receptor. | |
| WO2009025265A1 (en) | Piperazine derivative | |
| TH84747B (en) | The N-amide derivative of 8-azebicclo [3.2.1] OCT-3-il is the antagonist CCR1. | |
| EA201070532A1 (en) | NEW NEPEPTIDE DERIVATIVE CONNECTIONS AS B1 ANTAGONISTS OF BRADIKININ | |
| TW200604185A (en) | Chemical compounds |