TH83738B - Fluorine tedpiridine N-Oxide, a thrombin regulator and a process for N-oxidation of heteroaryyl Which contains nitrogen - Google Patents
Fluorine tedpiridine N-Oxide, a thrombin regulator and a process for N-oxidation of heteroaryyl Which contains nitrogenInfo
- Publication number
- TH83738B TH83738B TH601001770A TH0601001770A TH83738B TH 83738 B TH83738 B TH 83738B TH 601001770 A TH601001770 A TH 601001770A TH 0601001770 A TH0601001770 A TH 0601001770A TH 83738 B TH83738 B TH 83738B
- Authority
- TH
- Thailand
- Prior art keywords
- chemical formula
- oxidation
- tedpiridine
- heteroaryyl
- fluorine
- Prior art date
Links
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 title abstract 4
- NKCXQMYPWXSLIZ-PSRDDEIFSA-N (2S)-2-[[(2S)-1-[(2S)-5-amino-2-[[2-[[(2S)-6-amino-2-[[2-[[(2S)-2-[[(2S)-4-amino-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-2-[[(2S,3R)-2-amino-3-hydroxybutanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-3-hydroxybutanoyl]amino]propanoyl]amino]-4-oxobutanoyl]amino]-3-m Chemical compound O=C([C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@@H](N)[C@@H](C)O)[C@@H](C)O)C(C)C)N1CCC[C@H]1C(=O)N[C@@H](CO)C(O)=O NKCXQMYPWXSLIZ-PSRDDEIFSA-N 0.000 title abstract 2
- 108090000190 Thrombin Proteins 0.000 title abstract 2
- 229910052757 nitrogen Inorganic materials 0.000 title abstract 2
- 238000007254 oxidation reaction Methods 0.000 title abstract 2
- 229960004072 thrombin Drugs 0.000 title abstract 2
- 150000001204 N-oxides Chemical class 0.000 title 1
- 229910052731 fluorine Inorganic materials 0.000 title 1
- 239000011737 fluorine Substances 0.000 title 1
- YCKRFDGAMUMZLT-UHFFFAOYSA-N fluorine atom Chemical compound [F] YCKRFDGAMUMZLT-UHFFFAOYSA-N 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 239000000126 substance Substances 0.000 claims abstract 16
- 150000001875 compounds Chemical class 0.000 claims abstract 3
- 150000003839 salts Chemical class 0.000 claims abstract 2
- 239000011780 sodium chloride Substances 0.000 claims abstract 2
- 239000000203 mixture Substances 0.000 claims 2
- 239000000969 carrier Substances 0.000 claims 1
- 241000124008 Mammalia Species 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 125000005842 heteroatoms Chemical group 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
Abstract
การประดิษฐ์นี้อธิบายเกี่ยวกับสารประกอบที่มีสูตร I (สูตรเคมี) สูตร I ซึ่ง X คือ (สูตรเคมี) , (สูตรเคมี) , หรือ (สูตรเคมี) ; และ Y คือ (สูตรเคมี) , (สูตรเคมี) , หรือ (สูตรเคมี) หรือเกลือของสารดังกล่าวซึ่งเป็นที่ยอมรับทางเภสัชกรรม สำหรับการป้องกัน หรือ การรักษาโรค และภาวะที่เกี่ยวข้องกับการออกฤทธิ์ของธรอมบินในสัตว์เลี้ยงลูกด้วยนม การประดิษฐ์นี้เกี่ยวข้องกับ วิธี N-ออกซิเดชันแบบใหม่ ของเฮเทอโรแอริล ซึ่งมีไนโตรเจนอีกด้วย This invention describes a compound with formula I (chemical formula), formula I, where X is (chemical formula), (chemical formula), or (chemical formula); And Y is (chemical formula), (chemical formula), or (chemical formula) or salt of the said substance, which is pharmacologically acceptable. For the prevention or treatment of diseases and conditions related to the action of thrombin in mammals. The invention involves a new N-oxidation method. Of Hetero Aeril Which also has nitrogen
Claims (3)
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TH83738B true TH83738B (en) | 2007-03-29 |
| TH83738A TH83738A (en) | 2007-03-29 |
Family
ID=
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