TH83329B - Useful mixtures as inhibitors of GSK-3 - Google Patents
Useful mixtures as inhibitors of GSK-3Info
- Publication number
- TH83329B TH83329B TH301002756A TH0301002756A TH83329B TH 83329 B TH83329 B TH 83329B TH 301002756 A TH301002756 A TH 301002756A TH 0301002756 A TH0301002756 A TH 0301002756A TH 83329 B TH83329 B TH 83329B
- Authority
- TH
- Thailand
- Prior art keywords
- compounds
- protein kinase
- gsk
- inhibitors
- formula
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title abstract 3
- 239000000203 mixture Substances 0.000 title abstract 3
- 102000002254 Glycogen Synthase Kinase 3 Human genes 0.000 title 1
- 108010014905 Glycogen Synthase Kinase 3 Proteins 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims abstract 5
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 3
- 125000001931 aliphatic group Chemical group 0.000 claims 2
- 239000001257 hydrogen Substances 0.000 claims 2
- 229910052739 hydrogen Inorganic materials 0.000 claims 2
- 229910052757 nitrogen Inorganic materials 0.000 claims 2
- 229920006395 saturated elastomer Polymers 0.000 claims 2
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 1
- 125000004429 atom Chemical group 0.000 claims 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 1
- 229910052731 fluorine Inorganic materials 0.000 claims 1
- 239000011737 fluorine Substances 0.000 claims 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 239000001301 oxygen Substances 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
- 239000011593 sulfur Substances 0.000 claims 1
- 102000001253 Protein Kinase Human genes 0.000 abstract 3
- 108060006633 protein kinase Proteins 0.000 abstract 3
- 102000001267 GSK3 Human genes 0.000 abstract 1
- 108060006662 GSK3 Proteins 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000004615 ingredient Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- NFVJNJQRWPQVOA-UHFFFAOYSA-N n-[2-chloro-5-(trifluoromethyl)phenyl]-2-[3-(4-ethyl-5-ethylsulfanyl-1,2,4-triazol-3-yl)piperidin-1-yl]acetamide Chemical compound CCN1C(SCC)=NN=C1C1CN(CC(=O)NC=2C(=CC=C(C=2)C(F)(F)F)Cl)CCC1 NFVJNJQRWPQVOA-UHFFFAOYSA-N 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Abstract
การประดิษฐ์นี้จะจัดให้มีสารประกอบที่มีสูตร I (สูตรเคมี) หรือ อนุพันธ์ที่ยอมรับได้ทางเภสัชกรรมของสิ่งเหล่านี้ สารประกอบเหล่านี้ คือสารยับยั้ง ของโปรตีน ไคเนส โดยเฉพาะ สารยับยั้งของ GSK3 โปรตีน ไคเนส ของสัตว์เลี้ยงลูกด้วยนม การประดิษฐ์ยังจัดให้มีสารผสมที่ยอมรับได้ทางเภสัชกรรม ซึ่งประกอบด้วยสารประกอบของ การประดิษฐ์ และวิธีการของการใช้สารประกอบ และสารผสมเหล่านั้น ในการบำบัดรักษาของ โรคต่างๆ ที่มีโปรตีน ไคเนส เป็นสื่อ: This invention will provide compounds with formula I (chemical formula) or a chemically acceptable derivative of them. These compounds Is an inhibitor of protein kinase, especially an inhibitor of GSK3, a mammalian protein kinase. The invention also provides a mix of acceptable pharmaceutical ingredients. Which consists of fabrication compounds and methods of applying the compound And those mixtures In the treatment of diseases mediated by protein kinase:
Claims (1)
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TH83329A TH83329A (en) | 2007-03-01 |
| TH83329B true TH83329B (en) | 2007-03-01 |
Family
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