TH82746B - Substituted benzoquinolazine derivatives - Google Patents
Substituted benzoquinolazine derivativesInfo
- Publication number
- TH82746B TH82746B TH501005603A TH0501005603A TH82746B TH 82746 B TH82746 B TH 82746B TH 501005603 A TH501005603 A TH 501005603A TH 0501005603 A TH0501005603 A TH 0501005603A TH 82746 B TH82746 B TH 82746B
- Authority
- TH
- Thailand
- Prior art keywords
- benzoquinolazine
- derivatives
- substituted
- compound
- methoxy
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 claims abstract 3
- 239000000126 substance Substances 0.000 claims abstract 2
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 2
- 125000003282 alkyl amino group Chemical group 0.000 claims 1
- 125000004663 dialkyl amino group Chemical group 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- 125000004435 hydrogen atoms Chemical group [H]* 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
- 206010012601 Diabetes mellitus Diseases 0.000 abstract 2
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 abstract 2
- 101700062901 DPP Proteins 0.000 abstract 1
- 102100012353 DPP4 Human genes 0.000 abstract 1
- 101700039720 DPP4 Proteins 0.000 abstract 1
- 208000002705 Glucose Intolerance Diseases 0.000 abstract 1
- 102000004877 Insulin Human genes 0.000 abstract 1
- 108090001061 Insulin Proteins 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 201000001421 hyperglycemia Diseases 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000011780 sodium chloride Substances 0.000 abstract 1
Abstract
การประดิษฐ์นี้ได้เกี่ยวข้องกับสารประกอบของสูตร (l) (สูตรเคมี) l ซึ่ง R1 ถึง R4 ได้ถูกนิยามในการอธิบายและข้อถือสิทธิ, และเกลือที่ยอมรับทางเภสัช กรรมของมัน สารประกอบมีประโยชน์สำหรับการรักษาและ/หรือป้องกันของโรคซึ่งเกี่ยวเนื่องกับ DPP-IV, เช่นโรคเบาหวาน, โดยเฉพาะโรคเบาหวานที่น้ำตาลในเลือดสูงที่ไม่ขึ้นกับอินซูลีน, และ ความทนทานกลูโคสที่เสีย The invention involved a compound of formula (l) (chemical formula) l where R1 to R4 was defined in its description and claim, and its pharmacologically acceptable salt, the compound was useful for treatment and / or prevention. Of diseases related to DPP-IV, such as diabetes mellitus, especially diabetes with hyperglycemia independent of insulin, and impaired glucose tolerance
Claims (1)
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TH82746A TH82746A (en) | 2007-02-01 |
| TH82746B true TH82746B (en) | 2007-02-01 |
Family
ID=
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