TH8243A - Pyrimidine derivatives - Google Patents

Abstract

Compound of the formula (chemical formula I), where R1 is OH, NH2; R2 is the hetero-aerobic or aerobic displacement group, as defined in the claim, R3 is H, OH, F, OCH3 R4 is H, F, OH or the rest of The ether or ester of that substance, OCH3, CN, C = CH, N3, R5 is OH or the remainder of the ether or ester of that substance. Including mono-, chi-, and tri-phosphate ester (chemical formula) where n is o or 1 and M is hydrogen or counter. Pharmacologically acceptable ions such as sodium, potassium, ammonium or alkyl ammonium, and chemically acceptable salts. The pharmacokinetics of that substance, and its pharmaceutical mixtures contain, for example, the above compounds can be utilized. For the treatment and / or prevention of viral infections such as AIDS: drug patents.

Claims (1)

1. Methods for preparing compounds with this formula (chemical formula I), whose radicals R1, R2, R3, R4 and R5 are defined as follows: R1 is OH, NH2, R2 is (chemical formula), where X is O, S, N-R7, Se, R6 are H, C1-10 alkyl, not branched or branched. F, Cl, Br, I, X-R7, -CH = C-R7, CO2R7 CH2X-R7 R7 to H, C1-5 alkyl, unbranched or branched, R3 to H, OH, F, OCH3. ; R4 is an H, F, OH or ether or ester or ester of the above RATICAL OCH2, CN, C = CH, N3; And R5 is the OH, or ether, or esterification of this compound (chemical formula), where n is o or tag: drug patent.