TH82139B - Optimized Expression of HPV 45L1 in Yeast - Google Patents
Optimized Expression of HPV 45L1 in YeastInfo
- Publication number
- TH82139B TH82139B TH401003770A TH0401003770A TH82139B TH 82139 B TH82139 B TH 82139B TH 401003770 A TH401003770 A TH 401003770A TH 0401003770 A TH0401003770 A TH 0401003770A TH 82139 B TH82139 B TH 82139B
- Authority
- TH
- Thailand
- Prior art keywords
- hpv45
- yeast
- vlps
- protein
- hpv
- Prior art date
Links
- 240000004808 Saccharomyces cerevisiae Species 0.000 title 1
- 210000004027 cell Anatomy 0.000 claims abstract 4
- 108090000623 proteins and genes Proteins 0.000 claims abstract 2
- 102000004169 proteins and genes Human genes 0.000 claims abstract 2
- 210000005253 yeast cell Anatomy 0.000 claims abstract 2
- 150000007523 nucleic acids Chemical class 0.000 claims 3
- 108020004707 nucleic acids Proteins 0.000 claims 2
- 102000039446 nucleic acids Human genes 0.000 claims 2
- 239000013598 vector Substances 0.000 claims 2
- 108020004705 Codon Proteins 0.000 claims 1
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 1
- 239000002773 nucleotide Substances 0.000 claims 1
- 125000003729 nucleotide group Chemical group 0.000 claims 1
- 108091033319 polynucleotide Proteins 0.000 abstract 2
- 102000040430 polynucleotide Human genes 0.000 abstract 2
- 239000002157 polynucleotide Substances 0.000 abstract 2
- 230000014616 translation Effects 0.000 abstract 2
- 229960005486 vaccine Drugs 0.000 abstract 2
- 108020004414 DNA Proteins 0.000 abstract 1
- 102000053602 DNA Human genes 0.000 abstract 1
- 208000009608 Papillomavirus Infections Diseases 0.000 abstract 1
- 230000001900 immune effect Effects 0.000 abstract 1
- 230000036039 immunity Effects 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000002245 particle Substances 0.000 abstract 1
- 238000013519 translation Methods 0.000 abstract 1
Abstract
โมเลกุล DNA สังเคราะห์ ซึ่งให้การแปลรหัส HPV45 L1โปรตีนจะถูกจัดหา อย่างจำเพาะเจาะจง, การประดิษฐ์ครั้งนี้จะจัดหาโพลีนิวคลีโอไทด์ซึ่งให้การแปลรหัส HPV45 L1 โปรตีน,โดยที่โพลีนิวคลีโอไทด์ดังกล่าวได้ถูกทำให้เหมาะสมเชิงโคดอน เพื่อให้การแสดงออกที่ ระดับสูงในเซลล์ยีสต์ โมเลกุลสังเคราะห์อาจจะถูกใช้เพื่อผลิตอนุภาคที่คล้ายไวรัส HPV45 (VLPs), และเพื่อผลิตวัคซีนและสารผสมเชิงเภสัชกรรมซึ่งประกอบรวมด้วย HPV45 VLPs วัคซีนตามการประดิษฐ์ครั้งนี้จะให้การป้องกันเชิงภูมิคุ้มกันวิทยา ต่อต้านการติดเชื้อพาพิลโลมา ไวรัส โดยผ่านแอนติบอดี้ซึ่งทำให้การลบล้างฤทธิ์ และภูมิคุ้มกันที่สื่อโดยเซลล์ A synthetic DNA molecule which provides the HPV45 L1 protein translation. Specifically, this invention provides polynucleotides that provide translations of HPV45 L1 protein, where such polynucleotides are codon-optimized. To make the expression High levels in yeast cells Synthetic molecules may be used to produce HPV45 virus-like particles (VLPs), and to produce vaccines and pharmaceutical mixtures that include HPV45 VLPs. The invention vaccines provide immunological protection. Against Papillomavirus infection through an antibody that neutralizes its And immunity mediated by cells
Claims (4)
Publications (3)
| Publication Number | Publication Date |
|---|---|
| TH82139B true TH82139B (en) | 2007-01-04 |
| TH82139A TH82139A (en) | 2007-01-04 |
| TH72490B TH72490B (en) | 2019-11-08 |
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