TH81376B - Pyrazolo-pyrimidine derivative that is mGluR2 antagonist. - Google Patents

Pyrazolo-pyrimidine derivative that is mGluR2 antagonist.

Info

Publication number
TH81376B
TH81376B TH601000576A TH0601000576A TH81376B TH 81376 B TH81376 B TH 81376B TH 601000576 A TH601000576 A TH 601000576A TH 0601000576 A TH0601000576 A TH 0601000576A TH 81376 B TH81376 B TH 81376B
Authority
TH
Thailand
Prior art keywords
pyrazolo
pyrimidine derivative
mglur2 antagonist
treatment
formula
Prior art date
Application number
TH601000576A
Other languages
Thai (th)
Other versions
TH81376A (en
Inventor
กาตติ แม็คอาร์เธอร์ และคณะ นายซิลเวีย
Original Assignee
เอฟฮอฟฟ์แมนน์ลา โรช เอจี
Filing date
Publication date
Application filed by เอฟฮอฟฟ์แมนน์ลา โรช เอจี filed Critical เอฟฮอฟฟ์แมนน์ลา โรช เอจี
Publication of TH81376A publication Critical patent/TH81376A/en
Publication of TH81376B publication Critical patent/TH81376B/en

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Abstract

การประดิษฐ์นี้จะเกี่ยวข้องกับอนุพันธ์ของไพราโซโล-ไพริมิดีน ที่มีสูตร (I) (สูตรเคมี) (I) ซึ่ง R1 ถึง R4 และ A คือ ดังที่ถูกนิยามในรายละเอียดการประดิษฐ์, กระบวนการสำหรับการผลิต ของสิ่งเหล่านี้, การใช้ของพวกมันสำหรับการบำบัดรักษา หรือ การป้องกันความผิดปกติที่มี เมทาโบโทรปิก กลูตาเมต รีเซพเตอร์ เป็นสื่อ , การใช้ของพวกมันสำหรับการเตรียมของยาเวชภัณฑ์ สำหรับการบำบัดรักษาความผิดปกติดังกล่าวนี้ และสารผสมทางเสภัชกรรม ที่มีอนุพันธ์ดังกล่าว This invention involves pyrazolo-pyrimidine derivatives with the formula (I) (chemical formula) (I), where R1 to R4 and A are, as defined in the invention description, the process for manufacture Of these, their use for the treatment or prevention of disorders with metabolic glutamate receptor mediated, their use for the preparation of pharmaceutical drugs. For the treatment of this disorder And chemical mixtures With such derivatives

Claims (1)

1. สารประกอบตามสูตร (I) (สูตรเคมี) (I) ซึ่ง A จะเลือกได้จากกลุ่มที่ประกอบด้วย (สูตรเคมี) (สูตรเคมี) (สูตรเคมี) (a) (b) (c) Ra คือ H, ฮาโล หรือ C1-6-แอลคิล ; R1 คือ H, ฮาโล, C1-6-แอลคอกซี, C1-6-แอลคิล , C1-6-ฮาโลแอลคิล , C1-6-ฮาโลแอลคอกซี ; R2 คือ1. Compounds according to the formula (I) (chemical formula) (I), which A is selected from the group containing (chemical formula) (chemical formula) (chemical formula) (a) (b) (c) Ra is H, halo or C1-. 6-alkyl; R1 is H, halo, C1-6-Loxc, C1-6-alkyl, C1-6-haloalkyl, C1-6-halo. Lcoxy; R2 is
TH601000576A 2006-02-09 Pyrazolo-pyrimidine derivative that is mGluR2 antagonist. TH81376B (en)

Publications (2)

Publication Number Publication Date
TH81376A TH81376A (en) 2006-11-23
TH81376B true TH81376B (en) 2006-11-23

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