TH79792A - Compounds and mixtures that are protein kinase inhibitors - Google Patents
Compounds and mixtures that are protein kinase inhibitorsInfo
- Publication number
- TH79792A TH79792A TH501005228A TH0501005228A TH79792A TH 79792 A TH79792 A TH 79792A TH 501005228 A TH501005228 A TH 501005228A TH 0501005228 A TH0501005228 A TH 0501005228A TH 79792 A TH79792 A TH 79792A
- Authority
- TH
- Thailand
- Prior art keywords
- compounds
- kinase
- abl
- met
- abnormal
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title claims abstract 8
- 239000000203 mixture Substances 0.000 title abstract 3
- 229940045988 antineoplastic drugs Protein kinase inhibitors Drugs 0.000 title 1
- 239000003909 protein kinase inhibitor Substances 0.000 title 1
- 239000003814 drug Substances 0.000 claims abstract 2
- 229940079593 drugs Drugs 0.000 claims abstract 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 2
- 229910052739 hydrogen Inorganic materials 0.000 claims 2
- 239000001257 hydrogen Substances 0.000 claims 2
- 125000004435 hydrogen atoms Chemical group [H]* 0.000 claims 2
- 239000000126 substance Substances 0.000 claims 1
- 201000010099 disease Diseases 0.000 abstract 10
- 108091000081 Phosphotransferases Proteins 0.000 abstract 6
- 102000001253 Protein Kinases Human genes 0.000 abstract 6
- -1 MET Proteins 0.000 abstract 4
- 230000002159 abnormal effect Effects 0.000 abstract 4
- 102100001248 AKT1 Human genes 0.000 abstract 2
- 101700006234 AKT1 Proteins 0.000 abstract 2
- 108060006647 CHEK2 Proteins 0.000 abstract 2
- 102100019698 CHEK2 Human genes 0.000 abstract 2
- 102100020191 FGFR3 Human genes 0.000 abstract 2
- 101710009074 FLT3 Proteins 0.000 abstract 2
- 101710039816 NCU06544 Proteins 0.000 abstract 2
- 101700043017 NTRK1 Proteins 0.000 abstract 2
- 108060005033 NTRK2 Proteins 0.000 abstract 2
- 108060005034 NTRK3 Proteins 0.000 abstract 2
- 102100004939 PDGFRB Human genes 0.000 abstract 2
- 101710018346 PDGFRB Proteins 0.000 abstract 2
- 102100018393 PRRT2 Human genes 0.000 abstract 2
- 101700012359 PRRT2 Proteins 0.000 abstract 2
- 108010014608 Proto-Oncogene Proteins c-kit Proteins 0.000 abstract 2
- 102000016971 Proto-Oncogene Proteins c-kit Human genes 0.000 abstract 2
- 101700011174 ROCK2 Proteins 0.000 abstract 2
- 102100000533 ROCK2 Human genes 0.000 abstract 2
- 101710009878 RPS6KB1 Proteins 0.000 abstract 2
- 102100011601 RPS6KB1 Human genes 0.000 abstract 2
- 101700056898 SGK1 Proteins 0.000 abstract 2
- 102100002801 STK3 Human genes 0.000 abstract 2
- 101700025207 STK3 Proteins 0.000 abstract 2
- 101710037124 TEK Proteins 0.000 abstract 2
- 108010081267 Type 3 Fibroblast Growth Factor Receptor Proteins 0.000 abstract 2
- 239000005441 aurora Substances 0.000 abstract 2
- 230000000694 effects Effects 0.000 abstract 2
- 101700084897 mst2 Proteins 0.000 abstract 2
- 101710038852 pkc-3 Proteins 0.000 abstract 2
- 230000002265 prevention Effects 0.000 abstract 2
- 230000000638 stimulation Effects 0.000 abstract 2
Abstract
DC60 (03/02/49) การประดิษฐ์ที่จัดเตรียมสารประกอบชนิดใหม่, สารผสมทางเภสัชกรรมรวมไปถึง สารประกอบและวิธีของการใช้ เช่น สารประกอบดังกล่าวนี้ ในการรักษาหรือป้องกันโรค หรือ การ ผิดปกติของโรคที่เกี่ยวกับการออกฤทธิ์ของไคเนสที่ไม่เป็นปกติ หรือ ที่เอการควบคุมออกไป โดยเฉพาะโรคหรือความผิดปกติของโรคที่เกี่ยวพันคือการกระตุ้นที่ไม่เป็นปกติของไคเนสชนิด Abl, Bcr-Abl, cSrc, TPR-Met, Tie2, MET, FGFR3, ออโรร่า, Axl, Bmx, BTK, c-kit, CHK2, Flt3, MST2, p70S6K, PDGFR, PKB, PKCอัลฟา, Raf, ROCK-II, Rskl, SGK, TrkA, TrkB และ ไคเนส TrKC. การประดิษฐ์ที่จัดเตรียมสารประกอบชนิดใหม่, สารผสมทางเภสัชกรรมรวมไปถึง สารประกอบและวิธีของการใช้ เช่น สารประกอบดังกล่าวนี้ ในการรักษาหรือป้องกันโรค หรือ การ ผิดปกติของโรคที่เกี่ยวกับการออกฤทธิ์ของไคเนสที่ไม่เป็นปกติ หรือ ที่เอการควบคุมออกไป โดยเฉพาะโรคหรือความผิดปกติของโรคที่เกี่ยวพันคือการกระตุ้นที่ไม่เป็นปกติของไคเนสชนิด Abl, Bcr-Abl, cSrc, TPR-Met, Tie2, MET, FGFR3, ออโรร่า, Axl, Bmx, BTK, c-kit, CHK2, Flt3, MST2, p70S6K, PDGFR, PKB, PKCอัลฟา, Raf, ROCK-II, Rskl, SGK, TrkA, TrkB และ ไคเนส TrKC. สิทธิบัตรยา DC60 (03/02/49) An invention that provides new compounds, pharmaceutical mixtures including Compounds and methods of application such as these compounds In the treatment or prevention of diseases or disorders related to abnormal or controlled kinase activity. Specifically, disease or associated disease disorders are abnormal stimulation of Abl-type kinase, Bcr-Abl, cSrc, TPR-Met, Tie2, MET, FGFR3, Aurora, Axl, Bmx, BTK. , c-kit, CHK2, Flt3, MST2, p70S6K, PDGFR, PKB, PKC alpha, Raf, ROCK-II, Rskl, SGK, TrkA, TrkB and TrKC kinase. Invention that provides a new type of compound, Pharmaceutical mixtures, including Compounds and methods of application such as these compounds In the treatment or prevention of diseases or disorders related to abnormal or controlled kinase activity. Specifically, disease or associated disease disorders are abnormal stimulation of Abl-type kinase, Bcr-Abl, cSrc, TPR-Met, Tie2, MET, FGFR3, Aurora, Axl, Bmx, BTK. , c-kit, CHK2, Flt3, MST2, p70S6K, PDGFR, PKB, PKC alpha, Raf, ROCK-II, Rskl, SGK, TrkA, TrkB and TrKC kinase. Drug patent.
Claims (1)
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TH79792A true TH79792A (en) | 2006-09-07 |
| TH79792B TH79792B (en) | 2006-09-07 |
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