TH79014A - P analogues for the treatment of cancer - Google Patents

Abstract

DC60 (23/03/52) This invention encompasses a newly synthesized peptide analog, which is an antagonist against P-like peptides and related peptides and is useful for The invention of cancer treatment is particularly relevant to the design and synthesis of novel P antagonist analogs that combine alpha-acid, alpha-dialylate amino acids. In a specific format, the fabrication includes methods for making these peptides. Composition with these peptides and their pharmacological uses Of these peptides, especially in cancer treatment and prevention. The invention encompasses newly synthesized peptide analogs that are antagonists against P, P-like peptides and related peptides and are useful for cancer treatment. This is especially true for the design and synthesis of a new P-antagonist analogue combining amino acids, α-dialkylatedates, in a location-specific format. The fabrication covers a method for making peptides. These Mixtures containing these peptides and their pharmacological uses These peptides are especially common in cancer treatment and prevention.

Claims (2)

1.Peptides of the general formula XD-Arg-Pro-Lys-Pro-D-Phe-Gln-D-Trp-Phe-D-Trp-Leu-R-NH2, where X is acetyl or striated alkanoyl group. straight Is a branch or loop of carbon atoms from 3 to 16 atoms or has been cut R is Aib, Deg, Dpg, Ac5c or Ac6c, or a water-cutable carboxy block, or Pharmacy acceptable salt of peptides 2. Formula Peptides D-Phe-Gln-D-Trp-Phe-D-Trp-Leu-R-NH2 where R is Aib, Deg, D tags: