TH77917B - The 5-membered band of the hetero is replaced by the diaryl. - Google Patents
The 5-membered band of the hetero is replaced by the diaryl.Info
- Publication number
- TH77917B TH77917B TH501004148A TH0501004148A TH77917B TH 77917 B TH77917 B TH 77917B TH 501004148 A TH501004148 A TH 501004148A TH 0501004148 A TH0501004148 A TH 0501004148A TH 77917 B TH77917 B TH 77917B
- Authority
- TH
- Thailand
- Prior art keywords
- group
- replaced
- disorders
- formula
- diaryl
- Prior art date
Links
- 125000005842 heteroatoms Chemical group 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 claims abstract 2
- 150000001875 compounds Chemical class 0.000 claims abstract 2
- 125000003392 indanyl group Chemical group C1(CCC2=CC=CC=C12)* 0.000 claims abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims abstract 2
- 239000000126 substance Substances 0.000 claims abstract 2
- 125000004435 hydrogen atoms Chemical group [H]* 0.000 claims 1
- 125000004594 isoindolinyl group Chemical group C1(NCC2=CC=CC=C12)* 0.000 claims 1
- 125000002943 quinolinyl group Chemical group N1=C(C=CC2=CC=CC=C12)* 0.000 claims 1
- 208000002193 Pain Diseases 0.000 abstract 2
- 208000005298 Acute Pain Diseases 0.000 abstract 1
- 206010002855 Anxiety Diseases 0.000 abstract 1
- 206010057666 Anxiety disease Diseases 0.000 abstract 1
- 210000004369 Blood Anatomy 0.000 abstract 1
- 208000008581 Brain Disease Diseases 0.000 abstract 1
- 206010008120 Cerebral ischaemia Diseases 0.000 abstract 1
- 206010013663 Drug dependence Diseases 0.000 abstract 1
- 102100004351 GRM1 Human genes 0.000 abstract 1
- 208000008665 Gastrointestinal Disease Diseases 0.000 abstract 1
- 206010061218 Inflammation Diseases 0.000 abstract 1
- 206010061284 Mental disease Diseases 0.000 abstract 1
- 206010061536 Parkinson's disease Diseases 0.000 abstract 1
- 230000036506 anxiety Effects 0.000 abstract 1
- 239000008280 blood Substances 0.000 abstract 1
- 201000006474 brain ischemia Diseases 0.000 abstract 1
- 230000022534 cell killing Effects 0.000 abstract 1
- 230000009089 cytolysis Effects 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000004054 inflammatory process Effects 0.000 abstract 1
- 108010014719 metabotropic glutamate receptor type 1 Proteins 0.000 abstract 1
- 230000017074 necrotic cell death Effects 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 201000000980 schizophrenia Diseases 0.000 abstract 1
- 239000011780 sodium chloride Substances 0.000 abstract 1
- 230000000699 topical Effects 0.000 abstract 1
Abstract
การประดิษฐ์นี้จัดเตรียมสารประกอบที่แทนที่ด้วยสูตร (I) (สูตรเคมี) (I) (โดยที่ R1 แทนหมู่อินดานิลและอื่นๆ R2 แทนโลเวอร์อัลคิลและอื่นๆ R3 แทนหมู่ฟีนิลและอื่นๆ) หรือเกลือที่ยอมรับได้ทางเภสัชกรรมของมัน ที่มีผลที่ยับยั้ง mGluR1 และที่มีประโยชน์สำหรับการ ป้องกันหรือการบำบัดการชัก ความเจ็บปวดเฉียบพลัน ความเจ็บปวดจากการอักเสบ ความ เจ็บปวดเรื่อรัง ความผิดปกติทางสมอง เช่น เนื้อตายเหตุขาดเลือดที่สมองหรือการเกิดการขาด เลือดเฉพาะที่ชั่วคราว ความผิดปกติทางจิต เช่น โรคจิตเภท ความวิตกกังวล การติดยา โรคพาร์คินสันหรือความผิดปกติทางกระเพาะและลำไส้ This invention provides compounds replaced by formula (I) (chemical formula) (I) (where R1 represents indanyl group and so on, R2 represents lower alkyl and so on, R3 represents phenyl group, and so on. ) Or its pharmaceutical acceptable salt With effects that inhibit mGluR1 and is useful for Prevention or seizure treatment Acute pain Pain from inflammation Brain disorders, such as necrosis, cerebral ischemia or deficiency. Temporary topical blood Mental disorders such as schizophrenia, anxiety, drug addiction, Parkinson's disease, or gastrointestinal disorders.
Claims (1)
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TH77917B true TH77917B (en) | 2006-06-05 |
| TH77917A TH77917A (en) | 2006-06-05 |
Family
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