TH74842A - Pharmaceutical mixtures for the treatment of cardiovascular and cerebrovascular diseases. - Google Patents

Abstract

DC60 (20/12/47) This invention reveals a pharmaceutical mixture for the therapeutic use of cardiovascular and cerebrovascular diseases, composed of Radix Salvia miltiorrhea extract, Radix notoginseng extract, Radix ostragali extract, and borneol or lignum dal bergia odorifera oil. This mixture achieves significantly better anti-ischemic effects in the cerebral and myocardial tissues than the effects of salvianolic acid and Radix notoginseng saponin alone or in combination. This mixture can be formulated into various dosage forms with other pharmaceutical adjuvants, thus creating the possibility of providing a more effective and convenient combination of biologically active herbal compounds for clinical use. This invention reveals a pharmaceutical mixture for the therapeutic use of cardiovascular and cerebrovascular diseases, composed of... The extracts of Radix Salvia miltiorhicia, Radix notoginseng, Radix ostragali, and borneol or oil of Lignum dal Bergia odorifera, when combined, produce significantly better anti-ischemic effects in the cerebral cerebral and myocardial tissues than salvianolic acid and Radix notoginseng saponin alone or in combination. This mixture can be formulated into various dosage forms with other pharmaceutical adjuvants, thus creating the possibility of providing more effective and convenient combinations of biologically active herbal compounds for clinical use.

Claims (10)

1. Pharmaceutical mixture, containing extracts of Radix Salvia mystiorrhea; Radix notoginseng; ostragali; and borneol or oil of lignum dalbergia odorifera. 2. A mixture of claims 1, consisting of Radix Salvia miltiorhicia extract 5.0%-70.0%; Radix notoginseng extract 10.0%-85.0%; Radix austragali extract 5.0%-70.0%; and borneol or lignum dalbergia odorifera oil 1.0%-15.0%. 3. A mixture of claims 2, consisting of Radix Salvia miltiorhicia extract 15.0%-50.0%; Radix notoginseng extract 25.0%-65.0%; Radix austragali extract 15.0%-50.0%; and borneol or lignum dalbergia odorifera oil 2.0%-12.0%. 4. A mixture of claims 3, consisting of Radix Salvia miltiorhicia extract 20.0%-30.0%; Radix notoginseng extract 30.0%-55.0%; Radix austragali extract 20.0%-30.0%; and Borneol or lignum dalbergia odorifera oil 4.0%-10.0%. 5. A mixture of claim 4, consisting of 23% Radix Salvia miltiorhicia extract; 45% Radix notoginseng extract; 23% Radix austragali extract; and 9% borneol or lignum dalbergia odorifera oil. 6. A mixture of claims 1, 2, 3, 4, or 5 in which the said Radix Salvia milliorizia extract contains 45%-70% salvianolic acid B, 2%-10% salvianolic acid E, 4%-20% rosmarinic acid, 1%-10% lithospermic acid, and more than 70% salvinolic acid; in which the said Radix notoginseng extract contains 2%-10% notoginsenosite R1, 2%-6% ginsenosite Re, 15%-40% ginsenosite Rg1, 15%-40% ginsenosite Rb1, 5%-12% ginsenosite Rd, and more than 70% Radix notoginseng saponin; The Radic austragali extract contains 5%-15% austragaloside 1 and over 70% Radic austragali saponin. 7. A mixture of claims 6, in which the aforementioned Radix Salvia miltiorhicia extract contains more than 80% salvinolic acid; the aforementioned Radix notoginseng extract contains more than 80% Radix notoginseng saponin; and the aforementioned Radix austragali extract contains more than 80% Radix austragali saponin. 8. A combination of claims 1, 2, 3, 4, or 5 in which such combination is an injectable drug, flat tablet, assisted-release flat tablet, drop-form tablet, granule, powder for injection, capsule, or microgranule. 9. A mixture of claims 8, where such mixture is an injectable drug or an injectable powder. 10. The use of any combination of the compounds under Rights 1 through 9, where the compounds are used for the treatment of cardiovascular and cerebrovascular diseases.