TH716A - Process for the production of 2-oxoacetidine derivatives and their uses. - Google Patents
Process for the production of 2-oxoacetidine derivatives and their uses.Info
- Publication number
- TH716A TH716A TH8101000307A TH8101000307A TH716A TH 716 A TH716 A TH 716A TH 8101000307 A TH8101000307 A TH 8101000307A TH 8101000307 A TH8101000307 A TH 8101000307A TH 716 A TH716 A TH 716A
- Authority
- TH
- Thailand
- Prior art keywords
- chemical formula
- group
- formula
- acetate
- choose
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title claims abstract 3
- 239000000126 substance Substances 0.000 claims abstract 7
- 125000003277 amino group Chemical group 0.000 claims abstract 5
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 claims abstract 4
- 150000001875 compounds Chemical class 0.000 claims abstract 2
- 150000002148 esters Chemical class 0.000 claims abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 claims abstract 2
- 239000001257 hydrogen Substances 0.000 claims abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims abstract 2
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims abstract 2
- 150000003839 salts Chemical class 0.000 claims abstract 2
- 238000013329 compounding Methods 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 125000001475 halogen functional group Chemical group 0.000 claims 1
- 241001024304 Mino Species 0.000 abstract 1
- 230000000259 anti-tumor effect Effects 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical group 0.000 abstract 1
- 229940116108 lactase Drugs 0.000 abstract 1
- 125000000446 sulfanediyl group Chemical group *S* 0.000 abstract 1
Abstract
กรรมวิธีในการเตรียมอนุพันธ์ของ1-ซัลโฟ-2-ออกโซอะเธทิดีนของสูตรทั่วไป (สูตรเคมี) ซึ่งR1คือหมู่อะมิโนซึ่งอาจเลือกถูกแอซีเลท หรือถูกป้อง กัน,xคือไฮโดรเจนหรือเมทธอซีและR4คือแอไธโอ,เฮโลเจน,หมู่อะ มิโนซึ่งอาจเลือกถูกแอซิเลท หรือหมู่ของสูตร (สูตรเคมี) (ซึ่งR5คือหมู่ที่เป็นอนุมูลอินทรีย์ และnคือ0,1หรือ2)หรือ เกลือซึ่งเป็นที่ยอมรับทางเภสัชศาสตร์หรือเอสเทอร์ของสาร เหล่านั้น ตามแผนการต่อไปนี้ (สูตรเคมี) ซึ่งR2คือหมู่อะมิโนที่ถูกแอซิเลิทหรือถูกป้องกันR3คือ หมู่อะมิโนที่ถูกแอซิเลท,และมีR1และR4ตามที่นิยามแล้วข้าง บน สารประกอบ(I)มีฤทธิ์ต่อต้านจุดชีพและขัดขวาง บีทาแลคแท เบส สิทธิบัตรยา A process for preparing a 1-sulfo-2-oxoathidine derivative of the general formula (chemical formula) where R1 is an amino group, which may choose to be acetate or shielded, x is hydrogen or Methoxy and R4 is thio, halogen, moo. Mino, which may choose to be acetate Or formula group (chemical formula) (where R5 is the organic radical group And n is 0,1 or 2) or Pharmacologically acceptable salts or esters of them according to the following schemes (chemical formula), where R2 is an azylated or protected amino group, R3 is Acetate amino groups, with R1 and R4, as defined above, compound (I) has antitumor activity and inhibits beta-lactase.
Claims (1)
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TH716A true TH716A (en) | 1982-12-03 |
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