TH71060A - Method and product composition, skin whitening agent - Google Patents

Abstract

DC60 (02/03/47) Compounds of formula I, the same preparation methods and cosmetic product components and methods of skin whitening using compounds of formula I as skin whitening agents: (chemical formula) (I) where each A1 and/or A2 is independent, i.e. = H or COR, CO2R, CONHR, the latter three having the formula A as follows: (chemical formula), (chemical formula), (chemical formula) (A) where R = linear or branched hydrocarbons, saturated or unsaturated C1-C18; and each Y1 and/or Y2 is independent, i.e. H; saturated or unsaturated hydrocarbons C1-C18; or OZ, where Z = H or COR1, CO2R1, CONHR1 of formula B: (chemical formula), (chemical formula), (chemical formula) (B) and where R1 = linear hydrocarbons Or branched chain, saturated or unsaturated C1-C18 hydrocarbons; X is carbon, nitrogen, sulfur or oxygen; and N is an integer between 0 and 2. Compounds of formula I, the preparation methods are the same, and the components of cosmetic products and methods of skin whitening using compounds of formula I as skin whitening agents: (chemical formula) (I) where each A1 and/or A2 is independent, i.e. = H or COR, CO2R, CONHR, the latter three having the formula A as follows: (chemical formula) (A) where R = linear or branched chain, saturated or unsaturated C1-C18 hydrocarbons; and each Y1 and/or Y2 is independent, i.e. H; saturated or unsaturated C1-C18 hydrocarbons; or OZ, where Z = H or COR1, CO2R1, CONHR1 of formula B: (chemical formula) (B) and where R1 = linear hydrocarbons. Branched, saturated, or unsaturated chains C1-C18; X is carbon, nitrogen, sulfur, or oxygen; and N is an integer between 0 and 2.

Claims (18)

1. Cosmetic methods for skin whitening consist of applying to the skin a product containing: a. A compound of general formula I in approximately 0.000001 to approximately 50 percent (chemical formula) (I), where each A1 and/or A2 is independent, i.e. = H, COR, CO2R, CONHR, where R = saturated or unsaturated hydrocarbon C1-C18; and each Y1 and/or Y2 is independent, i.e. H, saturated or unsaturated hydrocarbon C1-C18, or OZ, where Z = H, COR1, CO2R1, CONHR1 and here R1 = saturated or unsaturated hydrocarbon C1-C18; X is carbon, nitrogen, sulfur, or oxygen; and N is an integer between 0 and 2; and b. A carrier can be obtained cosmetically. 2. Method of Claim 1, Here, the compound has the general formula II (chemical formula) (II). 3. Method of Claim 1, herein, the aforementioned product component includes sunscreen. 4. Method of claim 2, here the compound is a compound of formula III (chemical formula) (III). 5. In accordance with the method of claim 4, the hydroxyl groups of the compounds, i.e., esterified with acids, are selected from groups comprising ferulic acid, vanillic acid, zebasic acid, achaleic acid, benzoic acid, caffeic acid, coumaric acid, salicylic acid, cysteine, cysteine, lactic acid, glycolic acid and mixtures thereof. 6. Method of Claim 1, Herein, the aforementioned product component includes additional fragrance. 7. The cosmetic method complies with claim 1, in which the composition of the said product, in addition, contains substances beneficial to the skin, selected from a group of alpha-hydroxy acids, beta-hydroxy acids, polyhydroxy acids, hydroquinone, t-butylhydroquinone, vitamin C derivatives, dioic acid, retinoids, resorcinol derivatives, and mixtures of them. 8. The cosmetic product composition consists of: a. A compound of general formula I in approximately 0.000001 to approximately 50 percent (chemical formula) (I), where each A1 and/or A2 is independent, i.e. = H, COR, CO2R, CONHR, where R = saturated or unsaturated hydrocarbon C1-C18; and each Y1 and/or Y2 is independent, i.e. H, saturated or unsaturated hydrocarbon C1-C18; or OZ, where Z = H, COR1, CO2R1, CONHR1 and where R1 = saturated or unsaturated hydrocarbon C1-C18; X is carbon, nitrogen, sulfur, or oxygen; N is an integer between 0 and 2; and b. A carrier substance which may be accepted in cosmetics. 9. The components of the cosmetic product of claim 8, herein the compounds are the components of the general formula II: (chemical formula) (II) 10. The components of the cosmetic product of claim 8, herein, are compounds of formula III (chemical formula) (III). 11. The composition of the cosmetic product of claim 8, herein, contains compounds ranging from approximately 0.000001 percent to approximately 10 percent of the product's composition. 12. The cosmetic product components of claim 8, additionally, include sunscreen. 13. The cosmetic product components of claim 10, herein the hydroxyapatite group of the aforementioned compounds, i.e. esterified with acid, are selected from the group consisting of ferulic acid, vanillic acid, zebasic acid, achaleic acid, benzoic acid, caffeic acid, coumaric acid, salicylic acid, cysteine, cysteine, lactic acid, glycolic acid and mixtures thereof. 14. Compounds of general formula I (chemical formula) (I) here, each A1 and/or A2 is independent, i.e., = H, COR, CO2R, CONHR, where R = saturated or unsaturated hydrocarbon C1-C18; and each Y1 and/or Y2 is independent, i.e., H, saturated or unsaturated hydrocarbon C1-C18, or OZ, where Z = H, COR1, CO2R1, CONHR1 and here R1 = saturated or unsaturated hydrocarbon C1-C18; X is carbon, nitrogen, sulfur, or oxygen; and N is an integer between 0 and 2. 15. The compound of claim 14 has the general formula II: (chemical formula) (II) 16. The compound of claim 14 has the formula III (chemical formula) (III). 17. Compounds of claim 16, herein the hydroxyl group of such compounds is esterified with an acid selected from the group consisting of ferulic acid, vanillic acid, zebasic acid, achaleic acid, benzoic acid, caffeic acid, coumaric acid, salicylic acid, cysteine, cysteine, lactic acid, glycolic acid and mixtures thereof. 18. The procedure for the synthesis of 4-[2'-(1',3'-dithiacyclopentyl)]-1,3-dihydroxybenzene, 4,[2'-(1',3'-dithiacyclohexy)]-1,3-dihydroxybenzene, 4,[2'-(1',3'-dithiacyclohepty)]-1,3-dihydroxybenzene, or a mixture thereof, consists of: the reaction (a) 2,4-dihydroxybenzaldehyde; with (b) 1,2-dimercaptoethane, 1,3-dimercaptopropane, 1,4-dimercaptobutane, or a mixture thereof, respectively; in the participation of an acid catalyst; here, such acid catalyst is Selected from groups consisting of methane sulfonic acid, p-toluene sulfonic acid, sulfuric acid, hydrochloric acid, acidic resins, and mixtures of them.