TH69079A - Indole-3-carboxamide As a glucokinase (GK) stimulant - Google Patents
Indole-3-carboxamide As a glucokinase (GK) stimulantInfo
- Publication number
- TH69079A TH69079A TH301003700A TH0301003700A TH69079A TH 69079 A TH69079 A TH 69079A TH 301003700 A TH301003700 A TH 301003700A TH 0301003700 A TH0301003700 A TH 0301003700A TH 69079 A TH69079 A TH 69079A
- Authority
- TH
- Thailand
- Prior art keywords
- glucokinase
- formula
- stimulant
- carboxamide
- indole
- Prior art date
Links
- 102000030595 Glucokinase Human genes 0.000 title abstract 5
- 108010021582 Glucokinase Proteins 0.000 title abstract 5
- LSGKMZLPZFPAIN-UHFFFAOYSA-N 1h-indole-3-carboxamide Chemical compound C1=CC=C2C(C(=O)N)=CNC2=C1 LSGKMZLPZFPAIN-UHFFFAOYSA-N 0.000 title 2
- 239000000126 substance Substances 0.000 claims abstract 3
- -1 nitro, amino, cyano, methyl Chemical group 0.000 claims 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 125000004429 atom Chemical group 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 125000004432 carbon atom Chemical group C* 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 125000000753 cycloalkyl group Chemical group 0.000 claims 1
- 125000001475 halogen functional group Chemical group 0.000 claims 1
- 125000004356 hydroxy functional group Chemical group O* 0.000 claims 1
- 125000004170 methylsulfonyl group Chemical group [H]C([H])([H])S(*)(=O)=O 0.000 claims 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 1
- 230000003914 insulin secretion Effects 0.000 abstract 2
- 238000011282 treatment Methods 0.000 abstract 2
- 208000001072 type 2 diabetes mellitus Diseases 0.000 abstract 2
- 229940124828 glucokinase activator Drugs 0.000 abstract 1
Abstract
DC60 (06/11/46) การประดิษฐ์ครั้งนี้จะจัดหาตัวกระตุ้นกลูโคไคเนสตามสูตร I (สูตรเคมี) I โดยที่ R1, R2 และ R3 คือ ดังที่จำกัดความไว้ในรายละเอียดจำเพาะ ตัวกระตุ้นกลูโคไคเนสจะมี ประโยชน์สำหรับการเพิ่มการหลั่งอินซูลินในการทรีตเมนท์โรคเบาหวานชนิด II การประดิษฐ์ครั้งนี้จะจัดหาตัวกระตุ้นกลูโคไคเนสตามสูตร I: (สูตรเคมี) I โดยที่ R1, R2 และ R3 คือ ดังที่จำกัดความไว้ในรายละเอียดจำเพาะ ตัวกระตุ้นกลูโคไคเนสจะมี ประโยชน์สำหรับการเพิ่มการหลั่งอินซูลินในการทรีตเมนท์โรคเบาหวานชนิด II: DC60 (06/11/46) This invention supplies a glucokinase activator according to formula I (chemical formula) I, where R1, R2 and R3 are as defined in the specifications. Glucokinase stimulators will have Benefits for increasing insulin secretion in type II diabetes treatment, this invention provides a glucokinase stimulator based on formula I: (chemical formula) I, where R1, R2 and R3 are as shown below. Limited in specific details Glucokinase stimulators will have Benefits for increasing insulin secretion in type II diabetes treatments:
Claims (1)
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TH69079A true TH69079A (en) | 2005-06-07 |
Family
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