TH61315B - Complete human antibodies to human 4-1BB. - Google Patents

Abstract

DC60 (05/01/48) Human complement antibody and its antigen binding binding to human 4-1BB and permitting binding of human 4-1BB to 4-1BB ligand. In humans, on the one hand, the antibody is the IgG4 antibody given the other is a means for treating cancer in patients. which includes The dose of antibodies that are effective in therapy in such patients. The complete human antibody and its antigen binding binds to human 4-1BB and allows binding of human 4-1BB to human 4-1BB ligands. is the IgG4 antibody that has been given as a means for treating cancer in patients. which includes quantification of therapeutic antibodies to such patients, patent drug

Claims (9)

1. A monoclonal antibody or its antigen-binding fragment that binds specifically to 4-1BB, comprising a light chain variable region and a heavy chain variable region, wherein: said light chain variable region includes CDR1,CDR2, and CDR3 as shown in Figure 4; and said heavy chain variable region includes CDR1,CDR2, and CDR3 as shown in Figure 3. 2. The monoclonal antibody or the antigen-binding portion thereof of claim 1, wherein: said light chain comprises a variable region as shown in Figure 4; and said heavy chain comprises a variable region as shown in Figure 3. 3. Monoclonal antibody comprising a light chain and a heavy chain, the said light chain comprising amino acid groups 21-236 of SEQ ID NO:6 and the said heavy chain comprising amino acid groups 20-467 of SEQ ID NO:3. 4. A pharmaceutical mixture comprising: a monoclonal antibody or an antigen-binding fraction thereof of claim 1; and a pharmaceutically acceptable carrier. 5. A pharmaceutical mixture comprising: the monoclonal antibody of claim 3; and a pharmaceutically acceptable carrier. 6. Use of the monoclonal antibody or its antigen-binding portion of claim 1 for the production of a drug for the treatment of cancer in patients. 7. Selected polynucleotide, comprising the nucleotide sequence of the amino acid sequence code of amino acid group 20-467 of SEQ ID NO:3. 8. The polynucleotide of claim 7 comprising the nucleotide sequence of SEQ ID NO:1. 9. The isolated polynucleotide comprising a nucleotide sequence of the amino acid sequence of the amino acid group 21-236 of SEQ ID NO:6 1 0The polynucleotide of claim 9 comprising a nucleotide sequence of SEQ ID NO:4