TH4337A - Optical, 2-chloro-12- (3-dimethylamino-1-methylpropyl) -12H-dibenzo (d, g) (1- 3-6) dioxazosin and processes for its preparation - Google Patents
Optical, 2-chloro-12- (3-dimethylamino-1-methylpropyl) -12H-dibenzo (d, g) (1- 3-6) dioxazosin and processes for its preparationInfo
- Publication number
- TH4337A TH4337A TH8601000649A TH8601000649A TH4337A TH 4337 A TH4337 A TH 4337A TH 8601000649 A TH8601000649 A TH 8601000649A TH 8601000649 A TH8601000649 A TH 8601000649A TH 4337 A TH4337 A TH 4337A
- Authority
- TH
- Thailand
- Prior art keywords
- dimethylamino
- chloro
- dioxosin
- optical
- dibenzo
- Prior art date
Links
- -1 3-dimethylamino-1-methylpropyl Chemical group 0.000 title claims abstract 5
- 230000003287 optical effect Effects 0.000 title claims abstract 4
- 238000002360 preparation method Methods 0.000 title claims 2
- 238000000034 method Methods 0.000 title abstract 2
- 239000002253 acid Substances 0.000 claims abstract 4
- 239000003814 drug Substances 0.000 claims abstract 3
- 150000007513 acids Chemical class 0.000 claims abstract 2
- 229940079593 drug Drugs 0.000 claims abstract 2
- 150000007524 organic acids Chemical class 0.000 claims abstract 2
- 235000005985 organic acids Nutrition 0.000 claims abstract 2
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims abstract 2
- 150000003839 salts Chemical class 0.000 claims abstract 2
- 239000002904 solvent Substances 0.000 claims 1
- 208000018737 Parkinson disease Diseases 0.000 abstract 1
- 238000002425 crystallisation Methods 0.000 abstract 1
- 230000008025 crystallization Effects 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 239000007788 liquid Substances 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- 238000000926 separation method Methods 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Abstract
การประดิษฐ์นี้เกี่ยวข้องกับ ออพติคัลลี แอคทีฟ 2-คลอโร-12-(3-ไดเมธิลอะมิโน-1-เมธิลโพรพิล)-12H-ไดเบนโซ (d,g) (1-3-6) ไดออกซาโซซิน ของสูตร (สูตรเคมี) นี้ และเกลือของมันที่เกิดจากการรวมกับกรดซึ่งเป็นที่ยอม รับทางเภสัชกรรมอิแนนทิโอเมอร์เหล่านี้ มีฤทธิ์ต่อต้านโรค ของพาร์คินสันเป็นพิเศษ อิแนนทิโอเมอร์ชนิดออพทิคัลลี แอคทีฟ เหล่านี้ เตรียมขึ้น โดย a) การแยกเรซิมิค 2-คลอโร-12-(3-ไดเมธิลอะมิโน-2-เมธิล โพรพิล)-12H-ไดเบนโซ (d,g) (1-3-6) ไดออกซาโซซิน ด้วยกรด อินทรีย์ ชนิดออพทิคัลลี แอคทีฟ และแยกอิแนนทิโอเมอร์เหล่า นี้ออกจากกัน หรือ b) ละลาย เรซิมิค 2-คลอโร-12-(3-ไดเมธิลอะมิโน-2-เมธิล โพรพิล)-12H-ไดเบนโซ (d,g) (1-3-6) ไดออกซาโซซิน ในตัวทำละ ลายชนิดอินทรีย์ ทำให้ตกผลึก และแยกหนึ่งอิแนนทิโอเมอร์ออก เลือกละลาย เรซิมิค 2-คลอโร-12-(3-ไดเมธิลอะมิโน-2-เมธิล โพรพิล)-12H-ไดเบนโซ (d,g) (1-3-6) ไดออกซาโซซิน เพิ่มเติม ในของเหลวที่เหลือจากการตกผลึกออกแล้วที่ได้นี้ และทำให้ตก ผลึกออกมา และแยกออกจากอิแนนทิโอเมอร์อื่น และถ้าต้องการ ทำซ้ำกรรมวิธีทั้งหมดนี้ สิทธิบัตรยา The invention involved an optical 2-chloro-12- (3-dimethylamino-1-methylpropyl) -12H-dibenzo (d, g) (1-3-6) The dioxosin of this formula (chemical formula) and its salts formed by combining with acids, which are permissible. Get these inanthiomers pharmaceutical Has an effect against disease Parkinson's is special These optical inanthiomers are prepared by a) resimic separation. 2- Chloro-12- (3-dimethylamino-2-methyl Propyl) -12H-dibenzos (d, g) (1-3-6) dioxosin with optically active organic acids and inanthiomers. Or b) dissolve the 2-chloro-12- (3-dimethylamino-2-methyl) recimic acid. Propyl) -12H-dibenzos (d, g) (1-3-6) dioxosin in organic solvents, crystallizes and separates one inanthomer. Dissolve recimic 2-chloro-12- (3-dimethylamino-2-methyl Propyl) -12H-dibenzos (d, g) (1-3-6) additional dioxosin in the residual liquid from this crystallization obtained and then crystallized and separated. From another Inanthiomer And if you want All these processes are reproduced, patented drugs.
Claims (1)
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TH4337A true TH4337A (en) | 1987-08-03 |
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