TH4141A - GRF analogues (GRF) - Google Patents

Abstract

GRF from human pancreatic and hypothalamic GRF in humans and other mammals has been synthesized and studied for a long time. This invention represents a potent synthetic peptide for stimulating pituitary gland secretion in animals and humans, with the following formula (chemical formula), with substitution (formula), or (formula), or no substitution (formula), or natural amino acid (formula), and containing at least 4 radicals from the following radicals (formula), different from radicals appearing at the same position in the natural molecule. These peptides, or their non-toxic salts, are administered to animals, humans, and cold-blooded animals to stimulate GH secretion and may be used in disease diagnosis.

Claims (13)

1. Synthetic peptides with the formula (chemical formula). 2. Peptide as claimed in claim 1, where R15 is Ala. 3. The peptide as claimed in claim 1, where R9 is Ala. 4. Peptide of claim 1, where R7 is Ala, R12 is Arg, and R13 is Ala. 5. Peptide of claim 4, where R13, R15, and R27 are Leu, R28 is Ala, and Y is OH. 6. Peptide of claim 4, where R13 is Leu, R25 is Leu, R27 is Leu, R28 is Ala, and Y is NH2. 7. The peptide of claim 1, where R1 is Try, R2 is Ala, R3 is Asp, R7 is Trh, R8 is Gln, R12 is Orn, and R19 is Ser. 8. Peptide of claim 7, where R5 is Leu, R6 is Phe, R10 is Tyr, R11 is Arg, R20 is Arg, R21 is Arg, and R27 is Leu. 9. The peptide of claim 7, where R1 is His, R2 is Ala, R3 is Asp, R13 is Leu, R15 is Ala, R26 is Val, R27 is Leu, and R28 is Ala. 10. The peptide of claim 1 containing the formula (chemical formula). 11. The peptide of claim 1 containing the formula (chemical formula). 12. A pharmaceutical compound for the stimulation of GH release in animals containing the peptide of Pledge 1 or its non-toxic salts in an effective dose, and its pharmaceutically or veterinarily acceptable liquid or solid carrier. 13. Non-toxic salts of any of the peptides claimed in claims 1 through 11. (13 claims, 2 pages, 5 figures)