TH28905B - Morpholine and thymorpholene, which are the antagonis of the taxikinin receptor. - Google Patents

Abstract

Substantial etherocycle of the general structural formula (chemical formula) that is antagonist of the tacylkinin receptor. useful in the treatment of inflammation, pain or migraines and asthma, and as a calcium inhibitor useful in the treatment of cardiovascular diseases such as high-pitched seizure disorder or local blood shortage due to clogged blood tract, patent drug

Claims (1)

1. Compounds of the structural formula (chemical formula) or the pharmacologically acceptable salt of this substance, where R1 was selected from the group containing (1) hydrogen, (2) C1-C6 alkyl, no substitutions. Or is replaced with one or more of the selected substitution groups from (a) hydroxy (b) oxy (c) C1-C6 alkoxi (d) fennyl C1-C3 al Lcoxy (e) fennyl (f) -CN (g) halo (h) -NR9 R10, where R9 and R10 can be independently selected from (i) hydrogen (ii) C1-C6 al (Iii) Hydrogen C1-C6 alkyl and (iv) Phenyl (i) -NR9 COR10 where R9 and R10 are defined above (j) -NR9 COR10 where R9 and R10 are required. Above (k) -CONR9 R10 where R9 and R10 are defined above (l) -CONR9 where R9 is defined above (m) -CO2 R9 where R9 is defined above (n) Hate. Therocycle The heterocyclic was selected from a group containing (A) benzimidazolil (B) benzofuranyl (C) benzothiophenyl (D) benzocaine. Sasoyl (E) Furanil (F) Imidazole (G) Indoleil (H) Isooxazoleil (I) Isothiazole (J) Oxadai Solil (K) Oxasolil (L) Pyracinil (M) Pryrazoyl (N) Pyridil (O) Pyrimidil (P) Pirollil (O) Qui Noil (R) Tetracylil (S) Thyathydiacylil (T) Thyazoil (U) Thienil (V) Triazoleil (W) A SETTIDINIL (X) 1,4-DIOXANIL (Y) hexahydroacifenyl (Z) Oxanyl (AA) Piperacinil (AB) piperidi Nil (AC) Pirollidinil (AD) Tetra Hydrofuranil and (AE) Tetra Hydroethenyl. And by which the heterocyclic alkyl There are no substitutions or substitutions with one substitution group. Or more selected from (I) C1-6 alkyl, non-substituted or replaced with halo-CF3, -OCH3, or fenyl (ii) C1-6 alkyl (iii). Oxo (iv) hydroxy (v) thiolso (vi) -SR9 where R9 is as defined above (vii) halo (viii) cyan (iX) phenyl (X). Trifuoromethyl (xi) - (CH2) m-NR9 R10 where m is 0,1 or 2 and R9 and R10 are set above (xii) -NR9 COR10 where R9 and R10 are required. (Xiii) -CONR9 R10 where R9 and R10 are defined as above (xiv) -CO2 R9 where R9 is defined above and (xv) - (CH2) m-OR9 where m and R9. As defined above, (3) C2-6 alkyl, non-substituted or substituted with one or more groups of substitutes selectable from (a) hydroxy (b) oxy. (c) C1-C6 Alcoxy (d) Phenyl C1-C3 Alcoxy (e) Fenyl (f) -CN (g) Halo (h) -CONR9 R10 where R9 and R20. Is defined as above (i) -CO R9 where R9 is set above (j) -CO2 R9 where R9 is set above. (k) Heterocycle Where heterocycle is selected as above. (4) C2-6 alkanyl (5) non-substituted phenyl Or is replaced by one or more of the substituted groups Selectable from (a) Hydroxy (b) Oxy (c) C1-C6 Alcox (d) Phenyl C1-C3 Alcoxy (e) Fenyl (f) -CN. (g) -NO2 (h) -CF3 (i) - (CH2) m-NR9 R10 where m, R9 and R10 are set above (j) -NR9 CO2 R10, where R9 and R10 are set above. The beginning (k) -NR9 CO2 R10 where R9 and R10 are set above (l) -CONR9 R10 where R9 and R20 are specified above (m) -CO2 NR9 R10 where R9 and R10 are specified above. Above (n) -CO R9 where R9 is set above (o) -CO2 R9 where R9 is set above and R2 and R3 are selected as above (1) hydrogen (2) C1-. 6 alkyls have no substitutions. Or is substituted with one or more of the selected substitution groups from (a) hydroxy (b) oxo (c) C1-C6 alkoxi (d) fenyl C1-C3 al Lcoxy (e) fennyl (f) -CN (g) halo (h) -NR9 CO R10, where R9 and R10 can be independently selected from (i) -NR9 CO2 R10, where R9 and R10 is defined above (j) -CONR9 R10 where R9 and R10 are defined above (k) -CONR9 R10 where R9 and R10 are set above (l) -COR9 where R9 is defined above. The early (m) -CO2 R9 where R9 is defined above (3) C1-6 alkyl is not replaced. Or is substituted with one or more of the selected substitution groups from (a) hydroxy (b) oxo (c) C1-C6 alkoxi (d) fenyl C1-C3 al Lexxy (e) Fenil (f) -CN (g) Halo (h) -CON R9 R10 where R9 and R10 can be independently selected from (i) -COR9, where R9 is required. Above (j) -CO2 R9 where R9 is defined above (4) C2-6 alkyline (5) non-substituted phenyl. Or is replaced by one or more of the substituted groups Selectable from (a) hydroxy (b) C1-C6 alkoxy (c) C1-C6 alkyl (d) C2-6 alkyl (e) halo (f) - CN (g) -NO2 (h) -CF3 (i) - (CH2) m-NR9 R10 where m, R9 and R10 are set above (j) -NR9 COR10, where R9 and R10 are independently selected. It is possible from (k) -NR9 CO2 R10 where R9 and R10 are defined above (l) -CONR9 R10 where R9 and R10 are defined above (m) -CO2 NR9 R10 where R9 and R10 are. As defined above, (n) -COR9 where R9 is defined above, (o) -CO2 R9 where R9 is defined above, and this group of R1 and R2 may be joined together to form a ring hette. Arocyclic selectable from a group consisting of (a) pryrollidinil (b) piperidinil (c) pyridyl (d) pyridinil (e) imidazole. Il (f) oxasoleil and (g) thiazoleil, and by the aforementioned ring heterocyclic Not replaced Or was replaced with a substitute group One or more groups selected from (i) C1-6 alkyl (ii) oxo (iii) C1-C6 alkoxy (iv) -NR9 R10, where R9 and R10 are selected independently of each other. Obtained from (v) halo and (vi) trifuoromethyl and these R2 and R3 groups may be linked together to form a ring carbocyclic selectable from groups containing (a ) Cyclopentyl (b) cyclohexyl (c) phenyl and without this carbocyclic ring being replaced. Or is replaced by one or more of the selected substitution groups from (i) C1-6 alkyl (ii) C1-C6 Alkoxy (iii) -NR9 R10, where R9 and R10 are selected. This can be independently obtained from (iv) halo and (v) trifuoromethylation, and these R2 and R3 groups may be linked together to form an optional ringhexterocyclic. From a group containing (a) pryrollidinil (b) piperidinil (c) pyridinil (d) pyridinil (e) imidazole (f) furanil ( g) oxasoleil (h) thienzil and (i) thiazoleil and without this heterocyclic ring being replaced. Or is replaced by one or more of the selected substitution groups from (i) C1-6 alkyl (ii) oxo (iii) C1-C6 Alkoxi (iv) -NR9 R10 where R9 and R10 can be selected independently of (v) halo and (vi) trifuorometric, X can be selected from groups containing (1) -O- (2) -S- (3) -. SO- (4) -SO2- R4 was selected from a group containing (1) chemical formula (2) -Y-C1-8 alkyl without which alkyl was substituted. Or be replaced at one group Or more of moo Selectable substitutes from (a) Hydroxy (b) Oxo (c) C1-C6 Alcox (d) Fenyl C1-C3 Alcoxy (e) Fenyl (f). -CN (g) halo (h) -NR9 R10, where R9 and R10 can be independently selected from (i) -NR9 COR10, with R9 and R10 independently selected by (j) -NR9. COR10 where R9 and R10 are independently selected from each other from (k) -CONR9 R10 where R9 and R10 are set above (l) -COR9 where R9 is defined above (m) -CO2 R9 where Where R9 is defined above (3) -Y-C1-8 alkyl, without which such alkyl is not replaced. Or be replaced at one group Or more of moo Selectable substitutes from (a) Hydroxy (b) Oxo (c) C1-C6 Alcox (d) Fenyl C1-C3 Alcoxy (e) Fenyl (f). -CN (g) halo (h) -CONR9 R10 where R9 and R10 are set above (i) -COR9 where R9 is set above (j) -CO2 R9 where R9 is set above. (4) -O (CO) - Phenyl, without which this phenyl is not replaced. Or is replaced by one or more groups of R6, R7, and R8. R5 is a phenyl that is not replaced or replaced by one or more groups of R11, R12 and R13. R6, R7 and R8 can be selected independently of A group containing (1) hydrogen (2) C1-6 alkyl has no substitutions or is substituted with one or more of the selected substitution groups from (a) hydroxy (b) out. So (c) C1-C6 Alcoxy (d) Phenyl C1-C3 Alcoxy (e) Fenyl (f) -CN (g) Halo (h) -NR9 R10 where R9 and The R10 is independently selected from (i) -NR9 COR10, with R9 and R10 independently selected from (j) -NR9 CO2 R10, with R9 and R10 independently selected from (k). ) -CONR9 R10 where R9 and R10 are defined above (l) -COR9 where R9 is defined above (m) -CO2 R9 where R9 is defined above (3) o 2-6 al. Kenil does not have a replacement. Or is substituted with one or more of the selected substitution groups from (a) hydroxy (b) oxo (c) C1-C6 alkoxi (d) fenyl C1-C3 al Lcoxi (e) fennyl (f) -CN (g) halo (h) -CONR9 R10 where R9 and R10 are set above (i) -COR9 where R9 is defined above (j ) -CO2 R9 where R9 is defined above, (4) C2-6 alkyl (5), non-substituted phenyl. Or be replaced by one group Or greater of the substituted group selected from (a) hydroxy (b) C1-C6 alkoxy (c) C1-C6 alkyl (d) C2-6 alkyl (e). Halo (f) -CN (g) -NO2 (h) -CF3 (i) - (CH2) m-NR9 R10 where m, R9 and R10 are set above (j) -NR9 COR10 where R9. And R10 can be independently selected from (k) -NR9 CO2 R10 where R9 and R10 are set above (l) -CONR9 R10 where R9 and R10 are set above (m) -CO2 NR9 R10. Where R9 and R10 are defined above (n) -COR9 where R9 is defined above (o) -CO2 R9 where R9 is defined above (8) -CF3 (9) -NO2 (10). -SR14 where R14 is Hydrogen or C1-6 alkyl (11) -SOR14 where R14 is defined above (12) -SO2 R14 where R14 is defined above (13) -NR9 COR10 where R9 and R10 are independently selected from (14) -CONR9 R10 where R9 and R10 are set above (15) -NR9 R10, where R9 and R10 are set above (16) -NR9 COR10 where Where R9 and R10 are independently selected from each other from (17) hydroxy (18) C1-6 Alcox (19) COR9, where R9 is defined above (20) CO2 R9, where R9 is As set above R11, R12 and R13 can be selected independently from each other by their definitions, and Y can be selected from groups containing (1) one single bond (2) -o- (3) -S- (4) -CO-. (5) -CH2- (6) -CHR15 and (7) -CH15 R16, where R15 and R16 can be selected independently of the groups containing (a) alkylines, no substitutions. Or is replaced by one or more of the selected substitution groups from (i) hydroxy (ii) oxo (iii) C1-C6 alkoxi (iv) fenyl C1-C3 al (V) Fenil (vi) -CN (vii) halo (viii) -NR9 R10, where R9 and R10 can be independently selected from (ix) -NR9 CO2 R10, where R9 and R10 are available. Is defined above (x) -NR9 CO2 R10 where R9 and R10 are independently selected from each other from (xi) -CONR9 R10, where R9 and R10 are defined above (xii) -COR9, where R9 is. As defined above, (xiii) -CO2 R9 where R9 is defined above (b) non-substituted or substituted phenyl with one or more groups of substitutes. Selectable from (i) hydroxy (ii) C1-C6 alkoxy (iii) C1-C6 alkyl (iv) C2-5 alkyl (v) halo (vi) - CN (vii) -NO2 (vii) -CF3 (xi) - (CH2) m-NR9 R10 where m, R9 and R10 are set above (x) -NR9 COR10, where R9 and R10 are independently selected. Compatible from (xi) -NR9 CO2 R10 where R9 and R10 are set above (xii) -CO2NR9 R10 where R9 and R10 are specified above (xii) -CO2 NR9 R10 where R9 and R10 are. As defined above, (xiv) -COR9 where R9 is defined above (xv) -CO2 R9 where R9 is defined above, Z is selectable from (1) hydrogen (2) C1-4 alkyl and (3) Hydroxy, provided that Y is -O- then Z is anything other than hydroxy, or if Y is -CHR15 then Z and R15 may be connected to form a double bond. 2. Compound of claim 1 where R1 can be selected from a group containing; R1 can be selected from a group containing (1) C1-6 alkyl substituted by one or more of the substituted groups that can be selected from ( a) heterocycle The aforementioned heterocycle can be selected from a group containing (A) benzimidazoyl (B) imidazole (C) isooxasoyl (D). Isothiazoleil (E) Oxadaiasoyl (G) Piranil (H) Pyridyl (I) Piroleil (J) Tetrasoyl (K) Thy Adiazoleil (L) triazoleil and (M) piperidinil and where this heterocyclic is not replaced. Or is replaced by one or more groups Replaces selectable from (i) C1-6 non-substituted alkyl Or has been replaced by halo-CF3, -CH3 or fenyl (ii) C1-6 alkoxi (iv) oxo (v) thioxocyano (vi) C1-6 (vii) Fe. Aniline (viii) hydroxy (ix) trifluoromethyl (x) - (CH2) m-NR9 R10, where m is 0,1 or 2, and where R9 and R10 can be selected independently of (I) hydrogen, (II) hydroxy, C1-6 alkyl. And (IV) Fenyl (Xi) -NR9 CO R10, where R9 and R10 are set above (Xii) -CONR9 R10, where R9 and R10 are set above.R2 and R3 are freely selectable from category. Contains (1) hydrogen, (2) C1-6 alkyl, (3) C2-6 alkyl and (4) phenyl, x is -O-, R4 is (chemical formula), R5 is fennyl, where Not replaced or replaced with halo. R6, R7 and R8 can be selected independently from groups containing (1) hydrogen (2) C1-6 alkyl (3) halo (4) -CF3. Y is -O- and Z are hydrogen or C1-4 alkyl 3. Compound of claim 1 where R1 can be selected from the group (chemical formula) 4. Claim compound 1 of the structural formula III (chemical formula) or the salt of a substance acceptable from a group containing 1) 2- (3,5-bis (trifluoromethyl) benzyloxi) -3-Fe. Nonil-morpholine 2) (2R, S) -3,5 bis (trifluoromethyl) benzyloxi) - (3R) - phenyl - (6R) - Methyl-morpholine 3) (2R, S) -3,5 bis (trifluoromethyl) benzyloxi) - (3S) - phenyl - (6R) - methyl-morpholine 4) (+/-) -2- (3,5 bis (trifluoromethyl) benzyloxi) -3-phenyl-4 - Methylcarboxamido-morpholine 5) (+/-) -2- (3,5 bis (trifluoromethyl) benzyloxi) -3 -Phenyl-4-methox-carbonyl-methyl-morpholine 6) 2- (2- (3,5-bis (trifluoromethyl) phenyl) ethnyl) -3-phenyl) ethenyl-3-phenyl- 5- oxo-morpholine 7) 3- phenyl-2- (2- (3,5 bis (trifluoromethyl) -phenyl) -ethyl) mor Foline 8) 2- (R) - (3,5 bis (trifluoromethyl) benzyloxi) -3- (R) - phenyl-6- (S) - Methyl-morpholine 9) 2- (R) - (3,5 bis (trifluoromethyl) benzyloxi) -3- (S) - phenyl- 6- (S) - methyl-morpholine 10) 2- (R) - (3,5 bis (trifluoromethyl) benzyloxi) -3- (R ) -Phenyl-6- (S) - methyl-morpholine 11) 2- (R) - (3,5 bis (trifluoromethyl) benzyloxi ) -3- (S) - phenyl-6- (S) - methyl-morpholine 12) 2- (R) - (3,5 bis (trifluoromethyl ) Benzyloxi) -3- (R) - phenyl-6- (S) - methyl-morpholine 13) 2- (R) - (3,5 bis (tri Fluoromethyl) benzyloxi) -3- (S) - phenyl-6- (S) - methyl-morpholine 14) 2- (R) - (3, 5 bis (trifluoromethyl) benzyloxi) -3- (R) - phenyl -6- (S) - methyl-morpholine 15) 2- ( R) - (3,5 bis (trifluoromethyl) benzyloxi) -3- (S) - phenyl-6- (R) - methyl-morfoli N 16) 2- (R) - (3,5 bis (trifluoromethyl) benzyloxi) -3- (S) -phenylmorpholine 17) 4- (3- (1,2,4-triazolo) methyl) -2- (S) -3,5 bis (trifluoromethyl) benzyloxi) -3- ( S) - phenyl-morpholine 18) 4- (3- (5-oxo-1) H, 4H-1,2,4-triazolo) methyl) -2- (S) - (3,5 bis (trifluoromethyl) benzyloxi) -3 - (S) - phenylmorpholine 19) 2- (R) - (3,5 bis (trifluoromethyl) benzyloxi) -3- (R) - Phenyl-6- (R) - methyl-morpholine 20) 2- (S) - (3,5 bis (trifluoromethyl) benzyloxi) - 3- (R) -phenyl-6- (R) - methyl-morpholine 21) 2- (R) - (3,5 bis (trifluoromethyl) ben Syloxi) -3- (S) - phenyl -6- (R) - methyl-morpholine 22) 2- (S) - (3,5 bis (trifluor Romethyl) benzyloxi) -3- (S) - phenyl-6- (R) - methyl-morpholine 23) 2- (R) - (3,5 bis S (trifluoromethyl) benzyloxi) -3- (S) -phenyl-6- (S) -methyl-morpholine 24) 2- (S) - (3,5 bis (trifluoromethyl) benzyloxi) -3- (S) - phenyl-6- (S) - methyl-morpholine 25 ) 2- (R) - (3,5 bis (trifluoromethyl) benzyloxi) -3- (R) - phenyl-6- (S) - methyl- Morpholine 26) 2- (R) - (3,5 bis (trifluoromethyl) benzyloxi) -3- (S) - phenyl-6- (R ) - methyl-morpholine 27) 2- (S) - (3,5 bis (trifluoromethyl) benzyloxi) -3- (S) - phen Nyl-6- (R) - methyl-morpholine 28) 2- (S) - (3,5 bis (trifluoromethyl) benzyloxi) -3- (R) -phenyl-6- (S) - methyl-morpholine 29) 2- (R) - (3,5 bis (trifluoromethyl) benzyl Oxy) -3- (R) - Phenyl-6- (S) - methyl-morpholine 30) 2- (S) - (3,5 bis (trifluoromethyl) benzyloxi) - 6- (R) - methyl -3- (S) - phenyl -4- (3- (1,2,4-triazole) methyl) morpholine 31) 2- ( S) - (3,5 bis (trifluoromethyl) benzyloxi) -6- (R) - methyl-4- (3- (5-oxo-1H, 4H) -1,2,4 triazole) methyl) -3- (S) phenyl-morpholine 32) 2- (S) - (3,5 bis (trifluorome Methyl) benzyloxi) -3- (R) phenyl-morpholine 33) 4- (3-1,2,4 triazole) methyl) 2- (S) - (3,5 bis (trifluoromethyl) benzyloxi) -3- (R) phenyl-morpholine 34) 4- (3 (5-oxo-1) 4H-H 1,2,4 triazole) methyl) 2- (S) - (3,5 bis (trifluoromethyl) benzyloxi) -3- (R) Phenyl-morpholine 35) 4- (2- (imidazolo) methyl) 2- (S) - (3,5 bis (trifluoromethyl) ben Syloxi) -3- (R) phenyl-morpholine 36) 4- (4- (imidazolo) methyl) 2- (S) - (3,5 bis. (Trifluoromethyl) benzyloxi) -3- (R) phenyl-morpholine 37) 4- (aminocarbonylmethyl) -2- (S) - (3,5 bis (trifluoromethyl) benzyloxi) -3- (R) phenyl-morpholine 38) 4- (2- (i Midazolo) methyl) 2- (S) - (3,5 bis (trifluoromethyl) benzyloxi) -3- (S) phenyl-morpho Lean 39) 4- (4- (imidazolo) methyl) 2- (S) - (3,5 bis (trifluorometric) t On syloxi) -3- (S) phenyl-morpholine 40) 4- (4- (imidazolo) methyl) 2- (S) - (3,5 bi S (trifluoromethyl) benzyloxi) -3- (S) phenyl-6- (R) methyl-morpholine 41) 4- (2- (i Midazolo) methyl) 2- (S) - (3,5 bis (trifluoromethyl) benzyloxi) -3- (S) phenyl-6- ( R) methyl-morpholine 42) 2- (S) - (3,5 bis (trifluoromethyl) benzyloxi) -4 - ((6-hyd Oxy) hexyl) -3- (R) - phenyl-morpholine 43) 2- (S) - (3,5 bis (trifluoromethyl) benzene. Loxy) -4- (5- (methyl amino carbonyl) penyl) -3- (R) - phenyl-morpholine 44) 4- (3-1 , 2,4 triazole) methyl) -2- (3,5-dimethylmethylbenzyloxi) -3-phenyl-morpholine 45) 4- ( 3- (5-oxo 1H, 4H-1,2,4 triazole) methyl) -2- (3,5-di (t-butyl) benzyloxi) - 3- phenyl-morpholine 46) 4- (3-1,2,4 triazole) methyl) -2- (3,5-di (tert-butyl) Benzyloxi) -3-phenyl-morpholine 47) 4- (3- (5-oxo 1H, 4H-1,2,4 triazole) methyl) -2- (3,5-di (ter-butyl) benzyloxi) -3-phenyl-morpholine 48) 4- (3-1,2,4 triazole) Methyl) -2- (3- (terbutyl) -5-methylbenzyloxi) -3-phenyl-morpholine 49) 4- (3- (5-oxo 1H, 4H-1,2,4 triazole) methyl) -2- (3 (ter-butyl) -5-methylbenzyloxi) -3-phenyl-morpholine 50) 4- (3-1,2,4 triazole) methyl-2- (3-tri Fluoromethyl) -5-methylbenzyloxi) -3-phenyl-morpholine 51) 4- (3- (5-oxo 1H, 4H-1, 2,4 triazol) methyl) -2- (3 trifluoromethyl) -5-methylbenzyloxi) -3-phenyl-morpholine 52 ) 4- (3-1,2,4 triazole) methyl-2- (3- (terbutyl) -5- (trifluoromethyl) benzyl out C) -3-phenyl-morpholine 53) 4- (3- (5-oxo 1H, 4H-1,2,4 triazole) methyl) -2- (3 (pour Nor-butyl) -5- (trifluoromethyl) benzyloxi) -3-phenyl-morpholine 54) 4- (2- (imida Zoro) methyl) 2- (3,5 (Dimethyl benzyl Oxy) -3-phenyl-morpholine 55) 4- (4- (imidazolo) methyl) 2- (3,5 (dimethylbenzyloxi) -3-phenyl-morpholine 56) 4- (2- (imidazolo) methyl) 2- (3,5 (di (ter-butyl) benzene) Loxi) -3-phenyl-morpholine 57) 4- (4- (imidazolo) methyl) 2- (3,5 (di (ter-buty) L) benzyl oxy) -3-phenyl-morpholine 58) 4- (2- (imidazolo) methyl) 2- (3- (tyr-but Tyl) benzyl oxy) -3-phenyl-morpholine 59) 4- (4- (imidazolo) methyl) 2- (3- (ter-b Vtyl) benzyl oxy) -3-phenyl-morpholine 60) 4- (4- (imidazolo) methyl) 2- (3- (trifluor Romethyl) 5-methylbenzyl oxy) -3-phenyl-morpholine 61) 4- (2- (imidazolo) methyl) 2- (3 - (trifluoromethyl) 5-methylbenzyloxi) -3-phenyl-morpholine 62) 4- (4- (imidazolo) methyl) 2- (3- (ter-butyl) -5- (trifluoromethyl) benzyl out C) -3-phenyl-morpholine 63) 4- (4- (imidazolo) methyl) 2- (3- (ter-butyl) -5- (Trifluoromethyl) benzyloxi) -3-phenyl-morpholine 64) 2- (S) - (3,5-dichlorobenzyloxi) -3- (S) - phenyl-morpholine 65) 2- (S) - (3,5-dichlobenzyloxi) -4- (3- (5- oxo -1,2,4-triazolo) methyl) -3- (S) - phenylmorpholine 66) 2- (S) - (3,5-bis (triflu Auromethyl) benzyl oxy) -4- (methoxycarbonylmethyl) -3- (S) phenyl-morpholine 67) 2- (S) - (3,5-bis (trifluoromethyl) benzyloxi) -4- (carbonylmethyl) -3- (S) phenyl-morfoli Am68) 2- (S) - (3,5-bis (trifluoromethyl) benzyloxi) -4 - ((3-aminoethyl) aminoca Carbonylmethyl) -3- (S) phenyl-morpholine 69) 2- (S) - (3,5-bis (trifluoromethyl) benzyl Oxy) -4 - ((3-aminopropyl) amino carbonylmethyl) -3- (S) phenyl-morpholine 70) 4-benzyl -5- (S) -6- (R) dimethyl -3- (S) -phenylmorpholinone and 4-benzyl-5- (R) 6- (S) - Dai Methyl -3- (S) - phenylmorpholinone 71) 2- (R) - (3,5-bis (trifluoromethyl) benzyloxi) - 5- (S) 6- (S) or 5- (R) 6- (S) - dimethyl -3- (S) - phenyl morpholinone 72) 2- (S) - ( 3,5-bis (trifluoromethyl) benzyloxi) -5- (R) 6- (S) or 5- (S) 6- (R) - dimethyl- 3- (S) -phenylmorpholinone 73) 2- (S) - (3,5-bis (trifluoromethyl) benzyloxi) -4- (3 - (1,2,4-triazolo) methyl) - 5- (S) 6- (R) or 5- (R) 6- (S) - dimethyl) -3- ( S) - phenylmorpholinone 74) 2- (S) - (3,5-bis (trifluorometh Benzyl oxy) -4- (3- (1,2,4-triazolo) methyl) - 5- (S) 6- (R) or 5- (R) 6 - (S) - dimethyl) -3- (S) - phenyl morpholinone 75) 2- (S) - (3,5-bis (trifluoromethyl) Benzyl oxy) -4- (3- (1,2,4- triazolo) methyl) - 5- (S) 6- (R) or 5- (R) 6- (S ) - dimethyl) -3- (S) - phenyl morpholinone 76) 2- (S) -4- (fluorophenthyl) -4-benzyl-2 - morphorinone 78) 2- (S) - (3,5-bis (trifluoromethyl) benzyloxi) -3- (S) - (4- fluor Rophenyl) -4-benzylmorpholene 79) 2- (S) - (3,5-bis (trifluoromethyl) benzyloxi) -3- ( S) - (4- fluorophenyl) morpholine 80) 2- (S) - (3,5-bis (trifluoromethyl) benzyloxi) - 3- (S) - (4- fluorophenyl) -4- (3- (5-oxo, 1H, 4H-1,2,4 Triazol) benzylmorpholine 81) 2- (S) - (3,5-bis (trifluoromethyl) benzyloxi) -4 - ((3- Pyridyl) methyl carbonyl) 3- (R) - phenyl morpholine 82) 2- (S) - (3,5-bis (trifluoromethicone L) benzyl oxy) -4-methoxycarbonyl pentyl) 3- (R) - phenylmorpholine 83) 2- (S) - (3,5 - bis (trifluoromethyl) benzyloxi) -4-carbonyl pentyl) 3- (R) - phenylmorpholine 84) 2- ( S) - (3,5-bis (trifluoromethyl) benzyloxi) -4-methyl aminocarbonyl pentyl) -6-oxo- Hexyl) -3- (R) - phenylmorpholine and pharmacologically acceptable salts of those substances 6. Pharmaceutical constituents that comprise of pharmaceutical carriers acceptable And the effective quantity of the compound in claim 1 7. The use of a compound as in claim 1-5, for any of the above, in the manufacture of drugs for the treatment of ailments in the body that occur in conjunction with excess technicinin or receptor closure. Csikinin in mammals 8. The process for the preparation of compound structural formula IV (chemical formula) or the salts of a chemically acceptable substance, R1 was selected from a group containing (1) hydrogen, (2) C1-C6, non-substituted alkyl. Or is replaced by one or more of the selectable substitution groups from (a) hydroxy (b) oxy (c) C1-C6 alkoxy (d) fennyl C1-C3 al Cox (e) fennyl (f) -CN (G) halo (h) -NR9 R10, where R9 and R10 can be independently selected from (i) hydrogen (ii) C1-C6 a (Iii) hydroxy C1-C6 alkyl and (iv) phenyl (i) -NR9 COR10, where R9 and R10 are independently selected from (j) -NR9 COR10, where Where R9 and R10 are defined above (k) -CONR9 R10 where R9 and R10 are set above (l) -COR9 where R9 is set above (m) -CO2R9 where R9 is specified above. Early (n) heterocycle The aforementioned heterocyclic was selected from a group containing (A) benzimidazole (B) benzofuranyl (C) benzothiophenyl (D) benzene. Seoksa Solil (E) Furanil (F) Imida Solil (G) Indoleil (H) Isosoksasolil (I) Isothiazoleil (J ) Oxadaiasoyl (K) oxasolil (L) pyracinil (M) pyrazoyl (N) pyridyl (O) pyrimidyl (P) pi Roll il (Q) quinoleil (R) tetra solil (S) thiathodiazoleil (T) thiazole (U) thienil (V) tri Azoleil (W) acetidinyl (X) 1,4-dioxanil (Y) hexahydroacetyl (Z) oxanyl (AA) piperacy Nil (AB), Piperidinil (AC), pyrolidinil (AD), Tetra Hydrofuranil and (AE) Tetra Hydroethenyl. And by which the heterocyclic alkyl No substitutions or substitutions with one or more substitution groups selected from (I) C1-6 alkyls that are not replaced or have been replaced with halo-CF3, -OCH3, or Fe. Anil (ii) C1-6 Alkoxi (iii) Oxo (iv) Hydroxy (v) Thiolso (vi) -SR9 where R9 is as defined above (vii) halo. (viii) Cyano (iX) Phenyl (X) Trifuoromethyl (xi) - (CH2) m-NR9 R10 where m is 0,1 or 2 and R9 and R10 are set by the side. (Xii) -NR9 COR10 where R9 and R10 are defined as above (xiii) -CONR9 R10, where R9 and R10 are the above (xiv) -CO2 R9, where R9 is defined above; and (xv) - (CH2) m-OR9 where m and R9 are defined above. (3) C2-6 non-substituted alkyl, or substituted alkyl with one or more of the substituted groups at Selectable from (a) Hydroxy (b) Oxy (c) C1-C6 Alcox (d) Phenyl C1-C3 Alcoxy (e) Fenyl (f) -CN ( g) Halo (h) -CONR9 R10 where R9 and R20 are defined as above (i) -CO R9 where R9 is set above (j) -CO2 R9 where R9 is defined above. (k) Heterocycle Where the heterocycle is selected as above. (4) C2-6 Alkanyl (5) Phenyl without being replaced or replaced with one or more groups. replace Selectable from (a) Hydroxy (b) Oxy (c) C1-C6 Alcox (d) Phenyl C1-C3 Alcoxy (e) Fenyl (f) -CN. (g) -NO2 (h) -CF3 (i) - (CH2) m-NR9 R10 where m, R9 and R10 are set above (j) -NR9 CO2 R10, where R9 and R10 are set above. The beginning (k) -NR9 CO2 R10 where R9 and R10 are set above (l) -CONR9 R10 where R9 and R20 are set above (m) -CO2 NR9 R10 where R9 and R10 are specified above. Above (n) -CO R9 where R9 is set above (o) -CO2 R9 where R9 is set above and R2 and R3 are selected as above (1) hydrogen (2) C1-. 6 alkyls have no substitutions. Or is substituted with one or more of the selected substitution groups from (a) hydroxy (b) oxo (c) C1-C6 alkoxi (d) fenyl C1-C3 al Lcoxy (e) fennyl (f) -CN (g) halo (h) -NR9 R10, where R9 and R10 can be independently selected from (i) -NR9 CO2 R10, where R9 and R10. Is defined above (j) -CONR9 R10 where R9 and R10 are defined above (k) -CONR9 R10 where R9 and R10 are defined above (l) -COR9 where R9 is defined above. (m) -CO2 R9 where R9 is defined above (3) C1-6 alkyl is not substituted. Or is substituted with one or more of the selected substitution groups from (a) hydroxy (b) oxo (c) C1-C6 alkoxi (d) fenyl C1-C3 al Lexxy (e) Fenil (f) -CN (g) Halo (h) -CON R9 R10 where R9 and R10 can be independently selected from (i) -COR9, where R9 is required. Above (j) -CO2 R9 where R9 is defined above (4) C2-6 alkyline (5) non-substituted phenyl. Or is replaced by one or more of the substituted groups Selectable from (a) hydroxy (b) C1-C6 alkoxy (c) C1-C6 alkyl (d) C2-6 alkyl (e) halo (f) - CN (g) -NO2 (h) -CF3 (i) - (CH2) m-NR9 R10 where m, R9 and R10 are set above (j) -NR9 COR10, where R9 and R10 are independently selected. It is possible from (k) -NR9 CO2 R10 where R9 and R10 are defined above (l) -CONR9 R10 where R9 and R10 are defined above (m) -CO2 NR9 R10 where R9 and R10 are. As defined above, (n) -COR9 where R9 is defined above, (o) -CO2 R9 where R9 is defined above, and this group of R1 and R2 may be joined together to form a ring hette. Arocyclic selectable from a group consisting of (a) pryrollidinil (b) piperidinil (c) pyridyl (d) pyridinil (e) imidazole. Il (f) oxasoleil and (g) thiazoleil and without the aforementioned ring heterocyclic. Or was replaced with a substitute group One or more groups selected from (i) C1-6 alkyl (ii) oxo (iii) C1-C6 alkoxy (iv) -NR9 R10, where R9 and R10 are selected independently of each other. Obtained from (v) halo and (vi) trifuoromethyl and these R2 and R3 groups may be linked together to form a ring carbocyclic selectable from groups containing (a ) Cyclopentyl (b) cyclohexyl (c) phenyl and without this carbocyclic ring being replaced. Or is replaced by one or more of the selected substitution groups from (i) C1-6 alkyl (ii) C1-C6 Alkoxy (iii) -NR9 R10, where R9 and R10 are selected. This can be independently obtained from (iv) halo and (v) trifuoromethylation, and these R2 and R3 groups may be linked together to form an optional ringhexterocyclic. From a group containing (a) pryrollidinil (b) piperidinil (c) pyridinil (d) pyridinil (e) imidazole (f) furanil ( g) oxasoleil (h) thienzil and (i) thiazoleil and without this heterocyclic ring being replaced. Or is replaced by one or more of the selected substitution groups from (i) C1-6 alkyl (ii) oxo (iii) C1-C6 Alkoxi (iv) -NR9 R10 where R9 and R10 are independently selected from (v) halo, and (vi) trifuoromethylation R6, R7 and R8 independently from groups containing (1) hydrogen (2) C1-6. An alkyl that does not substitute or is substituted with one or more of the substituted groups. Selectable from (a) Hydroxy (b) Oxo (c) C1-C6 Alcox (d) Phenyl C1-C3 Alcoxy (e) Fenyl (f) -CN. (g) halo (h) -NR9 R10, where R9 and R10 can be independently selected from each other from (i) -NR9 COR10, where R9 and R10 can be independently selected from (j) -NR9 CO2 R10. Where R9 and R10 are independently selected from (k) -CONR9 R10, where R9 and R10 are set above (l) -COR9, where R9 is set above (m) -CO2 R9, where R9 is defined above. (3) C1-6 Alkyls that are not substituted or replaced with one or more of the substituted groups. Selectable from (a) Hydroxy (b) Oxo (c) C1-C6 Alcox (d) Phenyl C1-C3 Alcoxy (e) Fenyl (f) -CN. (g) halo (h) -CONR9 R10 where R9 and R10 are set above (i) -COR9 where R9 is set above (j) -CO2 R9 where R9 is set above (4. C2-6 Alkanyl (5) Non-substituted phenyl Or is replaced by one or more of the substituted groups Selectable from (a) Hydroxy (b) Oxy (c) C1-C6 Alcox (d) Phenyl C1-C3 Alcoxy (e) Fenyl (f) -CN. (g) -NO2 (h) -CF3 (i) - (CH2) m-NR9 R10 where m, R9 and R10 are set above (j) -NR9 CO2 R10, where R9 and R10 are set above. The beginning (k) -NR9 CO2 R10 where R9 and R10 are set above (l) -CONR9 R10 where R9 and R20 are set above (m) -CO2 NR9 R10 where R9 and R10 are specified above. Above (n) -CO R9 where R9 is defined above (o) -CO2 R9 where R9 is defined above (6) halo (7) -CN (8) -CF3 (9) -NO2 ( 10) -SR14 where R14 is Hydrogen or C1-6 Alkyl (11) -SOR14 where R14 is the above (12) -SO2 R14 where R14 is the above (13) -NR9 COR10. Where R9 and R10 can be independently selected from (14) -CONR9 R10, where R9 and R10 are set above, (15) -NR9 R10, where R9 and R10 are set above (16) -NR9. COR10, where R9 and R10 are independently selected from each other from (17) hydroxy (18) C1-6 Alcox (19) COR9, where R9 is defined above (20) CO2 R9 where R9 is set above, select R11, R 12 and R13 are independent of each other, from the definition of R6 and Y are -O- and Z is hydrogen or C1-4 alkyl, consisting of compound contact of formula V (chemical formula) where R1, R2, R3, R6, R7, R8, R11, R12 and R13 are defined above. With inorganic acids Or organic acids that can be selected from the groups containing Toluene sulfonic acid Methesulfonic acid, sulfuric acid, hydrochloric acid And mixtures of these substances In a selective apetic solvent from a group containing toluene, benzyl dimethyl formamide, tetrahydryphyran, diethyl ether. Diethoxyethene, ethylacetate and their mixtures at temperatures from 0C to the reflux temperature of the solvent, for the time when the fruit is sufficient for the compounds of Structural formula IV 9. The process for preparing compounds of structural formula VI (chemical formula) or salts of a chemically acceptable substance, R1 was selected from a group containing (1) hydrogen, (2) C1-C6, non-substituted alkyl. Or is replaced by one or more of the selectable substitution groups from (a) hydroxy (b) oxy (c) C1-C6 alkoxy (d) fennyl C1-C3 al Cox (e) fennyl (f) -CN (G) halo (h) -NR9 R10, where R9 and R10 can be independently selected from (i) hydrogen (ii) C1-C6 a (Iii) hydroxy C1-C6 alkyl and (iv) phenyl (i) -NR9 COR10, where R9 and R10 are independently selected from (j) -NR9 COR10, where Where R9 and R10 are defined above (k) -CONR9 R10 where R9 and R10 are set above (l) -COR9 where R9 is set above (m) -CO2R9 where R9 is specified above. Early (n) heterocycle The aforementioned heterocyclic was selected from a group containing (A) benzimidazole (B) benzofuranyl (C) benzothiophenyl (D) benzene. Seoksa Solil (E) Furanil (F) Imida Solil (G) Indoleil (H) Isosoksasolil (I) Isothiazoleil (J ) Oxadaiasoyl (K) oxasolil (L) pyracinil (M) pyrazoyl (N) pyridyl (O) pyrimidyl (P) pi Roll il (Q) quinoleil (R) tetra solil (S) thiathodiazoleil (T) thiazole (U) thienil (V) tri Azoleil (W) acetidinyl (X) 1,4-dioxanil (Y) hexahydroacetyl (Z) oxanyl (AA) piperacy Nil (AB), Piperidinil (AC), pyrolidinil (AD), Tetra Hydrofuranil and (AE) Tetra Hydroethenyl. And by which the heterocyclic alkyl There are no substitutions or substitutions with one substitution group. Or more selected from (I) C1-6 alkyl, non-substituted or replaced with halo-CF3, -OCH3, or fenyl (ii) C1-6 alkyl (iii). Oxo (iv) hydroxy (v) thiolso (vi) -SR9 where R9 is as defined above (vii) halo (viii) cyan (iX) phenyl (X). Trifuoromethyl (xi) - (CH2) m-NR9 R10 where m is 0,1 or 2 and R9 and R10 are set above (xii) -NR9 COR10 where R9 and R10 are required. (Xiii) -CONR9 R10 where R9 and R10 are defined as above (xiv) -CO2 R9 where R9 is defined above and (xv) - (CH2) m-OR9 where m and R9. As defined above, (3) C2-6 alkyl, non-substituted or substituted with one or more groups of substitutes selectable from (a) hydroxy (b) oxy. (c) C1-C6 Alcoxy (d) Phenyl C1-C3 Alcoxy (e) Fenyl (f) -CN (g) Halo (h) -CONR9 R10 where R9 and R20. Is defined as above (i) -CO R9 where R9 is set above (j) -CO2 R9 where R9 is set above. (k) Heterocycle Where the heterocycle is selected as above. (4) C2-6 Alkanyl (5) Phenyl without being replaced or replaced with one or more groups. replace Selectable from (a) Hydroxy (b) Oxy (c) C1-C6 Alcox (d) Phenyl C1-C3 Alcoxy (e) Fenyl (f) -CN. (g) -NO2 (h) -CF3 (i) - (CH2) m-NR9 R10 where m, R9 and R10 are set above (j) -NR9 CO2 R10, where R9 and R10 are set above. The beginning (k) -NR9 CO2 R10 where R9 and R10 are set above (l) -CONR9 R10 where R9 and R20 are specified above (m) -CO2 NR9 R10 where R9 and R10 are specified above. Above (n) -CO R9 where R9 is set above (o) -CO2 R9 where R9 is set above and R2 and R3 are selected as above (1) hydrogen (2) C1-. 6 Alkyls are not substituted, or are substituted with one or more of the substitution groups selected from (a) hydroxy (b) oxo (c) C1-C6 alkoxy ( d) Phenyl C1-C3 Alcoxi (e) Fenyl (f) -CN (g) Halo (h) -NR9 R10, where R9 and R10 can be independently selected from (i). -NR9 CO2 R10 where R9 and R10 are defined above (j) -CONR9 R10 where R9 and R10 are defined above (k) -CONR9 R10 where R9 and R10 are defined above (l) - COR9 where R9 is defined above (m) -CO2 R9 by which Where R9 is defined above. (3) C2-6 alkyl is not substituted. Or is substituted with one or more of the selected substitution groups from (a) hydroxy (b) oxo (c) C1-C6 alkoxi (d) fenyl C1-C3 al Lexxy (e) Fenil (f) -CN (g) Halo (h) -CON R9 R10 where R9 and R10 can be independently selected from (i) -COR9, where R9 is required. Above (j) -CO2 R9 where R9 is defined above (4) C2-6 alkyl (5) phenyl without substitutions or with one or more of the substituted groups. Selectable from (a) hydroxy (b) C1-C6 alkoxy (c) C1-C6 alkyl (d) C2-6 alkyl (e) halo (f) - CN (g) -NO2 (h) -CF3 (i) - (CH2) m-NR9 R10 where m, R9 and R10 are set above (j) -NR9 COR10, where R9 and R10 are independently selected. It is possible from (k) -NR9 CO2 R10 where R9 and R10 are defined above (l) -CONR9 R10 where R9 and R10 are defined above (m) -CO2 NR9 R10 where R9 and R10 are. As defined above, (n) -COR9 where R9 is defined above, (o) -CO2 R9 where R9 is defined above, and this group of R1 and R2 may be joined together to form a ring hette. Arocyclic selectable from a group consisting of (a) pryrollidinil (b) piperidinil (c) pyridyl (d) pyridinil (e) imidazole. Il (f) oxasoleil and (g) thiazoleil and without the aforementioned ring heterocyclic. Or was replaced with a substitute group One or more groups selected from (i) C1-6 alkyl (ii) oxo (iii) C1-C6 alkoxy (iv) -NR9 R10, where R9 and R10 are selected independently of each other. Obtained from (v) halo and (vi) trifuoromethyl and these R2 and R3 groups may be linked together to form a ring carbocyclic selectable from groups containing (a ) Cyclopentyl (b) cyclohexyl (c) phenyl and without this carbocyclic ring being replaced. Or is replaced by one or more of the selected substitution groups from (i) C1-6 alkyl (ii) C1-C6 Alkoxy (iii) -NR9 R10, where R9 and R10 are selected. The (iv) halo and (v) trifuoromethylation and the r2 and R3 groups may bind together to form the selected ringhecto-cyclic. Obtained from a group consisting of (a) pryrollidinil (b) piperidinil (c) pyridinil (d) pyridinil (e) imidazole (f) furanil. (g) oxasolil (h) thienzil and (i) thiazoleil and without the aforementioned ring heterocyclic Or is replaced by one or more of the selected substitution groups from (i) C1-6 alkyl (ii) oxo (iii) C1-C6 Alkoxi (iv) -NR9 R10 where R9 and R10 can be selected independently of (v) halo and (vi) trifuorometric, X can be selected from a group containing R6, R7 and R8 independently of the group containing 1) Hi. Droxy (2) C1-6 alkyl, not substituted Or is substituted with one or more of the substituted groups selected from (a) hydroxy (b) oxo (c) C1-C6 alkoxy (d) fennyl C1-C3. Alcoxie (e) Fenil (f) -CN (g) Halo (h) -NR9 R10, where R9 and R10 are independently selected from (i) -NR9 COR10, where R9 and R10. Can be independently selected from (j) -NR9 CO2 R10, where R9 and R10 can be independently selected from (k) -CONR9 R10, where R9 and R10 are set above (l) -COR9, where Where R9 is defined above (m) -CO2 R9 where R9 is defined above (3) C2-6 alkylenil has no substitutions. Or is substituted with one or more of the selected substitution groups from (a) hydroxy (b) oxo (c) C1-C6 alkoxi (d) fenyl C1-C3 al Lcoxi (e) fennyl (f) -CN (g) halo (h) -CONR9 R10 where R9 and R10 are set above (i) -COR9 where R9 is defined above (j ) -CO2 R9 where R9 is defined above, (4) C2-6 alkyl (5), non-substituted phenyl. Or be replaced by one group Or greater of the substituted group selected from (a) hydroxy (b) C1-C6 alkoxy (c) C1-C6 alkyl (d) C2-6 alkyl (e). Halo (f) -CN (g) -NO2 (h) -CF3 (i) - (CH2) m-NR9 R10 where m, R9 and R10 are set above (j) -NR9 COR10 where R9. And R10 can be independently selected from (k) -NR9 CO2 R10 where R9 and R10 are set above (l) -CONR9 R10 where R9 and R10 are set above (m) -CO2 NR9 R10. Where R9 and R10 are defined above (n) -COR9 where R9 is defined above (o) -CO2 R9 where R9 is defined above (6) halo (7) -CN (8). -CF3 (9) -NO2 (10) -SR14 where R14 is Hydrogen or C1-6 Alkyl (11) -SOR14 where R14 is the above (12) -SO2 R14 where R14 is defined. Above (13) -NR9 COR10 where R9 and R10 are independently selected from each other from (14) -CONR9 R10, where R9 and R10 are set above (15) -NR9 R10, where R9 and R10 are as follows. Given above (16) -NR9 COR10, where R9 and R10 can be independently selected from each other, from (17) hydroxy (18) C1-6 Alcoxy (19) COR9, where R9 is defined above. Early (20) CO2 R9, where R9 is As set above, R11, R12 and R13 are independently selected from the definitions of R6, R7 and R8, which consists of compound exposure of formula VII (chemical formula) where R1, R2, R3, R6, R7, R8. , R11, R12, and R13 are specified above with a selectable reducing agent from a group containing Diisobutyl aluminum hydride lithium tri (Secdandali - Butyl) Borohydride And lithium aluminum hydride In organic solvents at low temperatures Separating the resulting alcohol This was followed by alkylation of alcohol with benzyl hydride (where phenyl was replaced by R6, R7 and R8, where R6, R7 and R8 were defined above). With sodium hydride in organic solvents at the time affecting the production of compounds of structural formula VI. 1 0. The process for preparing compounds of structural formula VI (chemical formula) or salts of a chemically acceptable substance, R1 was selected from a group containing (1) hydrogen, (2) C1-C6, non-substituted alkyl. Or is replaced by one or more of the selectable substitution groups from (a) hydroxy (b) oxy (c) C1-C6 alkoxy (d) fennyl C1-C3 al Cox (e) fennyl (f) -CN (G) halo (h) -NR9 R10, where R9 and R10 can be independently selected from (i) hydrogen (ii) C1-C6 a (Iii) hydroxy C1-C6 alkyl and (iv) phenyl (i) -NR9 COR10, where R9 and R10 are independently selected from (j) -NR9 COR10, where Where R9 and R10 are defined above (k) -CONR9 R10 where R9 and R10 are set above (l) -COR9 where R9 is set above (m) -CO2R9 where R9 is specified above. Early (n) heterocycle, where such heterocycle was selected from a group containing (A) benzimidazoleil (B) benzofuranyl (C) ) Benzothiophenil (D) Benzoksasolil (E) Furanil (F) Imidazoleil (G) Indoleil (H) Isosoksasolyil (I) Isothiazoleil (J) Oxadiazole (K) Oxasolil (L) Pyracinil (M) Pyrazoid (N) Pyridyl (O) pyrimidil (P) pyroleil (Q) quinoleil (R) tetra solil (S) thiathodiazoleil (T) thiazo Il (U) thienil (V) triazoleil (W) acetidinil (X) 1,4-W Oxanyl (Y) hexahydroacetyl (Z) Oxanyl (AA) Piperacinil (AB) Piperidinil (AC) pyridylidin (AD) Tetra Hydrofuranil and (AE) Tetra Hydro Thienil And by which the heterocyclic alkyl There is no substitute or replaced with one substitution group. Or more selected from ((i) C1-6 non-substituted alkyl Or is replaced by Alo, -CF3, -OCH3, or phenyl (ii) C1-6 Alcoxy (iii) oxo (iv) hydroxy (v) thylso (vi) - SR9 where R9 is as defined above (vii) halo (viii) cyano (iX) fenyl (X) trifuoromethyl (xi) - (CH2) m-NR9 R10 where m is 0,1 or 2 and R9 and R10 are specified above (xii) -NR9 COR10, where R9 and R10 are specified above (xiii) -CONR9 R10, where R9 and R10 are specified above. (xiv) -CO2 R9 where R9 is defined above and (xv) - (CH2) m-OR9 where m and R9 are defined above. (3) C2-6 non-substituted alkyl. Or is replaced with one or more of the selected substitution groups from (a) hydroxy (b) oxy (c) C1-C6 alkoxi (d) fennyl C1-C3 al Lcoxi (e) fennyl (f) -CN (g) halo (h) -CONR9 R10 where R9 and R20 are defined as above (i) -CO R9 where R9 is set above. (j) -CO2 R9 where R9 is defined above. (k) Heterocycle Where the heterocycle is selected as above. (4) C2-6 Alkanyl (5) Phenyl without being replaced or replaced with one or more groups. replace Selectable from (a) Hydroxy (b) Oxy (c) C1-C6 Alcox (d) Phenyl C1-C3 Alcoxy (e) Fenyl (f) -CN. (g) -NO2 (h) -CF3 (i) - (CH2) m-NR9 R10 where m, R9 and R10 are set above (j) -NR9 CO2 R10, where R9 and R10 are set above. The beginning (k) -NR9 CO2 R10 where R9 and R10 are set above (l) -CONR9 R10 where R9 and R20 are set above (m) -CO2 NR9 R10 where R9 and R10 are specified above. For example, (n) -CO R9 where R9 is defined above (o) -CO2 R9 where R9 is defined above, and R2 and R3 can be selected independently of the group containing (1) hydrogen (2) C1-. 6 non-substituted alkyls Or is replaced with one or more groups of substitutes selected from (a) hydroxy (b) oxo (c) C1-6 alkoxy (d) fenyl-C1-3 al Lcoxy (e) fennyl (f) -CN (g) halo (h) -NR9R10 where R9 and R10 are set above (i) NR9COR10 where R9 and R10 are defined above (k ) -CONR9R10 where R9 and R10 are defined above (l) -COR9 where R9 is defined above (m) -cO2R9 where R9 is defined above (3) C2-6 alkyl at No substitutions or substitutions are made with one or more groups of substitutions selected from (a) hydroxy (b) oxy (c) C1-C6 alkoxy (d) fennyl. C1-C3 Alcoxy (e) Fenyl (f) -CN (g) halo (h) -CONR9 R10 where R9 and R20 are defined as above (i) -CO R9, where R9 is As defined above (j) -CO2 R9, where R9 is defined above. (k) Heterocycle Where the heterocycle is selected as above. (4) C2-6 Alkanyl (5) Phenyl without being replaced or replaced with one or more groups. replace Selectable from (a) Hydroxy (b) Oxy (c) C1-C6 Alcox (d) Phenyl C1-C3 Alcoxy (e) Fenyl (f) -CN. (g) -NO2 (h) -CF3 (i) - (CH2) m-NR9 R10 where m, R9 and R10 are set above (j) -NR9 CO2 R10, where R9 and R10 are set above. The beginning (k) -NR9 CO2 R10 where R9 and R10 are set above (l) -CONR9 R10 where R9 and R20 are set above (m) -CO2 NR9 R10 where R9 and R10 are specified above. For example, (n) -CO R9 where R9 is defined above, (o) -CO2 R9, where R9 is defined above, and this R1 and R2 group may be joined together, arranged as a ring hetero. Cyclic selectable from a group consisting of (a) pyridinil (b) piperidinil (c) pyridinil (d) pyridinil (e) imidazole. (f) oxasoleil and (g) thiazoyl, and with the aforementioned heterocyclic ring Not replaced Or was replaced with a substitute group One or more groups selected from (i) C1-6 alkyl (ii) oxo (iii) C1-C6 alkoxy (iv) -NR9 R10, where R9 and R10 are selected independently of each other. Obtained from (v) halo and (vi) trifuoromethyl and these R2 and R3 groups may be linked together to form a ring carbocyclic selectable from groups containing (a ) Cyclopentyl (b) cyclohexyl (c) phenyl and without this carbocyclic ring being replaced. Or is replaced by one or more of the selected substitution groups from (i) C1-6 alkyl (ii) C1-C6 Alkoxy (iii) -NR9 R10, where R9 and R10 are selected. Independent of (iv) halo and (v) trifuoromethyl and the R2 and R3 groups, they may bind together to form a ring ether, cyclic. Selectable from a group consisting of (a) pryrollidinil (b) piperidinil (c) pyridyl (d) pyridinil (e) imidazole (f) fluff. Rakyl (g) oxasoleil (h) thienzil and (i) thiazoleil and without the aforementioned ring heterocyclic. Or is replaced by one or more of the selected substitution groups from (i) C1-6 alkyl (ii) oxo (iii) C1-C6 Alkoxi (iv) -NR9 R10 where R9 and R10 can be selected independently of (v) halo and (vi) trifuoromethylation, R5 can be selected from a group containing R6, R7 and R8 independently of a group containing (1). Hydrogen (2) C1-6 alkyl non-substituted Or is replaced with one or more of the selected substitution groups from (a) hydroxy (b) oxo (c) C1-C6 alkoxi (d) fennyl C1-C3 al Lcoxy (e) fennyl (f) -CN (g) halo (h) -NR9 R10, where R9 and R10 can be independently selected from (i) -NR9 COR10, where R9 and R10 are Can be independently selected from (j) -NR9 CO2 R10 where R9 and R10 can be independently selected from (k) -CONR9 R10, where R9 and R10 are set above (l) -COR9, where R9 is defined above (m) -CO2 R9 where R9 is defined above. (3) o 2-6 Alkenyl has not been replaced or is substituted with one or more of the substituted groups. Selectable from (a) Hydroxy (b) Oxo (c) C1-C6 Alcoxy (d) Phenyl C1-C3 Alcoxy (e) Fenyl (f) -CN ( g) Halo (h) -CONR9 R10 where R9 and R10 are defined above (i) -COR9 where R9 is defined above (j) -CO2 R9 where R9 is defined above (4). C2-6 Alkenyl (5) UnReplaced Phenyl Or be replaced by one group Or greater of the substituted group selected from (a) hydroxy (b) C1-C6 alkoxy (c) C1-C6 alkyl (d) C2-6 alkyl (e). Halo (f) -CN (g) -NO2 (h) -CF3 (i) - (CH2) m-NR9 R10 where m, R9 and R10 are set above (j) -NR9 COR10 where R9. And R10 can be independently selected from (k) -NR9 CO2 R10 where R9 and R10 are set above (l) -CONR9 R10 where R9 and R10 are set above (m) -CO2 NR9 R10. Where R9 and R10 are defined above (n) -COR9 where R9 is defined above (o) -CO2 R9 where R9 is defined above (6) halo (7) -CN (8). -CF3 (9) -NO2 (10) -SR14 where R14 is Hydrogen or C1-6 Alkyl (11) -SOR14 where R14 is the above (12) -SO2 R14 where R14 is defined. Above (13) -NR9 COR10 where R9 and R10 are independently selected from each other from (14) -CONR9 R10, where R9 and R10 are set above (15) -NR9 R10, where R9 and R10 are as follows. Given above (16) -NR9 COR10, where R9 and R10 can be independently selected from each other, from (17) hydroxy (18) C1-6 Alcoxy (19) COR9, where R9 is defined above. Early (20) CO2 R9, where R9 is As defined above, R11, R12 and R13 can be selected as independent from their definitions. And which consists of compound contact of the formula (chemical formula), where R1, R2, R3, R6, R7, R8, R11, R12 and R13 are given above. With a reducing agent of hydride, which can be selected from a group containing Diisobutyl aluminum hydride lithium tri (Secdandali - Butyl) Borohydride And lithium aluminum hydride In organic solvents at low temperatures Followed by alkylation Of alcohol / alkoxides derived from wood, compounds with phenylmethyl group (which the phenyl group has been replaced with R6, R7 and R8, where R6, R7 and R8 are Set above And by selecting from the aforementioned detachment group from triflate, mycillate, tocillate, paranitrophenylsulfonate, bromo and iodos) in organic solvents at temperature low In time sufficient to produce the compound of structural formula VII.