TH2154A3 - Calcium phosphate synthesis from by-product material from animal bone gelatin industry. - Google Patents
Calcium phosphate synthesis from by-product material from animal bone gelatin industry.Info
- Publication number
- TH2154A3 TH2154A3 TH403000338U TH0403000338U TH2154A3 TH 2154 A3 TH2154 A3 TH 2154A3 TH 403000338 U TH403000338 U TH 403000338U TH 0403000338 U TH0403000338 U TH 0403000338U TH 2154 A3 TH2154 A3 TH 2154A3
- Authority
- TH
- Thailand
- Prior art keywords
- phosphate
- calcium
- formula
- dihydrate
- tetracalcium
- Prior art date
Links
- 239000001506 calcium phosphate Substances 0.000 title claims abstract 10
- QORWJWZARLRLPR-UHFFFAOYSA-H Tricalcium phosphate Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 title claims abstract 9
- 229910000389 calcium phosphate Inorganic materials 0.000 title claims abstract 5
- 235000011010 calcium phosphates Nutrition 0.000 title claims abstract 5
- 210000000988 Bone and Bones Anatomy 0.000 title abstract 3
- 108010010803 Gelatin Proteins 0.000 title abstract 3
- 239000006227 byproduct Substances 0.000 title abstract 3
- 229920000159 gelatin Polymers 0.000 title abstract 3
- 239000008273 gelatin Substances 0.000 title abstract 3
- 235000019322 gelatine Nutrition 0.000 title abstract 3
- 235000011852 gelatine desserts Nutrition 0.000 title abstract 3
- 239000000463 material Substances 0.000 title abstract 3
- 230000015572 biosynthetic process Effects 0.000 title abstract 2
- 238000003786 synthesis reaction Methods 0.000 title abstract 2
- 230000002194 synthesizing Effects 0.000 title abstract 2
- 239000011575 calcium Substances 0.000 claims abstract 8
- OYPRJOBELJOOCE-UHFFFAOYSA-N calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims abstract 3
- 229910052791 calcium Inorganic materials 0.000 claims abstract 3
- 229910052588 hydroxylapatite Inorganic materials 0.000 claims abstract 3
- OAICVXFJPJFONN-UHFFFAOYSA-N phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 claims abstract 3
- 239000011574 phosphorus Substances 0.000 claims abstract 3
- 229910052698 phosphorus Inorganic materials 0.000 claims abstract 3
- JUNWLZAGQLJVLR-UHFFFAOYSA-J Calcium pyrophosphate Chemical compound [Ca+2].[Ca+2].[O-]P([O-])(=O)OP([O-])([O-])=O JUNWLZAGQLJVLR-UHFFFAOYSA-J 0.000 claims 4
- 229940043256 Calcium Pyrophosphate Drugs 0.000 claims 3
- 235000019821 dicalcium diphosphate Nutrition 0.000 claims 3
- 239000010452 phosphate Substances 0.000 claims 3
- 235000019731 tricalcium phosphate Nutrition 0.000 claims 3
- JCAIWDXKLCEQEO-LXOWHHAPSA-N Copalyl diphosphate Natural products [P@@](=O)(OP(=O)(O)O)(OC/C=C(\CC[C@H]1C(=C)CC[C@H]2C(C)(C)CCC[C@@]12C)/C)O JCAIWDXKLCEQEO-LXOWHHAPSA-N 0.000 claims 2
- DWMSYEKNTCDAEJ-UHFFFAOYSA-F [Ca++].[Ca++].[Ca++].[Ca++].OP(O)([O-])=O.OP(O)([O-])=O.OP(O)([O-])=O.OP(O)([O-])=O.OP(O)([O-])=O.OP(O)([O-])=O.OP(O)([O-])=O.OP(O)([O-])=O Chemical compound [Ca++].[Ca++].[Ca++].[Ca++].OP(O)([O-])=O.OP(O)([O-])=O.OP(O)([O-])=O.OP(O)([O-])=O.OP(O)([O-])=O.OP(O)([O-])=O.OP(O)([O-])=O.OP(O)([O-])=O DWMSYEKNTCDAEJ-UHFFFAOYSA-F 0.000 claims 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-K [O-]P([O-])([O-])=O Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims 2
- XLYOFNOQVPJJNP-ZSJDYOACSA-N heavy water Substances [2H]O[2H] XLYOFNOQVPJJNP-ZSJDYOACSA-N 0.000 claims 2
- 229910000150 monocalcium phosphate Inorganic materials 0.000 claims 2
- 235000019691 monocalcium phosphate Nutrition 0.000 claims 2
- 229910000391 tricalcium phosphate Inorganic materials 0.000 claims 2
- 229940078499 tricalcium phosphate Drugs 0.000 claims 2
- 210000003229 CMP Anatomy 0.000 claims 1
- 229910014497 Ca10(PO4)6(OH)2 Inorganic materials 0.000 claims 1
- ROPDWRCJTIRLTR-UHFFFAOYSA-L Calcium metaphosphate Chemical compound [Ca+2].[O-]P(=O)=O.[O-]P(=O)=O ROPDWRCJTIRLTR-UHFFFAOYSA-L 0.000 claims 1
- NEFBYIFKOOEVPA-UHFFFAOYSA-K Dicalcium phosphate Chemical compound [Ca+2].[Ca+2].[O-]P([O-])([O-])=O NEFBYIFKOOEVPA-UHFFFAOYSA-K 0.000 claims 1
- 235000019739 Dicalciumphosphate Nutrition 0.000 claims 1
- LFULEKSKNZEWOE-UHFFFAOYSA-N Propanil Chemical compound CCC(=O)NC1=CC=C(Cl)C(Cl)=C1 LFULEKSKNZEWOE-UHFFFAOYSA-N 0.000 claims 1
- FUFJGUQYACFECW-UHFFFAOYSA-L calcium hydrogenphosphate Chemical compound [Ca+2].OP([O-])([O-])=O FUFJGUQYACFECW-UHFFFAOYSA-L 0.000 claims 1
- 229910000393 dicalcium diphosphate Inorganic materials 0.000 claims 1
- 229910000390 dicalcium phosphate Inorganic materials 0.000 claims 1
- 229940038472 dicalcium phosphate Drugs 0.000 claims 1
- 235000019700 dicalcium phosphate Nutrition 0.000 claims 1
- OLSDWRNWUGHKSY-UHFFFAOYSA-J dicalcium;phosphonato phosphate;dihydrate Chemical compound O.O.[Ca+2].[Ca+2].[O-]P([O-])(=O)OP([O-])([O-])=O OLSDWRNWUGHKSY-UHFFFAOYSA-J 0.000 claims 1
- 150000004683 dihydrates Chemical class 0.000 claims 1
- KBQIPTXDQGPPIO-UHFFFAOYSA-K heptacalcium;phosphate Chemical compound [Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O KBQIPTXDQGPPIO-UHFFFAOYSA-K 0.000 claims 1
- -1 phosphate DCPD dihydrate Chemical class 0.000 claims 1
- CKRORYDHXIRZCH-UHFFFAOYSA-N phosphoric acid;dihydrate Chemical compound O.O.OP(O)(O)=O CKRORYDHXIRZCH-UHFFFAOYSA-N 0.000 claims 1
- FDFYYWMHPJTGEO-UHFFFAOYSA-K tetracalcium;phosphate Chemical compound [Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O FDFYYWMHPJTGEO-UHFFFAOYSA-K 0.000 claims 1
- 235000010384 tocopherol Nutrition 0.000 claims 1
- 239000000654 additive Substances 0.000 abstract 1
- VHUUQVKOLVNVRT-UHFFFAOYSA-N ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 abstract 1
- 239000000908 ammonium hydroxide Substances 0.000 abstract 1
- 239000003462 bioceramic Substances 0.000 abstract 1
- 239000000919 ceramic Substances 0.000 abstract 1
- 239000003153 chemical reaction reagent Substances 0.000 abstract 1
- 239000007943 implant Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- GRYLNZFGIOXLOG-UHFFFAOYSA-N nitric acid Chemical compound O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 abstract 1
- 230000002588 toxic Effects 0.000 abstract 1
- 231100000331 toxic Toxicity 0.000 abstract 1
Abstract
การประดิษฐ์นี้เป็นการสังเคราะห์สารแคลเซียมฟอสเฟตที่ประกอบด้วย สัดส่วนโดยโมลของแคลเซียมต่อฟอสฟอรัส (Ca/P) ในช่วงประมาณ 1-0.5 จากวัสดุผล พลอยได้ (by-product) จากอุตสาหกรรมผลิตเจลาตินจากกระดูกสัตว์ โดยการละลายสารตั้ง ต้นที่ได้จากวัสดุผลพลอยได้ (by-product) จากอุตสาหกรรมผลิตเจลาตินจากกระดูกสัตว์ด้วย กรดไนตริก (HNO 3) แล้วตกตะกอนด้วยแอมโมเนียมไฮดรอกไซด์ (NH 4 OH) ซึ่งสาร แคลเซียมฟอสเฟตที่สังเคราะห์ได้มีราคาถูกและมีสารเจือปนที่เป็นพิษต่อร่างกายน้อย โดยมี ระดับอยู่ในมาตรฐาน ASTM Designation F 1185-88,Standard specification for Composition of Ceramic Hydroxyapatite for Surgical Implants โดยสารแคลเซียมฟอสเฟตที่ สังเคราะห์ได้สามารถนำไปใช้เป็นวัสดุไบโอเซรามิก (Bioceramic Material) ใช้งานในทาง การแพทย์และเภสัชกรรม (Biomedical Application) ได้: This invention is the synthesis of calcium phosphate containing The molar ratio of calcium to phosphorus (Ca / P) in the range of approximately 1-0.5 from the by-product material from the animal bone gelatin industry. By dissolving the reagent The plant was obtained from by-product material from the animal bone gelatin industry with nitric acid (HNO 3) and precipitated with ammonium hydroxide (NH 4 OH). It is synthetic, inexpensive and contains less toxic additives, and meets ASTM Designation F 1185-88, Standard specification for Composition of Ceramic Hydroxyapatite for Surgical Implants by calcium phosphate. Synthetic, it can be used as a bioceramic material in medical and pharmaceutical applications (Biomedical Application):
Claims (1)
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TH2154C3 TH2154C3 (en) | 2005-12-09 |
| TH2154A3 true TH2154A3 (en) | 2005-12-09 |
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